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Volumn 714, Issue 1-3, 2013, Pages 32-40

Mephedrone: Public health risk, mechanisms of action, and behavioral effects

Author keywords

Amphetamines; Bath salts; Mechanism; Mephedrone; Synthetic cathinone

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; 4' METHYLMETHCATHINONE; 4' METHYLMETHCATHINONE DERIVATIVE; AMPHETAMINE DERIVATIVE; COCAINE; DESIGNER DRUG; DOPAMINE; DRUG METABOLITE; METHAMPHETAMINE; METHCATHINONE; METHYLONE; SEROTONIN; UNCLASSIFIED DRUG;

EID: 84879496082     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.05.024     Document Type: Review
Times cited : (35)

References (106)
  • 1
    • 84863410323 scopus 로고    scopus 로고
    • Mephedrone, an abused psychoactive component of 'bath salts' and methamphetamine congener, does not cause neurotoxicity to dopamine nerve endings of the striatum
    • Angoa-Peréz, M., Kane, M.J., Francescutti, D.M., Sykes, K.E., Shah, M.M., Mohammed, A.M., Thomas, D.M., Kuhn, D.M., 2012. Mephedrone, an abused psychoactive component of 'bath salts' and methamphetamine congener, does not cause neurotoxicity to dopamine nerve endings of the striatum. J. Neurochem. 120, 1097-1107.
    • (2012) J. Neurochem. , vol.120 , pp. 1097-1107
    • Angoa-Peréz, M.1    Kane, M.J.2    Francescutti, D.M.3    Sykes, K.E.4    Shah, M.M.5    Mohammed, A.M.6    Thomas, D.M.7    Kuhn, D.M.8
  • 2
    • 0036720775 scopus 로고    scopus 로고
    • Changes in cardiovascular responsiveness and cardiotoxicity elicited during binge administration of ecstasy
    • Badon, LA, Hicks, A., Lord, K., Ogden, B.A., Meleg-Smith, S., Varner, K.J., 2002. Changes in cardiovascular responsiveness and cardiotoxicity elicited during binge administration of ecstasy. J. Pharmacol. Exp. Ther. 302, 898-901.
    • (2002) J. Pharmacol. Exp. Ther. , vol.302 , pp. 898-901
    • Badon, L.A.1    Hicks, A.2    Lord, K.3    Ogden, B.A.4    Meleg-Smith, S.5    Varner, K.J.6
  • 3
    • 79960590979 scopus 로고    scopus 로고
    • An analysis of legal highs - Do they contain what it says on the tin?
    • Baron, M., Elie, M., Elie, L, 2011. An analysis of legal highs - do they contain what it says on the tin? Drug Test. Anal. 3, 576-581.
    • (2011) Drug Test. Anal. , vol.3 , pp. 576-581
    • Baron, M.1    Elie, M.2    Elie, L.3
  • 4
    • 71749104455 scopus 로고    scopus 로고
    • Neural and cardiac toxicities associated with 3,4- methylenedioxymethamphetamine (MDMA)
    • Baumann, M.H., Rothmann, R.B., 2009. Neural and cardiac toxicities associated with 3,4-methylenedioxymethamphetamine (MDMA). Int Rev. Neurobiol. 88, 257-296.
    • (2009) Int Rev. Neurobiol. , vol.88 , pp. 257-296
    • Baumann, M.H.1    Rothmann, R.B.2
  • 9
    • 80052818083 scopus 로고    scopus 로고
    • Fragmentation pathways of drugs of abuse and their metabolites based on QTOF MS/MS and MSE accurate-mass spectra
    • Bijlsma, L, Sancho, J.V., Hernandez, F., Niessen, W.M.A., 2011. Fragmentation pathways of drugs of abuse and their metabolites based on QTOF MS/MS and MSE accurate-mass spectra. J. Mass Spectrom. 46, 865-875.
    • (2011) J. Mass Spectrom. , vol.46 , pp. 865-875
    • Bijlsma, L.1    Sancho, J.V.2    Hernandez, F.3    Niessen, W.M.A.4
  • 10
    • 0038741972 scopus 로고    scopus 로고
    • Short- and long-term effects of MDMA ("ecstasy") on synaptosomal and vesicular uptake of neurotransmitters in vitro and ex vivo
    • DOI 10.1016/S0197-0186(03)00027-5
    • Bogen, I.L., Haug, K.H., Myhre, O., Fonnum, F., 2003. Short-and long-term effects of MDMA ("ecstasy,") on synaptosomal and vesicular uptake of neurotransmitters in vitro and ex vivo. Neurochem. Int 43, 393-400. (Pubitemid 36561293)
    • (2003) Neurochemistry International , vol.43 , Issue.4-5 , pp. 393-400
    • Bogen, I.L.1    Haug, K.H.2    Myhre, O.3    Fonnum, F.4
  • 11
    • 77956642096 scopus 로고    scopus 로고
    • Analyses of second generation 'legal highs' in the UK: Initial findings
    • Brandt, S.D., Sumnall, H.R., Measham, F., Cole, J., 2010. Analyses of second generation 'legal highs' in the UK: initial findings. Drug Test. Anal 2, 377-381.
    • (2010) Drug Test. Anal , vol.2 , pp. 377-381
    • Brandt, S.D.1    Sumnall, H.R.2    Measham, F.3    Cole, J.4
  • 12
    • 83455205712 scopus 로고    scopus 로고
    • Instability of the ecstasy market and a new kid on the block: Mephedrone
    • Brunt, T.M., Poortman, A., Niesink, R.J.M., van den Vrink, W., 2011. Instability of the ecstasy market and a new kid on the block: mephedrone. J. Psychopharmacol. 25, 1543-1547.
