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Volumn 3, Issue 7-8, 2011, Pages 454-463

The pharmacology and toxicology of the synthetic cathinone mephedrone (4-methylmethcathinone)

Author keywords

4 methylmethcathinone; Mephedrone; Poisoning; Recreational drugs; Toxicity

Indexed keywords

4-METHYLMETHCATHINONE; ACUTE TOXICITY; CATHINONE; MEPHEDRONE; POISONING; RECREATIONAL DRUGS;

EID: 79960626573     PISSN: 19427603     EISSN: 19427611     Source Type: Journal    
DOI: 10.1002/dta.312     Document Type: Review
Times cited : (121)

References (58)
  • 1
    • 77953869937 scopus 로고    scopus 로고
    • An analysis of the 'legal high' mephedrone
    • S. Gibbons, M. Zloh. An analysis of the 'legal high' mephedrone. Bioorg. Med. Chem. Lett. 2010, 20, 4135.
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 4135
    • Gibbons, S.1    Zloh, M.2
  • 2
    • 85153002777 scopus 로고    scopus 로고
    • EWS: Early warning system. Available at: [14 April 2011].
    • EWS: Early warning system. Available at: [14 April 2011].
  • 3
    • 85153009651 scopus 로고    scopus 로고
    • Annex 1 to the Risk assessmentreport, Technical Report on Mephedrone, EMCDDA contractCT.10.EPI.057. Guy's and St Thomas' NHS Foundation Trust, London, UK, July, Available at: [14 June 2011].
    • P. I. Dargan, D. M. Wood. Annex 1 to the Risk assessmentreport, Technical Report on Mephedrone, EMCDDA contractCT.10.EPI.057. Guy's and St Thomas' NHS Foundation Trust, London, UK, July 2010, Available at: [14 June 2011].
    • (2010)
    • Dargan, P.I.1    Wood, D.M.2
  • 4
    • 85152994736 scopus 로고    scopus 로고
    • EMCDDA-Europol Joint Report: Joint Report on a new psychoactive substance: 4-methylmethcathinone (mephedrone). Reference 8145/10. Cordrogue 36 San 68. Available at: [14 April 2011].
    • EMCDDA-Europol Joint Report: Joint Report on a new psychoactive substance: 4-methylmethcathinone (mephedrone). Reference 8145/10. Cordrogue 36 San 68. Available at: [14 April 2011].
  • 5
    • 78649371984 scopus 로고    scopus 로고
    • Mephedrone use and associated adverse effects in school and college/university students before the UK legislation change
    • P. I. Dargan, S. Albert, D. M. Wood. Mephedrone use and associated adverse effects in school and college/university students before the UK legislation change. Q.J.M. 2010, 103, 875.
    • (2010) Q.J.M. , vol.103 , pp. 875
    • Dargan, P.I.1    Albert, S.2    Wood, D.M.3
  • 6
    • 85153019758 scopus 로고    scopus 로고
    • Erowid: 4-Methylmethcathinone effects. Available at: [14 April 2011].
    • Erowid: 4-Methylmethcathinone effects. Available at: [14 April 2011].
  • 7
    • 84993102085 scopus 로고    scopus 로고
    • Tweaking, bombing, dabbing and stockpiling: The emergence of mephedrone and the perversity of prohibition
    • F. Measham, K. Moore, R. Newcombe, Z. Welch. Tweaking, bombing, dabbing and stockpiling: The emergence of mephedrone and the perversity of prohibition. Drugs Alcohol Today 2010, 10, 14.
    • (2010) Drugs Alcohol Today , vol.10 , pp. 14
    • Measham, F.1    Moore, K.2    Newcombe, R.3    Welch, Z.4
  • 8
    • 78650726892 scopus 로고    scopus 로고
    • Clinical pattern of toxicity associated with the novel synthetic cathinone Mephedrone
    • DOI: 10.1136/emj.2010.092288.
