Ethanol affects acylated and total ghrelin levels in peripheral blood of alcohol-dependent rats

Addiction Biology

Volumn 18, Issue 4, 2013, Pages 689-701

  Szulc, Michal ^a   Mikolajczak, Przemyslaw L ^a,b   Geppert, Bogna ^a   Wachowiak, Roman ^a   Dyr, Wanda ^c   Bobkiewicz Kozlowska, Teresa ^a  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^b INSTITUTE OF NATURAL FIBRES AND MEDICINAL PLANTS   (Poland)

^c Instytute of Psychiatry and Neurology   (Poland)

Author keywords

Acute ethanol administration; acylated and total ghrelin blood level; alcohol preferring rats; ethanol concentration; voluntary alcohol intake

Indexed keywords

ALCOHOL; GHRELIN;

ALCOHOL CONSUMPTION; ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD; CONTROLLED STUDY; EXPERIMENTAL ANIMAL; INBRED STRAIN; NONHUMAN; PRIORITY JOURNAL; RAT;

ACYLATION; ALCOHOL DRINKING; ALCOHOLISM; ANALYSIS OF VARIANCE; ANIMALS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; FEMALE; FOOD PREFERENCES; GHRELIN; HUMANS; MALE; RATS; RATS, INBRED STRAINS; RATS, WISTAR; TEMPERANCE;

EID: 84879462709     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/adb.12025     Document Type: Article

References (54)