    • (2011) J. Psychopharmacol. , vol.25 , pp. 1543-1547
    • Brunt, T.M.1    Poortman, A.2    Niesink, R.J.M.3    Van Den Vrink, W.4
  • 13
    • 84878885272 scopus 로고    scopus 로고
    • Bath salts components mephedrone and methylenedioxypyrovalerone (MDPV) act syner-gistically at the human dopamine transporter
    • Cameron, K.N., Kolanos, R., Solis, E., Glennon, RA, De Felice, L.J., 2012. Bath salts components mephedrone and methylenedioxypyrovalerone (MDPV) act syner-gistically at the human dopamine transporter. Br. J. Pharmacol.
    • (2012) Br. J. Pharmacol
    • Cameron, K.N.1    Kolanos, R.2    Solis, E.3    Glennon, R.A.4    De Felice, L.J.5
  • 14
    • 84878115326 scopus 로고    scopus 로고
    • Mephedrone and methylenedioxypyrovalerone (MDPV), major constituents of "bath salts," produce opposite effects at the human dopamine transporter
    • (ePub)
    • Cameron, K., Kolanos, R., Verkariya, R., De Felice, L, Glennon, R.A., 2013. Mephedrone and methylenedioxypyrovalerone (MDPV), major constituents of "bath salts," produce opposite effects at the human dopamine transporter. Psycho-pharmacology. (ePub).
    • (2013) Psycho-pharmacology
    • Cameron, K.1    Kolanos, R.2    Verkariya, R.3    De Felice, L.4    Glennon, R.A.5
  • 17
    • 84862151728 scopus 로고    scopus 로고
    • Activity and biotransformation of three synthetic "legal highs,": Mephedrone, methylone, and 3,4-methylenodioxypyrovalerone
    • Ciechomska, M., Wozniakiewicz, M., Wietecha-Posluszny, R., 2012. Activity and biotransformation of three synthetic "legal highs,": mephedrone, methylone, and 3,4-methylenodioxypyrovalerone. Prob. Forensic Sci. 89, 71-85.
    • (2012) Prob. Forensic Sci. , vol.89 , pp. 71-85
    • Ciechomska, M.1    Wozniakiewicz, M.2    Wietecha-Posluszny, R.3
  • 19
    • 34248201610 scopus 로고    scopus 로고
    • Interpretation of oral fluid tests for drugs of abuse
    • Cone, E.J., Huestis, M.A., 2007. Interpretation of oral fluid tests for drugs of abuse. Ann. N.Y. Acad. Sci., 1098.
    • (2007) Ann. N.Y. Acad. Sci. , pp. 1098
    • Cone, E.J.1    Huestis, M.A.2
  • 20
    • 84859628524 scopus 로고    scopus 로고
    • Synthetic cathinones: Chemistry, pharmacology and toxicology of a new class of designer drugs of abuse marketed as "bath salts" or "plant food,"
    • Coppola, M., Mondola, R., 2012. Synthetic cathinones: chemistry, pharmacology and toxicology of a new class of designer drugs of abuse marketed as "bath salts" or "plant food,". Toxicol. Lett. 211, 144-149.
    • (2012) Toxicol. Lett. , vol.211 , pp. 144-149
    • Coppola, M.1    Mondola, R.2
  • 21
    • 84857653369 scopus 로고    scopus 로고
    • Regional c-fos and FosB/AFosB expression associated with chronic methamphetamine self-administration and methamphetamine-seeking behavior in rats
    • Cornish, J.L., Hunt, G.E., Robins, L., McGregor, I.S., 2012. Regional c-Fos and FosB/AFosB expression associated with chronic methamphetamine self-administration and methamphetamine-seeking behavior in rats. Neuroscience 206, 100-114.
    • (2012) Neuroscience , vol.206 , pp. 100-114
    • Cornish, J.L.1    Hunt, G.E.2    Robins, L.3    McGregor, I.S.4
  • 23
    • 0346874451 scopus 로고    scopus 로고
    • Methcathinone is a Substrate for the Serotonin Uptake Transporter
    • DOI 10.1046/j.1600-0773.2003.pto930504.x
    • Cozzi, N.V., Foley, K.F., 2003. Methcathinone is a substrate for the serotonin uptake transporter. Pharmacol. Toxicol. 93, 219-225. (Pubitemid 37521958)
    • (2003) Pharmacology and Toxicology , vol.93 , Issue.5 , pp. 219-225
    • Cozzi, N.V.1    Foley, K.F.2
  • 24
    • 0032856963 scopus 로고    scopus 로고
    • Inhibition of plasma membrane monoamine transporters by β- ketoamphetamines
    • DOI 10.1016/S0014-2999(99)00538-5, PII S0014299999005385
    • Cozzi, N.V., Sievert, M.K., Shulgin, A.T., Jacob III, P., Ruoho, A.E., 1999. Inhibition of plasma membrane monoamine transporters by b-ketoamphetamines. Eur. J. Pharmacol. 381, 63-69. (Pubitemid 29488590)
    • (1999) European Journal of Pharmacology , vol.381 , Issue.1 , pp. 63-69
    • Cozzi, N.V.1    Sievert, M.K.2    Shulgin, A.T.3    Jacob III, P.4    Ruoho, A.E.5
  • 25
    • 0025882430 scopus 로고
    • Monoamine reuptake inhibitors enhance the discriminative state induced by cocaine in the rat
    • Cunningham, K.A., Callahan, P.M., 1991. Monoamine reuptake inhibitors enhance the discriminative state induced by cocaine in the rat. Psychopharmacology 104, 177-180.
    • (1991) Psychopharmacology , vol.104 , pp. 177-180
    • Cunningham, K.A.1    Callahan, P.M.2
  • 26
    • 79960626573 scopus 로고    scopus 로고
    • The pharmacology and toxicology of the synthetic cathinone mephedrone (4-methylmethcathinone)
    • Dargan, P.I., Sedefov, R., Gallegos, A., Wood, D.M., 2011. The pharmacology and toxicology of the synthetic cathinone mephedrone (4-methylmethcathinone). Drug Test. Anal. 3, 454-464.