    • D. M. Wood, S. L. Greene, P. I. Dargan. Clinical pattern of toxicity associated with the novel synthetic cathinone Mephedrone. Emerg. Med. J. 2010, DOI: 10.1136/emj.2010.092288.
    • (2010) Emerg. Med. J.
    • Wood, D.M.1    Greene, S.L.2    Dargan, P.I.3
  • 10
    • 85153001897 scopus 로고    scopus 로고
    • Google Insights Search: Web Search Interest: mephedrone Worldwide, 2004-present. Available at: [14 April 2011].
    • Google Insights Search: Web Search Interest: mephedrone Worldwide, 2004-present. Available at: [14 April 2011].
  • 11
    • 85153017848 scopus 로고    scopus 로고
    • Council Decision: COUNCIL DECISION of 2 December 2010 on submitting 4-methylmethcathinone (mephedrone) to control measures (2010/759/EU). Available at: [5 June 2011].
    • Council Decision: COUNCIL DECISION of 2 December 2010 on submitting 4-methylmethcathinone (mephedrone) to control measures (2010/759/EU). Available at: [5 June 2011].
  • 12
    • 85153008047 scopus 로고    scopus 로고
    • Mephedrone. The use of Mephedrone (M-cat, Meow) in Middlesbrough. Lifeline Publications and Research, Manchester, UK. Available at: [14 April 2011].
    • R. Newcombe. Mephedrone. The use of Mephedrone (M-cat, Meow) in Middlesbrough. Lifeline Publications and Research, Manchester, UK. Available at: [14 April 2011].
    • Newcombe, R.1
  • 13
    • 85153028255 scopus 로고    scopus 로고
    • Psychonaut WebMapping Research Group, Mephedrone Report. Institute of Psychiatry, King's College London, London, UK. Available at: [14 April 2011].
    • Psychonaut WebMapping Research Group 2009, Mephedrone Report. Institute of Psychiatry, King's College London, London, UK. Available at: [14 April 2011].
    • (2009)
  • 14
    • 85153028163 scopus 로고    scopus 로고
    • Erowid: 4-Methylmethcathinone basics. Available at: [14 April 2011].
    • Erowid: 4-Methylmethcathinone basics. Available at: [14 April 2011].
  • 15
    • 85152999796 scopus 로고    scopus 로고
    • Drugs Forum. Mephedrone and Beta-Ketones. Available at: [14 April 2011].
    • Drugs Forum. Mephedrone and Beta-Ketones. Available at: [14 April 2011].
  • 16
    • 85152995280 scopus 로고    scopus 로고
    • EMCDDA Annual Report 2010: 2010 Annual report on the state of the drugs problem in Europe. Available at: [14 April 2011].
    • EMCDDA Annual Report 2010: 2010 Annual report on the state of the drugs problem in Europe. Available at: [14 April 2011].
  • 17
    • 85152990572 scopus 로고    scopus 로고
    • EMCDDA Drug Profile: EMCDDA-Drug Profiles: Synthetic Cathinones. Available at: [14 April 2011].
    • EMCDDA Drug Profile: EMCDDA-Drug Profiles: Synthetic Cathinones. Available at: [14 April 2011].
  • 19
  • 20
    • 77954702630 scopus 로고    scopus 로고
    • Second generation mephedrone. The confusing case of NRG-1
    • S. D. Brandt, H. R. Sumnall, F. Measham, J. Cole. Second generation mephedrone. The confusing case of NRG-1. B.M.J. 2010, 341, c3564.
    • (2010) B.M.J. , vol.341
    • Brandt, S.D.1    Sumnall, H.R.2    Measham, F.3    Cole, J.4
  • 21
    • 77956642096 scopus 로고    scopus 로고
    • Analyses of second-generation legal highs in the UK: initial findings
    • S. D. Brandt, H. R. Sumnall, F. Measham, J. Cole. Analyses of second-generation legal highs in the UK: initial findings. Drug Test. Analysis 2010, 2, 377.
