Antagonists and substrates differentially regulate serotonin transporter cell surface expression in serotonergic neurons

European Journal of Pharmacology

Volumn 629, Issue 1-3, 2010, Pages 63-67

  Kittler, Katharina ^a   Lau, Thorsten ^a   Schloss, Patrick ^a  

^a CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

Author keywords

Antidepressant; Cocaine; Ecstasy; Regulation; Serotonin transporter

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; ANTIBODY; CITALOPRAM; COCAINE; FLUOXETINE; PAROXETINE; SEROTONIN; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; SERTRALINE;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL LINE; CELL SURFACE; CONFOCAL LASER MICROSCOPY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EXPOSURE; IMAGE PROCESSING; IMMUNOFLUORESCENCE; INTERNALIZATION; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SEROTONINERGIC NERVE CELL;

ANIMALS; CELL LINE; CITALOPRAM; COCAINE; GENE EXPRESSION REGULATION; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; NEURONS; PROTEIN TRANSPORT; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS;

EID: 74149089780     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.12.010     Document Type: Article

References (26)

1. Benmansour S., Owens W.A., Cecchi M., Morilak D.A., and Frazer A. Serotonin clearance in vivo is altered to a greater extent by antidepressant-induced downregulation of the serotonin transporter than by acute blockade of this transporter. J Neurosci 22 (2002) 6766-6772
2. Blakely R.D., and Bauman A.L. Biogenic amine transporters: regulation in flux. Curr Opin Neurobiol 10 (2000) 328-336
3. Coyle J.T., and Duman R.S. Finding the intracellular signaling pathways affected by mood disorder treatments. Neuron 38 (2003) 157-160
4. Fredricson Overo K. Kinetics of citalopram in man; plasma levels in patients. Prog Neuropsychopharmacol Biol Psychiatry 6 (1982) 311-318
5. Horschitz S., Hummerich R., and Schloss P. Down-regulation of the rat serotonin transporter upon exposure to a selective serotonin reuptake inhibitor. NeuroReport 12 (2001) 2181-2184
6. Jayanthi L.D., and Ramamoorthy S. Regulation of monoamine transporters: influence of psychostimulants and therapeutic antidepressants. Aaps J 7 (2005) E728-E738
7. Lau T., Horschitz S., Berger S., Bartsch D., and Schloss P. Antidepressant-induced internalization of the serotonin transporter in serotonergic neurons. Faseb J 22 (2008) 1702-1714
8. Lau T., Horschitz S., Bartsch D., and Schloss P. Monitoring mouse serotonin transporter internalization in stem cell-derived serotonergic neurons by confocal laser scanning microscopy. Neurochem Int 54 (2009) 271-276
9. Launay J.M., Schneider B., Loric S., Da Prada M., and Kellermann O. Serotonin transport and serotonin transporter-mediated antidepressant recognition are controlled by 5-HT2B receptor signaling in serotonergic neuronal cells. Faseb J 20 (2006) 1843-1854
10. Little K.Y., Kirkman J.A., Carroll F.I., Clark T.B., and Duncan G.E. Cocaine use increases [3H]WIN 35428 binding sites in human striatum. Brain Res 628 (1993) 17-25
11. Little K.Y., Elmer L.W., Zhong H., Scheys J.O., and Zhang L. Cocaine induction of dopamine transporter trafficking to the plasma membrane. Mol Pharmacol 61 (2002) 436-445
12. Little K.Y., Zhang L., and Cook E. Fluoxetine-induced alterations in human platelet serotonin transporter expression: serotonin transporter polymorphism effects. J Psychiatry Neurosci 31 (2006) 333-339
13. Loric S., Maroteaux L., Kellermann O., and Launay J.M. Functional serotonin-2B receptors are expressed by a teratocarcinoma-derived cell line during serotoninergic differentiation. Mol Pharmacol 47 (1995) 458-466
14. Mash D.C., Staley J.K., Izenwasser S., Basile M., and Ruttenber A.J. Serotonin transporters upregulate with chronic cocaine use. J Chem Neuroanat 20 (2000) 271-280
15. Melikian H.E. Neurotransmitter transporter trafficking: endocytosis, recycling, and regulation. Pharmacol Ther 104 (2004) 17-27
16. Meltzer H. Serotonergic dysfunction in depression. Br J Psychiatry Suppl (1989) 25-31
17. Millan M.J. Multi-target strategies for the improved treatment of depressive states: conceptual foundations and neuronal substrates, drug discovery and therapeutic application. Pharmacol Ther 110 (2006) 135-370
18. Mouillet-Richard S., Mutel V., Loric S., Tournois C., Launay J.M., and Kellermann O. Regulation by neurotransmitter receptors of serotonergic or catecholaminergic neuronal cell differentiation. J Biol Chem 275 (2000) 9186-9192
19. Nadgir S.M., and Malviya M. In vivo effect of antidepressants on [3H]paroxetine binding to serotonin transporters in rat brain. Neurochem Res 33 (2008) 2250-2256
20. Nemeroff C.B. Psychopharmacology of affective disorders in the 21st century. Biol Psychiatry 44 (1998) 517-525
21. Pineyro G., Blier P., Dennis T., and de Montigny C. Desensitization of the neuronal 5-HT carrier following its long-term blockade. J Neurosci 14 (1994) 3036-3047
22. Ressler K.J., and Nemeroff C.B. Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders. Depress Anxiety 12 Suppl 1 (2000) 2-19
23. Rudnick G., and Wall S.C. The molecular mechanism of "ecstasy" [3, 4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release. Proc Natl Acad Sci U S A 89 (1992) 1817-1821
24. Schloss P., and Henn F.A. New insights into the mechanisms of antidepressant therapy. Pharmacol Ther 102 (2004) 47-60
25. Steiner J.A., Carneiro A.M., and Blakely R.D. Going with the flow: trafficking-dependent and -independent regulation of serotonin transport. Traffic 9 (2008) 1393-1402
26. Sur C., Betz H., and Schloss P. Immunocytochemical detection of the serotonin transporter in rat brain. Neuroscience 73 (1996) 217-231