    • (2011) Drug Test. Anal. , vol.3 , pp. 454-464
    • Dargan, P.I.1    Sedefov, R.2    Gallegos, A.3    Wood, D.M.4
  • 27
    • 0034882387 scopus 로고    scopus 로고
    • Methamphetamine neurotoxicity: Necrotic and apoptotic mechanisms and relevance to human abuse and treatment
    • DOI 10.1016/S0165-0173(01)00054-6, PII S0165017301000546
    • Davidson, C, Gow, A.J., Lee, T.H., Ellinwood, E.H., 2001. Methamphetamine neurotoxicity: necrotic and apoptotic mechanisms and relevance to human abuse and treatment. Brain Res. Rev. 36, 1-22. (Pubitemid 32763126)
    • (2001) Brain Research Reviews , vol.36 , Issue.1 , pp. 1-22
    • Davidson, C.1    Gow, A.J.2    Lee, T.H.3    Ellinwood, E.H.4
  • 28
    • 84866998018 scopus 로고    scopus 로고
    • Cardiovascular toxicity of novel psychoactive drugs: Lessons from the past
    • Dawson, P., Moffatt, J.D., 2012. Cardiovascular toxicity of novel psychoactive drugs: lessons from the past. Prog. Neuropsychopharmacol. Biol. Psychiatry 39, 244-252.
    • (2012) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.39 , pp. 244-252
    • Dawson, P.1    Moffatt, J.D.2
  • 30
    • 77953870712 scopus 로고    scopus 로고
    • Multiple-drug toxicity caused by the coadministration of 4-methylmethcathinone (mephedrone) and heroin
    • Dickson, A.J., Vorce, S.P., Levine, B., Past, M.R., 2010. Multiple-drug toxicity caused by the coadministration of 4-methylmethcathinone (mephedrone) and heroin. J. Anal. Toxicol. 34, 162-168.
    • (2010) J. Anal. Toxicol. , vol.34 , pp. 162-168
    • Dickson, A.J.1    Vorce, S.P.2    Levine, B.3    Past, M.R.4
  • 31
    • 84872684371 scopus 로고    scopus 로고
    • Illegal drug impersonators: The synthetic drug abuse boom
    • Falkowski, C, 2011. Illegal drug impersonators: the synthetic drug abuse boom. Minn. Med. 94, 52.
    • (2011) Minn. Med. , vol.94 , pp. 52
    • Falkowski, C.1
  • 33
    • 84857626061 scopus 로고    scopus 로고
    • Cognitive and subjective effects of mephedrone and factors influencing use of a 'new legal high'
    • Freeman, T.P., Morgan, C.J., Vaughn-Jones, J., Hussain, N., Karimi, K., Curran, H.V., 2012. Cognitive and subjective effects of mephedrone and factors influencing use of a 'new legal high'. Addiction 107, 792-800.
    • (2012) Addiction , vol.107 , pp. 792-800
    • Freeman, T.P.1    Morgan, C.J.2    Vaughn-Jones, J.3    Hussain, N.4    Karimi, K.5    Curran, H.V.6
  • 35
    • 4644282282 scopus 로고    scopus 로고
    • A review of the mechanisms involved in the acute MDMA (ecstasy)-induced hyperthermic response
    • DOI 10.1016/j.ejphar.2004.07.006, PII S0014299904007150
    • Green, A.R., O'Shea, E., Colado, M.I., 2004a. A review of the mechanisms involved in the acute MDMA (ecstasy)-induced hyperthermic response. Eur. J. Pharmacol 500, 3-13. (Pubitemid 39303992)
    • (2004) European Journal of Pharmacology , vol.500 , Issue.SPEC. ISS. , pp. 3-13
    • Green, A.R.1    O'Shea, E.2    Colado, M.I.3
  • 36
    • 2542597616 scopus 로고    scopus 로고
    • Effect of ambient temperature and a prior neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA) on the hyperthermic responce of rats to a single or ('binge' ingestion) low of MDMA
    • DOI 10.1007/s00213-003-1725-2
    • Green, A.R., Sanchez, V., O'Shea, E., Saadat, K.S., Elliott, J.M., Colado, M.I., 2004b. Effect of ambient temperature and a prior neurotoxic dose of 3,4-methylene-dioxymethamphetamine (MDMA) on the hyperthermic response of rats to a single or repeated ('binge' ingestion) low dose of MDMA. Psychopharmacology 173, 264-269. (Pubitemid 38703799)
    • (2004) Psychopharmacology , vol.173 , Issue.3-4 , pp. 264-269
    • Green, A.R.1    Sanchez, V.2    O'Shea, E.3    Saadat, K.S.4    Elliott, J.M.5    Colado, M.I.6
  • 39
    • 79960773236 scopus 로고    scopus 로고
    • Clinical characteristics of mephedrone toxicity reported to the UK national poisons information service
    • James, D., Adams, R.D., Spears, R., Cooper, G., Lupton, D.J., Thompson, J.P., Thomas, S. H.L, 2011. Clinical characteristics of mephedrone toxicity reported to the UK National Poisons Information Service. Emerg. Med. J. 28, 686-689.
    • (2011) Emerg. Med. J. , vol.28 , pp. 686-689
    • James, D.1    Adams, R.D.2    Spears, R.3    Cooper, G.4    Lupton, D.J.5    Thompson, J.P.6    Thomas, S.H.L.7
  • 40
    • 0023919322 scopus 로고
    • Cocaine: Analysis, pharmacokinetics, and metabolic disposition
    • Jatlow, P., 1988. Cocaine: analysis, pharmacokinetics, and metabolic disposition. Yale J. Biol. Med. 61, 105.
