메뉴 건너뛰기




Volumn 301, Issue 6, 2011, Pages

TGF-β1 mediates sirolimus and cyclosporine a-induced alteration of barrier function in renal epithelial cells via a noncanonical ERK1/2 signaling pathway

Author keywords

Claudin; Immunosuppressive drugs; Nephrotoxicity; Transepithelial electrical resistance

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; CLAUDIN; CLAUDIN 1; CYCLOSPORIN A; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOTRANSFERASE; RAPAMYCIN; SD 208; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA1 RECEPTOR KINASE; UNCLASSIFIED DRUG;

EID: 82755162650     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00188.2010     Document Type: Article
Times cited : (18)

References (38)
  • 2
    • 53149099360 scopus 로고    scopus 로고
    • Molecular mechanisms of TGF beta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506
    • Akoolel S, Doller A, Babelova A, Tsalastra W, Moreth K, Schaefer L, Pfeilschifter J, Eberhardt W. Molecular mechanisms of TGF beta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506. J Immunol 181: 2831-2845, 2008.
    • (2008) J Immunol , vol.181 , pp. 2831-2845
    • Akoolel, S.1    Doller, A.2    Babelova, A.3    Tsalastra, W.4    Moreth, K.5    Schaefer, L.6    Pfeilschifter, J.7    Eberhardt, W.8
  • 5
    • 17844386098 scopus 로고    scopus 로고
    • Cyclosporine and rapamycin act in a synergistic and dose-dependent manner in a model of immunosuppressant-induced kidney damage
    • Brook NR, Waller JR, Bicknell GR, Nicholson ML. Cyclosporine and rapamycin act in a synergistic and dose-dependent manner in a model of immunosuppressant-induced kidney damage. Transplant Proc 37: 837-838, 2005.
    • (2005) Transplant Proc , vol.37 , pp. 837-838
    • Brook, N.R.1    Waller, J.R.2    Bicknell, G.R.3    Nicholson, M.L.4
  • 8
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signaling
    • Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-beta family signaling. Nature 425: 577-584, 2003.
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 9
    • 0027436376 scopus 로고
    • Cytokine modulation of intestinal epithelial cell restitution: Central role of transforming growth factor beta
    • Dignass AU, Podolsky DK. Cytokine modulation of intestinal epithelial cell restitution: central role of transforming growth factor beta. Gastroenterology 105: 1323-1332, 1993.
    • (1993) Gastroenterology , vol.105 , pp. 1323-1332
    • Dignass, A.U.1    Podolsky, D.K.2
  • 10
    • 0034667761 scopus 로고    scopus 로고
    • Rapamycin induces transforming growth factor-beta production by lymphocytes
    • Dodge IL, Demirci G, Strom TB, Li XC. Rapamycin induces transforming growth factor-beta production by lymphocytes. Transplantation 70: 1104-1106, 2000.
    • (2000) Transplantation , vol.70 , pp. 1104-1106
    • Dodge, I.L.1    Demirci, G.2    Strom, T.B.3    Li, X.C.4
  • 11
    • 34249883550 scopus 로고    scopus 로고
    • Role for tgf-Beta in cyclosporine-induced modulation of renal epithelial barrier function
    • Feldman G, Kiely B, Martin N, Ryan G, McMorrow T, Ryan MP. Role for tgf-Beta in cyclosporine-induced modulation of renal epithelial barrier function. J Am Soc Nephrol 18: 1662-1671, 2007.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 1662-1671
    • Feldman, G.1    Kiely, B.2    Martin, N.3    Ryan, G.4    McMorrow, T.5    Ryan, M.P.6
  • 12
    • 33846062366 scopus 로고    scopus 로고
