Differential effects of acute and chronic ethanol exposure on orexin expression in the perifornical lateral hypothalamus

Alcoholism: Clinical and Experimental Research

Volumn 34, Issue 5, 2010, Pages 886-896

  Morganstern, Irene ^a   Chang, Guo Q ^a   Barson, Jessica R ^a,b   Ye, Zhiyu ^a   Karatayev, Olga ^a   Leibowitz, Sarah F ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b PRINCETON UNIVERSITY   (United States)

Author keywords

Ethanol; Lateral Hypothalamus; Orexin; Perifornical Hypothalamus; Sprague Dawley Rat

Indexed keywords

ALCOHOL; MESSENGER RNA; OREXIN;

ALCOHOL CONSUMPTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRINKING BEHAVIOR; FEEDBACK SYSTEM; GENE EXPRESSION; HISTOCHEMISTRY; IMMUNOFLUORESCENCE TEST; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; LATERAL HYPOTHALAMUS; MALE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ALCOHOL DRINKING; ANIMALS; BIOFEEDBACK, PSYCHOLOGY; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; GENE EXPRESSION REGULATION; HYPOTHALAMIC AREA, LATERAL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; NEUROPEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; REWARD;

ANIMALIA; RATTUS;

EID: 77951609645     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2010.01161.x     Document Type: Article

References (72)

