β-lapachone activates a Mre11p-Tel1p G1/S checkpoint in budding yeast

Cell Cycle

Volumn 5, Issue 21, 2006, Pages 2509-2516

  Menacho Márquez, Mauricio ^a   Murguia, José R ^a  

^a Universitat Politècnica de València   (Spain)

Author keywords

Cancer; Cell cycle checkpoint; DNA damage; Double strand break; Histone H2A; S. cerevisiae; lapachone

Indexed keywords

BETA LAPACHONE; CHECKPOINT KINASE 1; HISTONE H2A; MRE11 PROTEIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BUDDING; CELL CULTURE; CELL CYCLE PROGRESSION; CELL DEATH; CELL FUNCTION; CELL MUTANT; CELL SURVIVAL; PROTEIN PHOSPHORYLATION; YEAST;

SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

EID: 33751239743     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.5.21.3394     Document Type: Article

References (42)

1. Rouse J, Jackson SP. Interfaces between the detection, signaling, and repair of DNA damage. Science 2002; 297:547 51.
2. Zhou BB, Elledge SJ. The DNA damage response: putting checkpoints in perspective. Nature 2000; 408:433 9.
3. Paciotti V, Clerici M, Lucchini G, Longhese MP. The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1 dependent phosphorylation in budding yeast. Genes Dev 2000; 14:2046 59.
4. Sanchez Y, Desany BA, Jones WJ, Liu Q, Wang B, Elledge SJ. Regulation of RAD53 by the ATM like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science 1996; 271:357 60.
5. Morrow DM, Tagle DA, Shiloh Y, Collins FS, Hieter P. TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. Cell 1995; 82:831 40.
6. Gilbert CS, Green CM, Lowndes NF. Budding yeast Rad9 is an ATP dependent Rad53 activating machine. Mol Cell 2001; 8:129 36.
7. Burma S, Chen BP, Murphy M, Kurimasa A, Chen DJ. ATM phosphorylates histone H2AX in response to DNA double strand breaks. J Biol Chem 2001; 276:42462 7.
8. Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol 2000; 10:886 95.
9. Ward IM, Chen J. Histone H2AX is phosphorylated in an ATR dependent manner in response to replicational stress. J Biol Chem 2001; 276:47759 62.
10. Downs JA, Lowndes NF, Jackson SP. A role for Saccharomyces cerevisiae histone H2A in DNA repair. Nature 2000; 408:1001 4.
11. Redon C, Pilch DR, Rogakou EP, Orr AH, Lowndes NF, Bonner WM. Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint blind DNA damage. EMBO Rep 2003; 4:678 84.
12. van den BM, Bree RT, Lowndes NF. The MRN complex: coordinating and mediating the response to broken chromosomes. EMBO Rep 2003; 4:844 9.
13. Haber JE. The many interfaces of Mrell. Cell 1998; 95:583 6.
14. Lim DS, Kim ST, Xu B, Maser RS, Lin J, Petrini JH, Kastan MB. ATM phosphorylates p95/nbs1 in an S phase checkpoint pathway. Nature 2000; 404:613 7.
15. Wu X, Ranganathan V, Weisman DS, Heine WF, Ciccone DN, O'Neill TB, Crick KE, Pierce KA, Lane WS, Rathbun G, Livingston DM, Weaver DT. ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Nature 2000; 405:477 82.
16. Zhao S, Weng YC, Yuan SS, Lin YT, Hsu HC, Lin SC, Gerbino E, Song MH, Zdzienicka MZ, Gatti RA, Shay JW, Ziv Y, Shiloh Y, Lee EY. Functional link between ataxia telangiectasia and Nijmegen breakage syndrome gene products. Nature 2000; 405:473 7.
17. Grenon M, Gilbert C, Lowndes NF. Checkpoint activation in response to double strand breaks requires the Mre11/Rad50/Xrs2 complex. Nat Cell Biol 2001; 3:844 7.
18. D'Amours D, Jackson SP. The yeast Xrs2 complex functions in S phase checkpoint regulation. Genes Dev 2001; 15:2238 49.
19. Usui T, Ogawa H, Petrini JH. A DNA damage response pathway controlled by Tel1 and the Mre11 complex. Mol Cell 2001; 7:1255 66.
20. Pardee AB, Li YZ, Li CJ. Cancer therapy with beta lapachone. Curr Cancer Drug Targets 2002; 2:227 42.
21. Li CJ, Li YZ, Pinto AV, Pardee AB. Potent inhibition of tumor survival in vivo by beta lapachone plus taxol: Combining drugs imposes different artificial checkpoints. Proceedings of the National Academy of Sciences of the United States of America 1999; 96:13369 74.
