Chitin-glucan fiber effects on oxidized low-density lipoprotein: A randomized controlled trial

European Journal of Clinical Nutrition

Volumn 67, Issue 1, 2013, Pages 2-7

  Bays, H E ^a   Evans, J L ^b   Maki, K C ^c   Evans, M ^d   Maquet, V ^e   Cooper, R ^a   Anderson, J W ^f  

^a Louisville Metab Atherosclerosis R   (United States)

^b Stratum Nutrition ^*  (United States)

^c Provident Clinical Research   (United States)

^d KGK Synergize   (Canada)

^e KITOZYME SA   (Belgium)

^f UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Atherosclerosis; Cardiovascular disease; Chitin glucan; Fiber; LDL cholesterol; Oxidized LDL

Indexed keywords

ANTIINFLAMMATORY AGENT; ARTINIA; CHITIN GLUCAN; GLUCAN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NUTRACEUTICAL; OLIVE OIL EXTRACT; OXIDIZED LOW DENSITY LIPOPROTEIN; PLACEBO; PLANT EXTRACT; UNCLASSIFIED DRUG;

ADULT; ARTICLE; ASPERGILLUS NIGER; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DEFECATION; DIETARY FIBER; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; EXCESSIVE GAS; FEMALE; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL SYMPTOM; HUMAN; HYPERCHOLESTEROLEMIA; LIPOPROTEIN BLOOD LEVEL; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; MULTICENTER STUDY; PATIENT COMPLIANCE; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; TREATMENT DURATION;

ADULT; ANTICHOLESTEREMIC AGENTS; ATHEROSCLEROSIS; BODY MASS INDEX; CHITIN; DOUBLE-BLIND METHOD; FEMALE; FRUIT; GLUCANS; HUMANS; HYPERCHOLESTEROLEMIA; LIPOPROTEINS, LDL; MALE; MIDDLE AGED; MIDWESTERN UNITED STATES; OLEA; ONTARIO; OVERWEIGHT; PLANT EXTRACTS; POLYSACCHARIDES; PREBIOTICS; RISK;

ASPERGILLUS NIGER;

EID: 84872168577     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/ejcn.2012.121     Document Type: Article

References (43)

