Perspectives on alternatives to phthalate plasticized poly(vinyl chloride) in medical devices applications

Progress in Polymer Science

Volumn 38, Issue 7, 2013, Pages 1067-1088

  Chiellini, Federica ^a   Ferri, Marcella ^a   Morelli, Andrea ^a   Dipaola, Lucia ^c   Latini, Giuseppe ^b,c  

^a UNIVERSITY OF PISA   (Italy)

^b PERRINO HOSPITAL   (Italy)

^c CNR   (Italy)

Author keywords

Medical devices; Phthalates; Plasticizers; Poly(vinyl chloride)

Indexed keywords

BIOMEDICAL EQUIPMENT; CHLORINE COMPOUNDS; ESTERS; FUNCTIONAL POLYMERS; HEALTH RISKS; PACKAGING MATERIALS; PLASTICIZERS; REINFORCED PLASTICS; SOLVENTS; TOY MANUFACTURE;

ALTERNATIVE MATERIALS; DI-2-ETHYLHEXYL PHTHALATE; EXTERNAL ENVIRONMENTS; MEDICAL DEVICES; MEDICAL PLASTICS; PHTHALATE ESTER; PHTHALATES; RIGID MATERIAL;

POLYVINYL CHLORIDES;

EID: 84878925445     PISSN: 00796700     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.progpolymsci.2013.03.001     Document Type: Review

References (128)