1. Alberto CO, Trask RB, Quinlan ME, Hirasawa M (2006) Bidirectional dopaminergic modulation of excitatory synaptic transmission in orexin neurons. J Neurosci 26 : 10043 10050. (Pubitemid 44477165)
2. APA (2000) Diagnostic and Statistical Manual of Mental Disorders: DSM-IV-TR. American Psychiatric Association
3. Backberg M, Ultenius C, Fritschy JM, Meister B (2004) Cellular localization of GABA receptor alpha subunit immunoreactivity in the rat hypothalamus: relationship with neurones containing orexigenic or anorexigenic peptides. J Neuroendocrinol 16 : 589 604. (Pubitemid 39029092)
4. Becker C (2008) Alcohol dependence, withdrawal, and relapse. Alcohol Res Health 31 : 348 351.
5. Borgland SL, Taha SA, Sarti F, Fields HL, Bonci A (2006) Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine. Neuron 49 : 589 601. (Pubitemid 43221893)
6. Boutrel B, Kenny PJ, Specio SE, Martin-Fardon R, Markou A, Koob GF, de Lecea L (2005) Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior. Proc Natl Acad Sci USA 102 : 19168 19173. (Pubitemid 43049584)
7. Brodie MS, Shefner SA, Dunwiddie TV (1990) Ethanol increases the firing rate of dopamine neurons of the rat ventral tegmental area in vitro. Brain Res 508 : 65 69.
8. Bubser M, Fadel J, Jackson L, Meador-Woodruff J, Jing D, Deutch A (2005) Dopaminergic regulation of orexin neurons. Eur J Neurosci 21 : 2993 3001. (Pubitemid 40917063)
9. Chang G-Q, Gaysinskaya V, Karatayev O, Leibowitz SF (2008) Maternal high-fat diet and fetal programming: increased proliferation of hypothalamic peptide-producing neurons that increase risk for overeating and obesity. J Neurosci 28 : 12107 12119.
10. Chang G-Q, Karatayev O, Ahsan R, Avena NM, Lee C, Lewis MJ, Hoebel BG, Leibowitz SF (2007) Effect of ethanol on hypothalamic opioid peptides, enkephalin, and dynorphin: relationship with circulating triglycerides. Alcohol Clin Exp Res 31 : 249 259. (Pubitemid 46155224)
11. Chang G-Q, Karatayev O, Davydova Z, Leibowitz SF (2004) Circulating triglycerides impact on orexigenic peptides and neuronal activity in hypothalamus. Endocrinology 145 : 3904 3912. (Pubitemid 39037579)
12. Chang SL, Patel NA, Romero AA (1995) Activation and desensitization of Fos immunoreactivity in the rat brain following ethanol administration. Brain Res 679 : 89 98.
13. Chemelli RM, Willie JT, Sinton CM, Elmquist JK, Scammell T, Lee C, Richardson JA, Williams SC, Xiong Y, Kisanuki Y, Fitch TE, Nakazato M, Hammer RE, Saper CB, Yanagisawa M (1999) Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98 : 437 451. (Pubitemid 29402482)
14. Davis TJ, de Fiebre CM (2006) Alcohol's actions on neuronal nicotinic acetylcholine receptors. Alcohol Res Health 29 : 179 185.
15. Dayas C, McGranahan T, Martin-Fardon R, Weiss F (2008) Stimuli linked to ethanol availability activate hypothalamic CART and orexin neurons in a reinstatement model of relapse. Biol Psychiatry 63 : 152 157. (Pubitemid 350299313)
16. Deitrich RA, Dunwiddie TV, Harris RA, Erwin VG (1989) Mechanism of action of ethanol: initial central nervous system actions. Pharmacol Rev 41 : 489 537. (Pubitemid 20159865)
17. DiLeone RJ, Georgescu D, Nestler EJ (2003) Lateral hypothalamic neuropeptides in reward and drug addiction. Life Sci 73 : 759 768. (Pubitemid 36703270)
18. Espana RA, Reis KM, Valentino RJ, Berridge CW (2005) Organization of hypocretin/orexin efferents to locus coeruleus and basal forebrain arousal-related structures. J Comp Neurol 481 : 160 178.
19. Estabrooke IV, McCarthy MT, Ko E, Chou TC, Chemelli RM, Yanagisawa M, Saper CB, Scammell TE (2001) Fos expression in orexin neurons varies with behavioral state. J Neurosci 21 : 1656 1662. (Pubitemid 32182206)
20. Fadel J, Deutch AY (2002) Anatomical substrates of orexin-dopamine interactions: lateral hypothalamic projections to the ventral tegmental area. Neuroscience 111 : 379 387. (Pubitemid 34442621)
21. Fish EW, Riday TT, McGuigan MM, Faccidomo S, Hodge CW, Malanga CJ (2010) Alcohol, cocaine, and brain stimulation-reward in C57Bl6/J and DBA2/J mice. Alcohol Clin Exp Res 34 : 81 89.
22. Georgescu D, Zachariou V, Barrot M, Mieda M, Willie JT, Eisch AJ, Yanagisawa M, Nestler EJ, DiLeone RJ (2003) Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal. J Neurosci 23 : 3106 3111. (Pubitemid 36531950)
23. Gessa GL, Muntoni F, Collu M, Vargiu L, Mereu G (1985) Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area. Brain Res 348 : 201 203. (Pubitemid 16235764)
24. Gingras MA, Cools AR (1996) Analysis of the biphasic locomotor response to ethanol in high and low responders to novelty: a study in Nijmegen Wistar rats. Psychopharmacology (Berl) 125 : 258 264.