    • (1988) Yale J. Biol. Med. , vol.61 , pp. 105
    • Jatlow, P.1
  • 41
    • 84863009341 scopus 로고    scopus 로고
    • Synthetic legal intoxicating drugs: The emerging 'incense' and 'bath salt' phenomenon
    • Jerry, J., Collins, G., Streem, D., 2012. Synthetic legal intoxicating drugs: the emerging 'incense' and 'bath salt' phenomenon. Cleve. Clin. J. Med. 79, 258-264.
    • (2012) Cleve. Clin. J. Med. , vol.79 , pp. 258-264
    • Jerry, J.1    Collins, G.2    Streem, D.3
  • 42
    • 0025918369 scopus 로고
    • H monoamine releasing and uptake inhibition properties of 3,4-methylenedioxymethamphetamine and p-chlor-oamphetamine analogues
    • Johnson, M.P., Conarty, P.F., Nichols, D.E., 1991. H Monoamine releasing and uptake inhibition properties of 3,4-methylenedioxymethamphetamine and p-chlor-oamphetamine analogues. Eur. J. Pharmacol. 200, 9-16.
    • (1991) Eur. J. Pharmacol. , vol.200 , pp. 9-16
    • Johnson, M.P.1    Conarty, P.F.2    Nichols, D.E.3
  • 43
    • 0032521354 scopus 로고    scopus 로고
    • Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter
    • Jones, S.R., Gainetdinov, R.R., Wightman, R.M., Caron, M.G., 1998. Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter. J. Neurosci. 18, 1979-1986. (Pubitemid 28141404)
    • (1998) Journal of Neuroscience , vol.18 , Issue.6 , pp. 1979-1986
    • Jones, S.R.1    Gainetdinov, R.R.2    Mark Wightman, R.3    Caron, M.G.4
  • 44
    • 57049121885 scopus 로고    scopus 로고
    • Simultaneous analysis of new designer drug, methylone, and its metabolites in urine by gas chromatography mass spectrometry and liquid chromatography - Electrospray ionization mass spectrometry
    • Kamata, H.T., Shima, N., Zaiksu, K., Kamata, T., Nishikawa, M., Katagi, M., Miki, A., Tsuchihashi, H., 2007. Simultaneous analysis of new designer drug, methylone, and its metabolites in urine by gas chromatography mass spectrometry and liquid chromatography - electrospray ionization mass spectrometry. Jpn. J. Forensic Sci. Technol 12, 97-106.
    • (2007) Jpn. J. Forensic Sci. Technol , vol.12 , pp. 97-106
    • Kamata, H.T.1    Shima, N.2    Zaiksu, K.3    Kamata, T.4    Nishikawa, M.5    Katagi, M.6    Miki, A.7    Tsuchihashi, H.8
  • 45
    • 80053422684 scopus 로고    scopus 로고
    • GHB and synthetic cathinones - Clinical effects and potential consequences
    • Karila, L., Reynaud, M., 2011. GHB and synthetic cathinones - clinical effects and potential consequences. Drug Test. Anal 3, 552-559.
    • (2011) Drug Test. Anal , vol.3 , pp. 552-559
    • Karila, L.1    Reynaud, M.2
  • 46
    • 80054792045 scopus 로고    scopus 로고
    • Mephedrone, compared to MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and serotonin levels in nucleus accumbens of awake rats
    • Kehr, J., Ichinose, F., Yoshitake, S., Goiny, M., Sievertsson, T., Nyberg, F., Yoshitake, T, 2011. Mephedrone, compared to MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and serotonin levels in nucleus accumbens of awake rats. Br. J. Pharmacol. 164, 1949-1958.
    • (2011) Br. J. Pharmacol. , vol.164 , pp. 1949-1958
    • Kehr, J.1    Ichinose, F.2    Yoshitake, S.3    Goiny, M.4    Sievertsson, T.5    Nyberg, F.6    Yoshitake, T.7
  • 47
    • 85030416360 scopus 로고    scopus 로고
    • Elucidation of the phase I and phase II metabolic pathways of (±)-4'-methylmethcathinone (4-MMC) and (±)-4'-(trifluoromethyl) methcathinone (4-TFMMC) in rat liver hepatocytes using LC-MS and LC-MS
    • Khreit, O.I., Grant, M.H., Zhang, T., Henderson, C, Watson, D.G., Sutcliffe, O.B., 2012. Elucidation of the Phase I and Phase II metabolic pathways of (±)-4'-methylmethcathinone (4-MMC) and (±)-4'- (trifluoromethyl) methcathinone (4-TFMMC) in rat liver hepatocytes using LC-MS and LC-MS. J. Pharmaceut. Biomed. Anal.
    • (2012) J. Pharmaceut. Biomed. Anal.
    • Khreit, O.I.1    Grant, M.H.2    Zhang, T.3    Henderson, C.4    Watson, D.G.5    Sutcliffe, O.B.6
  • 48
    • 74149089780 scopus 로고    scopus 로고
    • Antagonists and substrates differentially regulate serotonin transporter cell surface expression in serotonergic neurons
    • Kittler, K., Lau, T., Schloss, P., 2010. Antagonists and substrates differentially regulate serotonin transporter cell surface expression in serotonergic neurons. Eur. J. Pharmacol. 629, 63-67.
    • (2010) Eur. J. Pharmacol. , vol.629 , pp. 63-67
    • Kittler, K.1    Lau, T.2    Schloss, P.3
  • 49
    • 77952889355 scopus 로고    scopus 로고
    • MDMA causes a redistribution of serotonin transporter from the cell surface to the intracellular compartment by a mechanism independent of phospho-p38-mitogen activated protein kinase activation
    • Kivell, B., Day, D., Bosch, P., Schenk, S., Miller, J., 2010. MDMA causes a redistribution of serotonin transporter from the cell surface to the intracellular compartment by a mechanism independent of phospho-p38-mitogen activated protein kinase activation. Neuroscience 168, 82-95.
