Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors

Arthritis and Rheumatism

Volumn 60, Issue 9, 2009, Pages 2558-2564

  Suarez Gestal, Marian ^a   Calaza, Manuel ^a   Dieguez Gonzalez, Rebeca ^a   Perez Pampin, Eva ^a   Pablos, Jose Luis ^b   Navarro, Federico ^c   Narvaez, Javier ^d   Marenco, Jose Luis ^e   Herrero Beaumont, Gabriel ^f   Fernandez Gutierrez, Benjamin ^g   Lamas, Jose Ramon ^g   De La Serna, Arturo Rodriguez ^h   Ortiz, Ana Maria ⁱ   Carreño, Luis ^j   Cañete, Juan D ^k   Caliz, Rafael ^l   Blanco, Francisco J ^m   Balsa, Alejandro ⁿ   Gomez Reino, Juan J ^o   Gonzalez, Antonio ^a  

^a Instituto de Salud Carlos III   (Spain)

^b HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^c HOSPITAL UNIVERSITARIO VIRGEN MACARENA   (Spain)

^d HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^e HOSPITAL UNIVERSITARIO DE VALME   (Spain)

^f Hospital UniversitarioFundación Jiménez Díaz   (Spain)

^g HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^h HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

ⁱ HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^j HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^k INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^l HOSPITAL UNIVERSITARIO VIRGEN DE LAS NIEVES   (Spain)

^m HOSPITAL JUAN CANALEJO   (Spain)

ⁿ HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^o UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC CITRULLINATED PEPTIDE ANTIBODY; EPITOPE; GENE PRODUCT; METHYL CPG BINDING PROTEIN 2; PROTEIN BANK1; PROTEIN C8ORF13 BLK; PROTEIN IQ 25 1; PROTEIN ITGAM; PROTEIN KIAA1542; PROTEIN KINASE TYK2; PROTEIN LY9; PROTEIN PXK; RHEUMATOID FACTOR; STAT4 PROTEIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PNEUMONIA; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; RHEUMATOID NODULE; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SJOEGREN SYNDROME; SPAIN; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADULT; ARTHRITIS, RHEUMATOID; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HLA ANTIGENS; HUMANS; INTERFERON REGULATORY FACTORS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 22; RISK FACTORS; STAT4 TRANSCRIPTION FACTOR;

EID: 69449090457     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.24748     Document Type: Article

References (46)

