The mitochondrial superoxide/thioredoxin-2/ask1 signaling pathway is critically involved in troglitazone-induced cell injury to human hepatocytes

Toxicological Sciences

Volumn 101, Issue 2, 2008, Pages 341-349

  Lim, Priscilla I K ^a   Liu, Jianchao ^b   Go, Mei I ^b   Boelsterli, Urs A ^a,b,c  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Idiosyncratic drug toxicity; Mito CP; Mitochondria; Oxidative stress; Thioredoxin 2; Troglitazone

Indexed keywords

ANTIOXIDANT; APOPTOSIS SIGNAL REGULATING KINASE 1; CYCLOSPORIN A; KETOCONAZOLE; MITOCHONDRIAL ENZYME; SCAVENGER; SUPEROXIDE; THIOREDOXIN; THIOREDOXIN 2; TROGLITAZONE; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; APOPTOSIS; ARTICLE; CELL MEMBRANE DEPOLARIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL DAMAGE; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL PERMEABILITY; OXIDATIVE STRESS; PATHOGENESIS; PROTEIN FUNCTION; PROTEIN TARGETING;

CELL LINE; CHROMANS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPATOCYTES; HUMANS; HYPOGLYCEMIC AGENTS; MAP KINASE KINASE KINASE 5; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA, LIVER; MITOCHONDRIAL PROTEINS; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; SUPEROXIDES; THIAZOLIDINEDIONES; THIOREDOXINS; TIME FACTORS;

VASCONCELLEA CANDICANS;

EID: 38149114639     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm273     Document Type: Article

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