메뉴 건너뛰기




Volumn 30, Issue 2, 2010, Pages 185-191

Protective effect of saffron extract and crocin on reactive oxygen species-mediated high glucose-induced toxicity in pc12 cells

Author keywords

Crocus sativus; Glucose; Iridaceae; PC12; ROS; Saffron; Toxicity

Indexed keywords

CROCIN; CROCUS SATIVUS EXTRACT; GLUCOSE; GLUTATHIONE; REACTIVE OXYGEN METABOLITE; ANTIOXIDANT; CAROTENOID; DIPEPTIDE; GAMMA-GLUTAMYLCYSTEINE; NEUROPROTECTIVE AGENT; PLANT EXTRACT;

EID: 77952093874     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10571-009-9441-z     Document Type: Article
Times cited : (141)

References (33)
  • 1
    • 0032536730 scopus 로고    scopus 로고
    • Crocin antagonizes ethanol inhibition of NMDA receptor-mediated responses in rat hippocampal neurons
    • DOI 10.1016/S0006-8993(97)01505-9, PII S0006899397015059
    • K Abe M Sugiura Y Shoyama H Saito 1998 Crocin antagonizes ethanol inhibition of NMDA receptor-mediated responses in rat hippocampal neurons Brain Res 787 1 132 138 10.1016/S0006-8993(97)01505-9 1:CAS:528:DyaK1cXhs1Cqtbc%3D 9518580 (Pubitemid 28279809)
    • (1998) Brain Research , vol.787 , Issue.1 , pp. 132-138
    • Abe, K.1    Sugiura, M.2    Shoyama, Y.3    Saito, H.4
  • 2
    • 29244478599 scopus 로고    scopus 로고
    • Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents
    • DOI 10.1002/ptr.1749
    • AN Assimopoulou Z Sinakos VP Papageorgiou 2005 Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents Phytother Res 19 997 1000 10.1002/ptr.1749 1:CAS:528:DC%2BD28Xnt12iuw%3D%3D 16317646 (Pubitemid 41820243)
    • (2005) Phytotherapy Research , vol.19 , Issue.11 , pp. 997-1000
    • Assimopoulou, A.N.1    Sinakos, Z.2    Papageorgiou, V.P.3
  • 4
    • 0025732948 scopus 로고
    • Role of oxidative stress in development of complications in diabetes
    • 10.2337/diabetes.40.4.405 1:CAS:528:DyaK3MXktVGqur8%3D 2010041
    • JW Baynes 1991 Role of oxidative stress in development of complications in diabetes Diabetes 40 405 412 10.2337/diabetes.40.4.405 1:CAS:528: DyaK3MXktVGqur8%3D 2010041
    • (1991) Diabetes , vol.40 , pp. 405-412
    • Baynes, J.W.1
  • 5
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • DOI 10.1038/414813a
    • M Brownlee 2001 Biochemistry and molecular cell biology of diabetic complications Nature 414 813 820 10.1038/414813a 1:CAS:528: DC%2BD38Xhtlyltg%3D%3D 11742414 (Pubitemid 34000785)
    • (2001) Nature , vol.414 , Issue.6865 , pp. 813-820
    • Brownlee, M.1
  • 6
    • 40849101612 scopus 로고    scopus 로고
    • Antioxidant potential of crocins and ethanol extracts of Gardenia jasminoides Ellis and Crocus sativus L.: A relationship investigation between antioxidant activity and crocin contents
    • 10.1016/j.foodchem.2007.09.080 1:CAS:528:DC%2BD1cXjt12rsLw%3D
    • Y Chen H Zhang X Tian C Zhao L Cai Y Liu L Jia HX Yin C Chen 2008 Antioxidant potential of crocins and ethanol extracts of Gardenia jasminoides Ellis and Crocus sativus L.: a relationship investigation between antioxidant activity and crocin contents Food Chem 109 484 492 10.1016/j.foodchem.2007.09. 080 1:CAS:528:DC%2BD1cXjt12rsLw%3D