1. M. Hakkarainen New PVC materials for medical applications-the release profile of PVC/polycaprolactone-polycarbonate aged in aqueous environments Polymer Degradation & Stability 80 2003 451 458
2. Anonymous. Medical Polymers Market to 2015 - Polyvinyl Chloride (PVC) dominating the medical devices and packaging markets. GBI Research Global Business Intelligence; 2010. http://gbiresearch.com/Report.aspx?ID=Medical- Polymers-Market-to-2015-Polyvinyl-Chloride-PVC-Dominating-the-Medical-Devices- and-Packaging-Markets&ReportType=Industry-Report&coreindustry= ALL&Title=Chemicals. Accessed March 2013. 116 pp.
3. X. Zhao, and J.M. Courtney Update on medical plasticized PVC 1st ed. 2009 Smithers Rapra Shrewsbury, UK 112 pp
4. Hakkarainen M, Aminlashgari N, Yin B. Biomass based plasticizers from liquefied waste paper. Angpanneforeningens Forskningsstiftelse; 2011. http://www.aforsk.se/images/pdf/10-065.pdf, Accessed March 2013. 10 pp.
5. Tickner JA, Rossi M, Haiama N, Lappe M, Hunt P. The use of di(2-ethylhexyl) phthalate in PVC medical devices: exposure, toxicity and alternatives. Lowell: Lowell Center for Sustainable Production, University of Massachussets; 1999. http://www.sustainableproduction.org/downloads/ DEHP%20Full%20Text.pdf, Accessed March 2013. 72 pp.
6. G. Wypych Plasticizer types G. Wypych, Handbook of plasticizers 2004 ChemTec Publishing Toronto, Ontario 7 73
7. Carlson K. Toxicity review of di(2-ethylhexyl) phthalate (DEHP). Bethesda, MD: US Consumer Product Safety Commision; 2010. http://www.cpsc.gov/ ABOUT/Cpsia/toxicityDEHP.pdf, Accessed March 2013. 329 pp.
8. G. Latini, C. De Felice, A. Del Vecchio, A. Barducci, M. Ferri, and F. Chiellini Di-(2-ethylhexyl)phthalate leakage and color changes in endotracheal tubes after application in high-risk newborns Neonatology 95 2009 317 323
9. M. Ferri, F. Chiellini, G. Pili, L. Grimaldi, E.T. Florio, S. Pili, F. Cucci, and G. Latini Di-(2-ethylhexyl)-phthalate migration from irradiated poly(vinyl chloride) blood bags for graft-vs-host disease prevention International Journal of Pharmaceutics 430 2012 86 88
10. F. Chiellini, M. Ferri, and G. Latini Physical-chemical assessment of di-(2-ethylhexyl)-phthalate leakage from poly(vinyl chloride) endotracheal tubes after application in high risk newborns International Journal of Pharmaceutics 409 2011 57 61
11. J.A. Tickner, T. Schettler, T. Guidotti, M. McCally, and M. Rossi Health risks posed by use of Di-2-ethylhexyl phthalate (DEHP) in PVC medical devices: A critical review American Journal of Industrial Medicine 39 2001 100 111
12. Miles-Richardson S. Toxicological profile for di(2-ethylhexyl)phthalate (DEHP). Agency for Toxic Substances and Disease Registry; 2002. http://www.atsdr.cdc.gov/toxprofiles/tp.asp?id=684&tid=65, Accessed March 2013. 336 pp.
13. P. Lefebvre, G. Chinetti, J.C. Fruchart, and B. Staels Sorting out the roles of PPARα in energy metabolism and vascular homeostasis Journal of Clinical Investigation 113 2005 571 580
14. J. Doull, R. Cattley, C. Elcombe, B.G. Lake, J. Swenberg, C. Wilkinson, G. Williams, and M. van Gemert A cancer risk assessment of di(2-ethylhexyl) phthalate: application of the new U.S. EPA risk assessment guidelines Regulatory Toxicology and Pharmacology 29 1999 327 357
15. C.N.A. Palmer, M.H. Hsu, K.J. Griffin, J.L. Raucy, and E.F. Johnson Peroxisome proliferator activated receptor-α expression in human liver Molecular Pharmacology 53 1998 14 22
16. R.L. Melnick Is peroxisome proliferation an obligatory precursor step in the carcinogenicity of di(2-ethylhexyl)phthalate (DEHP)? Environmental Health Perspectives 109 2001 437 442
17. Ito Y, Nakamura T, Yanagiba Y, Ramdhan DH, Yamagishi N, Naito H, Kamijima M, Gonzalez FJ, Nakajima T. Plasticizers may activate human hepatic peroxisome proliferator-activated receptor α less than that of a mouse but may activate constitutive androstane receptor in liver. PPAR Research 2012; 201284/1-11.