1. National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002; 106: 3143-3421.
2. Steinberg D, Witztum J. Oxidized low-density lipoprotein and atherosclerosis. Arterioscler Thromb Vasc Biol 2010; 30: 2311-2316.
3. Mori K, Kobayashi C, Tomita T, Inatomi S, Ikeda M. Antiatherosclerotic effect of the edible mushrooms Pleurotus eryngii (Eringi), Grifola frondosa (Maitake), and Hypsizygus marmoreus (Bunashimeji) in apolipoprotein E-deficient mice. Nutr Res 2008; 28: 335-342. (Pubitemid 351609207)
4. Sun JE, Ao ZH, Lu ZM, Xu HY, Zhang XM, Dou WF et al. Antihyperglycemic and antilipidperoxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice. J Ethnopharmacol 2008; 118: 7-13.
5. Anderson JW, Baird P, Davis Jr RH, Ferreri S, Knudtson M, Koraym A et al. Health benefits of dietary fiber. Nutr Rev 2009; 67: 188-205.
6. Van HL, McCoin M, Kris-Etherton PM, Burke F, Carson JA, Champagne CM et al. The evidence for dietary prevention and treatment of cardiovascular disease. J Am Diet Assoc 2008; 108: 287-331.
7. Nicolosi R, Bell SJ, Bistrian BR, Greenberg I, Forse RA, Blackburn GL. Plasma lipid changes after supplementation with beta-glucan fiber from yeast. Am J Clin Nutr 1999; 70: 208-212. (Pubitemid 29347565)
8. EFSA Panel on Dietetic Products NaAN. Scientific Opinion on the substantiation of health claims related to beta glucans and maintenance of normal blood cholesterol concentrations (ID 754, 755, 757, 801, 1465, 2934) and maintenance or achievement of a normal body weight (ID 820, 823) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA J 2009; 7: 1254.
9. Berecochea-Lopez A, Decorde K, Ventura E, Godard M, Bornet A, Teissedre PL et al. Fungal chitin-glucan from Aspergillus niger efficiently reduces aortic fatty streak accumulation in the high-fat fed hamster, an animal model of nutritionally induced atherosclerosis. J Agric Food Chem 2009; 57: 1093-1098.
10. Neyrinck A, Possemiers S, Verstraete W, De Backer F, Cani P, Delzenne N. Dietary modulation of clostridial cluster XIVa gut bacteria (Roseburia spp.) by chitinglucan fiber improves host metabolic alterations induced by high-fat diet in mice. J Nutr Biochem 2012; 23: 51-59.
11. Deschamps A, Nollevaux G, Gautier S, Keller F. Managing oxidative stress with a vegetal ingredient, chitin-glucan. AgroFood 2009; 20: 12-14.
12. Covas MI, Nyyssonen K, Poulsen HE, Kaikkonen J, Zunft HJ, Kiesewetter H et al. The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial. Ann Intern Med 2006; 145: 333-341. (Pubitemid 46768590)
13. Estruch R, Martinez-Gonzalez MA, Corella D, Salas-Salvado J, Ruiz-Gutierrez V, Covas MI et al. Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial. Ann Intern Med 2006; 145: 1-11. (Pubitemid 46780599)
14. Fito M, Guxens M, Corella D, Saez G, Estruch R, De la Torre R et al. Effect of a traditional Mediterranean diet on lipoprotein oxidation: a randomized controlled trial. Arch Intern Med 2007; 167: 1195-1203. (Pubitemid 46919824)
15. Serra-Majem L, Roman B, Estruch R. Scientific evidence of interventions using the Mediterranean diet: a systematic review. Nutr Rev 2006; 64(2 Part 2): S27-S47.
16. Sofi F, Cesari F, Abbate R, Gensini GF, Casini A. Adherence to Mediterranean diet and health status: meta-analysis. BMJ 2008; 337: a1344.
17. Covas MI, Konstantinidou V, Fito M. Olive oil and cardiovascular health. J Cardiovasc Pharmacol 2009; 54: 477-482.
18. Ortega RM. Importance of functional foods in the Mediterranean diet. Public Health Nutr 2006; 9: 1136-1140.
19. Perez-Jimenez F, Alvarez de CG, Badimon L, Barja G, Battino M, Blanco A et al. International conference on the healthy effect of virgin olive oil. Eur J Clin Invest 2005; 35(7): 421-424. (Pubitemid 40992770)
20. Perez-Jimenez F, Ruano J, Perez-Martinez P, Lopez-Segura F, Lopez-Miranda J. The influence of olive oil on human health: not a question of fat alone. Mol Nutr Food Res 2007; 51: 1199-1208. (Pubitemid 350013167)
21. Tripoli E, Giammanco M, Tabacchi G, Di MD, Giammanco S, La GM. The phenolic compounds of olive oil: structure, biological activity and beneficial effects on human health. Nutr Res Rev 2005; 18: 98-112. (Pubitemid 40826917)
22. Cicero AF, Nascetti S, Lopez-Sabater MC, Elosua R, Salonen JT, Nyyssonen K et al. Changes in LDL fatty acid composition as a response to olive oil treatment are inversely related to lipid oxidative damage: the EUROLIVE study. J Am Coll Nutr 2008; 27: 314-320.