    • (2008) Food Chem , vol.109 , pp. 484-492
    • Chen, Y.1    Zhang, H.2    Tian, X.3    Zhao, C.4    Cai, L.5    Liu, Y.6    Jia, L.7    Yin, H.X.8    Chen, C.9
  • 7
    • 0026469097 scopus 로고
    • Complications, neuropathy, pathogenetic considerations
    • 10.2337/diacare.15.12.1902 1:STN:280:DyaK3s%2FpvFOktg%3D%3D 1464245
    • DA Greene AAF Sima MJ Stevens EL Feldman SA Lattimer 1992 Complications, neuropathy, pathogenetic considerations Diabetes Care 15 1902 1925 10.2337/diacare.15.12.1902 1:STN:280:DyaK3s%2FpvFOktg%3D%3D 1464245
    • (1992) Diabetes Care , vol.15 , pp. 1902-1925
    • Greene, D.A.1    Sima, A.A.F.2    Stevens, M.J.3    Feldman, E.L.4    Lattimer, S.A.5
  • 8
    • 0032981514 scopus 로고    scopus 로고
    • Glucose-induced oxidative stress and programmed cell death in diabetic neuropathy
    • DOI 10.1016/S0014-2999(99)00356-8, PII S0014299999003568
    • DA Greene MJ Stevens I Obrosova EL Feldman 1999 Glucose-induced oxidative stress and programmed cell death in diabetic neuropathy Eur J Pharmacol 375 217 223 10.1016/S0014-2999(99)00356-8 1:CAS:528:DyaK1MXks1Crs7s%3D 10443578 (Pubitemid 29317606)
    • (1999) European Journal of Pharmacology , vol.375 , Issue.1-3 , pp. 217-223
    • Greene, D.A.1    Stevens, M.J.2    Obrosova, I.3    Feldman, E.L.4
  • 9
    • 0141746538 scopus 로고    scopus 로고
    • Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice
    • DOI 10.1186/1471-2210-2-7
    • H Hosseinzadeh HM Younesi 2002 Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice BMC Pharmacol 2 7 10.1186/1471-2210-2-7 11914135 (Pubitemid 38729257)
    • (2002) BMC Pharmacology , vol.2 , pp. 7
    • Hosseinzadeh, H.1    Younesi, H.M.2
  • 10
    • 33947583076 scopus 로고    scopus 로고
    • Antioxidant enzymes during hypoxia-anoxia signaling events in Crocus sativus L. corm
    • DOI 10.1196/annals.1378.055, Signal Transduction Pathways, Part B: Stress Signalling and Transcriptional Control
    • E Keyhani I Ghamsari J Keyhani M Hadizadeh 2006 Antioxidant enzymes during hypoxia-anoxia signaling events in Crocus sativus L. corm Ann NY Acad Sci 1091 65 75 10.1196/annals.1378.055 1:CAS:528:DC%2BD2sXjsFShurY%3D 17341603 (Pubitemid 47092225)
    • (2006) Annals of the New York Academy of Sciences , vol.1091 , pp. 65-75
    • Keyhani, E.1    Ghamsari, L.2    Keyhani, J.3    Hadizadeh, M.4
  • 11
    • 0026554428 scopus 로고
    • Evaluation of the probe 2', 7'-dihydrodichlorofluorescein as an indicator of reactive oxygen species formation and oxidative stress
    • 10.1021/tx00026a012 1:CAS:528:DyaK38XhsVGmtr8%3D 1322737
    • CP LeBel H Ischiropoulos SC Bondy 1992 Evaluation of the probe 2', 7'-dihydrodichlorofluorescein as an indicator of reactive oxygen species formation and oxidative stress Chem Res Toxicol 5 227 231 10.1021/tx00026a012 1:CAS:528:DyaK38XhsVGmtr8%3D 1322737
    • (1992) Chem Res Toxicol , vol.5 , pp. 227-231
    • Lebel, C.P.1    Ischiropoulos, H.2    Bondy, S.C.3
  • 13
    • 61349092819 scopus 로고    scopus 로고
    • Direct toxicity of Rose Bengal in MCF-7 cell line: Role of apoptosis
    • 10.1016/j.fct.2009.01.018 1:CAS:528:DC%2BD1MXis1aqs78%3D 19271285
