Regulated intramembrane proteolysis of megalin: Linking urinary protein and gene regulation in proximal tubule?

Kidney International

Volumn 69, Issue 10, 2006, Pages 1717-1721

  Biemesderfer, D ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Megalin; Presenilin; Proteinuria; Receptor mediated endocytosis; Signaling

Indexed keywords

GAMMA SECRETASE; MEGALIN; MEMBRANE ASSOCIATED C TERMINAL FRAGMENT; METALLOPROTEINASE; NOTCH RECEPTOR; PEPTIDE FRAGMENT; PRESENILIN; PROTEIN; PROTEIN KINASE C; SCAVENGER RECEPTOR; UNCLASSIFIED DRUG;

CARBOXY TERMINAL SEQUENCE; ECTODOMAIN SHEDDING; ENDOCYTOSIS; ENZYME SUBSTRATE; GENE CONTROL; GENE EXPRESSION REGULATION; GENETIC CONSERVATION; HUMAN; KIDNEY DISEASE; KIDNEY PROXIMAL TUBULE; NONHUMAN; NUCLEOCYTOPLASMIC TRANSPORT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN URINE LEVEL; PROTEINURIA; RECEPTOR MEDIATED ENDOCYTOSIS; REGULATED INTRAMEMBRANE PROTEOLYSIS; SHORT SURVEY; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; GENE EXPRESSION REGULATION; HYDROLYSIS; IMMUNOHISTOCHEMISTRY; KIDNEY TUBULES, PROXIMAL; LDL-RECEPTOR RELATED PROTEIN 2; MODELS, BIOLOGICAL; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY;

EID: 33646708967     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/sj.ki.5000298     Document Type: Short Survey

References (20)

1. Gekle M. Renal tubule albumin transport. Annu Rev Physiol 2005; 67: 573-594.
2. Christensen EI, Birn H. Megalin and cubilin: multifunctional endocytic receptors. Nat Rev Mol Cell Biol 2002; 3: 256-266.
3. Kerjaschki D, Farquhar MG. The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border. Proc Natl Acad Sci USA 1982; 79: 5557-5581.
4. Brown MS, Goldstein JL. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 1997; 89: 331-340.
5. Schroeter EH, Kisslinger JA, Kopan R. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature 1998; 393: 382-386.
6. Hartmann D, Tournoy J, Saftig P et al. Implication of APP secretases in notch signaling. J Mol Neurosci 2001; 17: 171-181.
7. Xia W, Wolfe MS. Intramembrane proteolysis by presenilin and presenilin-like proteases. J Cell Sci 2003; 116: 2839-2844.
8. Gupta-Rossi N, Six E, LeBail O et al. Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor. J Cell Biol 2004; 166: 73-83.
9. May P, Reddy YK, Herz J. Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain. J Biol Chem 2002; 277: 18736-18743.
10. May P, Bock HH, Herz J. Integration of endocytosis and signal transduction by lipoprotein receptors. Sci STKE 2003; 2003: PE12.
11. Nykjaer A, Dragun D, Walther D et al. An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. Cell 1999; 96: 507-515.
12. Petersen HH, Hilpert J, Militz D et al. Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule. J Cell Sci 2003; 116: 453-461.
13. Zou Z, Chung B, Nguyen T et al. Linking receptor-mediated endocytosis and cell signaling: Evidence for regulated intramembrane proteolysis of megalin in proximal tubule. J Biol Chem 2004; 279: 34302-34310.
14. Zhai XY, Nielsen R, Birn H et al. Cubilin- and megalin-mediated uptake of albumin in cultured proximal tubule cells of opossum kidney. Kidney Int 2000; 58: 1523-1533.
15. Donadelli R, Zanchi C, Morigi M et al. Protein overload induces fractalkine upregulation in proximal tubular cells through nuclear factor kappaB- and p38 mitogen-activated protein kinase-dependent pathways. J Am Soc Nephrol 2003; 14: 2436-2446.
16. Zoja C, Donadelli R, Colleoni S et al. Protein overload stimulates RANTES production by proximal tubular cells depending on NF-kappa B activation. Kidney Int 1998; 53: 1608-1615.
17. Klisic J, Zhang J, Nief V et al. Albumin regulates the Na+/H+ exchanger 3 in OKP cells. J Am Soc Nephrol 2003; 14: 3008-3016.
18. Di Fiore PP, De Camilli P. Endocytosis and signaling; an inseparable partnership. Cell 2001; 106: 1-4.
19. Cavalli V, Corti M, Gruenberg J. Endocytosis and signaling cascades: a close encounter. FEBS Lett 2001; 498: 190-196.
20. Piwon N, Gunther W, Schwake M et al. ClC-5 Cl- -channel disruption impairs endocytosis in a mouse model for Dent's disease. Nature 2000; 408: 369-373.