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Volumn 73, Issue 12, 2013, Pages 3511-3524

Kinetic modeling-based detection of genetic signatures that provide chemoresistance via the E2F1-p73/DNp73-miR-205 network

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; DOXORUBICIN; ERLOTINIB; LAPATINIB; MICRORNA 205; PROTEIN P73; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR TWIST; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84879088218     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-4095     Document Type: Article
Times cited : (49)

References (50)
  • 1
    • 78650236850 scopus 로고    scopus 로고
    • Chemotherapy, chemoresistance and the changing treatment landscape for NSCLC
    • Chang A. Chemotherapy, chemoresistance and the changing treatment landscape for NSCLC. Lung Cancer 2011;71:3-10.
    • (2011) Lung Cancer , vol.71 , pp. 3-10
    • Chang, A.1
  • 2
    • 33646047403 scopus 로고    scopus 로고
    • E2F1-induced apoptosis: Turning killers into therapeutics
    • Stanelle J, Pützer BM. E2F1-induced apoptosis: turning killers into therapeutics. Trends Mol Med 2006;12:177-85.
    • (2006) Trends Mol Med , vol.12 , pp. 177-185
    • Stanelle, J.1    Pützer, B.M.2
  • 3
    • 0032939925 scopus 로고    scopus 로고
    • Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53
    • Blattner C, Sparks A, Lane D. Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53. Mol Cell Biol 1999;19:3704-13. (Pubitemid 29193830)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.5 , pp. 3704-3713
    • Blattner, C.1    Sparks, A.2    Lane, D.3
  • 4
    • 77957931294 scopus 로고    scopus 로고
    • Translating DNA damage into cancer cell death-A roadmap for E2F1 apoptotic signalling and opportunities for new drug combinations to overcome chemoresistance
    • Engelmann D, Pützer BM. Translating DNA damage into cancer cell death-A roadmap for E2F1 apoptotic signalling and opportunities for new drug combinations to overcome chemoresistance. Drug Resist Updat 2010;13:119-31.
    • (2010) Drug Resist Updat , vol.13 , pp. 119-131
    • Engelmann, D.1    Pützer, B.M.2
  • 5
    • 0035477398 scopus 로고    scopus 로고
    • Therapeutic efficacy of E2F1 in pancreatic cancer correlates with TP73 induction
    • Rödicker F, Stiewe T, Zimmermann S, Pützer BM. Therapeutic efficacy of E2F1 in pancreatic cancer correlates with TP73 induction. Cancer Res 2001;61:7052-5. (Pubitemid 32946495)
    • (2001) Cancer Research , vol.61 , Issue.19 , pp. 7052-7055
    • Rodicker, F.1    Stiewe, T.2    Zimmermann, S.3    Putzer, B.M.4
  • 6
    • 0033666776 scopus 로고    scopus 로고
    • Role of the p53-homologue p73 in E2F1-induced apoptosis
    • Stiewe T, Pützer BM. Role of the p53-homologue p73 in E2F1-induced apoptosis. Nat Genet 2000;26:464-9.
    • (2000) Nat Genet , vol.26 , pp. 464-469
    • Stiewe, T.1    Pützer, B.M.2
  • 7
    • 77953497421 scopus 로고    scopus 로고
    • Targeting the p53-family in cancer and chemosensitivity: Triple threat
    • Chung J, Irwin MS. Targeting the p53-family in cancer and chemosensitivity: triple threat. Curr Drug Targets 2010;11:667-81.