    • SH Mousavi J Tavakkol-Afshari A Brook I Jafari-Anarkooli 2009 Direct toxicity of Rose Bengal in MCF-7 cell line: role of apoptosis Food Chem Toxicol 47 855 859 10.1016/j.fct.2009.01.018 1:CAS:528:DC%2BD1MXis1aqs78%3D 19271285
    • (2009) Food Chem Toxicol , vol.47 , pp. 855-859
    • Mousavi, S.H.1    Tavakkol-Afshari, J.2    Brook, A.3    Jafari-Anarkooli, I.4
  • 14
    • 0028834324 scopus 로고
    • Saffron chemoprevention in biology and medicine, a review
    • 1:CAS:528:DyaK28XltlyqtA%3D%3D 8590890
    • SC Nair SK Kurumboor JH Hasegawa 1995 Saffron chemoprevention in biology and medicine, a review Cancer Biother 10 257 264 1:CAS:528:DyaK28XltlyqtA%3D%3D 8590890
    • (1995) Cancer Biother , vol.10 , pp. 257-264
    • Nair, S.C.1    Kurumboor, S.K.2    Hasegawa, J.H.3
  • 16
    • 0023770113 scopus 로고    scopus 로고
    • Free radicals and diabetes
    • 10.1016/0891-5849(88)90036-6
    • LW Oberley 1998 Free radicals and diabetes Free Radic Biol Med 5 113 124 10.1016/0891-5849(88)90036-6
    • (1998) Free Radic Biol Med , vol.5 , pp. 113-124
    • Oberley, L.W.1
  • 17
    • 2442604428 scopus 로고    scopus 로고
    • Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of α-tocopherol
    • DOI 10.1016/j.neulet.2004.02.067, PII S0304394004002629
    • T Ochiai S Ohno S Soeda H Tanaka Y Shoyama H Shimeno 2004 Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of a-tocopherol Neurosci Lett 362 61 64 10.1016/j.neulet. 2004.02.067 1:CAS:528:DC%2BD2cXktVCksL4%3D 15147781 (Pubitemid 38638385)
    • (2004) Neuroscience Letters , vol.362 , Issue.1 , pp. 61-64
    • Ochiai, T.1    Ohno, S.2    Soeda, S.3    Tanaka, H.4    Shoyama, Y.5    Shimeno, H.6
  • 19
    • 29044434874 scopus 로고    scopus 로고
    • Hyperglycemia potentiates carbonyl stress-induced apoptosis in naïve PC-12 cells: Relationship to cellular redox and activator protease factor-1 expression
    • DOI 10.2174/156720205774962665
    • M Okouchi N Okayama TY Aw 2005 Hyperglycemia potentiates carbonyl stress-induced apoptosis in naive PC-12 cells, relationship to cellular redox and activator protease factor-1 expression Curr Neurovasc Res 2 375 386 10.2174/156720205774962665 1:CAS:528:DC%2BD28XntVCqtg%3D%3D 16375719 (Pubitemid 41789604)
    • (2005) Current Neurovascular Research , vol.2 , Issue.5 , pp. 375-386
    • Okouchi, M.1    Okayama, N.2    Aw, T.Y.3
  • 20
    • 0034939115 scopus 로고    scopus 로고
    • The role of oxidative stress in the onset and progression of diabetes and its complications: A summary of a congress series sponsored by UNESCO-MCBN, the American diabetes association and the German diabetes society
    • DOI 10.1002/dmrr.196
    • P Osen PP Nawroth G King W Ller HJ Tritschler L Packer 2001 The role of oxidative stress in the onset and progression of diabetes and its complications, a summary of a congress series sponsored by UNESCO-MCBN, the American diabetes association and the German diabetes society Diabetes Metab Res Rev 17 189 212 10.1002/dmrr.196 (Pubitemid 32624602)
    • (2001) Diabetes/Metabolism Research and Reviews , vol.17 , Issue.3 , pp. 189-212