1. Addolorato G, Capristo E, Leggio L, Ferrulli A, Abenavoli L, Malandrino N, Farnetti S, Domenicali M, D'Angelo C, Vonghia L, Mirijello A, Cardone S, Gasbarrini G, (2006) Relationship between ghrelin levels, alcohol craving and nutritional status in current alcoholics. Alcohol Clin Exp Res 30: 1933-1937. (Pubitemid 44630097)
2. Badaoui A, Saeger C, Duchemin J, Gihousse D, Timary P, Stärkel P, (2008) Alcohol dependence is associated with reduced plasma and fundic ghrelin levels. Eur J Clin Invest 38: 397-403. (Pubitemid 351712921)
3. Bellone S, Rapa A, Vivenza D, Castellino N, Petri A, Bellone J, Me E, Broglio F, Prodam F, Ghigo E, Bona G, (2002) Circulating ghrelin levels as function of gender, pubertal status and adiposity in childhood. J Endocrinol Invest 25: 13-15.
4. Calissendorff J, Danielsson O, Brismar K, Rojdmark S, (2005) Inhibitory effect of alcohol on ghrelin secretion in normal man. Eur J Endocrinol 152: 743-747. (Pubitemid 40744543)
5. Ciccocioppo R, (2013) Genetically selected alcohol preferring rats to model human alcoholism. Curr Top Behav Neurosci 13: 251-269.
6. Clifford PS, Rodriguez J, Schul D, Hughes S, Kniffin T, Hart N, Eitan S, Brunel L, Fehrentz JA, Martinez J, Wellman PJ, (2012) Attenuation of cocaine-induced locomotor sensitization in rats sustaining genetic or pharmacologic antagonism of ghrelin receptors. Addict Biol 17: 956-963.
7. Cummings DE, Weigle DS, Frayo RS, Breen PA, Ma MK, Dellinger EP, Purnell JQ, (2002) Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 346: 1623-1630. (Pubitemid 34755670)
8. Daoust M, Lhuintre JP, Moore N, Saligant C, Filipo JL, Boismare F, (1987) Is initial sensitivity to ethanol correlated with alcohol preference in alcohol-drinking and non-drinking rats? Alcohol Alcohol 22: 409-414.
9. Davis KW, Wellman PJ, Clifford PS, (2007) Augmented cocaine conditioned place preference in rats pretreated with systemic ghrelin. Regul Pept 140: 148-152. (Pubitemid 46418913)
10. Dyr W, Kostowski W, (2008) Warsaw high-preferring (WHP) and Warsaw low-preferring (WLP) lines of rats selectively bred for high and low voluntary ethanol intake: preliminary phenotypic characterization. Alcohol 42: 161-170. (Pubitemid 351508378)
11. Dyr W, Krzascik P, Dudek K, Witanowska A, Dzierzkowska J, Kostowski W, (1999) A new line of Wistar rats selected for preference for alcohol: behavioral characteristics. Alkoholizm i Narkomania 37: 525-543.
12. Egecioglu E, Jerlhag E, Salomé N, Skibicka KP, Haage D, Bohlooly YM, Andersson D, Bjursell M, Perrissoud D, Engel JA, Dickson SL, (2010) Ghrelin increases intake of rewarding food in rodents. Addict Biol 15: 304-311.
13. Gomez G, Englander EW, Greeley GH Jr, (2004) Nutrient inhibition of ghrelin secretion in the fasted rat. Regul Pept 117: 33-36. (Pubitemid 37548396)
14. Hammoumi S, Naassila M, Daoust M, (1997) Experimental findings in the study of the reduction of alcohol intake. Eur Neuropsychopharmacol 7: S337-S340. (Pubitemid 27487899)
15. Jerlhag E, (2008) Systemic administration of ghrelin induces conditioned place preference and stimulates accumbal dopamine. Addict Biol 13: 358-363.
16. Jerlhag E, Egecioglu E, Dickson S, Andersson M, Svensson L, Engel JA, (2006) Ghrelin stimulates locomotor activity and accumbal dopamine overflow via central cholinergic systems in mice: implications for its involvement in brain reward. Addict Biol 11: 45-54. (Pubitemid 46696736)
17. Jerlhag E, Egecioglu E, Landgren S, Salome N, Heilig M, Moechars D, (2009) Requirement of central ghrelin signaling for alcohol reward. Proc Natl Acad Sci U S A 106: 11318-11323.
18. Kalra SP, Kalra PS, (2004) Overlapping and interactive pathways regulating appetite and craving. J Addict Dis 23: 5-21. (Pubitemid 39045338)
19. Khisti RT, Wolstenholme J, Shelton KL, Miles MF, (2006) Characterization of the ethanol-deprivation effect in substrains of C57BL/6 mice. Alcohol 40: 119-126. (Pubitemid 46329323)
20. Kim DJ, Yoon SJ, Choi B, Kim TS, Woo YS, Kim W, Myrick H, Peterson BS, Choi YB, Kim YK, Jeong J, (2005) Increased fasting plasma ghrelin levels during alcohol abstinence. Alcohol Alcohol 40: 76-79.
21. Koob GF, (2000) Animal models of craving for ethanol. Addiction 95: S73-S81. (Pubitemid 30650373)
22. Kraus T, Schanze A, Gröschl M, Bayerlein K, Hillemacher T, Reulbach U, Kornhuber J, Bleich S, (2005) Ghrelin levels are increased in alcoholism. Alcohol Clin Exp Res 29: 2154-2157. (Pubitemid 43042806)
23. Kumar S, Porcu P, Werner DF, Matthews DB, Diaz-Granados JL, Helfand RS, Morrow AL, (2009) The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress. Psychopharmacology (Berl) 205: 529-564.
24. Landgren S, Engel JA, Hyytiä P, Zetterberg H, Blennow K, Jerlhag E, (2011) Expression of the gene encoding the ghrelin receptor in rats selected for differential alcohol preference. Behav Brain Res 221: 182-188.
25. Landgren S, Jerlhag E, Hallman J, Oreland L, Lissner L, Strandhagen E, Thelle DS, Zetterberg H, Blennow K, Engel JA, (2010) Genetic variation of the ghrelin signaling system in females with severe alcohol dependence. Alcohol Clin Exp Res 34: 1519-1524.
26. Landgren S, Simms JA, Hyytiä P, Engel JA, Bartlett SE, Jerlhag E, (2012) Ghrelin receptor (GHS-R1A) antagonism suppresses both operant alcohol self-administration and high alcohol consumption in rats. Addict Biol 17: 86-94.
27. Leggio L, Ferrulli A, Cardone S, Nesci A, Miceli A, Malandrino N, Capristo E, Canestrelli B, Monteleone P, Kenna GA, Swift RM, Addolorato G, (2012) Ghrelin system in alcohol-dependent subjects: role of plasma ghrelin levels in alcohol drinking and craving. Addict Biol 17: 452-464.