    • (2010) Neuroscience , vol.168 , pp. 82-95
    • Kivell, B.1    Day, D.2    Bosch, P.3    Schenk, S.4    Miller, J.5
  • 50
    • 0032553621 scopus 로고    scopus 로고
    • Nature of methamphetamine-induced rapid and reversible changes in dopamine transporters
    • DOI 10.1016/S0014-2999(98)00741-9, PII S0014299998007419
    • Kokoshka, J.M., Vaughan, R.A., Hanson, G.R., Fleckenstein, A.E., 1998. Nature of methamphetamine-induced rapid and reversible changes in dopamine transporters. Eur. J. Pharmacol. 361, 269-275. (Pubitemid 29000982)
    • (1998) European Journal of Pharmacology , vol.361 , Issue.2-3 , pp. 269-275
    • Kokoshka, J.M.1    Vaughan, R.A.2    Hanson, G.R.3    Fleckenstein, A.E.4
  • 51
    • 0023763088 scopus 로고
    • Cellular and molecular mechanisms of drug dependence
    • Koob, G.F., Bloom, F.E., 1988. Cellular and molecular mechanisms of drug dependence. Science 242, 715-723.
    • (1988) Science , vol.242 , pp. 715-723
    • Koob, G.F.1    Bloom, F.E.2
  • 53
    • 84867893013 scopus 로고    scopus 로고
    • Mephedrone ('bath salt') elicits conditioned place preference and dopamine-sensitive motor activation
    • Lisek, R., Xu, W, Yuvasheva, E., Chiu, Y, Reitz, A.B., Liu-Chen, L., Rawls, S.M., 2012. Mephedrone ('bath salt') elicits conditioned place preference and dopamine-sensitive motor activation. Drug Alcohol Depen 126, 257-262.
    • (2012) Drug Alcohol Depen , vol.126 , pp. 257-262
    • Lisek, R.1    Xu, W.2    Yuvasheva, E.3    Chiu, Y.4    Reitz, A.B.5    Liu-Chen, L.6    Rawls, S.M.7
  • 54
    • 84862133102 scopus 로고    scopus 로고
    • Bath salt-induced agitated paranoia: A case series
    • Loeffler, G., Penn, A., Ledden, B., 2012. Bath salt-induced agitated paranoia: a case series. J. Stud. Alcohol Drugs 73, 706.
    • (2012) J. Stud. Alcohol Drugs , vol.73 , pp. 706
    • Loeffler, G.1    Penn, A.2    Ledden, B.3
  • 55
    • 84865424242 scopus 로고    scopus 로고
    • Comparative neuropharmacology of three psychostimulant cathinone derivatives: Butylone, mephedrone and methylone
    • Lopez-Arnua, R., Martinez-Clemente, J., Pubill, D., Escubedo, E., Camarasa, J., 2012. Comparative neuropharmacology of three psychostimulant cathinone derivatives: butylone, mephedrone and methylone. Br. J. Pharmacol. 167, 407-420.
    • (2012) Br. J. Pharmacol. , vol.167 , pp. 407-420
    • Lopez-Arnua, R.1    Martinez-Clemente, J.2    Pubill, D.3    Escubedo, E.4    Camarasa, J.5
  • 56
    • 84867232376 scopus 로고    scopus 로고
    • Effects of synthetic cathinones contained in "bath salts," on motor behavior and a functional observational battery in mice
    • Marusich, JA, Grant, K.R., Blough, B.E., Wiley, J.E., 2012. Effects of synthetic cathinones contained in "bath salts," on motor behavior and a functional observational battery in mice. Neurotoxicology 33, 1303-1315.
    • (2012) Neurotoxicology , vol.33 , pp. 1303-1315
    • Marusich, J.A.1    Grant, K.R.2    Blough, B.E.3    Wiley, J.E.4
  • 58
    • 85030404667 scopus 로고    scopus 로고
    • Clinical toxicology and management of intoxications with synthetic cathinones ("bath salts,")
    • Mas-Morey, P., Visser, M.H.M., Winkelmolen, L., Touw, D.J., 2012. Clinical toxicology and management of intoxications with synthetic cathinones ("bath salts,"). J. Pharm. Pract. (Epub).
    • (2012) J. Pharm. Pract. (Epub)
    • Mas-Morey, P.1    Visser, M.H.M.2    Winkelmolen, L.3    Touw, D.J.4
  • 59
    • 0032531781 scopus 로고    scopus 로고
    • 11C]WIN-35,428
    • McCann, U.D., Wong, D.F., Yokoi, F., Villemagne, V., Dannals, R.F., Ricuarte, G.A., 1998. Reduced striatal dopamine transporter density in abstinent methamphetamine and methcathinone users: evidence from positron emission tomography studies with [11C]WIN-35,428. J. Neurosci. 18, 8417-8422. (Pubitemid 28465016)
    • (1998) Journal of Neuroscience , vol.18 , Issue.20 , pp. 8417-8422
    • McCann, U.D.1    Wong, D.F.2    Yokoi, F.3    Villemagne, V.4    Dannals, R.F.5    Ricaurte, G.A.6
  • 60
    • 79953040907 scopus 로고    scopus 로고
    • Experiences with mephedrone pre-and post-legislative controls: Perceptions of safety and sources of supply
    • McElrath, K., O'Neill, C, 2011. Experiences with mephedrone pre-and post-legislative controls: perceptions of safety and sources of supply. Int. J. Drug Policy 22, 120-127.
    • (2011) Int. J. Drug Policy , vol.22 , pp. 120-127
    • McElrath, K.1    O'Neill, C.2
  • 61
    • 84866487793 scopus 로고    scopus 로고
    • The coingestion of alcohol and mephedreon - An emerging cause of acute medical admissions in young adults and a potential cause of tachyarrhythmias
    • McGaw, C, Kankam, O., 2010. The coingestion of alcohol and mephedreon - an emerging cause of acute medical admissions in young adults and a potential cause of tachyarrhythmias. West London Med. J 2, 9-13.