    • (2010) Curr Drug Targets , vol.11 , pp. 667-681
    • Chung, J.1    Irwin, M.S.2
  • 9
    • 0344394363 scopus 로고    scopus 로고
    • E2F1 expression is related with the poor survival of lymph node-positive breast cancer patients treated with fluorouracil, doxorubicin and cyclophosphamide
    • DOI 10.1023/B:BREA.0000003843.53726.63
    • Han S, Park K, Bae B-N, Kim KH, Kim H-J, Kim Y-D, et al. E2F1 expression is related with the poor survival of lymph node-positive breast cancer patients treated with fluorouracil, doxorubicin and cyclophosphamide. Breast Cancer Res Treat 2003;82:11-6. (Pubitemid 37476014)
    • (2003) Breast Cancer Research and Treatment , vol.82 , Issue.1 , pp. 11-16
    • Han, S.1    Park, K.2    Bae, B.-N.3    Kim, K.H.4    Kim, H.-J.5    Kim, Y.-D.6    Kim, H.-Y.7
  • 11
    • 0038751809 scopus 로고    scopus 로고
    • Increased DeltaN-p73 expression in tumors by upregulation of the E2F1-regulated, TA-promoter-derived DeltaN′-p73 transcript [2]
    • DOI 10.1038/sj.cdd.4401205
    • Pützer BM, Tuve S, Tannapfel A, Stiewe T. Increased DeltaN-p73 expression in tumors by upregulation of the E2F1-regulated, TA-promoter-derived DeltaN′-p73 transcript. Cell Death Differ 2003;10:612-4. (Pubitemid 36656651)
    • (2003) Cell Death and Differentiation , vol.10 , Issue.5 , pp. 612-614
    • Putzer, B.M.1    Tuve, S.2    Tannapfel, A.3    Stiewe, T.4
  • 13
    • 0345256343 scopus 로고    scopus 로고
    • Alterations of DeltaTA-p73 splice transcripts during melanoma development and progression
    • DOI 10.1002/ijc.11552
    • Tuve S, Wagner SN, Schittek B, Pützer BM. Alterations of DeltaTA-p73 splice transcripts during melanoma development and progression. Int J Cancer 2004;108:162-6. (Pubitemid 37444460)
    • (2004) International Journal of Cancer , vol.108 , Issue.1 , pp. 162-166
    • Tuve, S.1    Wagner, S.N.2    Schitrek, B.3    Putzer, B.M.4
  • 14
    • 69849096670 scopus 로고    scopus 로고
    • Antisense gapmers selectively suppress individual oncogenic p73 splice isoforms and inhibit tumor growth in vivo
    • Emmrich S, Wang W, John K, Li W, Pützer BM. Antisense gapmers selectively suppress individual oncogenic p73 splice isoforms and inhibit tumor growth in vivo. Mol Cancer 2009;8:61.
    • (2009) Mol Cancer , vol.8 , pp. 61
    • Emmrich, S.1    Wang, W.2    John, K.3    Li, W.4    Pützer, B.M.5
  • 15
    • 84865344231 scopus 로고    scopus 로고
    • E2F1 confers anticancer drug resistance by targeting ABC transporter family members and Bcl-2 via the p73/DNp73-miR-205 circuitry
    • Alla V, Kowtharapu BS, Engelmann D, Emmrich S, Schmitz U, Steder M, et al. E2F1 confers anticancer drug resistance by targeting ABC transporter family members and Bcl-2 via the p73/DNp73-miR-205 circuitry. Cell Cycle 2012;11:3067-78.
    • (2012) Cell Cycle , vol.11 , pp. 3067-3078
    • Alla, V.1    Kowtharapu, B.S.2    Engelmann, D.3    Emmrich, S.4    Schmitz, U.5    Steder, M.6
  • 16
    • 84856557109 scopus 로고    scopus 로고
    • The dark side of E2F1: In transit beyond apoptosis
    • Engelmann D, Pützer BM. The dark side of E2F1: in transit beyond apoptosis. Cancer Res 2012;72:571-5.
    • (2012) Cancer Res , vol.72 , pp. 571-575
    • Engelmann, D.1    Pützer, B.M.2
  • 17
    • 59049094552 scopus 로고    scopus 로고
    • A system biology approach to understand functional activity of cell communication systems
    • Vera J, Wolkenhauer O. A system biology approach to understand functional activity of cell communication systems. Methods Cell Biol 2008;90:399-415.
    • (2008) Methods Cell Biol , vol.90 , pp. 399-415
    • Vera, J.1    Wolkenhauer, O.2
  • 18
    • 77957928119 scopus 로고    scopus 로고
    • Investigating dynamics of inhibitory and feedback loops in ERK signalling using power-law models
    • Vera J, Rath O, Balsa-Canto E, Banga JR, Kolch W, Wolkenhauer O. Investigating dynamics of inhibitory and feedback loops in ERK signalling using power-law models. Mol Biosyst 2010;6:2174-91.
    • (2010) Mol Biosyst , vol.6 , pp. 2174-2191
    • Vera, J.1    Rath, O.2    Balsa-Canto, E.3    Banga, J.R.4    Kolch, W.5    Wolkenhauer, O.6
  • 19
    • 0030970085 scopus 로고    scopus 로고
    • Harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)
    • DOI 10.1093/emboj/16.7.1686
    • Inohara N, Ding L, Chen S, Núñez G. harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L). EMBO J 1997;16:1686-94. (Pubitemid 27151963)
    • (1997) EMBO Journal , vol.16 , Issue.7 , pp. 1686-1694
    • Inohara, N.1    Ding, L.2    Chen, S.3    Nunez, G.4
  • 20
    • 80054861063 scopus 로고    scopus 로고
    • DARPP-32 increases interactions between epidermal growth factor receptor and ERBB3 to promote tumor resistance to ge fitinib
    • Zhu S, Belkhiri A, El-Rifai W. DARPP-32 increases interactions between epidermal growth factor receptor and ERBB3 to promote tumor resistance to ge fitinib. Gastroenterology 2011;141:1738-48. e1-2.