    • Rosen, P.1    Nawroth, P.P.2    King, G.3    Moller, W.4    Tritschler, H.-J.5    Packer, L.6
  • 21
    • 0026676309 scopus 로고
    • Antioxidant effects of carotenoids in vivo and in vitro: An overview
    • DOI 10.1016/0076-6879(92)13142-K
    • P Palozza NI Krinsky 1992 Antioxidant effects of carotenoids in vivo and in vitro, an overview Meth Enzymol 213 403 420 10.1016/0076-6879(92)13142-K 1:CAS:528:DyaK3sXpvVKhsA%3D%3D 1435313 (Pubitemid 23012237)
    • (1992) Methods in Enzymology , vol.213 , pp. 403-420
    • Palozza, P.1    Krinsky, N.I.2
  • 22
    • 33845266924 scopus 로고    scopus 로고
    • Total antioxidant capacity of spices, dried fruits, nuts, pulses, cereals and sweets consumed in Italy assessed by three different in vitro assays
    • DOI 10.1002/mnfr.200600067
    • N Pellegrini M Serafini S Salvatore DD Rio M Bianchi F Brighenti 2006 Total antioxidant capacity of spices, dried fruits, nuts, pulses, cereals and sweets consumed in Italy assessed by three different in vitro assays Mol Nutr Food Res 50 1030 1038 10.1002/mnfr.200600067 1:CAS:528:DC%2BD28Xht1yjsL3J 17039458 (Pubitemid 44861498)
    • (2006) Molecular Nutrition and Food Research , vol.50 , Issue.11 , pp. 1030-1038
    • Pellegrini, N.1    Serafini, M.2    Salvatore, S.3    Del Rio, D.4    Bianchi, M.5    Brighenti, F.6
  • 23
    • 77952097762 scopus 로고
    • Osmania Oriental publications Bureau, Osmania University Hyderabad-7. (in Arabic)
    • Rhazes MZ (1968) Kitabu'l Hawi fi't-Tibb vol 20 part. 2. Osmania Oriental publications Bureau, Osmania University, Hyderabad-7, pp 548-553 (in Arabic)
    • (1968) Kitabu'l Hawi Fi't-Tibb Vol 20 Part. 2 , pp. 548-553
    • Rhazes, M.Z.1
  • 24
    • 0029934789 scopus 로고    scopus 로고
    • An update review of saffron and its active constituents
    • DOI 10.1002/(SICI)1099-1573(199605)10:3<189::AID-PTR754>3.0.CO;2-C
    • JL Rvos MC Recio RM Giner S Manez 1996 An update review of saffron and its active constituents Phytother Res 10 189 193 10.1002/(SICI)1099-1573(199605) 10:3<189::AID-PTR754>3.0.CO;2-C (Pubitemid 26164562)
    • (1996) Phytotherapy Research , vol.10 , Issue.3 , pp. 189-193
    • Rios, J.L.1    Recio, M.C.2    Giner, R.M.3    Menez, S.4
  • 25
    • 33750499954 scopus 로고    scopus 로고
    • Effects of glucose concentration on redox status in rat primary cortical neurons under hypoxia
    • DOI 10.1016/j.neulet.2006.09.066, PII S0304394006010421
    • H Shi KJ Liu 2006 Effects of glucose concentration on redox status in rat primary cortical neurons under hypoxia Neurosci Lett 13 410(1) 57 61 10.1016/j.neulet.2006.09.066 (Pubitemid 44667256)
    • (2006) Neuroscience Letters , vol.410 , Issue.1 , pp. 57-61
    • Shi, H.1    Liu, K.J.2
  • 26
    • 54449093368 scopus 로고    scopus 로고
    • Study of cytotoxic and apoptogenic properties of saffron extract in human cancer cell lines
    • 10.1016/j.fct.2008.08.018 1:CAS:528:DC%2BD1cXhtlalsrbL 18790714
    • J Tavakkol Afshari A Brook SH Mousavi 2008 Study of cytotoxic and apoptogenic properties of saffron extract in human cancer cell lines Food Chem Toxicol 46 3443 3447 10.1016/j.fct.2008.08.018 1:CAS:528:DC%2BD1cXhtlalsrbL 18790714