    • (2010) West London Med. J , vol.2 , pp. 9-13
    • McGaw, C.1    Kankam, O.2
  • 62
    • 80355125371 scopus 로고    scopus 로고
    • Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the rat
    • Meng, H., Cao, J., Kang, J., Ying, X., Ji, J., Reynolds, W., Rampe, W, 2012. Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the rat. Toxicol. Lett. 208, 62-68.
    • (2012) Toxicol. Lett. , vol.208 , pp. 62-68
    • Meng, H.1    Cao, J.2    Kang, J.3    Ying, X.4    Ji, J.5    Reynolds, W.6    Rampe, W.7
  • 63
    • 77953493759 scopus 로고    scopus 로고
    • Metabolism of designer drugs of abuse: An updated review
    • Meyer, M., Maurer, H., 2010. Metabolism of designer drugs of abuse: an updated review. Curr. Drug Metab. 11, 468-482.
    • (2010) Curr. Drug Metab. , vol.11 , pp. 468-482
    • Meyer, M.1    Maurer, H.2
  • 64
    • 54349126394 scopus 로고    scopus 로고
    • The role of human hepatic cytochrome P450 isozymes in the metabolism of racemic 3,4-methylenedioxymethamphe-tamine and its enantiomers
    • Meyer, M.R., Peters, F.T., Maurer, H.H., 2008. The role of human hepatic cytochrome P450 isozymes in the metabolism of racemic 3,4- methylenedioxymethamphe-tamine and its enantiomers. Drug Metab. Dispos. 36, 2345-2354.
    • (2008) Drug Metab. Dispos. , vol.36 , pp. 2345-2354
    • Meyer, M.R.1    Peters, F.T.2    Maurer, H.H.3
  • 65
    • 77953475735 scopus 로고    scopus 로고
    • Beta-keto amphetamines: Studies on the metabolism of the designer drug mephedrone and toxicological detection of mephedrone, butylone, and methylone in urine using gas chromatography-mass spectrometry
    • Meyer, M.R., Wilhelm, J., Peters, F.T., Maurer, H.H., 2010. Beta-keto amphetamines: studies on the metabolism of the designer drug mephedrone and toxicological detection of mephedrone, butylone, and methylone in urine using gas chromatography-mass spectrometry. Anal. Bioanal. Chem. 397, 1225-1233.
    • (2010) Anal. Bioanal. Chem. , vol.397 , pp. 1225-1233
    • Meyer, M.R.1    Wilhelm, J.2    Peters, F.T.3    Maurer, H.H.4
  • 66
    • 79958740730 scopus 로고    scopus 로고
    • Behavioral and rewarding effects of methylone, an analog of MDMA in mice
    • Miyazawa, M., Kojima, T., Nakaji, S., 2011. Behavioral and rewarding effects of methylone, an analog of MDMA in mice. Hirosaki Igaku 62, 56-71.
    • (2011) Hirosaki Igaku , vol.62 , pp. 56-71
    • Miyazawa, M.1    Kojima, T.2    Nakaji, S.3
  • 67
    • 84857652623 scopus 로고    scopus 로고
    • Mephedrone (4-methylmethcathinone, 'meow'): Acute behavioral effects and distribution of fos expression in adolescent rats
    • Motbey, C.P., Hunt, G.E., Bowen, M.T., Artiss, S., McGregor, I.S., 2011. Mephedrone (4-methylmethcathinone, 'meow'): acute behavioral effects and distribution of Fos expression in adolescent rats. Addict. Biol. 17, 409-422.
    • (2011) Addict. Biol. , vol.17 , pp. 409-422
    • Motbey, C.P.1    Hunt, G.E.2    Bowen, M.T.3    Artiss, S.4    McGregor, I.S.5
  • 69
    • 33847113912 scopus 로고    scopus 로고
    • The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain
    • DOI 10.1016/j.ejphar.2006.11.075, PII S0014299906013811
    • Nagai, F., Nonaka, R., Satoh Hishashi Kamimura, K., 2007. The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain. Eur. J. Pharmacol 559, 132-137. (Pubitemid 46295399)
    • (2007) European Journal of Pharmacology , vol.559 , Issue.2-3 , pp. 132-137
    • Nagai, F.1    Nonaka, R.2    Satoh Hisashi Kamimura, K.3
  • 70
    • 28044462059 scopus 로고    scopus 로고
    • (Report No. DOT HS 809 725)
    • National Highway Traffic Safety Administration, 2004. Drugs and Human Performance Fact Sheet. (Report No. DOT HS 809 725). Retrieved from: (www.nhtsa.gov/people/injury/research/job185drugs/drugs-web.pdf).
    • (2004) Drugs and Human Performance Fact Sheet
  • 71
    • 84885426489 scopus 로고    scopus 로고
    • Epidemiologic trends in drug abuse
    • National Institute on Drug Abuse
    • National Institute on Drug Abuse, 2011. Epidemiologic trends in drug abuse. In: Proceedings of the Community Epidemiology Work Group. Retrieved from: (www.drugabuse.gov/sites/default/%20files/cewgjune2011-vol-ii-508.pdf).
    • (2011) Proceedings of the Community Epidemiology Work Group
  • 73
    • 84908504370 scopus 로고    scopus 로고
    • Cognitive impairments in drug addicts, brain damage
    • Gonzalez-Quevedo, A. (Ed.) InTech
    • Nyberg, F., 2012. Cognitive impairments in drug addicts, brain damage. In: Gonzalez-Quevedo, A. (Ed.), Bridging Between Basic Research and Clinics. InTech.
