Mitochondrial signals in glucose-stimulated insulin secretion in the beta cell

Journal of Physiology

Volumn 529, Issue 1, 2000, Pages 49-56

  Maechler, Pierre ^a   Wollheim, Claes B ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CITRIC ACID; GLUCOSE; GLUTAMATE DEHYDROGENASE; GLUTAMIC ACID; INSULIN; MALONYL COENZYME A; MITOCHONDRIAL DNA; OLIGOMYCIN; POTASSIUM ION; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; ADENOSINE TRIPHOSPHATE; CALCIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CALCIUM TRANSPORT; CELL FUNCTION; CITRIC ACID CYCLE; CONTROLLED STUDY; EXOCYTOSIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLYCOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; INSULIN RELEASE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; POINT MUTATION; PRIORITY JOURNAL; RAT; RESPIRATORY CHAIN; REVIEW; SIGNAL TRANSDUCTION; STIMULUS SECRETION COUPLING; HYPERINSULINISM; HYPOGLYCEMIA; MEMBRANE DEPOLARIZATION;

EID: 0034668772     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.2000.00049.x     Document Type: Review

References (70)

1. Autonomic regulation of islet hormone secretion-implications for health and disease
2. Molecular or pharmacologic perturbation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion. A re-evaluation of the long-chain acyl-CoA hypothesis
3. Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter
4. 2+ in pancreatic islets correspond to pulsatile insulin release
5. Evidence for a glutamate receptor of the AMPA subtype which mediates insulin release from rat perfused pancreas
6. ATP-dependent and ATP-independent pathways of exocytosis revealed by interchanging glutamate and chloride as the major anion in permeabilized mast cells
7. 2+, substrate and ADP
8. The role of long-chain fatty acyl-CoA esters in beta-cell signal transduction
9. Levels of α-ketoglutarate and glutamate in stimulated pancreatic β-cells
10. On the role of the calcium transport cycle in heart and other mammalian mitochondria
11. Two sites of glucose control of insulin release with distinct dependence on the energy state in pancreatic B-cells
12. Contributions of mitochondria to animal physiology: From homeostatic sensor to calcium signalling and cell death
13. Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion
14. Regulation of insulin release by factors that also modify glutamate dehydrogenase
15. Glucose-regulated anaplerosis and cataplerosis in pancreatic β-cells: Possible implication of a pyruvate/citrate shuttle in insulin secretion
16. Glucose regulation of glutaminolysis and its role in insulin secretion
17. + channels in mouse B cells
18. Role of glucose as a regulator and precursor of amino acids in the pancreatic beta-cells
19. Relation between mitochondrial calcium transport and control of energy metabolism
20. Ethidium bromide-induced inhibition of mitochondrial gene transcription suppresses glucose-stimulated insulin release in the mouse pancreatic beta-cell line betaHC9
21. Methodological approaches to studies on the pancreatic islets
22. L-glutamate dehydrogenases: Distribution, properties and mechanism
23. Increased tricarboxylic acid cycle flux in rat brain during forepaw stimulation detected with 1H[13C]NMR
24. Expression and role of ionotropic glutamate receptors in pancreatic islet cells
25. Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in beta cells
26. What couples glycolysis to mitochondrial signal generation in glucose-stimulated insulin secretion?
27. Type 2 diabetes: When insulin secretion fails to compensate for insulin resistance
28. Effects of depletion of mitochondrial DNA in metabolism secretion coupling in INS-1 cells
29. 2+ in aequorin-expressing INS-1 cells
30. In situ characterization of islets in diabetes with a mitochondrial DNA mutation at nucleotide position 3243
31. Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion
32. Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and Go or by the expression of their active G alpha subunits
33. Maternally inherited diabetes and deafness: A new diabetes subtype
34. High content of mitochondrial glycerol-3-phosphate dehydrogenase in pancreatic islets and its inhibition by diazoxide
35. Feasibility of a mitochondrial pyruvate malate shuttle in pancreatic islets. Further implication of cytosolic NADPH in insulin secretion
36. Glutamate is not a messenger in insulin secretion
37. Modulation of glutamate generation in the mitochondria affects hormone secretion in INS-1E beta cells
38. Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic β-cells
39. 2+ and insulin secretion responses in the beta cell
40. Glutamate acts as a mitochondrially derived messenger in glucose-induced insulin exocytosis
41. The stimulus-secretion coupling of glucose-induced insulin release. XLVI. Physiological role of L-glutamine as a fuel for pancreatic islets
42. Glutamate production in islets of Langerhans: Properties of phosphate-activated glutaminase
43. Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice
44. Glucose intolerance caused by a defect in the entero-insular axis: A study in gastric inhibitory polypeptide receptor knockout mice
45. Metabolic coupling factors in pancreatic β-cell signal transduction
46. Newer aspects of glutamine/glutamate metabolism: The role of acute pH changes
47. Glutamate transport and storage in synaptic vesicles
48. Beta-cells in type II diabetes mellitus
49. Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion
50. 2+ revealed by specifically targeted recombinant aequorin
51. The pancreatic beta-cell as a fuel sensor: An electrophysiologist's viewpoint
52. 2+ influx in rat pancreatic B-cell
53. Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells
54. Sur1 knockout mice. A model for K(ATP) channel-independent regulation of insulin secretion
55. Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing
56. Insulinotropic action of glutamic acid dimethyl ester
57. L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase
58. 2+-sensitive 2-ketoglutarate dehydrogenase in the regulation of mitochondrial function
59. Mechanisms of inhibition of insulin release
60. Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13C NMR
61. Increased expression of GAD65 and GABA in pancreatic β-cell impairs first phase insulin secretion
62. Mitochondrial DNA is required for regulation of glucose-stimulated insulin secretion in a mouse pancreatic beta cell line, MIN6
63. Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene
64. Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons
65. Changes of L-α-amino acid profile in rat islets stimulated to secrete insulin
66. Creation and characterization of a mitochondrial DNA-depleted pancreatic beta-cell line: Impaired insulin secretion induced by glucose, leucine, and sulfonylureas
67. Functional and morphological abnormalities of mitochondria harbouring the tRNA(Leu)(UUR) mutation in mitochondrial DNA derived from patients with maternally inherited diabetes and deafness (MIDD) and progressive kidney disease
68. Differential expression of glutamate receptor subtypes in rat pancreatic islets
69. Beta-cell mitochondria in the regulation of insulin secretion: A new culprit in Type II diabetes
70. Hyperinsulinism-hyperammonemia syndrome caused by mutant glutamate dehydrogenase accompanied by novel enzyme kinetics