23. Covas MI, de la Torre K, Farre-Albaladejo M, Kaikkonen J, Fito M, Lopez-Sabater C et al. Postprandial LDL phenolic content and LDL oxidation are modulated by olive oil phenolic compounds in humans. Free Radic Biol Med 2006; 40: 608-616. (Pubitemid 43170812)
24. Covas MI. Bioactive effects of olive oil phenolic compounds in humans: reduction of heart disease factors and oxidative damage. Inflammopharmacology 2008; 16: 216-218.
25. Fito M, De la Torre R, Covas MI. Olive oil and oxidative stress. Mol Nutr Food Res 2007; 51: 1215-1224. (Pubitemid 350013169)
26. Gimeno E, Torre-Carbot K, Lanuela-Raventos RM, Castellote AI, Fito M, de la Torre R et al. Changes in the phenolic content of low density lipoprotein after olive oil consumption in men. A randomized crossover controlled trial. Br J Nutr 2007; 98: 1243-1250. (Pubitemid 350193792)
27. Marrugat J, Covas MI, Fito M, Schroder H, Miro-Casas E, Gimeno E et al. Effects of differing phenolic content in dietary olive oils on lipids and LDL oxidation-a randomized controlled trial. Eur J Nutr 2004; 43: 140-147. (Pubitemid 38828662)
28. Weinbrenner T, Fito M, De la Torre R, Saez GT, Rijken P, Tormos C et al. Olive oils high in phenolic compounds modulate oxidative/antioxidative status in men. J Nutr 2004; 134: 2314-2321. (Pubitemid 39201602)
29. Glantz S. Primer of Biostatistics. 6th edn. (McGraw-Hill Medical: New York, 2005.
30. Azar RR, Badaoui G, Sarkis A, Azar M, Aydanian H, Harb S et al. Effect of ezetimibe/atorvastatin combination on oxidized low density lipoprotein cholesterol in patients with coronary artery disease or coronary artery disease equivalent. Am J Cardiol 2010; 106: 193-197.
31. Holvoet P, Theilmeier G, Shivalkar B, Flameng W, Collen D. LDL hypercholesterolemia is associated with accumulation of oxidized LDL, atherosclerotic plaque growth, and compensatory vessel enlargement in coronary arteries of miniature pigs. Arterioscler Thromb Vasc Biol 1998; 18: 415-422. (Pubitemid 28125636)
32. Bays HE. Adiposopathy: is sick fat a cardiovascular disease? J Am Coll Cardiol 2011; 57: 2461-2473.
33. Heidenreich PA, Trogdon JG, Khavjou OA, Butler J, Dracup K, Ezekowitz MD et al. Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association. Circulation 2011; 123: 933-944.
34. Schwedhelm E, Bartling A, Lenzen H, Tsikas D, Maas R, Brummer J et al. Urinary 8-iso-prostaglandin F2alpha as a risk marker in patients with coronary heart disease: a matched case-control study. Circulation 2004; 109: 843-848. (Pubitemid 38252735)
35. Biorklund M, van RA, Mensink RP, Onning G. Changes in serum lipids and postprandial glucose and insulin concentrations after consumption of beverages with beta-glucans from oats or barley: a randomised dose-controlled trial. Eur J Clin Nutr 2005; 59: 1272-1281. (Pubitemid 41655632)
36. Makelainen H, Anttila H, Sihvonen J, Hietanen RM, Tahvonen R, Salminen E et al. The effect of beta-glucan on the glycemic and insulin index. Eur J Clin Nutr 2007; 61: 779-785. (Pubitemid 47232357)
37. Maki KC, Galant R, Samuel P, Tesser J, Witchger MS, Ribaya-Mercado JD et al. Effects of consuming foods containing oat b-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress in men and women with elevated blood pressure. Eur J Clin Nutr 2007; 61: 786-795. (Pubitemid 47232358)
38. Maki KC, Rains TM. Fiber and insulin sensitivity. In: Zimering MB (ed). Topics in the Prevention, Treatment and Complications of Type 2 Diabetes. InTech: New York, 2011, pp 177-190. Available at http://www.intechopen.com/ contact.html.
39. Maki KC, Pelkman CL, Kelley KM, Lawless AL, Schild A, Rains TM. Effects of type 2 resistant starch consumption on insulin sensitivity in men and women. FASEB J 2011; 25: 587.9.
40. Hertog MG, Kromhout D, Aravanis C, Blackburn H, Buzina R, Fidanza F et al. Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch Intern Med 1995; 155: 381-386.
41. Vissers MN, Zock PL, Katan MB. Bioavailability and antioxidant effects of olive oil phenols in humans: a review. Eur J Clin Nutr 2004; 58: 955-965. (Pubitemid 38923195)
42. Jonker D, Kuper CF, Maquet V, Nollevaux G, Gautier S. Subchronic (13-week) oral toxicity study in rats with fungal chitin-glucan from Aspergillus niger. Food Chem Toxicol 2010; 48: 2695-2701.
43. Soni MG, Burdock GA, Christian MS, Bitler CM, Crea R. Safety assessment of aqueous olive pulp extract as an antioxidant or antimicrobial agent in foods. Food Chem Toxicol 2006; 44: 903-915. (Pubitemid 43850084)