1. Gregersen PK. Genetics of rheumatoid arthritis: confronting complexity. Arthritis Res 1999;1:37-44. (Pubitemid 32223665)
2. Nath SK, Kilpatrick J, Harley JB. Genetics of human systemic lupus erythematosus: the emerging picture. Curr Opin Immunol 2004;16:794-800. (Pubitemid 39423671)
3. Ronnblom L, Pascual V. The innate immune system in SLE: type I interferons and dendritic cells. Lupus 2008;17:394-399 (Pubitemid 351798715)
4. Malmstrom V, Trollmo C, Klareskog L. The additive role of innate and adaptive immunity in the development of arthritis. Am J Med Sci 2004;327:196-201. (Pubitemid 38480804)
5. Bowes J, Barton A. Recent advances in the genetics of RA susceptibility. Rheumatology (Oxford) 2008;47:399-402.
6. Rhodes B, Vyse TJ. The genetics of SLE: an update in the light of genome-wide association studies. Rheumatology (Oxford) 2008;47:1603-1611
7. Graham RR, Cotsapas C, Davies L, Hackett R, Lessard CJ, Leon JM, et al. Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus. Nat Genet 2008;40:1059-1061
8. Musone SL, Taylor KE, Lu TT, Nititham J, Ferreira RC, Ortmann W, et al. Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus. Nat Genet 2008;40:1062-1064
9. Fernandez A, Quintana G, Rondon F, Restrepo JF, Sanchez A, Matteson EL, et al. Lupus arthropathy: a case series of patients with rhupus. Clin Rheumatol 2006;25:164-167 (Pubitemid 43372312)
10. Gregersen PK, Behrens TW. Genetics of autoimmune diseases: disorders of immune homeostasis. Nat Rev Genet 2006;7:917-928 (Pubitemid 44871395)
11. Becker KG. The common variants/multiple disease hypothesis of common complex genetic disorders. Med Hypotheses 2004;62:309-317 (Pubitemid 38253403)
12. Lin JP, Cash JM, Doyle SZ, Peden S, Kanik K, Amos CI, et al. Familial clustering of rheumatoid arthritis with other autoimmune diseases. Hum Genet 1998;103:475-482 (Pubitemid 28542960)
13. Payami H, Joe S, Thomson G. Autoimmune thyroid disease in type I diabetic families. Genet Epidemiol 1989;6:137-141 (Pubitemid 19081923)
14. Fernando MM, Stevens CR, Walsh EC, De Jager PL, Goyette P, Plenge RM, et al. Defining the role of the MHC in autoimmunity: a review and pooled analysis. PLoS Genet 2008;4:e1000024. (Pubitemid 351656688)
15. Becker KG, Simon RM, Bailey-Wilson JE, Freidlin B, Biddison WE, McFarland HF, et al. Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases. Proc Natl Acad Sci U S A 1998;95:9979-9984 (Pubitemid 28415280)
16. Griffiths MM, Encinas JA, Remmers EF, Kuchroo VK, Wilder RL. Mapping autoimmunity genes. Curr Opin Immunol 1999;11:689-700.
17. Dieguez-Gonzalez R, Calaza M, Perez-Pampin E, de la Serna AR, Fernandez-Gutierrez B, Castaneda S, et al. Association of interferon regulatory factor 5 haplotypes, similar to that found in systemic lupus erythematosus, in a large subgroup of patients with rheumatoid arthritis. Arthritis Rheum 2008;58:1264-1274 (Pubitemid 351705915)
18. Sigurdsson S, Padyukov L, Kurreeman FA, Liljedahl U, Wiman AC, Alfredsson L, et al. Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis. Arthritis Rheum 2007;56:2202-2210 (Pubitemid 47173567)
19. Suarez-Gestal M, Calaza M, Endreffy E, Pullmann R, Ordi-Ros J, Domenico Sebastiani G, et al. Replication of recently identified systemic lupus erythematosus genetic associations: a case control study. Arthritis Res Ther 2009;11:R69.
20. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-324
21. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005;21:263-265 (Pubitemid 40202029)
22. Dupont WD, Plummer WD Jr. Power and sample size calculations: a review and computer program. Control Clin Trials 1990;11:116-128
23. Raman K, Mohan C. Genetic underpinnings of autoimmunity: lessons from studies in arthritis, diabetes, lupus and multiple sclerosis. Curr Opin Immunol 2003;15:651-659 (Pubitemid 37434073)
24. Ioannidis JP, Ntzani EE, Trikalinos TA, Contopoulos-Ioannidis DG. Replication validity of genetic association studies. Nat Genet 2001;29:306-309 (Pubitemid 33096456)
25. Todd JA. Statistical false positive or true disease pathway? Nat Genet 2006;38:731-733
26. International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN), Harley JB, Alarcon-Riquelme ME, Criswell LA, Jacob CO, Kimberly RP, et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet 2008;40:204-210
27. Kozyrev SV, Abelson AK, Wojcik J, Zaghlool A, Linga Reddy MV, Sanchez E, et al. Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus. Nat Genet 2008;40:211-216 (Pubitemid 351171404)
28. Hom G, Graham RR, Modrek B, Taylor KE, Ortmann W, Garnier S, et al. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. N Engl J Med 2008;358:900-909
29. Raychaudhuri S, Remmers EF, Lee AT, Hackett R, Guiducci C, Burtt NP, et al. Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat Genet 2008;40:1216-1223
30. Plenge RM, Cotsapas C, Davies L, Price AL, de Bakker PI, Maller J, et al. Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. Nat Genet 2007;39:1477-1482 (Pubitemid 350191346)
31. Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007;447:661-678
32. Sigurdsson S, Nordmark G, Goring HH, Lindroos K, Wiman AC, Sturfelt G, et al. Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. Am J Hum Genet 2005;76:528-537 (Pubitemid 40250533)
33. Sawalha AH, Webb R, Han S, Kelly JA, Kaufman KM, Kimberly RP, et al. Common variants within MECP2 confer risk of systemic lupus erythematosus. PLoS ONE 2008;3:e1727. (Pubitemid 351903230)
34. Cunninghame Graham DS, Vyse TJ, Fortin PR, Montpetit A, Cai YC, Lim S, et al. Association of LY9 in UK and Canadian SLE families. Genes Immun 2008;9:93-102. (Pubitemid 351351652)
35. Cunninghame Graham DS, Akil M, Vyse TJ. Association of polymorphisms across the tyrosine kinase gene, TYK2 in UK SLE families. Rheumatology (Oxford) 2007;46:927-930
36. Plenge RM, Padyukov L, Remmers EF, Purcell S, Lee AT, Karlson EW, et al. Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4. Am J Hum Genet 2005;77:1044-1060 (Pubitemid 41698524)
37. Orozco G, Abelson AK, Gonzalez-Gay MA, Balsa A, Pascual-Salcedo D, Garcia A, et al. Study of functional variants of the BANK1 gene in rheumatoid arthritis. Arthritis Rheum 2009;60:372-379
38. Lee HS, Remmers EF, Le JM, Kastner DL, Bae SC, Gregersen PK. Association of STAT4 with rheumatoid arthritis in the Korean population. Mol Med 2007;13:455-460 (Pubitemid 47585739)
39. Remmers EF, Plenge RM, Lee AT, Graham RR, Hom G, Behrens TW, et al. STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. N Engl J Med 2007;357:977-986 (Pubitemid 47367077)
40. Barton A, Thomson W, Ke X, Eyre S, Hinks A, Bowes J, et al. Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility. Hum Mol Genet 2008;17:2274-2279
41. Kobayashi S, Ikari K, Kaneko H, Kochi Y, Yamamoto K, Shimane K, et al. Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population. Arthritis Rheum 2008;58:1940-1946 (Pubitemid 351988085)
42. Orozco G, Alizadeh BZ, Delgado-Vega AM, Gonzalez-Gay MA, Balsa A, Pascual-Salcedo D, et al. Association of STAT4 with rheumatoid arthritis: a replication study in three European populations. Arthritis Rheum 2008;58:1974-1980 (Pubitemid 351988089)
43. Martinez A, Varade J, Marquez A, Cenit MC, Espino L, Perdigones N, et al. Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases. Arthritis Rheum 2008;58:2598-2602
44. Zervou MI, Sidiropoulos P, Petraki E, Vazgiourakis V, Krasoudaki E, Raptopoulou A, et al. Association of a TRAF1 and a STAT4 gene polymorphism with increased risk for rheumatoid arthritis in a genetically homogeneous population. Hum Immunol 2008;69:567-571
45. Palomino-Morales RJ, Rojas-Villarraga A, Gonzalez CI, Ramirez G, Anaya JM, Martin J. STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians. Genes Immun 2008;9:379-382 (Pubitemid 351791494)
46. Plenge RM, Seielstad M, Padyukov L, Lee AT, Remmers EF, Ding B, et al. TRAF1-C5 as a risk locus for rheumatoid arthritis: a genomewide study. N Engl J Med 2007;357:1199-1209 (Pubitemid 47443179)