Characterization of the substrate specificity of human carboxypeptidase A4 and implications for a role in extracellular peptide processing

Journal of Biological Chemistry

Volumn 285, Issue 24, 2010, Pages 18385-18396

  Tanco, Sebastian ^a   Zhang, Xin ^b   Morano, Cain ^b   Avilés, Francesc Xavier ^a   Lorenzo, Julia ^a   Fricker, Lloyd D ^b  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC RESIDUES; CANCER CELLS; CARBOXYPEPTIDASE; CHROMOGENIC SUBSTRATE; CLEAVAGE SPECIFICITY; EXTRACELLULAR; EXTRACELLULAR ENVIRONMENTS; HYDROPHOBIC RESIDUES; IN-CELL; KINETIC ANALYSIS; MOUSE BRAIN; NEGATIVE INFLUENCE; NEUROPEPTIDES; NEUROTENSIN; NEW SERIES; PEPTIDE PROCESSING; PEPTIDOMICS; PROSTATE CANCERS; SODIUM BUTYRATE; SUBSTRATE SPECIFICITY; SYNTHETIC PEPTIDE; TERMINAL RESIDUES;

CELL PROLIFERATION; HYDROPHOBICITY; MASS SPECTROMETRY; PEPTIDES; SODIUM;

SUBSTRATES;

CARBOXYPEPTIDASE; CARBOXYPEPTIDASE A4; GLYCINE; ISOLEUCINE; LEUCINE; METHIONINE; NEUROTENSIN; OPIATE PEPTIDE; PHENYLALANINE; PROLINE; TRYPSIN; TYROSINE; UNCLASSIFIED DRUG; VALINE;

ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRAIN HEK293; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME RELEASE; ENZYME SPECIFICITY; EXTRACELLULAR SPACE; HELA CELL; HUMAN; HUMAN CELL; HYDROPHOBICITY; MASS SPECTROMETRY; MOUSE; NONHUMAN; PEPTIDOMICS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN PROCESSING; SKIN FIBROBLAST;

ANIMALS; BRAIN; CARBOXYPEPTIDASES; CARBOXYPEPTIDASES A; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; HELA CELLS; HUMANS; KINETICS; MICE; PEPTIDES; PICHIA; PROTEIN STRUCTURE, TERTIARY; PROTEOMICS; SUBSTRATE SPECIFICITY;

EID: 77953299875     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.060350     Document Type: Article

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