    • The effects of different immunosuppressants on chronic allograft nephropathy by affecting the transforming growth factor-beta and Smads signal pathways
    • Gao R, Lu Y, Xin YP, Zhang XH, Wang J, Li YP. The effects of different immunosuppressants on chronic allograft nephropathy by affecting the transforming growth factor-beta and Smads signal pathways. Transplant Proc 38: 2154-2157, 2006.
    • (2006) Transplant Proc , vol.38 , pp. 2154-2157
    • Gao, R.1    Lu, Y.2    Xin, Y.P.3    Zhang, X.H.4    Wang, J.5    Li, Y.P.6
  • 14
    • 28244493047 scopus 로고    scopus 로고
    • Transforming growth factor-beta regulation of epithelial tight junction proteins enhances barrier function and blocks enterohemorrhagic Escherichia coli O157:H7-induced increased permeability
    • Howe KL, Reardon C, Wang A, Nazli A, McKay DM. Transforming growth factor-beta regulation of epithelial tight junction proteins enhances barrier function and blocks enterohemorrhagic Escherichia coli O157:H7-induced increased permeability. Am J Pathol 167: 1587-1597, 2005.
    • (2005) Am J Pathol , vol.167 , pp. 1587-1597
    • Howe, K.L.1    Reardon, C.2    Wang, A.3    Nazli, A.4    McKay, D.M.5
  • 15
    • 0017052382 scopus 로고
    • The origin and characteristics of a pig kidney cell strain
    • Hull RN, Cherry WR, Weaver GW. The origin and characteristics of a pig kidney cell strain, LLC-PK. In Vitro 12: 670-677, 1976.
    • (1976) LLC-PK. In Vitro , vol.12 , pp. 670-677
    • Hull, R.N.1    Cherry, W.R.2    Weaver, G.W.3
  • 16
  • 17
    • 33746530366 scopus 로고    scopus 로고
    • Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: A randomised multicentre study. The Rapamune US Study Group
    • Kahan BD. Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: a randomised multicentre study. The Rapamune US Study Group. Lancet 356: 194-202, 2000.
    • (2000) Lancet , vol.356 , pp. 194-202
    • Kahan, B.D.1
  • 18
    • 0033610638 scopus 로고    scopus 로고
    • Sirolimus reduces the incidence of acute rejection episodes despite lower cyclosporine doses in caucasian recipients of mismatched primary renal allografts: A phase II trial. Rapamune Study Group
    • Kahan BD, Julian BA, Pescovitz MD, Vanrenterghem Y, Neylan J. Sirolimus reduces the incidence of acute rejection episodes despite lower cyclosporine doses in caucasian recipients of mismatched primary renal allografts: a phase II trial. Rapamune Study Group. Transplantation 68: 1526-1532, 1999.
    • (1999) Transplantation , vol.68 , pp. 1526-1532
    • Kahan, B.D.1    Julian, B.A.2    Pescovitz, M.D.3    Vanrenterghem, Y.4    Neylan, J.5
  • 19
  • 20
    • 0034721335 scopus 로고    scopus 로고
    • Mechanism of the combination immunosuppressive effects of rapamycin with either cyclosporine or tacrolimus
    • Khanna AK. Mechanism of the combination immunosuppressive effects of rapamycin with either cyclosporine or tacrolimus. Transplantation 70: 690-694, 2000.
    • (2000) Transplantation , vol.70 , pp. 690-694
    • Khanna, A.K.1
  • 21
    • 0033608710 scopus 로고    scopus 로고
    • Transforming growth factor (TGF)-beta mimics and anti-TGF-beta antibody abrogates the in vivo effects of cyclosporine: Demonstration of a direct role of TGF-beta in immunosuppression and nephrotoxicity of cyclosporine
    • Khanna AK, Cairns VR, Becker CG, Hosenpud JD. Transforming growth factor (TGF)-beta mimics and anti-TGF-beta antibody abrogates the in vivo effects of cyclosporine: demonstration of a direct role of TGF-beta in immunosuppression and nephrotoxicity of cyclosporine. Transplantation 67: 882-889, 1999.