    • (2012) Bridging Between Basic Research and Clinics
    • Nyberg, F.1
  • 75
    • 33748588942 scopus 로고    scopus 로고
    • Escalating dose pretreatment induces pharmacodynamic and not pharmacokinetic tolerance to a subsequent high-dose methamphetamine binge
    • DOI 10.1002/syn.20320
    • O'Neil, M.L, Kuczenski, R., Segal, D.S., Cho, A.K., Lacan, G., Melega, W.P., 2006. Escalating dose pretreatment induces pharmacodynamic and not pharmacokinetic tolerance to a subsequent high-dose methamphetamine binge. Synapse 60, 465-473. (Pubitemid 44380158)
    • (2006) Synapse , vol.60 , Issue.6 , pp. 465-473
    • O'Neil, M.L.1    Kuczenski, R.2    Segal, D.S.3    Cho, A.K.4    Lacan, G.5    Melega, W.P.6
  • 77
    • 77957223512 scopus 로고    scopus 로고
    • Psychonaut WebMapping Research Group King's College London, London UK
    • Psychonaut WebMapping Research Group, 2009. Mephedrone Report: Institute of Psychiatry. King's College London, London UK
    • (2009) Mephedrone Report: Institute of Psychiatry
  • 79
    • 84863517250 scopus 로고    scopus 로고
    • Mephedrone (4-methylmathcathinone and intracranial self-stimulation in C57BL/6 J mice: Comparison to cocaine
    • Robinson, J.E., Agoglia, A.E., Fish, E.W, Krouse, M.C., Malanga, C.J., 2012. Mephedrone (4-methylmathcathinone and intracranial self-stimulation in C57BL/6 J mice: comparison to cocaine. Behav. Brain Res. 234, 76-81.
    • (2012) Behav. Brain Res. , vol.234 , pp. 76-81
    • Robinson, J.E.1    Agoglia, A.E.2    Fish, E.W.3    Krouse, M.C.4    Malanga, C.J.5
  • 80
    • 0035218082 scopus 로고    scopus 로고
    • Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin
    • Rothman, R.B., Baumann, M.H., Dersch, CM., Romero, D.V., Rice, K.C., Carroll, F.I., Partilla, J.S., 2001. Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin. Synapse 39, 32-41.
    • (2001) Synapse , vol.39 , pp. 32-41
    • Rothman, R.B.1    Baumann, M.H.2    Dersch, C.M.3    Romero, D.V.4    Rice, K.C.5    Carroll, F.I.6    Partilla, J.S.7
  • 83
    • 79953647218 scopus 로고    scopus 로고
    • Mephedrone (4-methylmethcathinone;'meow meow'): Chemical, pharmacological and clinical issues
    • Schifano, F., Albanese, A., Fergus, S., Stair, J.L, DeLuca, P., Corazza, O., 2011. Mephedrone (4-methylmethcathinone;'meow meow'): chemical, pharmacological and clinical issues. Psychopharmacology 214, 593-602.
    • (2011) Psychopharmacology , vol.214 , pp. 593-602
    • Schifano, F.1    Albanese, A.2    Fergus, S.3    Stair, J.L.4    DeLuca, P.5    Corazza, O.6
  • 84
    • 70350449261 scopus 로고    scopus 로고
    • Extended methamphetamine self-administration in rats results in a selective reduction of dopamine transporter levels in the prefrontal cortex and dorsal striatum not accumpanied by marked monoaminergic depletion
    • Schwendt, M., Rocha, A., See, R.E., Pacchioni, A.M., McGinty, J.F., Kalivas, P.W, 2009. Extended methamphetamine self-administration in rats results in a selective reduction of dopamine transporter levels in the prefrontal cortex and dorsal striatum not accumpanied by marked monoaminergic depletion. J. Pharmacol. Exper. Ther 331, 555-562.
    • (2009) J. Pharmacol. Exper. Ther , vol.331 , pp. 555-562
    • Schwendt, M.1    Rocha, A.2    See, R.E.3    Pacchioni, A.M.4    McGinty, J.F.5    Kalivas, P.W.6
  • 85
    • 68949109862 scopus 로고    scopus 로고
    • Direct analysis of conjugate metabolites of methamphetamine, 3,4-methylenedioxymethamphetamine, and their designer drugs in biological fluids
    • Shima, N., Katagi, M., Tsuchihashi, H., 2009. Direct analysis of conjugate metabolites of methamphetamine, 3,4-methylenedioxymethamphetamine, and their designer drugs in biological fluids. J. Health Sci. 55, 495-502.
    • (2009) J. Health Sci. , vol.55 , pp. 495-502
    • Shima, N.1    Katagi, M.2    Tsuchihashi, H.3
  • 86
    • 84872908982 scopus 로고    scopus 로고
    • Differential effects of cathinone compounds and MDMA on body temperature in the rat, and pharmacological characterization of mephedrone-induced hypothermia
    • Shortall, S.E., Green, A.R., Swift, K.M., Fone, K.C.F., King, M.V., 2013. Differential effects of cathinone compounds and MDMA on body temperature in the rat, and pharmacological characterization of mephedrone-induced hypothermia. Br. J. Pharmacol. 168, 966-977.
    • (2013) Br. J. Pharmacol. , vol.168 , pp. 966-977
    • Shortall, S.E.1    Green, A.R.2    Swift, K.M.3    Fone, K.C.F.4    King, M.V.5
  • 89
    • 84885429688 scopus 로고    scopus 로고
    • Ecstasy returns and the emerging class of drugs
    • October. National Drug and Alcohol Research Centre, University of New South Wales, Sydney
    • Sindicich, N., Burns, L, 2012. Ecstasy returns and the emerging class of drugs, EDRS Drug Trends Bulletin, October. National Drug and Alcohol Research Centre, University of New South Wales, Sydney p. 2012.
