Changes in cardiovascular responsiveness and cardiotoxicity elicited during binge administration of ecstasy

Journal of Pharmacology and Experimental Therapeutics

Volumn 302, Issue 3, 2002, Pages 898-907

  Badon, Lisa A ^b   Hicks, Alissa ^a   Lord, Kevin ^a   Ogden, Brian A ^a   Meleg Smith, Suzanne ^c   Varner, Kurt J ^a  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOYOLA UNIVERSITY   (United States)

^c TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; ATROPINE; NITROPRUSSIDE SODIUM; PHENYLEPHRINE; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRADYCARDIA; CARDIOTOXICITY; CARDIOVASCULAR REFLEX; CARDIOVASCULAR RESPONSE; CELL DEATH; HEART ARREST; HEART RATE; HYPOTENSION; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; TACHYCARDIA; TELEMETRY;

ACETYLCHOLINE; ANIMALS; ATROPINE; BLOOD PRESSURE; DRUG INTERACTIONS; ELECTROCARDIOGRAPHY; HALLUCINOGENS; HEART DISEASES; HEART RATE; HEMODYNAMIC PROCESSES; INJECTIONS, INTRAVENOUS; MALE; MUSCARINIC ANTAGONISTS; MYOCARDIUM; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; NITROPRUSSIDE; PHENYLEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANCE-RELATED DISORDERS; TELEMETRY; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

EID: 0036720775     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.302.3.898     Document Type: Article

References (28)

1. 3H)paroxetine-labeled serotonin uptake sites
2. A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart rejections study group
3. Agony and Ecstasy: A review of MDMA effects and toxicity
4. Biochemical and histological evidence that methylenedioxymethamphetamine (MDMA) is toxic to neurons in the rat brain
5. "Eve" and "Ecstasy": A report of five deaths associated with the use of MDEA and MDMA
6. Myocardial injury following endogenous catecholamine release in rabbits
7. Sympathomimetic actions of methylenedioxymethamphetamine in rat and rabbit isolated cardiovascular tissues
8. Review of the pharmacology and clinical pharmacology of 3, 4-methylenedioxymethamphetamine (MDMA or "Ecstasy")
9. Methamphetamine-induced toxicity in cultured adult rat cardiomyocytes
10. Catecholamine cardiomyopathy: Review and analysis of pathogenetic mechanisms
11. Neurochemistry of amphetamine
12. Cardiovascular and neuroendocrine effects and pharmacokinetics of 3,4-methylenedioxymethamphetamine in humans
13. Use and abuse of ring-substituted amphetamines
14. Vascular actions of MDMA involve α1 and α2 adrenoceptors in the anaesthetized rat
15. Pathology of deaths associated with "ecstasy" and "eve" misuse
16. Myocardial ischemia
17. Ecstasy (MDMA): A review of its possible persistent psychological effects
18. Cardiovascular and sympathetic responses and reflex changes elicited by MDMA
19. Antioxidants attenuate myocyte apoptosis in the remote non-infarcted myocardium following large myocardial infarction
20. Neurotoxic amphetamine analogues: Effects in monkeys and implications for humans
21. Coronary vasoconstriction and catecholamine cardiomyopathy
22. Increased p53 protein expression in human failing myocardium
23. Cardiovascular responses elicited by the "binge" administration of methamphetamine
24. Hypoxia-activated apoptosis of cardiac myocytes requires reoxygenation or a pH shift and is independent of p53
25. A primary culture system of postnatal rat heart cells for the study of cocaine and methamphetamine toxicity
26. Upregulation of p53 protein in rat heart subjected to a transient occlusion of the coronary artery followed by reperfusion
27. Cardiovascular, thermal and behavioral sensitization to methamphetamine in freely moving rats
28. Memory impairment in abstinent MDMA ("Ectasy") users: A longitudinal investigation