18. G. Latini, A. Verrotti, and C. De Felice Di-2-ethylhexyl phthalate and endocrine disruption: a review Current Drug Targets - Immune, Endocrine & Metabolic Disorders 4 2004 37 40
19. G. Latini Monitoring phthalate exposure in humans Clinica Chimica Acta 361 2005 20 29
20. D. Danschutter, F. Braet, E. Van Gyseghem, S. Hachimi-Idrissi, B. Van Bruwaene, P. Moloney-Harmon, and L. Huyghens Di-(2-ethylhexyl)phthalate and deep venous thrombosis in children: a clinical and experimental analysis Pediatrics 119 2007 742 753
21. H. von Rettberg, T. Hannman, U. Subotic, J. Brade, T. Schaible, K.L. Waag, and S. Loff Use of di(2-ethylhexyl)phthalatecontaining infusion systems increases the risk for cholestasis Pediatrics 124 2009 710 716
22. R. Green, R. Hauser, A.M. Calafat, J. Weuve, T. Schettler, S. Ringer, K. Huttner, and H. Hu Use of di(2-ethylhexyl) phthalate-containing medical products and urinary levels of mono(2-ethylhexyl) phthalate in neonatal intensive care unit infants Environment Health Perspectives 113 2005 1222 1225
23. G. Latini, M. Ferri, and F. Chiellini Materials degradation in PVC medical devices, DEHP leaching and neonatal outcomes Current Medicinal Chemistry 17 2010 2979 2989
24. A.M. Calafat, L.L. Needham, M.J. Silva, and G. Lambert Exposure to di-(2-ethylhexyl) phthalate among premature neonates in a neonatal intensive care unit Pediatrics 113 2004 429 434
25. E.D.S. Van Vliet, E.M. Reitano, J.S. Chhabra, G.P. Bergen, and R.M. Whyatt A review of alternatives to di (2-ethylhexyl) phthalate-containing medical devices in the neonatal intensive care unit Journal of Perinatology 31 2011 551 560
26. M. Rahman, and C.S. Brazel Review: An assessment of traditional plasticizers and research trends for development of novel plasticizers Progress in Polymer Science 29 2004 1223 1248
27. Anonymous. Opinion on the safety of medical devices containing DEHP plasticized PVC or other plasticizers on neonates and other groups possibly at risk. Scientific Committee on Emerging and Newly-Identified Health Risks. Brussels (SCHENIR): European Commission; 2007. http://ec.europa.eu/health/ archive/ph-risk/committees/04-scenihr/docs/scenihr-o-014.pdf, Accessed 2013. 91 pp.
28. R. Kavlock, K. Boekelheide, R. Chapin, M. Cunningham, E. Faustman, P. Foster, M. Golub, R. Henderson, I. Hinberg, R. Little, J. Seed, K. Shea, S. Tabacova, R. Tyl, P. Williams, and T. Zacharewski NTP Center for the evaluation of risks to human reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-isodecyl phthalate Reproductive Toxicology 16 2002 655 678
29. K.M. Shea Pediatric exposure and potential toxicity of phthalate plasticizers Pediatrics 111 2003 1467 1474
30. M.A. Babich, S.B. Chen, M.A. Greene, C.T. Kiss, W.K. Porter, T.P. Smith, M.L. Wind, and W.W. Zamula Risk assessment of oral exposure to diisononyl phthalate from children's products Regulatory Toxicology and Pharmacology 40 2004 151 167
31. J.A. Deyo Carcinogenicity and chronic toxicity of di-2-ethylhexyl terephthalate (DEHT) following a 2-year dietary exposure in Fischer 344 rats Food & Chemical Toxicology 46 2008 990 1005
32. E.D. Barber, J.A. Fox, and C.J. Giordano Hydrolysis, absorption and metabolism of di(2-ethylhexyl) terephthalate in the rat Xenobiotica 24 1994 441 450
33. A.M. Mitchell, J.C. Lhuguenot, J.W. Bridges, and C.R. Elcombe Identification of the proximate peroxisome proliferator(s) derived from Di(2-ethylhexyl) phthalate Toxicology & Applied Pharmcology 80 1985 23 32
34. I. Tomita, Y. Nakamura, N. Aoki, and N. Inui Mutagenic/carcinogenic potential of DEHP and MEHP Environment Health Perspectives 45 1982 119 125
35. M. Dalgaard, C. Nellemann, H.R. Lam, I.K. Sørensen, and O. Ladefoged The acute effects of mono(2-ethylhexyl)phthalate (MEHP) on testes of prepubertal Wistar rats Toxicology Letters 122 2001 69 79
