Synthesis of 3β, 7α, 11α-trihydroxy-pregn-21-benzylidene-5-en-20-one derivatives and their cytotoxic activities

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 23, 2009, Pages 6637-6639

  Shan, Li Hong ^a   Liu, Hong Min ^a   Huang, Ke Xue ^b   Dai, Gui Fu ^a   Cao, Chen ^a   Dong, Rui Jing ^a  

^a ZHENGZHOU UNIVERSITY   (China)

^b HUNAN NORMAL UNIVERSITY   (China)

Author keywords

Biotransformation; Claisen Schimidt condensation; Cytotoxicity; Hydroxylation; Mucor circinelloides lusitanicus; Pregnenolone

Indexed keywords

3BETA,7ALPHA,11ALPHA TRIHYDROXY PREGN 21 BENZYLIDENE 5 EN 20 ONE DERIVATIVE; ANTINEOPLASTIC AGENT; MAGNESIUM; ORIDONIN; PREGNENOLONE; UNCLASSIFIED DRUG; DRUG DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG SYNTHESIS; DRUG TRANSFORMATION; FERMENTATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MUCOR; MUCOR CIRCINELLOIDES LUSITANICUS; PH; PROTON NUCLEAR MAGNETIC RESONANCE; X RAY CRYSTALLOGRAPHY; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

MUCOR CIRCINELLOIDES;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUCOR; PREGNENOLONE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 71749089264     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.10.019     Document Type: Article

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