The metalloprotease, NN-PF3 from Naja naja venom inhibits platelet aggregation primarily by affecting α2β1 integrin

Annals of Hematology

Volumn 90, Issue 5, 2011, Pages 569-577

  Kumar, M S ^a   Girish, K S ^b   Vishwanath, B S ^b   Kemparaju, K ^b  

^a Government College for Women   (India)

^b UNIVERSITY OF MYSORE   (India)

Author keywords

2 1 integrin; Antiplatelet property; Disintegrin like domain; GPVI; NN PF3; SVMPs

Indexed keywords

ADENOSINE DIPHOSPHATE; ADRENALIN; ARACHIDONIC ACID; COLLAGEN; COLLAGEN RECEPTOR; COLLAGEN TYPE 1; EDETIC ACID; FIBRINOGEN; FIBRONECTIN; GLYCOPROTEIN VI; METALLOPROTEINASE; MONOCLONAL ANTIBODY; NN PF3; PHOSPHOTYROSINE; RISTOCETIN; SNAKE VENOM; THROMBIN; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 2;

ANIMAL EXPERIMENT; ANTICOAGULATION; ARTICLE; BINDING KINETICS; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; SNAKE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE RICH PLASMA; WESTERN BLOTTING;

ANIMALS; ANTICOAGULANTS; BLOOD PLATELETS; CALCIUM; CHELATING AGENTS; COBRA VENOMS; COLLAGEN TYPE I; EDETIC ACID; HUMANS; INTEGRIN ALPHA2BETA1; METALLOENDOPEPTIDASES; MICE; PHOSPHORYLATION; PLATELET ADHESIVENESS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET COUNT; PLATELET MEMBRANE GLYCOPROTEINS; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN PROCESSING, POST-TRANSLATIONAL; ZINC;

EID: 79956148120     PISSN: 09395555     EISSN: 14320584     Source Type: Journal    
DOI: 10.1007/s00277-010-1103-1     Document Type: Article

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