36. L.E. Gray, J. Ostby, J. Furr, M. Price, D.N.R. Veeramachaneni, and L. Parks Perinatal exposure to the phthalates DEHP, BBP, and DINP, but Not DEP, DMP, or DOTP, alters sexual differentiation of the male rat Toxicological Science 58 2000 350 365
37. W.D. Faber, J.A. Deyo, D.G. Stump, L. Navarro, K. Ruble, and J. Knapp Developmental toxicity and uterotrophic studies with di-2-ethylhexyl terephthalate Birth Defects Research B 80 2007 396 405
38. W.D. Faber, J.A. Deyo, D.G. Stump, and K. Ruble Two-generation reproduction study of di-2-ethylhexyl terephthalate in Crl:CD rats Birth Defects Research B 80 2007 69 81
39. Maag J, Lassen C, Brandt UK, Kjølholt J, Molander L, Mikkelsen SH. Identification and assessment of alternatives to selected phthalates. COWI: Environmental Project No. 1341 2010 Miljøprojekt. Copenhagen: Danish EPA; 2010. http://www2.mst.dk/udgiv/publications/2010/978-87-92708-00-7/pdf/978-87- 92708-01-4.pdf, Accessed March 2013. 288 pp.
40. E.D. Barber, and D.C. Topping Subchronic 90-day oral toxicology of Di(2-ethylhexyl) terephthalate in the rat Food & Chemical Toxicology 33 1995 971 978
41. L.G. Krauskopf, and A. Godwin Plasticizers C.E. Wilkes, J.W. Summers, C.A. Daniels, PVC 2005 Carl Hanser Verlag Munich 173 199
42. Anonymous. Assessment of data availability and test plan for acetyl tributyl citrate (ATBC). US EPA High Production Volume (HPV) Chemicals Challenge Program; 2003. http://www.epa.gov/HPV/pubs/summaries/acetlcit/c15025.pdf, Accessed March 2013. 132 pp.
43. W.J. Johnson Final report on the safety assessment of acetyl triethyl citrate, acetyl tributyl citrate, acetyl trihexyl citrate, and acetyl trioctyl citrate International Journal of Toxicology 21 2002 1 17
44. Hull EH. Medical articles and method. US 4,710,532, Morflex Chemical Co.; 1987.
45. Hull EH. Citrate esters and methods. US 4,824,893, Morflex Chemical Company, Inc.; 1989.
46. C.D. Hillyer Blood banking and transfusion medicine 2nd ed. 2007 Churchill Livingstone/Elsevier Philadelphia 887 pp
47. R. Ito, N. Miura, H. Iguchi, H. Nakamura, M. Ushiro, N. Wakui, K. Nakahashi, Y. Iwasaki, K. Saito, T. Suzuki, and H. Nakazawa Determination of tris(2-ethylhexyl)trimellitate released from PVC tube by LC-MS/MS International Journal of Pharmaceutics 360 2008 91 95
48. K. Kambia, T. Dine, R. Azar, B. Gressier, M. Luyckx, and C. Brunet Comparative study of the leachability of di(2-ethylhexyl) phthalate and tri(2-ethylhexyl) trimellitate from haemodialysis tubing International Journal of Pharmaceutics 229 2001 139 146
49. R. Ito, F. Seshimo, N. Miura, M. Kawaguchi, K. Saito, and H. Nakazawa Effect of sterilization process on the formation of mono(2-ethylhexyl)phthalate from di(2-ethylhexyl)phthalate Journal of Pharmaceutical & Biomedical Analysis 41 2006 455 460
50. R. Ito, N. Miura, M. Ushiro, M. Kawaguchi, H. Nakamura, H. Iguchi, J. Ogino, M. Oishi, N. Wakui, Y. Iwasaki, K. Saito, and H. Nakazawa Effect of gamma-ray irradiation on degradation of di(2-ethylhexyl)phthalate in polyvinyl chloride sheet International Journal of Pharmaceutics 376 2009 213 218
51. 2 reporter gene cell lines Journal of Agricultural & Food Chemistry 54 2006 4407 4416
52. K. Kambia, T. Dine, B. Gressier, T. Dupin-Spriet, M. Luyckx, and C. Brunet Evaluation of the direct toxicity of trioctyltrimellitate (TOTM), di(2-ethylhexyl) phthalate (DEHP) and theirhydrolysis products on isolated rat hepatocytes International Journal of Artificial Organs 27 2004 971 978
53. R.M. David, L.K. Lockhart, and K.M. Ruble Lack of sensitization for trimellitate, phthalate, terephthalate and isobutyrate plasticizers in a human repeated insult patch test Food & Chemical Toxicology 41 2003 589 593
54. M. Rahman Effectiveness of imidazolium, ammonium and phosphonium based ionic liquids as plasticizers for poly(vinyl chloride) and poly(methyl methacrylate) 2004 University of Alabama Tuscaloosa, AL 220 pp
