Integrative toxicoproteomics implicates impaired mitochondrial glutathione import as an off-target effect of troglitazone

Journal of Proteome Research

Volumn 12, Issue 6, 2013, Pages 2933-2945

  Lee, Yie Hou ^a,f   Goh, Wilson Wen Bin ^b   Ng, Choon Keow ^c   Raida, Manfred ^a,c,d   Wong, Limsoon ^d   Lin, Qingsong ^d   Boelsterli, Urs A ^e   Chung, Maxey C M ^a,d  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c Agency for Science   (Singapore)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e UNIVERSITY OF CONNECTICUT   (United States)

^f SINGAPORE MIT ALLIANCE FOR RESEARCH AND TECHNOLOGY   (Singapore)

Author keywords

drug induced liver injury; mitochondria; proteomics; SOD2; toxicology

Indexed keywords

DICARBOXYLIC ACID; GLUTATHIONE; MITOCHONDRIAL PROTEIN; PROTEOME; TRANSCRIPTION FACTOR FKHRL1; TROGLITAZONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; FEMALE; GLUTATHIONE METABOLISM; MASS SPECTROMETRY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEOMICS; TOXICOPROTEOMICS;

EID: 84879329299     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr400219s     Document Type: Article

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