    • (2010) Drug Test. Analysis , vol.2 , pp. 377
    • Brandt, S.D.1    Sumnall, H.R.2    Measham, F.3    Cole, J.4
  • 22
    • 78149303571 scopus 로고    scopus 로고
    • Mephedrone: still available and twice the price
    • A. Winstock, L. Mitcheson, J. Marsden. Mephedrone: still available and twice the price. Lancet 2010, 376, 1537.
    • (2010) Lancet , vol.376 , pp. 1537
    • Winstock, A.1    Mitcheson, L.2    Marsden, J.3
  • 23
    • 85153002603 scopus 로고    scopus 로고
    • EMCDDA. EWS Guidelines, 2007. Early-warning system on new psychoactive substances-operating guidelines. Publications Office of the European Union, Luxembourg. Available at: [14 April 2011].
    • EMCDDA. EWS Guidelines, 2007. Early-warning system on new psychoactive substances-operating guidelines. Publications Office of the European Union, Luxembourg. Available at: [14 April 2011].
  • 24
    • 79952453776 scopus 로고    scopus 로고
    • Instability of the ecstasy market and a new kid on the block: mephedrone
    • Sep 8, Epub ahead of print.
    • T. M. Brunt, A. Poortman, R. J. Niesink, W. van den Brink. Instability of the ecstasy market and a new kid on the block: mephedrone.J. Psychopharmacol. 2010, Sep 8, Epub ahead of print.
    • (2010) J. Psychopharmacol.
    • Brunt, T.M.1    Poortman, A.2    Niesink, R.J.3    van den Brink, W.4
  • 27
    • 77954414662 scopus 로고    scopus 로고
    • Head shop compound abuse amongst attendees of the drug treatment centre board
    • S. McNamara, S. Stokes, N. Coleman. Head shop compound abuse amongst attendees of the drug treatment centre board. Irish Med. J. 2010, 103, 136.
    • (2010) Irish Med. J. , vol.103 , pp. 136
    • McNamara, S.1    Stokes, S.2    Coleman, N.3
  • 28
    • 79953653319 scopus 로고
    • Sur un homologue de l'ephedrine
    • Saem de Burnaga Sanchez. Sur un homologue de l'ephedrine. Bull. Soc. Chim. Fr. 1929, 45, 284.
    • (1929) Bull. Soc. Chim. Fr. , vol.45 , pp. 284
    • Sanchez, S.D.B.1
  • 29
    • 77950299390 scopus 로고    scopus 로고
    • Chemical analysis of four capsules containing the controlled substance analogues 4-methylmethcathinone, 2-fluoromethamphetamine, alpha-phthalimidopropiophenone and N-ethylcathinone
    • A. Camilleri, M. R. Johnston, M. Brennan, S. Davis, D. G. Caldicott. Chemical analysis of four capsules containing the controlled substance analogues 4-methylmethcathinone, 2-fluoromethamphetamine, alpha-phthalimidopropiophenone and N-ethylcathinone. Forensic Sci. Int. 2010, 197, 59.
    • (2010) Forensic Sci. Int. , vol.197 , pp. 59
    • Camilleri, A.1    Johnston, M.R.2    Brennan, M.3    Davis, S.4    Caldicott, D.G.5
  • 35
    • 65449133527 scopus 로고    scopus 로고
    • Parkinsonism due to ephedrone neurotoxicity: a case report
    • C. Colosimo, M. Guidi. Parkinsonism due to ephedrone neurotoxicity: a case report. Eur. J. Neurol. 2009, 16, e114.
