메뉴 건너뛰기




Volumn 124, Issue 2, 2009, Pages 710-716

Use of Di(2-ethylhexyl)phthalate-containing infusion systems increases the risk for cholestasis

Author keywords

Cholestasis; DEHP; Di(2 ethylhexyl) phthalate; Infants; Liver function; Parenteral nutrition; Total parenteral nutrition associated cholestasis; TPNAC

Indexed keywords

PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; POLYVINYLCHLORIDE;

EID: 67749139649     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2008-1765     Document Type: Article
Times cited : (57)

References (46)
  • 1
    • 0018419788 scopus 로고
    • Intrahepatic cholestasis associated with parenteral nutrition in premature infants
    • Beale EF, Nelson RM, Bucciarelli RL, Donnelly WH, Eitzman DV. Intrahepatic cholestasis associated with parenteral nutrition in premature infants. Pediatrics. 1979;64(3):342-347
    • (1979) Pediatrics , vol.64 , Issue.3 , pp. 342-347
    • Beale, E.F.1    Nelson, R.M.2    Bucciarelli, R.L.3    Donnelly, W.H.4    Eitzman, D.V.5
  • 3
    • 0022871301 scopus 로고
    • Cholestasis associated with total parenteral nutrition
    • Merritt RJ. Cholestasis associated with total parenteral nutrition. J Pediatr Gastroenterol Nutr. 1986;5(1):9-22
    • (1986) J Pediatr Gastroenterol Nutr , vol.5 , Issue.1 , pp. 9-22
    • Merritt, R.J.1
  • 5
    • 0019485977 scopus 로고
    • Hepatobiliary dysfunction in infants and children associated with long-term total parenteral nutrition: A clinico-pathologic study
    • Benjamin DR. Hepatobiliary dysfunction in infants and children associated with long-term total parenteral nutrition: a clinico-pathologic study. Am J Clin Pathol. 1981;76(3):276-283
    • (1981) Am J Clin Pathol , vol.76 , Issue.3 , pp. 276-283
    • Benjamin, D.R.1
  • 6
    • 0032820269 scopus 로고    scopus 로고
    • New approaches to understanding the etiology and treatment of total parenteral nutrition-associated cholestasis
    • Moss RL, Amii LA. New approaches to understanding the etiology and treatment of total parenteral nutrition-associated cholestasis. Semin Pediatr Surg. 1999;8(3):140-147
    • (1999) Semin Pediatr Surg , vol.8 , Issue.3 , pp. 140-147
    • Moss, R.L.1    Amii, L.A.2
  • 7
    • 0027225243 scopus 로고
    • Surgical treatment of intractable cholestasis associated with total parenteral nutrition in premature infants
    • Rintala R, Lindahl H, Pohjavuori M, Saxen H, Sariola H. Surgical treatment of intractable cholestasis associated with total parenteral nutrition in premature infants. J Pediatr Surg. 1993;28(5): 716-719
    • (1993) J Pediatr Surg , vol.28 , Issue.5 , pp. 716-719
    • Rintala, R.1    Lindahl, H.2    Pohjavuori, M.3    Saxen, H.4    Sariola, H.5
  • 8
    • 0019905163 scopus 로고
    • Hepatic failure in infants on total parenteral nutrition (TPN): Clinical and histopathologic observations
    • Hodes JE, Grosfeld JL, Weber TR, Schreiner RL, Fitzgerald JF, Mirkin LD. Hepatic failure in infants on total parenteral nutrition (TPN): clinical and histopathologic observations. J Pediatr Surg. 1982;17(5):463-468
    • (1982) J Pediatr Surg , vol.17 , Issue.5 , pp. 463-468
    • Hodes, J.E.1    Grosfeld, J.L.2    Weber, T.R.3    Schreiner, R.L.4    Fitzgerald, J.F.5    Mirkin, L.D.6
  • 9
    • 0027504635 scopus 로고
    • Total parenteral nutrition-associated cholestasis: Clinical and histopathologic correlation
    • discussion 1274-1275
    • Moss RL, Das JB, Raffensperger JG. Total parenteral nutrition-associated cholestasis: clinical and histopathologic correlation. J Pediatr Surg. 1993;28(10):1270-1274; discussion 1274-1275
    • (1993) J Pediatr Surg , vol.28 , Issue.10 , pp. 1270-1274
    • Moss, R.L.1    Das, J.B.2    Raffensperger, J.G.3