    • (2012) EDRS Drug Trends Bulletin , pp. 2012
    • Sindicich, N.1    Burns, L.2
  • 91
    • 0023228746 scopus 로고
    • 3H] monoamines into synaptosomes from different regions of rat brain
    • DOI 10.1016/0006-2952(87)90594-6
    • Steele, T.D., Nichols, D.E., Yim, G.K., 1987. Stereochemical effects of 3,4-methylene-dioxymethamphetamine MDMA and related amphetamine derivatives on inhibition of uptake of H monoamines into synaptosomes from different regions of rat brain. Biochem. Pharmacol 36, 2297-2303. (Pubitemid 17097404)
    • (1987) Biochemical Pharmacology , vol.36 , Issue.14 , pp. 2297-2303
    • Steele, T.D.1    Nichols, D.E.2    Yim, G.K.W.3
  • 92
    • 84855920424 scopus 로고    scopus 로고
    • Serotonin syndrome
    • Thanacoody, R., 2012. Serotonin syndrome. Medicine 40, 63-64.
    • (2012) Medicine , vol.40 , pp. 63-64
    • Thanacoody, R.1
  • 93
    • 65949093297 scopus 로고    scopus 로고
    • Increases in cytoplasmic dopamine compromise the normal resistance of the nucleus accum-bens to methamphetamine neurotoxicity
    • Thomas, D.M., Francescutti-Verbeem, D.M., Kuhn, D.M., 2009. Increases in cytoplasmic dopamine compromise the normal resistance of the nucleus accum-bens to methamphetamine neurotoxicity. J. Neurochem. 109, 1745-1755.
    • (2009) J. Neurochem. , vol.109 , pp. 1745-1755
    • Thomas, D.M.1    Francescutti-Verbeem, D.M.2    Kuhn, D.M.3
  • 94
    • 59649128018 scopus 로고    scopus 로고
    • Dramatically decreased cocaine self-administration in dopamine but not serotonin transporter knock-out mice
    • Thomsen, M., Hall, F.S., Uhl, G.R., Caine, S.B., 2009. Dramatically decreased cocaine self-administration in dopamine but not serotonin transporter knock-out mice. J. Neurosci. 29, 1087-1092.
    • (2009) J. Neurosci. , vol.29 , pp. 1087-1092
    • Thomsen, M.1    Hall, F.S.2    Uhl, G.R.3    Caine, S.B.4
  • 95
    • 78049479388 scopus 로고    scopus 로고
    • Development and validation of a gas chromatography/ion trap-mass spectrometry method for simultaneous quantification of cocaine and its metabolites benzoylechonine and norcocaine: Application to the study of cocaine metabolism in human primary cultured renal cells
    • Valente, M.J., Carcalho, F., Bastos, M.L., Carvalho, M., Guedes de Pinho, P., 2010. Development and validation of a gas chromatography/ion trap-mass spectrometry method for simultaneous quantification of cocaine and its metabolites benzoylechonine and norcocaine: application to the study of cocaine metabolism in human primary cultured renal cells. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci 878, 3083-3088.
    • (2010) J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci , vol.878 , pp. 3083-3088
    • Valente, M.J.1    Carcalho, F.2    Bastos, M.L.3    Carvalho, M.4    Guedes De Pinho, P.5
  • 96
    • 84857841114 scopus 로고    scopus 로고
    • "Bump and grind,": An exploratory study of mephedrone users; perceptions of sexuality and sexual risk
    • Van Hout, M.C., Brennan, R., 2011. "Bump and grind,": an exploratory study of mephedrone users; perceptions of sexuality and sexual risk. Drugs Alcohol Today 11, 93-103.
    • (2011) Drugs Alcohol Today , vol.11 , pp. 93-103
    • Van Hout, M.C.1    Brennan, R.2
  • 97
    • 84860244663 scopus 로고    scopus 로고
    • A costly turn on: Patterns of use and perceived consequences of mephedrone based head shop products amongst irish injectors
    • Van Hout, M.C., Bingham, T., 2012. A Costly Turn On: patterns of use and perceived consequences of mephedrone based head shop products amongst Irish injectors. Int. J. Drug Policy 23, 188-197.
    • (2012) Int. J. Drug Policy , vol.23 , pp. 188-197
    • Van Hout, M.C.1    Bingham, T.2
  • 98
    • 79551630789 scopus 로고    scopus 로고
    • Drugs for youth via internet and the example of mephedrone
    • Vardakou, I., Pistos, C, Spiliopoulou, C, 2011. Drugs for youth via Internet and the example of mephedrone. Toxicol. Lett. 201, 191-195.
    • (2011) Toxicol. Lett. , vol.201 , pp. 191-195
    • Vardakou, I.1    Pistos, C.2    Spiliopoulou, C.3
  • 101
    • 0031783570 scopus 로고    scopus 로고
    • Psychological and cardiovascular effects and short-term sequelae of MDMA ('Ecstasy') in MDMA-naive healthy volunteers
    • DOI 10.1016/S0893-133X(98)00013-X, PII S0893133X9800013X
    • Vollenweider, F.X., Gamma, A., Liechti, M., Huber, T, 1998. Psychological and cardiovascular effects and short-term sequelae of MDMA ("ecstasy, ") in MDMA-naïve healthy volunteers. Neuropsychopharmacology 19, 241-251. (Pubitemid 28491334)
    • (1998) Neuropsychopharmacology , vol.19 , Issue.4 , pp. 241-251
    • Vollenweider, F.X.1    Gamma, A.2    Liechti, M.3    Huber, T.4
  • 104
    • 84866986754 scopus 로고    scopus 로고
    • Mephedrone (4-methylmethcathinone): What is new in our understanding of its use and toxicity
    • Wood, D.M., Dargan, P.I., 2012. Mephedrone (4-methylmethcathinone): what is new in our understanding of its use and toxicity. Prog. Neuropsychopharmacol. Biol. Psychiatry 39, 227-233.
    • (2012) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.39 , pp. 227-233
    • Wood, D.M.1    Dargan, P.I.2


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