    • (2009) Eur. J. Neurol. , vol.16
    • Colosimo, C.1    Guidi, M.2
  • 37
    • 77953475735 scopus 로고    scopus 로고
    • Beta-keto amphetamines: studies on the metabolism of the designer drug mephedrone and toxicological detection of mephedrone, butylone, and methylone in urine using gas chromatography-mass spectrometry
    • M. R. Meyer, J. Wilhelm, F. T. Peters, H. H. Maurer. Beta-keto amphetamines: studies on the metabolism of the designer drug mephedrone and toxicological detection of mephedrone, butylone, and methylone in urine using gas chromatography-mass spectrometry. Anal. Bioanal. Chem. 2010, 397, 1225.
    • (2010) Anal. Bioanal. Chem. , vol.397 , pp. 1225
    • Meyer, M.R.1    Wilhelm, J.2    Peters, F.T.3    Maurer, H.H.4
  • 38
    • 85152983538 scopus 로고    scopus 로고
    • Erowid. 4-Methylmethcathinone reports. Available at: [14 April 2011].
    • Erowid. 4-Methylmethcathinone reports. Available at: [14 April 2011].
  • 40
    • 85153011581 scopus 로고    scopus 로고
    • Erowid. 4-Methylmethcathinone dose. Available at: [14 April 2011].
    • Erowid. 4-Methylmethcathinone dose. Available at: [14 April 2011].
  • 41
    • 78649903535 scopus 로고    scopus 로고
    • Headshop heartache: acute mephedrone meow myocarditis
    • P. J. Nicholson, M. J. Quinn, J. D. Dodd. Headshop heartache: acute mephedrone meow myocarditis. Heart 2010, 96, 2051.
    • (2010) Heart , vol.96 , pp. 2051
    • Nicholson, P.J.1    Quinn, M.J.2    Dodd, J.D.3
  • 42
    • 79952443761 scopus 로고    scopus 로고
    • Clinical characteristics of mephedrone toxicity reported to the UK National Poisons Information Service
    • on behalf of the National Poisons Information Service. ., Aug 25, Epub ahead of print.
    • D. James, R. D. Adams, R. Spears, G. Cooper, D. J. Lupton, J. P. Thompson, S. H. Thomas, on behalf of the National Poisons Information Service. Clinical characteristics of mephedrone toxicity reported to the UK National Poisons Information Service. Emerg. Med. J. 2010, Aug 25, Epub ahead of print.
    • (2010) Emerg. Med. J.
    • James, D.1    Adams, R.D.2    Spears, R.3    Cooper, G.4    Lupton, D.J.5    Thompson, J.P.6    Thomas, S.H.7
  • 44
    • 84856313118 scopus 로고    scopus 로고
    • Increasing abuse of new cathinone derivatives in Sweden-a poisons centre study for the years 2008-2009
    • R. Hägerkvist, P. Hultén, M. Personne. Increasing abuse of new cathinone derivatives in Sweden-a poisons centre study for the years 2008-2009. Clin. Toxicol. 2010, 48, 291.
    • (2010) Clin. Toxicol. , vol.48 , pp. 291
    • Hägerkvist, R.1    Hultén, P.2    Personne, M.3
  • 45
    • 81855175383 scopus 로고    scopus 로고
    • Mephedrone toxicity in a Scottish emergency department
    • DOI:10.1136/emj.2010.103093.
    • L. Regan, M. Mitchelson, C. Macdonald. Mephedrone toxicity in a Scottish emergency department. Emerg. Med. J. DOI:10.1136/emj.2010.103093.
    • Emerg. Med. J.
    • Regan, L.1    Mitchelson, M.2    Macdonald, C.3
  • 46
    • 85152999763 scopus 로고    scopus 로고
    • Belfast Telegraph: Anonymous. Missing mephedrone boy's body found, 30th April 2010. Available at: [14 April 2011].
    • Belfast Telegraph: Anonymous. Missing mephedrone boy's body found, 30th April 2010. Available at: [14 April 2011].
  • 47
    • 85153021211 scopus 로고    scopus 로고
    • rd March 2010. Available at: [14 April 2011].
    • rd March 2010. Available at: [14 April 2011].
  • 48
    • 85153023937 scopus 로고    scopus 로고
    • th March 2010. Available at: [14 April 2011].
