Bone marrow-derived cells contribute to cerulein-induced pancreatic fibrosis in the mouse

International Journal of Experimental Pathology

Volumn 93, Issue 2, 2012, Pages 130-138

  Lin, Wey Ran ^a,b,c   Inatomi, Osamu ^c,d   Lee, Chung Y ^c   Kallis, Yiannis N ^c,e   Otto, William R ^c   Jeffery, Rosemary ^c   Poulsom, Richard ^c   Alison, Malcolm R ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^d SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^e ST MARY S HOSPITAL   (United Kingdom)

Author keywords

Bone marrow; Fibrocytes; Fibrosis; Myofibroblasts; Pancreatitis

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CD45 ANTIGEN; CERULETIDE; COLLAGEN 1 ALPHA 1; COLLAGEN TYPE 1; MESSENGER RNA; PROCOLLAGEN; PROCOLLAGEN TYPE 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CELL DIFFERENTIATION; CELL TYPE; CONTROLLED STUDY; CYSTIC FIBROSIS; FEMALE; FIBROCYTE; GENOTYPE; IN SITU HYBRIDIZATION; MALE; MOUSE; MYOFIBROBLAST; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE; Y CHROMOSOME;

ANIMALS; ANTIGENS, CD45; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CAERULEIN; CELL MOVEMENT; CELL TRANSDIFFERENTIATION; COLLAGEN; DISEASE MODELS, ANIMAL; FEMALE; FIBROBLASTS; FIBROSIS; MALE; MICE; MICE, INBRED C57BL; PANCREATIC DISEASES;

EID: 84862830091     PISSN: 09599673     EISSN: 13652613     Source Type: Journal    
DOI: 10.1111/j.1365-2613.2011.00804.x     Document Type: Article

References (32)