55. M. Rahman, and C.S. Brazel Ionic liquids: New generation stable plasticizers for poly(vinyl chloride) Polymer Degradation & Stability 91 2006 3371 3382
56. J. Kastner, D.G. Cooper, M. Marić, P. Dodd, and V. Yargeau Aqueous leaching of di-2-ethylhexyl phthalate and "green" plasticizers from poly(vinyl chloride) Science Total Environment 432 2012 357 364
57. J.E. Crespo, R. Balart, L. Sanchez, and J. López Substitution of di(2-ethylhexyl) phthalate by di(isononyl) cyclohexane-1,2-dicarboxylate as a plasticizer for industrial vinyl plastisol formulations Journal of Applied Polymer Science 104 2007 1215 1220
58. N. Burgos, and A. Jiménez Degradation of poly(vinyl chloride) plasticized with non-phthalate plasticizers under sterilization conditions Polymer Degradation & Stability 94 2009 1473 1478
59. M. Manfredini, D. Atzei, B. Elsener, A. Marchetti, and A. Rossi Degradation of plasticized PVC for biomedical disposable device under soft X-ray irradiation Surface & Interface Analysis 35 2003 294 300
60. G.M. Vinhas, R.M. Souto Maior, and Y.M.B. de Almeida Radiolytic degradation and stabilization of poly(vinyl chloride) Polymer Degradation & Stability 83 2004 429 433
61. D. Atzei, B. Elsener, M. Manfredini, A. Marchetti, M. Malagoli, F. Galavotti, and A. Rossi Radiation-induced migration of additives in PVC-based biomedical disposable devices Part 2. Surface analysis by XPS Surface & Interface Analysis 35 2003 673 681
62. B.L. Wadey An innovative plasticizer for sensitive applications Journal of Vinyl & Additive Technology 9 2003 172 176
63. W.D. Arendt, and J. Lang New benzoate plasticizers for polyvinyl chloride: Introduction and performance example Journal of Vinyl & Additive Technology 4 1998 184 188
64. N. Gil, M. Saska, and I. Negulescu Evaluation of the effects of biobased plasticizers on the thermal and mechanical properties of poly(vinyl chloride) Journal of Applied Polymer Science 102 2006 1366 1373
65. B.L. Shah, and V.V. Shertukde Effect of plasticizers on mechanical, electrical, permanence, and thermal properties of poly(vinyl chloride) Journal of Applied Polymer Science 90 2003 3278 3284
66. M.C. Sunny, P. Ramesh, and K.E. George Use of polymeric plasticizers in polyvinyl chloride to reduce conventional plasticizer migration for critical applications Journal of Elastomers & Plastics 36 2004 19 31
67. S.Y. Soong, R.E. Cohen, and M.C. Boyce Polyhedral oligomeric silsesquioxane as a novel plasticizer for poly(vinyl chloride) Polymer 48 2007 1410 1418
68. A. Lindström, and M. Hakkarainen Environmentally friendly plasticizers for poly(vinyl chloride) - Improved mechanical properties and compatibility by using branched poly(butylene adipate) as a polymeric plasticizer Journal of Applied Polymer Science 100 2006 2180 2188
69. Q. Wang, and B.K. Storm Migration of additives from poly(vinyl chloride) (PVC) tubes into aqueous media Macromolecular Symposia 225 2005 191 204
70. U. Subotic, T. Hannmann, M. Kiss, J. Brade, K. Breitkopf, and S. Loff Extraction of the plasticizers diethylhexylphthalate and polyadipate from polyvinylchloride nasogastric tubes through gastric juice and feeding solution Journal of Pediatric Gastroenterology and Nutrition 44 2007 71 76
71. M. Penco, L. Sartore, F. Bignotti, M. Rossini, A. D'Amore, and F. Fassio Binary blends based on poly(vinyl chloride) and multi-block copolymers containing poly(ε-caprolactone) and poly(ethylene glycol) segments Macromolecular Symposia 180 2002 9 22
72. P. Ferruti, I. Mancin, E. Ranucci, C. De Felice, G. Latini, and M. Laus Polycaprolactone/poly(ethylene glycol) multiblock copolymers as potential substitutes for di(ethylhexyl) phthalate in flexible poly(vinyl chloride) formulations Biomacromolecules 4 2003 181 188
73. Ferruti P, Latini G. Polymeric materials of the polyester-carbonate family and reactions for the formation of such materials. EP 1036806 A2, EVC Compounds (Italy) S.P.A.; 2000.