25. Hansson AC, Rimondini R, Neznanova O, Sommer WH, Heilig M (2008) Neuroplasticity in brain reward circuitry following a history of ethanol dependence. Eur J Neurosci 27 : 1912 1922. (Pubitemid 351521481)
26. Hara J, Beuckmann CT, Nambu T, Willie JT, Chemelli RM, Sinton CM, Sugiyama F, Yagami K, Goto K, Yanagisawa M, Sakurai T (2001) Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron 30 : 345 354. (Pubitemid 32530580)
27. Harris GC, Aston-Jones G (2006) Arousal and reward: a dichotomy in orexin function. Trends Neurosci 29 : 571 577. (Pubitemid 44416459)
28. Harris GC, Wimmer M, Aston-Jones G (2005) A role for lateral hypothalamic orexin neurons in reward seeking. Nature 437 : 556 559. (Pubitemid 41613553)
29. Haynes AC, Jackson B, Overend P, Buckingham RE, Wilson S, Tadayyon M, Arch JR (1999) Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat. Peptides 20 : 1099 1105. (Pubitemid 29424217)
30. Jarjour S, Bai L, Gianoulakis C (2009) Effect of acute ethanol administration on the release of opioid peptides from the midbrain including the ventral tegmental area. Alcohol Clin Exp Res 33 : 1033 1043.
31. Kaneyuki T, Morimasa T, Shohmori T (1995) Neurotransmitter interactions in the striatum and hypothalamus of mice after single and repeated ethanol treatment. Acta Med Okayama 49 : 13 17.
32. Khatib SA, Murphy JM, McBride WJ (1988) Biochemical evidence for activation of specific monoamine pathways by ethanol. Alcohol 5 : 295 299.
33. Korotkova TM, Sergeeva OA, Eriksson KS, Haas HL, Brown RE (2003) Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins/hypocretins. J Neurosci 23 : 7 11. (Pubitemid 36050397)
34. Lawrence AJ, Cowen MS, Yang HJ, Chen F, Oldfield B (2006) The orexin system regulates alcohol-seeking in rats. Br J Pharmacol 148 : 752 759. (Pubitemid 44079404)
35. de Lecea L, Kilduff T, Peyron C, Gao X, Foye P, Danielson P, Fukuhara C, Battenberg E, Gautvik V, Bartlett FN, Frankel W, van den Pol A, Bloom F, Gautvik K, Sutcliffe J (1998) The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci U S A 95 : 322 327. (Pubitemid 28103952)
36. Leibowitz SF (2007) Overconsumption of dietary fat and alcohol: mechanisms involving lipids and hypothalamic peptides. Physiol Behav 91 : 513 521.
37. Leibowitz SF, Avena NM, Chang GQ, Karatayev O, Chau DT, Hoebel BG (2003) Ethanol intake increases galanin mRNA in the hypothalamus and withdrawal decreases it. Physiol Behav 79 : 103 111. (Pubitemid 36734834)
38. Lewis MJ, Johnson DF, Waldman D, Leibowitz SF, Hoebel BG (2004) Galanin microinjection in the third ventricle increases voluntary ethanol intake. Alcohol Clin Exp Res 28 : 1822 1828. (Pubitemid 39665198)
39. Li Y, van den Pol AN (2005) Direct and indirect inhibition by catecholamines of hypocretin/orexin neurons. J Neurosci 25 : 173 183. (Pubitemid 40110778)
40. Lin L, Faraco J, Li R, Kadotani H, Rogers W, Lin X, Qiu X, de Jong PJ, Nishino S, Mignot E (1999) The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98 : 365 376. (Pubitemid 29380571)
41. Lucas LR, Pompei P, Ono J, McEwen BS (1998) Effects of adrenal steroids on basal ganglia neuropeptide mRNA and tyrosine hydroxylase radioimmunoreactive levels in the adrenalectomized rat. J Neurochem 71 : 833 843. (Pubitemid 28480433)
42. Mocsary Z, Bradberry CW (1996) Effect of ethanol on extracellular dopamine in nucleus accumbens: comparison between Lewis and Fischer 344 rat strains. Brain Res 706 : 194 198. (Pubitemid 26046717)
43. Moragues N, Ciofi P, Lafon P, Tramu G, Garret M (2003) GABAA receptor epsilon subunit expression in identified peptidergic neurons of the rat hypothalamus. Brain Res 967 : 285 289. (Pubitemid 36324309)
44. Muraki Y, Yamanaka A, Tsujino N, Kilduff T, Goto K, Sakurai T (2004) Serotonergic regulation of the orexin/hypocretin neurons through the 5-HT1A receptor. J Neurosci 24 : 7159 7166. (Pubitemid 39096381)
45. Narita M, Nagumo Y, Hashimoto S, Narita M, Khotib J, Miyatake M, Sakurai T, Yanagisawa M, Nakamachi T, Shioda S, Suzuki T (2006) Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine. J Neurosci 26 : 398 405. (Pubitemid 43237102)
46. Novak CM, Levine JA (2009) Daily intraparaventricular orexin-A treatment induces weight loss in rats. Obesity (Silver Spring) 17 : 1493 1498.
47. Ogilvie K, Lee S, Rivier C (1997) Effect of three different modes of alcohol administration on the activity of the rat hypothalamic-pituitary-adrenal axis. Alcohol Clin Exp Res 21 : 467 476. (Pubitemid 27217191)