    • th March 2010. Available at: [14 April 2011].
  • 49
    • 85152992081 scopus 로고    scopus 로고
    • Daily Mail: James Slack. Is Lois, 24, victim number six of 'legal high' meow meow drug? 24 March 2010. Available at: [14 April 2011].
    • Daily Mail: James Slack. Is Lois, 24, victim number six of 'legal high' meow meow drug? 24 March 2010. Available at: [14 April 2011].
  • 50
    • 85152991323 scopus 로고    scopus 로고
    • Daily Mail: Chris Brooke. Action pledged on 'Meow, Meow' drug after two teen friends die within hours of taking legal high, 14 April 2010. Available at: [14 April 2011].
    • Daily Mail: Chris Brooke. Action pledged on 'Meow, Meow' drug after two teen friends die within hours of taking legal high, 14 April 2010. Available at: [14 April 2011].
  • 51
    • 85153013069 scopus 로고    scopus 로고
    • The Guardian: Paul Walker. Three arrested over suspected mephedrone deaths, 17 March 2010. Available at: [14 April 2011].
    • The Guardian: Paul Walker. Three arrested over suspected mephedrone deaths, 17 March 2010. Available at: [14 April 2011].
  • 52
    • 85152990752 scopus 로고    scopus 로고
    • The Sun: Staff Reporter. Two held over meow deaths, 16 March 2010. Available at: [14 April 2011].
    • The Sun: Staff Reporter. Two held over meow deaths, 16 March 2010. Available at: [14 April 2011].
  • 53
    • 85153029112 scopus 로고    scopus 로고
    • th January 2010. Available at: [14 April 2011].
    • th January 2010. Available at: [14 April 2011].
    • Bolezatu, O.1
  • 54
    • 70350311005 scopus 로고    scopus 로고
    • Mephedrone-Internet drug which seems to have come and stay. Fatal cases in Sweden have drawn attention to previously unknown substance
    • D. Gustavsson, C. Escher. Mephedrone-Internet drug which seems to have come and stay. Fatal cases in Sweden have drawn attention to previously unknown substance. Lakartidningen 2009, 106, 2769.
    • (2009) Lakartidningen , vol.106 , pp. 2769
    • Gustavsson, D.1    Escher, C.2
  • 55
    • 78650758648 scopus 로고    scopus 로고
    • The detection of mephedrone (4-methylmethcathinone) in 4 fatalities in Scotland
    • H. Torrance, G. Cooper. The detection of mephedrone (4-methylmethcathinone) in 4 fatalities in Scotland. Forensic Sci. Int. 2010, 202, e62.
    • (2010) Forensic Sci. Int. , vol.202
    • Torrance, H.1    Cooper, G.2
  • 56
    • 77953870712 scopus 로고    scopus 로고
    • Multiple-drug toxicity caused by coadministration of 4-methylmethcathinon (mephedrone) and heroin
    • A. J. Dickson, S. P. Vorce, B. Levine, M. R. Past. Multiple-drug toxicity caused by coadministration of 4-methylmethcathinon (mephedrone) and heroin. J. Anal. Toxicol. 2010, 34, 162.
    • (2010) J. Anal. Toxicol. , vol.34 , pp. 162
    • Dickson, A.J.1    Vorce, S.P.2    Levine, B.3    Past, M.R.4
  • 58
    • 84875252562 scopus 로고    scopus 로고
    • Dependence and psychosis with 4-methylmethcathinone (mephedrone) use
    • DOI:10.1136/bcr.02.2010.2780.
    • N. Bajaj, D. Mullen, S. Wylie. Dependence and psychosis with 4-methylmethcathinone (mephedrone) use. B.M.J. Case Reports 2010, DOI:10.1136/bcr.02.2010.2780.
    • (2010) B.M.J. Case Reports
    • Bajaj, N.1    Mullen, D.2    Wylie, S.3


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