Cyclotides Suppress Human T-Lymphocyte Proliferation by an Interleukin 2-Dependent Mechanism

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Gründemann, Carsten ^a,b   Thell, Kathrin ^a   Lengen, Karin ^b   Garcia Käufer, Manuel ^b   Huang, Yen Hua ^c   Huber, Roman ^b   Craik, David J ^c   Schabbauer, Gernot ^a   Gruber, Christian W ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF FREIBURG   (Germany)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

cyclotide; cytokine; immunosuppression; lymphocytes; peptide; plant; proliferation

Indexed keywords

CYCLOSPORIN A; CYCLOTIDE; CYTOKINE; GAMMA INTERFERON; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; KALATA B1; MUTANT PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DEGRANULATION; DRUG ANALYSIS; DRUG MECHANISM; DRUG STRUCTURE; EFFECTOR CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; IC 50; IL 2 GENE; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; NORMAL HUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE; CELL CULTURE; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; LYMPHOCYTE ACTIVATION; METABOLISM; MONONUCLEAR CELL; RUBIACEAE;

CELL PROLIFERATION; CELLS, CULTURED; CYCLOTIDES; HUMANS; INTERLEUKIN-2; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; RUBIACEAE; T-LYMPHOCYTES;

EID: 84879484015     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0068016     Document Type: Article

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