74. Ferruti P, Latini G. Polymeric materials with a polyvinyl chloride and polyester-carbonate base. EP1036816 A1, EVC Compounds (Italy) S.P.A.; 2000.
75. Biesiada K, Fisch M, Peveler R. Propanedol-derived polyesters as PVC plasticizers. US 6,111,004. Velsicol Chemical Corp.; 2000.
76. J. Choi, and S.Y. Kwak Hyperbranched poly(ε-caprolactone) as a nonmigrating alternative plasticizer for phthalates in flexible PVC Environmental Science & Technology 41 2007 3763 3768
77. A. Lindström, and M. Hakkarainen Migration resistant polymeric plasticizer for poly(vinyl chloride) Journal of Applied Polymer Science 104 2007 2458 2467
78. A. Lindström, and M. Hakkarainen Designed chain architecture for enhanced migration resistance and property preservation in poly(vinyl chloride)/polyester blends Biomacromolecules 8 2007 1187 1194
79. B. Yin, and M. Hakkarainen Oligomeric isosorbide esters as alternative renewable resource plasticizers for PVC Journal of Applied Polymer Science 119 2011 2400 2407
80. F. Breme, J. Buttstaedt, and G. Emig Coating of polymers with titanium-based layers by a novel plasma-assisted chemical vapor deposition process Thin Solid Films 377-378 2000 755 759
81. M. Messori, M. Toselli, F. Pilati, E. Fabbri, P. Fabbri, L. Pasquali, and S. Nannarone Prevention of plasticizer leaching from PVC medical devices by using organic-inorganic hybrid coatings Polymer 45 2004 805 813
82. V.A. Karle, B.L. Short, G.R. Martin, D.I. Bulas, P.R. Getson, N.L.C. Luban, A.M. O'Brien, and R.J. Rubin Extracorporeal membrane oxygenation exposes infants to the plasticizer, di(2-ethylhexyl)phthalate Critical Care in Medicine 25 1997 696 703
83. S.L. Hildebrand, H.D. Lehmann, R. Wodarz, G. Ziemer, and H. Wendel PVC-plasticizer DEHP in medical products: do thin coatings really reduce DEHP leaching into blood? Perfusion 20 2005 351 357
84. H. Sakurai, M. Maeda, K. Miyahara, M. Nakayama, H. Murayama, H. Hasegawa, M. Hayakawa, T. Sugiura, and K. Kamikura Extraction of di-2-ethylhexyl phthalate from a cardiopulmonary bypass circuit Kyobu Geka. Japanese Journal of Thoracic Surgery 54 2001 471 474
85. X. Zhao, and J.M. Courtney Surface modification of polymeric biomaterials: Utilization of cyclodextrins for blood compatibility improvement Journal of Biomedical Material Research Part A 80 2007 539 553
86. B.Y. Yu, J.W. Chung, and S.Y. Kwak Reduced migration from flexible poly(vinyl chloride) of a plasticizer containing β-cyclodextrin derivative Environmental Science & Technology 42 2008 7522 7527
87. J.W. Chung, S.H. Kim, S.J. Jung, and S.Y. Kwak Encapsulation of β-cyclodextrin by in situ polymerization with vinyl chloride leading to suppressing the migration of endocrine disrupting phthalate plasticizer European Polymer Journal 45 2009 2164 2171
88. X.Q. Wen, X.H. Liu, and G.S. Liu Prevention of plasticizer leaching from the inner surface of narrow polyvinyl chloride tube by DC glow discharge plasma IEEE Transactions on Plasma Science 38 2010 3152 3155
89. R. Ito, F. Seshimo, Y. Haishima, C. Hasegawa, K. Isama, T. Yagami, K. Nakahashi, H. Yamazahi, K. Inoue, Y. Yoshimura, K. Saito, T. Tsuchiya, and H. Nakazawa Reducing the migration of di-2-ethylhexyl phthalate from polyvinyl chloride medical devices International Journal of Pharmaceutics 303 2005 104 112
90. S. Baccaro, V. Brunella, A. Cecilia, and L. Costa γ irradiation of poly(vinyl chloride) for medical applications Nuclear Instruments & Methods B 208 2003 195 198
91. F.F. da Silva, S. da, K.A. Aquino, and E.S. Araújo Effects of gamma irradiation on poly(vinyl chloride)/polystyrene blends: Investigation of radiolytic stabilization and miscibility of the mixture Polymer Degradation & Stability 93 2008 2199 2203
92. A. Jayakrishnan, and M.C. Sunny Phase transfer catalysed surface modification of plasticized poly(vinyl chloride) in aqueous media to retard plasticizer migration Polymer 37 1996 5213 5218