    • (1999) Transplantation , vol.67 , pp. 882-889
    • Khanna, A.K.1    Cairns, V.R.2    Becker, C.G.3    Hosenpud, J.D.4
  • 22
    • 11144256945 scopus 로고    scopus 로고
    • Anti-transforming growth factor antibody at low but not high doses limits cyclosporine-mediated nephrotoxicity without altering rat cardiac allograft survival: Potential of therapeutic applications
    • Khanna AK, Plummer MS, Hilton G, Pieper GM, Ledbetter S. Anti-transforming growth factor antibody at low but not high doses limits cyclosporine-mediated nephrotoxicity without altering rat cardiac allograft survival: potential of therapeutic applications. Circulation 110: 3822-3829, 2004.
    • (2004) Circulation , vol.110 , pp. 3822-3829
    • Khanna, A.K.1    Plummer, M.S.2    Hilton, G.3    Pieper, G.M.4    Ledbetter, S.5
  • 23
    • 0035892775 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 and tumor growth factor-beta-inducible gene-H3 in nonrenal transplant cyclosporine nephropathy
    • Langham RG, Egan MK, Dowling JP, Gilbert RE, Thomson NM. Transforming growth factor-beta1 and tumor growth factor-beta-inducible gene-H3 in nonrenal transplant cyclosporine nephropathy. Transplantation 72: 1826-1829, 2001.
    • (2001) Transplantation , vol.72 , pp. 1826-1829
    • Langham, R.G.1    Egan, M.K.2    Dowling, J.P.3    Gilbert, R.E.4    Thomson, N.M.5
  • 26
    • 0037306606 scopus 로고    scopus 로고
    • Therapeutic role of TGF-beta-neutralizing antibody in mouse cyclosporine A nephropathy: Morphologic improvement associated with functional preservation
    • Ling H, Li X, Jha S, Wang W, Karetskaya L, Pratt B, Ledbetter S. Therapeutic role of TGF-beta-neutralizing antibody in mouse cyclosporine A nephropathy: morphologic improvement associated with functional preservation. J Am Soc Nephrol 14: 377-388, 2003.
    • (2003) J Am Soc Nephrol , vol.14 , pp. 377-388
    • Ling, H.1    Li, X.2    Jha, S.3    Wang, W.4    Karetskaya, L.5    Pratt, B.6    Ledbetter, S.7
  • 28
    • 77649087944 scopus 로고    scopus 로고
    • Sirolimus and cyclosporine A alter barrier function in renal proximal tubular cells through stimulation of ERK1/2 signaling and claudin-1 expression
    • Martin-Martin N, Ryan G, McMorrow T, Ryan MP. Sirolimus and cyclosporine A alter barrier function in renal proximal tubular cells through stimulation of ERK1/2 signaling and claudin-1 expression. Am J Physiol Renal Physiol 298: F672-F682, 2010.
    • (2010) Am J Physiol Renal Physiol , vol.298
    • Martin-Martin, N.1    Ryan, G.2    McMorrow, T.3    Ryan, M.P.4
  • 29
    • 0028062982 scopus 로고
    • Regulation of intestinal epithelial barrier function by TGF-beta 1. Evidence for its role in abrogating the effect of a T cell cytokine
    • Planchon SM, Martins CA, Guerrant RL, Roche JK. Regulation of intestinal epithelial barrier function by TGF-beta 1. Evidence for its role in abrogating the effect of a T cell cytokine. J Immunol 153: 5730-5739, 1994.
    • (1994) J Immunol , vol.153 , pp. 5730-5739
    • Planchon, S.M.1    Martins, C.A.2    Guerrant, R.L.3    Roche, J.K.4
  • 30
    • 0029857451 scopus 로고    scopus 로고
    • Cyclosporine nephropathy: Pathophysiology and clinical impact
    • Shihab FS. Cyclosporine nephropathy: pathophysiology and clinical impact. Semin Nephrol 16: 536-547, 1996.
    • (1996) Semin Nephrol , vol.16 , pp. 536-547