22. Li CJ, Averboukh L, Pardee AB. Beta Lapachone, A Novel Dna Topoisomerase I Inhibitor with A Mode of Action Different from Camptothecin. Journal of Biological Chemistry 1993; 268:22463 8.
23. Li YZ, Sun XG, Lamont JT, Pardee AB, Li CJ. Selective killing of cancer cells by beta lapachone: Direct checkpoint activation as a strategy against cancer. Proceedings of the National Academy of Sciences of the United States of America 2003; 100:2674 8.
24. Pink JJ, Planchon SM, Tagliarino C, Varnes ME, Siegel D, Boothman DA. NAD(P)H : quinone oxidoreductase activity is the principal determinant of beta lapachone cytotoxicity. Journal of Biological Chemistry 2000; 275:5416 24.
25. Brunelli JP, Pall ML. A series of yeast/Escherichia coli lambda expression vectors designed for directional cloning of cDNAs and cre/lox mediated plasmid excision. Yeast 1993; 9(12):1309 1318.
26. Brill SJ, Sternglanz R. Transcription dependent DNA supercoiling in yeast DNA topoisomerase mutants. Cell 1988; 54:403 11.
27. de la Torre Ruiz MA, Green CM, Lowndes NF. RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation. EMBO J 1998; 17:2687 98.
28. Redon C, Pilch DR, Rogakou EP, Orr AH, Lowndes NF, Bonner WM. Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint blind DNA damage. EMBO Rep 2003; 4:678 84.
29. Nakada D, Shimomura T, Matsumoto K, Sugimoto K. The ATM related Tel1 protein of Saccharomyces cerevisiae controls a checkpoint response following phleomycin treatment. Nucleic Acids Res 2003; 31:1715 24.
30. Frydman B, Marton LJ, Sun JS, Neder K, Witiak DT, Liu AA, Wang HM, Mao Y, Wu HY, Sanders MM, Liu LF. Induction of DNA topoisomerase II mediated DNA cleavage by beta lapachone and related naphthoquinones. Cancer Research 1997; 57:620 7.
31. Renou SG, Asis SE, Abasolo MI, Bekerman DG, Bruno AM. Monoarylhydrazones of alpha lapachone: synthesis, chemical properties and antineoplastic activity. Pharmazie 2003; 58:690 5.
32. Reinicke KE, Bey EA, Bentle MS, Pink JJ, Ingalls ST, Hoppel CL, Misico RI, Arzac GM, Burton G, Bornmann WG, Sutton D, Gao J, Boothman DA. Development of {beta} Lapachone Prodrugs for Therapy Against Human Cancer Cells with Elevated NAD(P)H: Quinone Oxidoreductase 1 Levels. Clin Cancer Res 2005; 11:3055 64.
33. Tagliarino C, Pink JJ, Dubyak GR, Nieminen AL, Boothman DA. Calcium Is a Key Signaling Molecule in beta Lapachone mediated Cell Death. Journal of Biological Chemistry 2001; 276:19150 9.
34. Asher G, Lotem J, Cohen B, Sachs L, Shaul Y. Regulation of p53 stability and p53 dependent apoptosis by NADH quinone oxidoreductase 1. PNAS 2001; 98:1188 93.
35. Asher G, Lotem J, Kama R, Sachs L, Shaul Y. NQO1 stabilizes p53 through a distinct pathway. PNAS 2002; 99:3099 104.
36. Asher G, Tsvetkov P, Kahana C, Shaul Y. A mechanism of ubiquitin independent proteasomal degradation of the tumor suppressors p53 and p73. Genes Dev 2005; 19:316 21.
37. Lin WC, Lin FT, Nevins JR. Selective induction of E2F1 in response to DNA damage, mediated by ATM dependent phosphorylation. Genes Dev 2001; 15:1833 44.
38. Maser RS, Mirzoeva OK, Wells J, Olivares H, Williams BR, Zinkel RA, Farnham PJ, Petrini JH. Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis. Mol Cell Biol 2001; 21:6006 16.
39. Rogoff HA, Pickering MT, Frame FM, Debatis ME, Sanchez Y, Jones S, Kowalik TF. Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2. Mol Cell Biol 2004; 24:2968 77.
40. Schaefer JB, Breeden LL. RB from a bud's eye view. Cell 2004; 117:849 50.
41. Sidorova JM, Breeden LL. Rad53 dependent phosphorylation of Swi6 and down regulation of CLN1 and CLN2 transcription occur in response to DNA damage in Saccharomyces cerevisiae. Genes Dev 1997; 11:3032 45.
42. Sidorova JM, Breeden LL. Rad53 checkpoint kinase phosphorylation site preference identified in the Swi6 protein of Saccharomyces cerevisiae. Mol Cell Biol 2003; 23:3405 16.