Effects of conformational alteration induced by d -/ l -isonucleoside incorporation in siRNA on their stability in serum and silencing activity

Bioconjugate Chemistry

Volumn 24, Issue 6, 2013, Pages 951-959

  Huang, Ye ^a   Chen, Zhuo ^a   Chen, Yue ^a   Zhang, Hao ^a   Zhang, Yichao ^b   Zhao, Yilei ^b   Yang, Zhenjun ^a   Zhang, Lihe ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b Shanghai Jiao Tong University   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; CHEMICAL MODIFICATION; CONFORMATIONS; DICHROISM; THERMODYNAMIC STABILITY;

ANTISENSE; BIOLOGICAL PROPERTIES; CIRCULAR DICHROISM SPECTRA; CIRCULAR DICHROISM SPECTRUMS; CLINICAL APPLICATION; OPTIMISATIONS; SERUM STABILITY;

RNA;

D ISONUCLEOSIDE; L ISONUCLEOSIDE; NUCLEOSIDE DERIVATIVE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; EMBRYO; GENE SILENCING; HUMAN; HUMAN CELL; PROTEIN DENATURATION; PROTEIN MODIFICATION; RNA CONFORMATION; RNA HYBRIDIZATION; THERMOSTABILITY;

EID: 84879346861     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc300642u     Document Type: Article

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