    • Shihab, F.S.1
  • 31
    • 1642463505 scopus 로고    scopus 로고
    • Sirolimus increases transforming growth factor-beta1 expression and potentiates chronic cyclosporine nephrotoxicity
    • Shihab FS, Bennett WM, Yi H, Choi SO, Andoh TF. Sirolimus increases transforming growth factor-beta1 expression and potentiates chronic cyclosporine nephrotoxicity. Kidney Int 65: 1262-1271, 2004.
    • (2004) Kidney Int , vol.65 , pp. 1262-1271
    • Shihab, F.S.1    Bennett, W.M.2    Yi, H.3    Choi, S.O.4    Andoh, T.F.5
  • 32
    • 0023837450 scopus 로고
    • Quality of life after kidney transplantation. A prospective, randomized comparison of cyclosporine and conventional immunosuppressive therapy
    • Simmons RG, Abress L, Anderson CR. Quality of life after kidney transplantation. A prospective, randomized comparison of cyclosporine and conventional immunosuppressive therapy. Transplantation 45: 415-421, 1988.
    • (1988) Transplantation , vol.45 , pp. 415-421
    • Simmons, R.G.1    Abress, L.2    Anderson, C.R.3
  • 33
    • 25144460253 scopus 로고    scopus 로고
    • Cyclosporine A-induced renal fibrosis: A role for epithelial-mesenchymal transition
    • Slattery C, Campbell E, McMorrow T, Ryan MP. Cyclosporine A-induced renal fibrosis: a role for epithelial-mesenchymal transition. Am J Pathol 167: 395-407, 2005.
    • (2005) Am J Pathol , vol.167 , pp. 395-407
    • Slattery, C.1    Campbell, E.2    McMorrow, T.3    Ryan, M.P.4
  • 34
    • 48949116154 scopus 로고    scopus 로고
    • Protein kinase C beta overexpression induces fibrotic effects in human proximal tubular epithelial cells
    • Slattery C, Ryan MP, McMorrow T. Protein kinase C beta overexpression induces fibrotic effects in human proximal tubular epithelial cells. Int J Biochem Cell Biol 40: 2218-2229, 2008.
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 2218-2229
    • Slattery, C.1    Ryan, M.P.2    McMorrow, T.3
  • 35
    • 0037180933 scopus 로고    scopus 로고
    • Rapamycin increases transforming growth factor-beta mRNA expression in immortalized rat proximal renal tubular cells
    • Swinford RD, Pascual M, Diamant D, Tang SS, Ingelfinger JR. Rapamycin increases transforming growth factor-beta mRNA expression in immortalized rat proximal renal tubular cells. Transplantation 73: 319-320, 2002.
    • (2002) Transplantation , vol.73 , pp. 319-320
    • Swinford, R.D.1    Pascual, M.2    Diamant, D.3    Tang, S.S.4    Ingelfinger, J.R.5
  • 36
    • 0030067318 scopus 로고    scopus 로고
    • Antagonistic regulation of tight junction dynamics by glucocorticoids and transforming growth factor-beta in mouse mammary epithelial cells
    • Woo PL, Cha HH, Singer KL, Firestone GL. Antagonistic regulation of tight junction dynamics by glucocorticoids and transforming growth factor-beta in mouse mammary epithelial cells. J Biol Chem 271: 404-412, 1996.
    • (1996) J Biol Chem , vol.271 , pp. 404-412
    • Woo, P.L.1    Cha, H.H.2    Singer, K.L.3    Firestone, G.L.4
  • 37
    • 33745269545 scopus 로고    scopus 로고
    • Rapamycin attenuates unilateral ureteral obstruction-induced renal fibrosis
    • Wu MJ, Wen MC, Chiu YT, Chiou YY, Shu KH, Tang MJ. Rapamycin attenuates unilateral ureteral obstruction-induced renal fibrosis. Kidney Int 69: 2029-2036, 2006.
    • (2006) Kidney Int , vol.69 , pp. 2029-2036
    • Wu, M.J.1    Wen, M.C.2    Chiu, Y.T.3    Chiou, Y.Y.4    Shu, K.H.5    Tang, M.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.