    • (2011) Gastroenterology , vol.141
    • Zhu, S.1    Belkhiri, A.2    El-Rifai, W.3
  • 21
    • 79954627096 scopus 로고    scopus 로고
    • Acquisition of chemoresistance and EMT phenotype is linked with activation of the endothelin A receptor pathway in ovarian carcinoma cells
    • Rosanò L, Cianfrocca R, Spinella F, Di Castro V, Nicotra MR, Lucidi A, et al. Acquisition of chemoresistance and EMT phenotype is linked with activation of the endothelin A receptor pathway in ovarian carcinoma cells. Clin Cancer Res 2011;17:2350-60.
    • (2011) Clin Cancer Res , vol.17 , pp. 2350-2360
    • Rosanò, L.1    Cianfrocca, R.2    Spinella, F.3    Di Castro, V.4    Nicotra, M.R.5    Lucidi, A.6
  • 22
    • 77949529981 scopus 로고    scopus 로고
    • Functional interplay between E2F1 and chemotherapeutic drugs defines immediate E2F1 target genes crucial for cancer cell death
    • Engelmann D, Knoll S, Ewerth D, Steder M, Stoll A, Pützer BM. Functional interplay between E2F1 and chemotherapeutic drugs defines immediate E2F1 target genes crucial for cancer cell death. Cell Mol Life Sci 2010;67:931-48.
    • (2010) Cell Mol Life Sci , vol.67 , pp. 931-948
    • Engelmann, D.1    Knoll, S.2    Ewerth, D.3    Steder, M.4    Stoll, A.5    Pützer, B.M.6
  • 24
    • 58149382580 scopus 로고    scopus 로고
    • MicroRNA regulation of a cancer network: Consequences of the feedback loops involving miR-17-92, E2F, and Myc
    • Aguda BD, Kim Y, Piper-Hunter MG, Friedman A, Marsh CB. MicroRNA regulation of a cancer network: consequences of the feedback loops involving miR-17-92, E2F, and Myc. Proc Natl Acad Sci USA 2008;105:19678-83.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 19678-19683
    • Aguda, B.D.1    Kim, Y.2    Piper-Hunter, M.G.3    Friedman, A.4    Marsh, C.B.5
  • 25
    • 65549115615 scopus 로고    scopus 로고
    • miR-205 Exerts tumor-suppressive functions in human prostate through down-regulation of protein kinase Cepsilon
    • Gandellini P, Folini M, Longoni N, Pennati M, Binda M, Colecchia M, et al. miR-205 Exerts tumor-suppressive functions in human prostate through down-regulation of protein kinase Cepsilon. Cancer Res 2009;69:2287-95.
    • (2009) Cancer Res , vol.69 , pp. 2287-2295
    • Gandellini, P.1    Folini, M.2    Longoni, N.3    Pennati, M.4    Binda, M.5    Colecchia, M.6
  • 26
    • 64149089915 scopus 로고    scopus 로고
    • Suppression of cell growth and invasion by miR-205 in breast cancer
    • Wu H, Zhu S, Mo Y-Y. Suppression of cell growth and invasion by miR-205 in breast cancer. Cell Res 2009;19:439-48.
    • (2009) Cell Res , vol.19 , pp. 439-448
    • Wu, H.1    Zhu, S.2    Mo, Y.-Y.3
  • 28
    • 41949088521 scopus 로고    scopus 로고
    • DNp73 a matter of cancer: Mechanisms and clinical implications
    • Buhlmann S, Pützer BM. DNp73 a matter of cancer: mechanisms and clinical implications. Biochim Biophys Acta 2008;1785:207-16.
    • (2008) Biochim Biophys Acta , vol.1785 , pp. 207-216
    • Buhlmann, S.1    Pützer, B.M.2
  • 29
    • 27644458185 scopus 로고    scopus 로고
    • Aberrant expression of DeltaNp73 in benign and malignant tumours of the prostate: Correlation with Gleason score
    • DOI 10.1136/jcp.2005.026955
    • Guan M, Chen Y. Aberrant expression of DeltaNp73 in benign and malignant tumours of the prostate: correlation with Gleason score. J Clin Pathol 2005;58:1175-9. (Pubitemid 41566462)
    • (2005) Journal of Clinical Pathology , vol.58 , Issue.11 , pp. 1175-1179
    • Guan, M.1    Chen, Y.2
  • 30
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in Cancer
    • Massagué J. TGFbeta in Cancer. Cell 2008;134:215-30.