  • 10
    • 0029077352 scopus 로고
    • Total parenteral nutrition-associated cholestasis in surgical neonates may be reversed by intravenous cholecystokinin: A preliminary report
    • Rintala RJ, Lindahl H, Pohjavuori M. Total parenteral nutrition-associated cholestasis in surgical neonates may be reversed by intravenous cholecystokinin: a preliminary report. J Pediatr Surg. 1995;30(6):827-830
    • (1995) J Pediatr Surg , vol.30 , Issue.6 , pp. 827-830
    • Rintala, R.J.1    Lindahl, H.2    Pohjavuori, M.3
  • 11
    • 0018886311 scopus 로고
    • Physiologic cholestasis
    • Lester R. Physiologic cholestasis. Gastroenterology. 1980;78(4):864-865
    • (1980) Gastroenterology , vol.78 , Issue.4 , pp. 864-865
    • Lester, R.1
  • 12
    • 0016762396 scopus 로고
    • Bile salt metabolism in the human premature infant: Preliminary observations of pool size and synthesis rate following prenatal administration of dexamethasone and phenobarbital
    • Watkins JB, Szczepanik P, Gould JB, Klein P, Lester R. Bile salt metabolism in the human premature infant: preliminary observations of pool size and synthesis rate following prenatal administration of dexamethasone and phenobarbital. Gastroenterology. 1975;69(3):706-713
    • (1975) Gastroenterology , vol.69 , Issue.3 , pp. 706-713
    • Watkins, J.B.1    Szczepanik, P.2    Gould, J.B.3    Klein, P.4    Lester, R.5
  • 13
    • 0015592211 scopus 로고
    • Bile-salt metabolism in the newborn: Measurement of pool size and synthesis by stable isotope technic
    • Watkins JB, Ingall D, Szczepanik P, Klein PD, Lester R. Bile-salt metabolism in the newborn: measurement of pool size and synthesis by stable isotope technic. N Engl J Med. 1973;288(9):431- 434
    • (1973) N Engl J Med , vol.288 , Issue.9 , pp. 431-434
    • Watkins, J.B.1    Ingall, D.2    Szczepanik, P.3    Klein, P.D.4    Lester, R.5
  • 14
    • 0020607713 scopus 로고
    • Immaturity of the enterohepatic circulation in early life: Factors predisposing to "physiologic" maldigestion and cholestasis
    • Balistreri WF, Heubi JE, Suchy FJ. Immaturity of the enterohepatic circulation in early life: factors predisposing to "physiologic" maldigestion and cholestasis. J Pediatr Gastroenterol Nutr. 1983;2(2):346 -354
    • (1983) J Pediatr Gastroenterol Nutr , vol.2 , Issue.2 , pp. 346-354
    • Balistreri, W.F.1    Heubi, J.E.2    Suchy, F.J.3
  • 16
    • 0242494348 scopus 로고    scopus 로고
    • Comparison of oxidative stress and changes of xenobiotic metabolizing enzymes induced by phthalates in rats
    • Seo KW, Kim KB, Kim YJ, Choi JY, Lee KT, Choi KS. Comparison of oxidative stress and changes of xenobiotic metabolizing enzymes induced by phthalates in rats. Food Chem Toxicol. 2004;42(1):107-114
    • (2004) Food Chem Toxicol , vol.42 , Issue.1 , pp. 107-114
    • Seo, K.W.1    Kim, K.B.2    Kim, Y.J.3    Choi, J.Y.4    Lee, K.T.5    Choi, K.S.6
  • 17
    • 3242885420 scopus 로고    scopus 로고
    • Exposure to di-(2-ethylhexyl) phthalate among premature neonates in a neonatal intensive care unit
    • Available at
    • Calafat AM, Needham LL, Silva MJ, Lambert G. Exposure to di-(2-ethylhexyl) phthalate among premature neonates in a neonatal intensive care unit. Pediatrics. 2004;113(5). Available at: www.pediatrics.org/cgi/ content/full/113/5/e429
    • (2004) Pediatrics , vol.113 , Issue.5
    • Calafat, A.M.1    Needham, L.L.2    Silva, M.J.3    Lambert, G.4
  • 18
    • 0022413883 scopus 로고
    • Dispositions of di- and mono-(2-ethylhexyl) phthalate in newborn infants subjected to exchange transfusions
    • Sjöberg P, Bondesson U, Sedin G, Gustafsson J. Dispositions of di- and mono-(2-ethylhexyl) phthalate in newborn infants subjected to exchange transfusions. Eur J Clin Invest. 1985;15(6):430-436