93. S. Lakshmi, and A. Jayakrishnan Photocross-linking of dithiocarbamate-substituted PVC reduces plasticizer migration Polymer 39 1998 151 157
94. S. Lakshmi, and A. Jayakrishnan Synthesis, surface properties and performance of thiosulphate-substituted plasticized poly(vinyl chloride) Biomaterials 23 2002 4855 4862
95. S. Lakshmi, and A. Jayakrishnan Properties and performance of sulfide-substituted plasticized poly(vinyl chloride) as a biomaterial Journal of Biomedical Material Research Part B 65 2003 204 210
96. N.N. Reddy, Y.M. Mohan, K. Varaprasad, S. Ravindra, K. Vimala, and K.M. Raju Surface treatment of plasticized poly(vinyl chloride) to prevent plasticizer migration Journal of Applied Polymer Science 115 2010 1589 1597
97. B. Zhao, and W.J. Brittain Polymer brushes: surface-immobilized macromolecules Progress in Polymer Science 25 2000 677 710
98. S. Lakshmi, and A. Jayakrishnan Migration resistant, blood-compatible plasticized polyvinyl chloride for medical and related applications Artificial Organs 22 1998 222 229
99. K.M. McGinty, and W.J. Brittain Hydrophilic surface modification of poly(vinyl chloride) film and tubing using physisorbed free radical grafting technique Polymer 49 2008 4350 4357
100. R. Navarro, M. Perez Perrino, M. Gomez Tardajos, and H. Reinecke Phthalate plasticizers covalently bound to PVC: plasticization with suppressed migration Macromolecules 43 2010 2377 2381
101. J.C. Wagner, and A.E.S. Green Correlation of chlorinated organic compound emissions from incineration with chlorinated organic input Chemosphere 26 1993 2039 2054
102. Anonymous. DEHP. In: Five chemicals alternatives assessment study.Toxics Use Reduction Institute (TURI). Lowell MA: Univ. of Massachusetts; 2006. http://www.turi.org/About/Library/TURI-Publications/2006-Five-Chemicals- Alternatives-Assessment-Study/Final-Report/Chapter-7.-DEHP. Accessed March 2013, 92 pp [chapter 7].
103. K. Kambia, T. Dine, B. Gressier, S. Bah, A.F. Germe, M. Luyckx, C. Brunet, L. Michaud, and F. Goltrand Evaluation of childhood exposure to di(2-ethylhexyl) phthalate from perfusion kits during long-term parenteral nutrition International Journal of Pharmaceutics 262 2003 83 91
104. M. Dopico-García, J. López-Vilariñó, and M. Gonzalez-Rodríguez Antioxidant content of and migration from commercial polyethylene, polypropylene, and polyvinyl chloride packages Journal of Agriculture & Food Chemistry 55 2007 3225 3231
105. M. Dopico-García, J. López-Vilariñó, and M. Gonzalez-Rodríguez Determination of antioxidant migration levels from low-density polyethylene films into food simulants Journal of Chromatography A 1018 2003 53 62
106. L. Tovar, J. Salafranca, C. Sanchez, and C. Nerin Migration studies to assess the safety in use of a new antioxidant active packaging Journal of Agriculture & Food Chemistry 53 2005 5270 5275
107. B. Marcato, S. Guerra, M. Vianello, and S. Scalia Migration of antioxidant additives from various polyolefinic plastics into oleaginous vehicles International Journal of Pharmaceutics 257 2003 217 225
108. S. Loff, U. Subotic, F. Reinicke, H. Wischmann, and J. Brade Extraction of Di-ethylhexyl-phthalate from perfusion lines of various material, length and brand by lipid emulsions Journal of Pediatric Gastroenterology and Nutrition 39 2004 341 345
109. V. Satou-Miranda, F. Brigas, S. Vanheerswynghels, and J. Chopineau Compatibility of paclitaxel in 5% glucose solution with ECOFLAC® low-density polyethylene containers-stability under different storage conditions International Journal of Pharmaceutics 178 1999 77 82
110. S. Al-Malaika Perspectives in stabilisation of polyolefins A.C. Albertsson, Long Term Properties of Polyolefins 2004 Springer Berlin/Heidelberg 121 150
