γ-Secretase inhibition promotes fibrotic effects of albumin in proximal tubular epithelial cells

British Journal of Pharmacology

Volumn 169, Issue 6, 2013, Pages 1239-1251

  Slattery, C ^a   Jang, Y ^b   Kruger, W A ^c   Hryciw, D H ^d   Lee, A ^b   Poronnik, P ^c,e  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c RMIT UNIVERSITY   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e UNIVERSITY OF SYDNEY   (Australia)

Author keywords

secretase; albuminuria; epidermal growth factor receptor; renal epithelial cell; renal fibrosis

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; ALBUMIN; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBRONECTIN; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; KIDNEY FIBROSIS; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE EPITHELIUM; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; UPREGULATION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BENZODIAZEPINONES; CATTLE; CELL LINE; CULTURE MEDIA, SERUM-FREE; ENDOCYTOSIS; ENZYME INHIBITORS; FIBRONECTINS; FIBROSIS; HUMANS; KIDNEY TUBULES, PROXIMAL; MAP KINASE SIGNALING SYSTEM; OPOSSUMS; PROTEOLYSIS; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; SERUM ALBUMIN, BOVINE; TRANSFORMING GROWTH FACTOR BETA1; TYRPHOSTINS; UROTHELIUM;

EID: 84879355816     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12214     Document Type: Article

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