Identification through high-throughput screening of 4'-methoxyflavone and 3',4'-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos

British Journal of Pharmacology

Volumn 169, Issue 6, 2013, Pages 1263-1278

  Fatokun, A A ^a,b   Liu, J O ^a   Dawson, V L ^a   Dawson, T M ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

flavone; high throughput screen; methoxylation; neurodegeneration; neurotherapeutics; PARP 1 inhibitors

Indexed keywords

3' ,4' DIMETHOXYFLAVONE; 4' METHOXYFLAVONE; N METHYL DEXTRO ASPARTIC ACID; NEUROPROTECTIVE AGENT; POLY(ADENOSINE DIPHOSPHATE RIBOSE); UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN CORTEX; BRAIN NERVE CELL; CELL DEATH; CELL STRAIN; CELL VIABILITY; CONTROLLED STUDY; DRUG STRUCTURE; FETUS; HELA CELL; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SH SY5Y CELLS; STRUCTURE ACTIVITY RELATION;

ALKYLATING AGENTS; ANIMALS; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; DRUG DISCOVERY; EMBRYO, MAMMALIAN; ENZYME ACTIVATION; FLAVONES; FLAVONOIDS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; METHYLNITRONITROSOGUANIDINE; MICE, INBRED STRAINS; NERVE TISSUE PROTEINS; NEURONS; NEUROPROTECTIVE AGENTS; POLY(ADP-RIBOSE) POLYMERASES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84879369568     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12201     Document Type: Article

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