    • (2008) Cell , vol.134 , pp. 215-230
    • Massagué, J.1
  • 31
    • 59449093537 scopus 로고    scopus 로고
    • Activation of ErbB3, EGFR and Erk is essential for growth of human breast cancer cell lines with acquired resistance to fulvestrant
    • Frogne T, Benjaminsen RV, Sonne-Hansen K, Sorensen BS, Nexo E, Laenkholm A-V, et al. Activation of ErbB3, EGFR and Erk is essential for growth of human breast cancer cell lines with acquired resistance to fulvestrant. Breast Cancer Res Treat 2009;114:263-75.
    • (2009) Breast Cancer Res Treat , vol.114 , pp. 263-275
    • Frogne, T.1    Benjaminsen, R.V.2    Sonne-Hansen, K.3    Sorensen, B.S.4    Nexo, E.5    Laenkholm, A.-V.6
  • 32
  • 34
    • 43149108161 scopus 로고    scopus 로고
    • A bistable Rb-E2F switch underlies the restriction point
    • Yao G, Lee TJ, Mori S, Nevins JR, You L. A bistable Rb-E2F switch underlies the restriction point. Nat. Cell Biol 2008;10:476-82.
    • (2008) Nat. Cell Biol , vol.10 , pp. 476-482
    • Yao, G.1    Lee, T.J.2    Mori, S.3    Nevins, J.R.4    You, L.5
  • 35
    • 77957767333 scopus 로고    scopus 로고
    • Coordination between cell cycle progression and cell fate decision by the p53 and E2F1 pathways in response to DNA damage
    • Zhang X-P, Liu F, Wang W. Coordination between cell cycle progression and cell fate decision by the p53 and E2F1 pathways in response to DNA damage. J Biol Chem 2010;285:31571-80.
    • (2010) J Biol Chem , vol.285 , pp. 31571-31580
    • Zhang, X.-P.1    Liu, F.2    Wang, W.3
  • 36
    • 79251573545 scopus 로고    scopus 로고
    • Viral-mediated noisy gene expression reveals biphasic E2f1 response to MYC
    • Wong JV, Yao G, Nevins JR, You L. Viral-mediated noisy gene expression reveals biphasic E2f1 response to MYC. Mol Cell 2011;41:275-85.
    • (2011) Mol Cell , vol.41 , pp. 275-285
    • Wong, J.V.1    Yao, G.2    Nevins, J.R.3    You, L.4
  • 37
    • 53049097596 scopus 로고    scopus 로고
    • Hedgehog signaling, epithelial-to-mesenchymal transition and miRNA
    • review
    • Katoh Y, Katoh M. Hedgehog signaling, epithelial-to-mesenchymal transition and miRNA (review). Int J Mol Med 2008;22:271-5.
    • (2008) Int J Mol Med , vol.22 , pp. 271-275
    • Katoh, Y.1    Katoh, M.2
  • 38
    • 79551469293 scopus 로고    scopus 로고
    • Coordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancer
    • Wiklund ED, Bramsen JB, Hulf T, Dyrskjøt L, Ramanathan R, Hansen TB, et al. Coordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancer. Int J Cancer 2011;128:1327-34.
    • (2011) Int J Cancer , vol.128 , pp. 1327-1334
    • Wiklund, E.D.1    Bramsen, J.B.2    Hulf, T.3    Dyrskjøt, L.4    Ramanathan, R.5    Hansen, T.B.6
  • 39
    • 70350122931 scopus 로고    scopus 로고
    • Amphiregulin induces the alternative splicing of p73 into its oncogenic isoform DeltaEx2p73 in human hepatocellular tumors
    • Castillo J, Goñi S, Latasa MU, Perugorría MJ, Calvo A, Muntané J, et al. Amphiregulin induces the alternative splicing of p73 into its oncogenic isoform DeltaEx2p73 in human hepatocellular tumors. Gastroenterology 2009;137:1805-15.e1-4.
    • (2009) Gastroenterology , vol.137
    • Castillo, J.1    Goñi, S.2    Latasa, M.U.3    Perugorría, M.J.4    Calvo, A.5    Muntané, J.6
  • 40
    • 77956320116 scopus 로고    scopus 로고
    • Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming
    • Samavarchi-Tehrani P, Golipour A, David L, Sung H-K, Beyer TA, Datti A, et al. Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell 2010;7:64-77.
