Viper venom-induced oxidative stress and activation of inflammatory cytokines: A therapeutic approach for overlooked issues of snakebite management

Inflammation Research

Volumn 62, Issue 7, 2013, Pages 721-731

  Santhosh, M Sebastin ^a   Sundaram, M Shanmuga ^a   Sunitha, K ^a   Kemparaju, K ^a   Girish, K S ^a  

^a UNIVERSITY OF MYSORE   (India)

Author keywords

Crocin; Envenomation; Inflammation; Oxidative damage; PLA2; Systemic toxicity; Vipera russelli

Indexed keywords

CATALASE; CROCIN; CYCLOOXYGENASE 2; GLUTATHIONE; HYALURONIDASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LACTATE DEHYDROGENASE; SUPEROXIDE DISMUTASE; THIOL; TUMOR NECROSIS FACTOR ALPHA; VIPER VENOM;

ARTICLE; BLOOD SAMPLING; CELL DAMAGE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG MECHANISM; ENVENOMATION; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; INFLAMMATION; LIPID PEROXIDATION; NORMAL HUMAN; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; TREATMENT RESPONSE;

ALKALINE PHOSPHATASE; ANTIOXIDANTS; CAROTENOIDS; CATALASE; CYCLOOXYGENASE 2; CYTOKINES; GLUTATHIONE; GLYCOSIDE HYDROLASES; HUMANS; HYALURONOGLUCOSAMINIDASE; L-LACTATE DEHYDROGENASE; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SERUM; SNAKE BITES; SULFHYDRYL COMPOUNDS; SUPEROXIDE DISMUTASE; VIPER VENOMS;

EID: 84879211095     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-013-0627-y     Document Type: Article

References (54)

