Downregulation of NF-κB signaling by mutant huntingtin proteins induces oxidative stress and cell death

Cellular and Molecular Life Sciences

Volumn 67, Issue 11, 2010, Pages 1929-1941

  Reijonen, Sami ^a   Kukkonen, Jyrki P ^a,b   Hyrskyluoto, Alise ^a   Kivinen, Jenny ^a   Kairisalo, Minna ^a   Takei, Nobuyuki ^c   Lindholm, Dan ^a   Korhonen, Laura ^a,d  

^a MINERVA FOUNDATION INSTITUTE FOR MEDICAL RESEARCH   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c NIIGATA UNIVERSITY   (Japan)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Calpastatin; Cell death; Endoplasmic reticulum stress; Nuclear factor appa B; Oxidative stress

Indexed keywords

ANTIOXIDANT; CALPAIN; CALPASTATIN; HUNTINGTIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; MUTANT PROTEIN; POLYGLUTAMINE; PROTEIN IRE1; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR RELA; CALCIUM BINDING PROTEIN; HD PROTEIN, HUMAN; HYBRID PROTEIN; MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL PROTEIN; NERVE PROTEIN; NUCLEAR PROTEIN; PRIMER DNA; RELA PROTEIN, HUMAN; SUPEROXIDE DISMUTASE; THIOREDOXIN; TXN2 PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DEATH; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME REGULATION; GENE OVEREXPRESSION; MUTANT; NERVE CELL; OXIDATIVE STRESS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; CALCIUM SIGNALING; CELL LINE; CELL STRAIN; GENETICS; HUMAN; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; RAT;

ANIMALS; BASE SEQUENCE; CALCIUM SIGNALING; CALCIUM-BINDING PROTEINS; CALPAIN; CELL DEATH; CELL LINE; DNA PRIMERS; DOWN-REGULATION; HUMANS; MITOCHONDRIAL PROTEINS; MUTATION; NERVE TISSUE PROTEINS; NF-KAPPA B; NUCLEAR PROTEINS; OXIDATIVE STRESS; PC12 CELLS; RATS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; THIOREDOXINS; TRANSCRIPTION FACTOR RELA;

EID: 77952568816     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-010-0305-y     Document Type: Article

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