Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways

Investigational New Drugs

Volumn 31, Issue 3, 2013, Pages 545-557

  Grogan, Patrick T ^a,b   Sleder, Kristina D ^a   Samadi, Abbas K ^a   Zhang, Huaping ^c   Timmermann, Barbara N ^c   Cohen, Mark S ^a,b  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN HOSPITALS   (United States)

^c UNIVERSITY OF KANSAS   (United States)

Author keywords

Akt mTOR pathway; Glioblastoma multiforme; Heat shock response; MAPK pathway; Oxidative stress; Withaferin A

Indexed keywords

ACETYLCYSTEINE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 70; HEAT SHOCK TRANSCRIPTION FACTOR 1; HEME OXYGENASE 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; PROTEIN P85; S6 KINASE; SCATTER FACTOR RECEPTOR; TUBERIN; UNCLASSIFIED DRUG; WITHAFERIN A;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GLIOBLASTOMA; HEAT SHOCK RESPONSE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; DNA-BINDING PROTEINS; GLIOBLASTOMA; HEAT-SHOCK PROTEINS; HEAT-SHOCK RESPONSE; HUMANS; MICE; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS; WITHANOLIDES;

EID: 84879110131     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-012-9888-5     Document Type: Article

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