1. Kasturiratne A, Wickremasinghe AR, de Silva N, Gunawardena NK, Pathmeswaran A, Premaratna R, Savioli L, Lalloo DG, de Silva HJ. The global burden of snakebite: a literature analysis and modeling based on regional estimates of envenoming and deaths. PLoS Med. 2008;5:e218.
2. Warrel DA. Snakebite. Lancet. 2010;375:77-88.
3. Ushanandini S, Nagaraju S, Nayaka SC, Kumar KH, Kemparaju K, Girish KS. The anti-ophidian properties of Anacardium occidentale bark extract. Immunopharmacol Immunotoxicol. 2009;31(4):607-15.
4. Girish KS, Kemparaju K. Overlooked issues of snakebite management: time for strategic approach. Curr Top Med Chem. 2011;11:2494-508.
5. Kini RM. Excitement ahead: structure, function and mechanism of snake venom phospholipase A2 enzymes. Toxicon. 2003;42(8):827-40.
6. Teixeira CF, Landucci EC, Antunes E, Chacur M, Cury Y. Inflammatory effects of snake venom myotoxic phospholipases A2. Toxicon. 2003;42(8):947-62.
7. Santos-Filho NA, Silveira LB, Oliveira CZ, Bernardes CP, Menaldo DL, Fuly AL, Arantes EC, Sampaio SV, Mamede CC, Beletti ME, de Oliveira F, Soares AM. A new acidic myotoxic, anti-platelet and prostaglandin I2 inductor phospholipase A2 isolated from Bothrops moojeni snake venom. Toxicon. 2008;52(8):908-17.
8. Montecucco C, Gutierrez JM, Lomonte B. Cellular pathology induced by snake venom phospholipase A2 myotoxins and neurotoxins: common aspects of their mechanisms of action. Cell Mol Life Sci. 2008;65(18):2897-912.
9. Diz Filho EB, Marangoni S, Toyama DO, Fagundes FH, Oliveira SC, Fonseca FV, Calgarotto AK, Joazeiro PP, Toyama MH. Enzymatic and structural characterization of new PLA2 isoform isolated from white venom of Crotalus durissus ruruima. Toxicon. 2008;53(1):104-14.
10. Perumal Samy R, Gopalakrishnakone P, Bow H, Puspharaj PN, Chow VT. Identification and characterization of a phospholipase A2 from the venom of the Saw-scaled viper: novel bactericidal and membrane damaging activities. Biochimie. 2010;92(12):1854-66.
11. Matsui T, Fujimura Y, Titani K. Snake venom proteases affecting hemostasis and thrombosis. Biochim Biophys Acta. 2000;1477(1-2):146-56.
12. Cortelazzo A, Guerranti R, Bini L, Hope-Onyekwere N, Muzzi C, Leoncini R, et al. Effects of snake venom proteases on human fibrinogen chains. Blood Transfus. 2010;3:s120-5.
13. Kumar MS, Girish KS, Vishwanath BS, Kemparaju K. The metalloprotease, NN-PF3 from Naja naja venom inhibits platelet aggregation primarily by affecting α2β1 integrin. Ann Hematol. 2011;90(5):569-77.
14. Sajevic T, Leonardi A, Krizaj I. Haemostatically active proteins in snake venoms. Toxicon. 2011;57(5):627-45.
15. Takeda S, Takeya H, Iwanaga S. Snake venom metalloproteinases: structure, function and relevance to the mammalian ADAM/ADAMTS family proteins. Biochim Biophys Acta. 2012;1824(1):164-76.
16. Valeriano-Zapana JA, Segovia-Cruz FS, Rojas-Hualpa JM, Martins-de-Souza D, Ponce-Soto LA, Marangoni S. Functional and structural characterization of a new serine protease with thrombin-like activity TLBan from Bothrops andianus (Andean Lancehead) snake venom. Toxicon. 2012;59(2):231-40.
17. Girish KS, Shashidharamurthy R, Nagaraju S, Gowda TV, Kemparaju K. Isolation and characterization of hyaluronidase a "spreading factor" from Indian cobra (Naja naja) venom. Biochimie. 2004;86(3):193-202.
18. Dhananjaya BL, D'Souza CJ. The pharmacological role of nucleotidases in snake venoms. Cell Biochem Funct. 2010;28(3):171-7.
19. Girish KS, Kemparaju K, Nagaraju S, Vishwanath BS. Hyaluronidase inhibitors a biological and therapeutic perspective. Curr Med Chem. 2009;16:2261-88.
20. Guo C, Liu S, Yao Y, Zhang Q, Sun MZ. Past decade study of snake venom l-amino acid oxidase. Toxicon. 2012;60(3):302-11.
21. Sunitha K, Hemshekhar M, Santhosh MS, Kumar MS, Kemparaju K, Girish KS. Inhibition of hemorrhagic activity of viper venoms by N-acetyl cysteine: involvement of N-acetyl and thiol groups. Curr Top Med Chem. 2011;11(20):2589-3000.
22. Sebastin Santhosh M, Hemshekhar M, Sunitha K, Thushara RM, Jnaneshwari S, Kemparaju K, Girish KS. Management of local manifestations of snakebite by plant based secondary metabolites: an auxiliary therapy to antivenin therapy. Mini Rev Med Chem. 2013;13:106-23.
23. da Silva JG, da Silva Soley B, Gris V, do Rocio Andrade Pires A, Caderia SM, Eler GJ, Hermoso AP, Bracht A, Dalsenter PR, Acco A. Effects of the Crotalus durissus terrificus snake venom on hepatic metabolism and oxidative stress. J Biochem Mol Toxicol. 2011;25(3):195-203.
24. Sebastin Santhosh M, Hemshekhar M, Thushara RM, Devaraja S, Kemparaju K, Girish KS. Vipera russelli venom induced oxidative stress and hematological alterations: amelioration by crocin a dietary colorant. Cell Biochem Funct. 2013;31(1):41-50.
25. Nam KN, Park YM, Jung HJ, Lee JY, Min BD, Park SU, Jung WS, Cho KH, Park JH, Kang I, Hong JW, Lee EH. Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells. Eur J Pharmacol. 2010;648(1-3):110-6.
26. Hosseinzadeh H, Jahanian Z. Effect of Crocus sativus L. (saffron) stigma and its constituents, crocin and safranal, on morphine withdrawal syndrome in mice. Phytother Res. 2010;24:726-30.
