Development and validation of a gas chromatography/ion trap-mass spectrometry method for simultaneous quantification of cocaine and its metabolites benzoylecgonine and norcocaine: Application to the study of cocaine metabolism in human primary cultured renal cells

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 30, 2010, Pages 3083-3088

  Valente, Maria João ^a   Carvalho, Félix ^a   Bastos, M Lourdes ^a   Carvalho, Márcia ^a,b   de Pinho, Paula Guedes ^a  

^a Campus Universitário de Santiago   (Portugal)

^b UNIVERSIDADE FERNANDO PESSOA   (Portugal)

Author keywords

Cocaine; GC IT MS; Human proximal tubular cells; Metabolites

Indexed keywords

BENZOYLECGONINE; CELLULAR MATRIX; COCAINE; COMMON FINDINGS; DERIVATIZATIONS; GC/IT-MS; IN-VITRO; IN-VIVO; KIDNEY CELLS; LIMIT OF DETECTION; LIMIT OF QUANTIFICATIONS; METHYL ESTERS; PHYSIOLOGICAL CONDITION; PRIMARY CULTURE; RENAL CELL; RENAL FAILURE; SOLID-PHASE EXTRACTION; TRIFLUOROACETAMIDES; TRIMETHYLSILYL; TUBULAR CELLS;

BIOMOLECULES; ESTERIFICATION; ESTERS; EXTRACTION; MASS SPECTROMETRY; METABOLISM; METABOLITES;

CELL CULTURE;

ANHYDROECGONINE METHYL ESTER; BENZOYLECGONINE; COCAINE; ECGONINE METHYL ESTER; NORCOCAINE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CONTROLLED STUDY; DERIVATIZATION; DRUG DETERMINATION; DRUG METABOLISM; GAS CHROMATOGRAPHY; HUMAN; HUMAN CELL; ION TRAP MASS SPECTROMETRY; KIDNEY CELL CULTURE; PRIORITY JOURNAL; SOLID PHASE EXTRACTION; VALIDATION STUDY;

ACUTE KIDNEY INJURY; CELLS, CULTURED; COCAINE; COCAINE-RELATED DISORDERS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; KIDNEY TUBULES, PROXIMAL; MODELS, BIOLOGICAL;

EID: 78049479388     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.09.010     Document Type: Article

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