    • (2008) Food Chem Toxicol , vol.46 , pp. 3443-3447
    • Tavakkol Afshari, J.1    Brook, A.2    Mousavi, S.H.3
  • 27
    • 37349025717 scopus 로고    scopus 로고
    • Glucose neurotoxicity
    • DOI 10.1038/nrn2294, PII NRN2294
    • DR Tomlinson NJ Gardiner 2008 Glucose neurotoxicity Nat Rev Neurosci 9 36 45 10.1038/nrn2294 1:CAS:528:DC%2BD2sXhsVGjtr7O 18094705 (Pubitemid 350295687)
    • (2008) Nature Reviews Neuroscience , vol.9 , Issue.1 , pp. 36-45
    • Tomlinson, D.R.1    Gardiner, N.J.2
  • 28
    • 4143110556 scopus 로고    scopus 로고
    • Oxidative stress in the pathogenesis of diabetic neuropathy
    • DOI 10.1210/er.2003-0019
    • AM Vincent JW Russell P Low EL Feldman 2004 Oxidative stress in the pathogenesis of diabetic neuropathy Endocr Rev 25 612 628 10.1210/er.2003-0019 1:CAS:528:DC%2BD2cXns1Ght78%3D 15294884 (Pubitemid 39096072)
    • (2004) Endocrine Reviews , vol.25 , Issue.4 , pp. 612-628
    • Vincent, A.M.1    Russell, J.W.2    Low, P.3    Feldman, E.L.4
  • 30
    • 0025853670 scopus 로고
    • Protein glycation and oxidative stress in diabetes mellitus and ageing
    • 10.1016/0891-5849(91)90040-A 1:CAS:528:DyaK3MXktVKjsrY%3D 1855674
    • SP Wolff ZY Jiang JV Hunt 1991 Protein glycation and oxidative stress in diabetes mellitus and ageing Free Radic Biol Med 10 339 352 10.1016/0891- 5849(91)90040-A 1:CAS:528:DyaK3MXktVKjsrY%3D 1855674
    • (1991) Free Radic Biol Med , vol.10 , pp. 339-352
    • Wolff, S.P.1    Jiang, Z.Y.2    Hunt, J.V.3
  • 31
    • 0033289624 scopus 로고    scopus 로고
    • Increased plasma oxidizability and decreased erythrocyte and plasma antioxidative capacity in patients with NIDDM
    • 1:STN:280:DC%2BD3c7pt1eguw%3D%3D 10731349
    • H Zaltzberg Y Kanter M Aviram Y Levy 1999 Increased plasma oxidizability and decreased erythrocyte and plasma antioxidative capacity in patients with NIDDM Isr Med Assoc J 1 228 231 1:STN:280:DC%2BD3c7pt1eguw%3D%3D 10731349
    • (1999) Isr Med Assoc J , vol.1 , pp. 228-231
    • Zaltzberg, H.1    Kanter, Y.2    Aviram, M.3    Levy, Y.4
  • 32
    • 4444372444 scopus 로고    scopus 로고
    • Staurosporine induces apoptosis of melanoma by both caspase-dependent and -independent apoptotic pathways
    • XD Zhang SK Gillespie P Hersey 2004 Staurosporine induces apoptosis of melanoma by both caspase-dependent and independent apoptotic pathways Mol Cancer Ther 3 187 197 1:CAS:528:DC%2BD2cXhsFCitrw%3D 14985459 (Pubitemid 39193693)
    • (2004) Molecular Cancer Therapeutics , vol.3 , Issue.2 , pp. 187-197
    • Zhang, X.D.1    Gillespie, S.K.2    Hersey, P.3
  • 33
    • 0035856920 scopus 로고    scopus 로고
    • Global and societal implications of the diabetes epidemic
    • DOI 10.1038/414782a
    • P Zimmet KGMM Alberti J Shaw 2001 Global and societal implications of the diabetes epidemic Nature 414 782 787 10.1038/414782a 1:CAS:528: DC%2BD38Xhtlymtg%3D%3D 11742409 (Pubitemid 34000780)
    • (2001) Nature , vol.414 , Issue.6865 , pp. 782-787
    • Zimmet, P.1    Alberti, K.G.M.M.2    Shaw, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.