1. Abe R., Donnelly S.C., Peng T., Bucala R., Metz C.N. (2001) Peripheral blood fibrocytes: differentiation pathway and migration to wound sites. J. Immunol. 166, 7556-7562.
2. Andersen D.K. (2007) Mechanisms and emerging treatments of the metabolic complications of chronic pancreatitis. Pancreas 35, 1-15.
3. Bamba S., Lee C.Y., Brittan M. et al. (2006) Bone marrow transplantation ameliorates pathology in interleukin-10 knockout colitic mice. J. Pathol. 209, 265-273.
4. Barth P.J., Ebrahimsade S., Hellinger A., Moll R., Ramaswamy A. (2002) CD34+ fibrocytes in neoplastic and inflammatory pancreatic lesions. Virchows Arch. 440, 128-133.
5. Behrman S.W. & Fowler E.S. (2007) Pathophysiology of chronic pancreatitis. Surg. Clin. North Am. 87, 1309-1324.
6. Bellini A. & Mattoli S. (2007) The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses. Lab. Invest. 87, 858-870.
7. Broekema M., Harmsen M.C., van Luyn M.J. et al. (2007) Bone marrow-derived myofibroblasts contribute to the renal interstitial myofibroblast population and produce procollagen I after ischemia/reperfusion in rats. J. Am. Soc. Nephrol. 18, 165-175.
8. Chesney J., Metz C., Stavitsky A.B., Bacher M., Bucala R. (1998) Regulated production of type I collagen and inflammatory cytokines by peripheral blood fibrocytes. J. Immunol. 160, 419-425.
9. Direkze N.C., Forbes S.J., Brittan M. et al. (2003) Multiple organ engraftment by bone-marrow-derived myofibroblasts and fibroblasts in bone-marrow-transplanted mice. Stem Cells 21, 514-520.
10. Frid M.G., Brunetti J.A., Burke D.L. et al. (2006) Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage. Am. J. Pathol. 168, 659-669.
11. Hartlapp I., Abe R., Saeed R.W. et al. (2001) Fibrocytes induce an angiogenic phenotype in cultured endothelial cells and promote angiogenesis in vivo. FASEB J. 15, 2215-2224.
12. Haudek S.B., Xia Y., Huebener P. et al. (2006) Bone marrow-derived fibroblast precursors mediate ischemic cardiomyopathy in mice. Proc. Natl Acad. Sci. USA 103, 18284-18289.
13. Issa R., Zhou X., Trim N. et al. (2003) Mutation in collagen-1 that confers resistance to the action of collagenase results in failure of recovery from CCl4-induced liver fibrosis, persistence of activated hepatic stellate cells, and diminished hepatocyte regeneration. FASEB J. 17, 47-49.
14. Kuroda N., Toi M., Nakayama H. et al. (2004) The distribution and role of myofibroblasts and CD34-positive stromal cells in normal pancreas and various pancreatic lesions. Histol. Histopathol. 19, 59-67.
15. Lin W.R., Brittan M., Alison M.R. (2008) The role of bone marrow-derived cells in fibrosis. Cells Tissues Organs 188, 178-188.
16. Liu X., Wu H., Byrne M., Jeffrey J., Krane S., Jaenisch R. (1995) A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling. J. Cell Biol. 130, 227-237.
17. Lowenfels A.B., Maisonneuve P., Cavallini G. et al. (1993) Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group. N. Engl. J. Med. 328, 1433-1437.
18. Malka D., Hammel P., Maire F. et al. (2002) Risk of pancreatic adenocarcinoma in chronic pancreatitis. Gut 51, 849-852.
19. Marrache F., Pendyala S., Bhagat G., Betz K.S., Song Z., Wang T.C. (2008) Role of bone marrow-derived cells in experimental chronic pancreatitis. Gut 57, 1113-1120.
20. Mori L., Bellini A., Stacey M.A., Schmidt M., Mattoli S. (2005) Fibrocytes contribute to the myofibroblast population in wounded skin and originate from the bone marrow. Exp. Cell Res. 304, 81-90.
21. Nolan D.J., Ciarrocchi A., Mellick A.S. et al. (2007) Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization. Genes Dev. 21, 1546-1558.
22. Omary M.B., Lugea A., Lowe A.W., Pandol S.J. (2007) The pancreatic stellate cell: a star on the rise in pancreatic diseases. J. Clin. Invest. 117, 50-59.
23. Pilling D., Buckley C.D., Salmon M., Gomer R.H. (2003) Inhibition of fibrocyte differentiation by serum amyloid P. J. Immunol. 171, 5537-5546.
24. Pilling D., Tucker N.M., Gomer R.H. (2006) Aggregated IgG inhibits the differentiation of human fibrocytes. J. Leukoc. Biol. 79, 1242-1251.
25. Rangan G.K. & Tesch G.H. (2007) Quantification of renal pathology by image analysis. Nephrology 12, 553-558.
26. Reilkoff R.A., Bucala R., Herzog E.L. (2011) Fibrocytes: emerging effector cells chronic inflammation. Nat. Immunol. 11, 427-435.
27. Russo F.P., Alison M.R., Bigger B.W. et al. (2006) The bone marrow functionally contributes to liver fibrosis. Gastroenterology 130, 1807-1821.
28. Schmidt M., Sun G., Stacey M.A., Mori L., Mattoli S. (2003) Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma. J. Immunol. 171, 380-389.
29. Varcoe R.L., Mikhail M., Guiffre A.K. et al. (2006) The role of the fibrocyte in intimal hyperplasia. J. Thromb. Haemost. 4, 1125-1133.
30. Watanabe T., Masamune A., Kikuta K. et al. (2009) Bone marrow contributes to the population of pancreatic stellate cells in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 297, G1138-G1146.
31. Witt H., Apte M.V., Keim V., Wilson J.S. (2007) Chronic pancreatitis: challenges and advances in pathogenesis, genetics, diagnosis, and therapy. Gastroenterology 132, 1557-1573.
32. Wu H., Byrne M.H., Stacey A. et al. (1990) Generation of collagenase-resistant collagen by site-directed mutagenesis of murine pro alpha 1(I) collagen gene. Proc. Natl Acad. Sci. USA 87, 5888-5892.