27. Mousavi SH, Tayarani NZ, Parsaee H. Protective effect of saffron extract and crocin on reactive oxygen species-mediated high glucose-induced toxicity in PC12 cells. Cell Mol Neurobiol. 2010;30(2):185-91.
28. Driver AS, Kodavanti PS, Mundy WR. Age related changes in reactive oxygen species production in rat brain homogenates. Neurotoxicol Teratol. 2000;22:175-81.
29. 2 generation in isolated mitochondria. J Bioenerg Biomembr. 2002;34:227-33.
30. Ohkawa H, Ohnishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95:351-8.
31. Tunez I, Montilla P, Del Carmen Muñoz M, Feijoo M, Salcedo M. Protective effect of melatonin on 3-nitropropionic acid-induced oxidative stress in synaptosomes in an animal model of Huntington's disease. J Pineal Res. 2004;37(4):252-6.
32. Chandrashekar KN, Muralidhara. d-Aspartic acid induced oxidative stress and mitochondrial dysfunctions in testis of prepubertal rats. Amino Acids. 2010;38:817-27.
33. Kostyuk VA, Potapovich AI. Superoxide driven oxidation of quercetin under simple sensitive assay for determination of superoxide dismutase. Biochem Int. 1989;19:1117-24.
34. Aebi H. Catalase. Methods Enzymol. 1059;1984:121-5.
35. Popko J, Marciniak J, Ilendo E, Knas M, Guszczyn T, Stasiak-Barmuta A, Moniuszko T, Zwierz K, Wysocka J. Profile of exoglycosidases in synovial cell cultures derived from human synovial membrane. Cell Biochem Biophys. 2008;51:89-95.
36. Tenniswood M, Bird CE, Clark AF. Acid phosphatases: androgen dependent markers of rat prostate. Can J Biochem. 1976;54(4):350-7.
37. Girish KS, Jagadeesha DK, Rajeev KB, Kemparaju K. Snake venom hyaluronidase: an evidence for isoforms and extracellular matrix degradation. Mol Cell Biochem. 2002;240:105-10.
38. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement using folin-phenol reagent. J Biol Chem. 1951;193:265-75.
39. Frezzatti R, Silveira PF. Allopurinol reduces the lethality associated with acute renal failure induced by Crotalus durissus terrificus snake venom: comparison with probenecid. PLoS Negl Trop Dis. 2011;5(9):e1312.
40. White J. Snake venoms and coagulopathy. Toxicon. 2005;45:951-67.
41. Al Asmari A, Al Moutaery K, Manthari RA, Khan HA. Time-course of lipid peroxidation in different organs of mice treated with Echil pyramidum snake venom. J Biochem Mol Toxicol. 2006;20:93.
42. Alam MI, Gomes A. Viper venom-induced inflammation and inhibition of free radical formation by pure compound (2-hydroxy-4-methoxy benzoic acid) isolated and purified from anantimul (Hemidesmus indicus R. BR) root extract. Toxicon. 1998;36:207-15.
43. Chojnowska S, Kȩpka A, Szajda SD, Waszkiewicz N, Bierc M, Zwierz K. Exoglycosidase markers of diseases. Biochem Soc Trans. 2011;39(1):406-9.
44. Mukherjee AK, Ghosal SK, Maity CR. Lysosomal membrane stabilization by alpha-tocopherol against the damaging action of Vipera russelli venom phospholipase A2. Cell Mol Life Sci. 1997;53(2):152-5.
45. Gonçalves DA, Silva EV, Graça FA, Lira EC, Zanon NM, Mendes GE, Burdmann EA, Migliorini RH, Kettelhut IC, Navegantes LC. In vivo effects of Bothrops jararaca venom on metabolic profile and on muscle protein metabolism in rats. Am J Trop Med Hyg. 2008;79(5):771-8.
46. Noble PW. Hyaluronan and its catabolic products in tissue injury and repair. Matrix Biol. 2002;1:25-9.
47. Girish KS, Kemparaju K. The magic glue hyaluronan and its eraser hyaluronidase: a biological overview. Life Sci. 2007;80:1921-43.
48. Campo GM, Avenoso A, Campo S, D'Ascola A, Nastasi G, Calatroni A. Small hyaluronan oligosaccharides induce inflammation by engaging both Toll-like-4 and CD44 receptors in human chondrocytes. Biochem Pharmacol. 2010;80(4):480-90.
49. Ahn CM, Sandler H, Saldeen T. Decreased lung hyaluronan in a model of ARDS in the rat: effect of an inhibitor of leukocyte elastase. Ups J Med Sci. 2012;117(1):1-9.
50. Zuliani JP, Fernandes CM, Zamuner SR, Gutiérrez JM, Teixeira CF. Inflammatory events induced by Lys-49 and Asp-49 phospholipases A2 isolated from Bothrops asper snake venom: role of catalytic activity. Toxicon. 2005;45(3):335-46 Epub 2005 Jan 5.
51. Zamuner SR, Zuliani JP, Fernandes CM, Gutiérrez JM, de Fátima Pereira Teixeira C. Inflammation induced by Bothrops asper venom: release of proinflammatory cytokines and eicosanoids, and role of adhesion molecules in leukocyte infiltration. Toxicon. 2005;46(7):806-13 Epub 2005 Sep 29.
52. Petricevich VL, Teixeira CFP, Tambourgi DV, Gutiérrez JM. Increments in cytokine and nitric oxide serum levels in mice injected with Bothrops asper and Bothrops jararaca snake venoms. Toxicon. 2000;38:1253-66.
53. Moreira V, Zamuner SR, Wallace JL, Teixeira Cde F. Bothrops jararaca and Crotalus durissus terrificus venoms elicit distinct responses regarding to production of prostaglandins E2 and D2, and expression of cyclooxygenases. Toxicon. 2007;49(5):615-24.
54. Kiran KM, More SS, Gadag JR. Biochemical and clinicopathological changes induced by Bungarus coeruleus venom in a rat model. J Basic Clin Physiol Pharmacol. 2004;15(3-4):277-87.