48. Ogilvie KM, Lee S, Rivier C (1998) Divergence in the expression of molecular markers of neuronal activation in the parvocellular paraventricular nucleus of the hypothalamus evoked by alcohol administration via different routes. J Neurosci 18 : 4344 4352. (Pubitemid 28243827)
49. Olds J (1958) Self-stimulation of the brain; its use to study local effects of hunger, sex, and drugs. Science 127 : 315 324.
50. Olds J, Milner P (1954) Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain. J Comp Physiol Psychol 47 : 419 427.
51. Paxinos G, Watson C (1986) The Rat Brain in Stereotaxic Coordinates. Academic Press
52. Peyron C, Tighe DK, Van Den Pol AN, de Lecea L, Heller HC, Sutcliffe JG, Kilduff TS (1998) Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 18 : 9996 10015. (Pubitemid 28543775)
53. Rada P, Avena NM, Leibowitz SF, Hoebel BG (2004) Ethanol Intake is Increased by PVN Galanin Injection and Reduced by a GAL Antagonist. Alcohol 33 : 91 97.
54. Reagan LP, Rosell DR, Wood GE, Spedding M, Munoz C, Rothstein J, McEwen BS (2004) Chronic restraint stress up-regulates GLT-1 mRNA and protein expression in the rat hippocampus: reversal by tianeptine. Proc Natl Acad Sci USA 101 : 2179 2184. (Pubitemid 38229035)
55. Rossi M, Choi SJ, O'Shea D, Miyoshi T, Ghatei MA, Bloom SR (1997) Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight. Endocrinology 138 : 351 355. (Pubitemid 27009443)
56. Ryabinin AE, Criado JR, Henriksen SJ, Bloom FE, Wilson MC (1997) Differential sensitivity of c-Fos expression in hippocampus and other brain regions to moderate and low doses of alcohol. Mol Psychiatry 2 : 32 43.
57. Sakurai T (1999) Orexins and orexin receptors: implication in feeding behavior. Regul Pept 85 : 25 30. (Pubitemid 29505282)
58. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92 : 573 585. (Pubitemid 28101119)
59. Schaefer GJ, Michael RP (1987) Ethanol and current thresholds for brain self-stimulation in the lateral hypothalamus of the rat. Alcohol 4 : 209 213.
60. Schneider ER, Rada P, Darby RD, Leibowitz SF, Hoebel BG (2007) Orexigenic peptides and alcohol intake: Differential effects of orexin, galanin, and ghrelin. Alcohol Clin Exp Res 31 : 1858 1865. (Pubitemid 47609647)
61. Sweet DC, Levine AS, Billington CJ, Kotz CM (1999) Feeding response to central orexins. Brain Res 821 : 535 538.
62. Thiele TE, van Dijk G, Bernstein IL (1997) Ethanol-induced c-Fos expression in rat lines selected for low and high alcohol consumption. Brain Res 756 : 278 282. (Pubitemid 27241637)
63. Vittoz NM, Berridge CW (2006) Hypocretin/orexin selectively increases dopamine efflux within the prefrontal cortex: involvement of the ventral tegmental area. Neuropsychopharmacology 31 : 384 395.
64. Wang B, You ZB, Wise RA (2009) Reinstatement of cocaine seeking by hypocretin (orexin) in the ventral tegmental area: independence from the local corticotropin-releasing factor network. Biol Psychiatry 65 : 857 862.
65. WHO (2009) Management of Substance Abuse: Alcohol. World Health Organization
66. Wortley K, Chang G, Davydova Z, Leibowitz S (2003) Peptides that regulate food intake: orexin gene expression is increased during states of hypertriglyceridemia. Am J Physiol Regul Integr Comp Physiol 284 : R1454 R1465.
67. Xie XM, Crowder TL, Yamanaka A, Morairty SR, LeWinter RD, Sakurai T, Kilduff TS (2006) GABA(B) receptor-mediated modulation of hypocretin/orexin neurones in mouse hypothalamus. J Physiol-London 574 : 399 414.
68. Yamanaka A, Sakurai T, Katsumoto T, Yanagisawa M, Goto K (1999) Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight. Brain Res 849 : 248 252.
69. Yamane F, Tohyama Y, Diksic M (2003) Continuous ethanol administration influences rat brain 5-hyroxytrytamine synthesis non-umiformly: alpha-[14C]methyl-L-trytophan autoradiographic measurements. Alcohol Alcohol 38 : 115 120. (Pubitemid 36372399)
70. Yoshimoto K, McBride WJ, Lumeng L, Li TK (1992) Alcohol stimulates the release of dopamine and serotonin in the nucleus accumbens. Alcohol 9 : 17 22.
71. Zhou Y, Bendor J, Hofmann L, Randesi M, Ho A, Kreek MJ (2006) Mu opioid receptor and orexin/hypocretin mRNA levels in the lateral hypothalamus and striatum are enhanced by morphine withdrawal. J Endocrinol 191 : 137 145. (Pubitemid 44756516)
72. Zhou Y, Cui CL, Schlussman SD, Choi JC, Ho A, Han JS, Kreek MJ (2008) Effects of cocaine place conditioning, chronic escalating-dose "binge" pattern cocaine administration and acute withdrawal on orexin/hypocretin and preprodynorphin gene expressions in lateral hypothalamus of Fischer and Sprague-Dawley rats. Neuroscience 153 : 1225 1234.