28. Lin RC, Guthrie S, Xie CY, Mai K, Lee DY, Lumeng L, Li TK, (1996) Isoflavonoid compounds extracted from Pueraria lobata suppresses alcohol preference in a pharmacogenetic rat model of alcoholism. Alcohol Clin Exp Res 20: 659-663. (Pubitemid 26186931)
29. Linakis JG, Cunningham CL, (1979) Effects of concentration of ethanol injected intraperitoneally on taste aversion, body temperature and activity. Psychopharmacology 64: 61-65. (Pubitemid 9227043)
30. Makovey J, Naganathan V, Seibel M, Sambrook P, (2007) Gender differences in plasma ghrelin and its relations to body composition and bone-an opposite-sex twin study. Clin Endocrinol 66: 530-537. (Pubitemid 46434935)
31. McGregor IS, Gallate JE, (2004) Rats on the grog: novel pharmacotherapies for alcohol craving. Addict Behav 29: 1341-1357. (Pubitemid 39165993)
32. Mikolajczak P, Okulicz-Kozaryn I, Kaminska E, Szulc M, Dyr W, Kostowski W, (2003) Lack of ifenprodil anxiolytic activity after its multiple treatment in chronically ethanol-treated rats. Alcohol Alcohol 38: 310-315. (Pubitemid 36826977)
33. Mikolajczak P, Okulicz-Kozaryn I, Kaminska E, Wiktorowicz K, Lesniewska K, Dyr W, Kostowski W, (2002) Effect of subchronic ethanol treatment on plasma and cerebrospinal fluid leptin levels in rats selectively bred for high and low alcohol preference. Pol J Pharmacol 54: 127-132. (Pubitemid 34546195)
34. Mikolajczak P, Okulicz-Kozaryn I, Szczawinska K, Kaminska E, Kus K, (1999) Zolpidem in involvement on memory in hypnotic effects of ethanol in chronically ethanol-treated rats. Alcohol Alcohol 34: 511-519. (Pubitemid 29371695)
35. Mikolajczak P, Wiktorowicz K, Okulicz-Kozaryn I, Kostrzewa A, Kaminska E, (2000) Analysis of the distribution of peripheral blood lymphocyte subsets associated with chronic ethanol treatment in rats with a disturbed circadian cycle. Drug Alcohol Depend 60: 303-309.
36. Morganstern I, Chang GQ, Barson JR, Ye Z, Karatayev O, Leibowitz SF, (2010) Differential effects of acute and chronic ethanol exposure on orexin expression in the perifornical lateral hypothalamus. Alcohol Clin Exp Res 34: 886-896.
37. Okulicz-Kozaryn I, Mikolajczak P, Kaminska E, Kaminska I, Szulc M, Bobkiewicz-Kozlowska T, (2004) Effect of naltrexone on short-term memory in chronically ethanol treated rats. Alcohol Alcohol 39: 14-19. (Pubitemid 38111666)
38. Ripley TL, Stephens DN, (2011) Critical thoughts on current rodent models for evaluating potential treatments of alcohol addiction and withdrawal. Br J Pharmacol 164: 1335-1356.
39. Rodd ZA, Bell RL, Kuc KA, Murphy JM, Lumeng L, McBride WJ, (2009) Effects of concurrent access to multiple ethanol concentrations and repeated deprivations on alcohol intake of high-alcohol-drinking (HAD) rats. Addict Biol 14: 152-164.
40. Samson HH, (2000) The microstructure of ethanol drinking: genetic and behavioral factors in the control of drinking patterns. Addiction 95: S61-S72. (Pubitemid 30650372)
41. Sanchis-Segura C, Spanagel R, (2006) Behavioural assessment of drug reinforcement and addictive features in rodents: an overview. Addict Biol 11: 2-38. (Pubitemid 46696746)
42. Schneider E, Rada P, Darby RD, Leibowitz S, Hoebel B, (2007) Orexigenic peptides and alcohol intake: differential effects of orexin, galanin, and ghrelin. Alcohol Clin Exp Res 31: 1858-1865. (Pubitemid 47609647)
43. Shiiya T, Nakazato M, Mizuta M, Date Y, Mondal MS, Tanaka M, Nozoe S, Hosoda H, Kangawa K, Matsukura S, (2002) Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab 87: 240-244. (Pubitemid 34084697)
44. Skibicka KP, Hansson C, Egecioglu E, Dickson SL, (2012) Role of ghrelin in food reward: impact of ghrelin on sucrose self-administration and mesolimbic dopamine and acetylcholine receptor gene expression. Addict Biol 17: 95-107.
45. Spanagel R, (2003) Alcohol addiction research: from animal models to clinics. Best Pract Res Clin Gastroenterol 17: 507-518.
46. Spanagel R, Holter SM, (2000) Pharmacological validation of a new animal model of alcoholism. J Neural Transm 107: 669-680. (Pubitemid 30364707)
47. Spanagel R, Kiefer F, (2008) Drugs for relapse prevention of alcoholism: ten years of progress. Trends Pharmacol Sci 29: 109-115.
48. Thiele TE, Navarro M, Sparta DR, Fee JR, Knapp D, Cubero I, (2003) Alcoholism and obesity: overlapping neuropeptide pathways? Neuropeptides 37: 321-327.
49. Tschop M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, Heiman ML, (2001) Circulating ghrelin levels are decreased in human obesity. Diabetes 50: 707-709. (Pubitemid 32242624)
50. Wellman PJ, Clifford PS, Rodriguez JA, Hughes S, Di Francesco C, Melotto S, Tessari M, Corsi M, Bifone A, Gozzi A, (2012) Brain reinforcement system function is ghrelin dependent: studies in the rat using pharmacological fMRI and intracranial self-stimulation. Addict Biol 17: 908-919.
51. Wellman PJ, Davis KW, Nation JR, (2005) Augmentation of cocaine hyperactivity in rats by systemic ghrelin. Regul Pept 125: 151-154. (Pubitemid 39593719)
52. Wurst FM, Graf I, Ehrenthal HD, Klein S, Backhaus J, Blank S, Graf M, Pridzun L, Wiesbeck GA, Junghanns K, (2007) Gender differences for ghrelin levels in alcohol-dependent patients and differences between alcoholics and healthy controls. Alcohol Clin Exp Res 31: 2006-2011. (Pubitemid 350150748)
53. Zeren U, Sönmez MB, Vardar E, (2011) Evaluation of the levels of leptin, ghrelin, and prolactin in alcohol dependent patients. Bull Clin Psychopharmacol 21: 122-130.
54. Zimmermann US, Buchmann A, Steffin B, Dieterle C, Uhr M, (2007) Alcohol administration acutely inhibits ghrelin secretion in an experiment involving psychosocial stress. Addict Biol 12: 17-21. (Pubitemid 46405991)