111. P.D.S. Loff, U. Subotic, J. Oulmi-Kagermann, B. Kränzlin, M.F. Reinecke, and C. Staude Diethylhexylphthalate extracted by typical newborn lipid emulsions from polyvinylchloride infusion systems causes significant changes in histology of rabbit liver Journal of Parenteral & Enteral Nutrition 31 2007 188 193
112. S. Loff, T. Hannmann, U. Subotic, F.M. Reinecke, H. Wischmann, and J. Brade Extraction of diethylhexylphthalate by home total parenteral nutrition from polyvinyl chloride infusion lines commonly used in the home Journal of Pediatric Gastroenterology and Nutrition 47 2008 81 86
113. J. Sampson, and D. de Korte DEHP-plasticised PVC: relevance to blood services Transfusion Medicine 21 2011 73 83
114. M.C. Sunny, P. Ramesh, P.V. Mohanan, and K.E. George Metallocene based polyolefin: a potential candidate for the replacement of flexible poly (vinyl chloride) in the medical field Polymers for Advanced Technologies 21 2010 621 631
115. V.R. Sastri Plastics in medical devices. Properties, requirements and applications 1st ed. 2010 William Andrew/Elsevier Burlington, MA 352 pp
116. S. Bagel-Boithias, Sautou-Miranda Vr, D. Bourdeaux, V. Tramier, A. Boyer, and J. Chopineau Leaching of diethylhexyl phthalate from multilayer tubing into etoposide infusion solutions American Journal of Health System Pharmacy 62 2005 182 188
117. D. Bourdeaux, Sautou-Miranda Vr, S. Bagel-Boithias, A. Boyer, and J. Chopineau Analysis by liquid chromatography and infrared spectrometry of di(2-ethylhexyl)phthalate released by multilayer infusion tubing Journal of Pharmaceutical & Biomedical Analysis 35 2004 57 64
118. Anonymous. The Immunotoxicity of Silicone. National Toxicology Program. Department of Health and Human Services. Report MM89050 (Abstract); 2012. http://ntp.niehs.nih.gov/index.cfm?objectid=03E82B79-FF50-8E65-2104927658C2EF01, Accessed 2013.
119. A. Mitchell, S. Atkins, G.T. Royle, and M.G.W. Kettlewell Reduced catheter sepsis and prolonged catheter life using a tunnelled silicone rubber catheter for total parenteral nutrition British Journal of Surgery 69 1982 420 422
120. J. Trudel, M.W.L. Gauderer, M.J. Drews, and M. LaBerge Lipid uptake by silicone enteral access feeding devices Journal of Pediatric Surgery 33 1998 880 884
121. A.A. Mair, and E.A. Mair Can plastic tracheotomy tubes harm baby boys? Otolaryngology - Head & Neck Surgery 140 2009 13 14
122. G.L.J. Kennedy, M.L. Keplinger, and J.C. Calandra Reproductive, teratologic, and mutagenic studies with some polydimethylsiloxanes Journal of Toxicology & Environmental Health 1 1976 909 920
123. E.J. Hobbs, O.E. Fancher, and J.C. Calandra Effect of selected organopolysiloxanes on male rat and rabbit reproductive organs Toxicology & Applied Pharmcology 21 1972 45 54
124. G. Björling, S. Axelsson, U.B. Johansson, M. Lysdahl, A. Markström, U. Schedin, R.E. Aune, C. Frostell, and S. Karlsson Clinical use and material wear of polymeric tracheostomy tubes Laryngoscope 117 2007 1552 1559
125. S. Sartori, L. Trevisani, I. Nielsen, D. Tassinari, P. Ceccotti, and V. Abbasciano Longevity of silicone and polyurethane catheters in long-term enteral feeding via percutaneous endoscopic gastrostomy Aliment Pharmacology & Therapeutics 17 2003 853 856
126. J. Blacka, J. Donoghue, M. Sutherland, I. Martincich, S. Mitten-Lewis, P. Morris, and G. Meredith Dwell time and functional failure in percutaneous endoscopic gastrostomy tubes: a prospective randomized-controlled comparison between silicon polymer and polyurethane percutaneous endoscopic gastrostomy tubes Aliment Pharmacology & Therapeutics 20 2004 875 882
127. J. Simmchen, R. Ventura, and J. Segura Progress in the removal of di-(2-ethylhexyl)-phthalate as plasticizer in blood bags Transfusion Medicine 26 2012 27 37
128. S.T. Cragg Polyurethanes, miscellaneous organic polymers, and silicones E. Bingham, B. Cohrssen, Patty's toxicology 2012 John Wiley & Sons Inc. New York 999 1038