    • (2010) Cell Stem Cell , vol.7 , pp. 64-77
    • Samavarchi-Tehrani, P.1    Golipour, A.2    David, L.3    Sung, H.-K.4    Beyer, T.A.5    Datti, A.6
  • 41
    • 84855359334 scopus 로고    scopus 로고
    • A microRNA gene expression signature predicts response to erlotinib in epithelial cancer cell lines and targets EMT
    • Bryant JL, Britson J, Balko JM, Willian M, Timmons R, Frolov A, et al. A microRNA gene expression signature predicts response to erlotinib in epithelial cancer cell lines and targets EMT. Br J Cancer 2012;106:148-56.
    • (2012) Br J Cancer , vol.106 , pp. 148-156
    • Bryant, J.L.1    Britson, J.2    Balko, J.M.3    Willian, M.4    Timmons, R.5    Frolov, A.6
  • 42
    • 84867499417 scopus 로고    scopus 로고
    • Computational analysis of target hub gene repression regulated by multiple and cooperative miRNAs
    • Lai X, Schmitz U, Gupta SK, Bhattacharya A, Kunz M, Wolkenhauer O, et al. Computational analysis of target hub gene repression regulated by multiple and cooperative miRNAs. Nucleic Acids Res 2012;40:8818-34.
    • (2012) Nucleic Acids Res , vol.40 , pp. 8818-8834
    • Lai, X.1    Schmitz, U.2    Gupta, S.K.3    Bhattacharya, A.4    Kunz, M.5    Wolkenhauer, O.6
  • 43
    • 80054711591 scopus 로고    scopus 로고
    • MicroRNA-mediated positive feedback loop and optimized bistable switch in a cancer network Involving miR-17-92
    • Li Y, Li Y, Zhang H, Chen Y. MicroRNA-mediated positive feedback loop and optimized bistable switch in a cancer network Involving miR-17-92. PLoS ONE 2011;6:e26302.
    • (2011) PLoS ONE , vol.6
    • Li, Y.1    Li, Y.2    Zhang, H.3    Chen, Y.4
  • 44
    • 33845243362 scopus 로고    scopus 로고
    • Cancer as an evolutionary and ecological process
    • DOI 10.1038/nrc2013, PII NRC2013
    • Merlo LMF, Pepper JW, Reid BJ, Maley CC. Cancer as an evolutionary and ecological process. Nat Rev Cancer 2006;6:924-35. (Pubitemid 44862677)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.12 , pp. 924-935
    • Merlo, L.M.F.1    Pepper, J.W.2    Reid, B.J.3    Maley, C.C.4
  • 45
    • 33646183071 scopus 로고    scopus 로고
    • Evolution of resistance during clonal expansion
    • Iwasa Y, Nowak MA, Michor F. Evolution of resistance during clonal expansion. Genetics 2006;172:2557-66.
    • (2006) Genetics , vol.172 , pp. 2557-2566
    • Iwasa, Y.1    Nowak, M.A.2    Michor, F.3
  • 46
    • 70350236539 scopus 로고    scopus 로고
    • Lessons from applied ecology: Cancer control using an evolutionary double bind
    • Gatenby RA, Brown J, Vincent T. Lessons from applied ecology: cancer control using an evolutionary double bind. Cancer Res 2009;69:7499-502.
    • (2009) Cancer Res , vol.69 , pp. 7499-7502
    • Gatenby, R.A.1    Brown, J.2    Vincent, T.3
  • 47
    • 70349437076 scopus 로고    scopus 로고
    • p53 and E2f: Partners in life and death
    • Polager S, Ginsberg D. p53 and E2f: partners in life and death. Nat Rev Cancer 2009;9:738-48.
    • (2009) Nat Rev Cancer , vol.9 , pp. 738-748
    • Polager, S.1    Ginsberg, D.2
  • 50
    • 0036203514 scopus 로고    scopus 로고
    • Autoinhibitory regulation of p73 by DeltaNp73 to modulate cell survival and death through a p73-specific target element within the DeltaNp73 promoter
    • DOI 10.1128/MCB.22.8.2575-2585.2002
    • Nakagawa T, Takahashi M, Ozaki T, Watanabe K-I, Todo S, Mizuguchi H, et al. Autoinhibitory regulation of P73 by DNp73 to modulate cell survival and death through a P73-specific target element within the DNp73 promoter. Mol Cell Biol 2002;22:2575-85. (Pubitemid 34262980)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.8 , pp. 2575-2585
    • Nakagawa, T.1    Takahashi, M.2    Ozaki, T.3    Watanabe, K.-I.4    Todo, S.5    Mizuguchi, H.6    Hayakawa, T.7    Nakagawara, A.8


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