    • (1985) Eur J Clin Invest , vol.15 , Issue.6 , pp. 430-436
    • Sjöberg, P.1    Bondesson, U.2    Sedin, G.3    Gustafsson, J.4
  • 19
    • 0022402052 scopus 로고
    • Exposure of newborn infants to plasticizers: Plasma levels of di-(2-ethylhexyl) phthalate and mono-(2-ethylhexyl) phthalate during exchange transfusion
    • Sjöberg PO, Bondesson UG, Sedin EG, Gustafsson JP. Exposure of newborn infants to plasticizers: plasma levels of di-(2-ethylhexyl) phthalate and mono-(2-ethylhexyl) phthalate during exchange transfusion. Transfusion. 1985;25(5):424-428
    • (1985) Transfusion , vol.25 , Issue.5 , pp. 424-428
    • Sjöberg, P.O.1    Bondesson, U.G.2    Sedin, E.G.3    Gustafsson, J.P.4
  • 20
    • 85036974190 scopus 로고    scopus 로고
    • Extraction of plasticizer from PVC-infusion lines for newborn intensive care units
    • in German
    • Loff S, Kabs F, Witt K, Hosie S, Waag KL. Extraction of plasticizer from PVC-infusion lines for newborn intensive care units (in German). Z Ernährungsökol. 2000;1(1):19-24
    • (2000) Z Ernährungsökol , vol.1 , Issue.1 , pp. 19-24
    • Loff, S.1    Kabs, F.2    Witt, K.3    Hosie, S.4    Waag, K.L.5
  • 21
    • 0023272191 scopus 로고
    • Hypotension and cardiac arrest in rats after infusion of mono(2-ethylhexyl) phthalate (MEHP), a contaminant of stored blood
    • Rock G, Labow RS, Franklin C, Burnett R, Tocchi M. Hypotension and cardiac arrest in rats after infusion of mono(2-ethylhexyl) phthalate (MEHP), a contaminant of stored blood. N Engl J Med. 1987;316(19):1218 -1219
    • (1987) N Engl J Med , vol.316 , Issue.19 , pp. 1218-1219
    • Rock, G.1    Labow, R.S.2    Franklin, C.3    Burnett, R.4    Tocchi, M.5
  • 22
    • 0020334796 scopus 로고
    • Toxic potential of the plasticizer Di(2-ethylhexyl) phthalate in the context of its disposition and metabolism in primates and man
    • Peck CC, Albro PW. Toxic potential of the plasticizer Di(2-ethylhexyl) phthalate in the context of its disposition and metabolism in primates and man. Environ Health Perspect. 1982;45(11): 11-17
    • (1982) Environ Health Perspect , vol.45 , Issue.11 , pp. 11-17
    • Peck, C.C.1    Albro, P.W.2
  • 23
    • 67749129626 scopus 로고    scopus 로고
    • Scientific Committee on Toxicity, Ecotoxicity, and the Environment. Opinion on phthalate migration from soft PVC toys and child-care articles. Presented at: 6th Scientific Committee on Toxicity, Ecotoxicity, and the Environment plenary meeting; November 26 and 27, 1998; Brussels, Belgium
    • Scientific Committee on Toxicity, Ecotoxicity, and the Environment. Opinion on phthalate migration from soft PVC toys and child-care articles. Presented at: 6th Scientific Committee on Toxicity, Ecotoxicity, and the Environment plenary meeting; November 26 and 27, 1998; Brussels, Belgium
  • 24
    • 67749096502 scopus 로고    scopus 로고
    • Scientific Committee on Toxicity, Ecotoxicity, and the Environment. Opinion on the results of a second risk assessment of bi(2-ethylhexyl)phthalate (DEHP) human health part. Presented at: 41st Scientific Committee on Toxicity, Ecotoxicity, and the Environment plenary meeting; January 8, 2004; Brussels, Belgium
    • Scientific Committee on Toxicity, Ecotoxicity, and the Environment. Opinion on the results of a second risk assessment of bi(2-ethylhexyl)phthalate (DEHP) human health part. Presented at: 41st Scientific Committee on Toxicity, Ecotoxicity, and the Environment plenary meeting; January 8, 2004; Brussels, Belgium
  • 25
    • 0033668245 scopus 로고    scopus 로고
    • Polyvinylchloride infusion lines expose infants to large amounts of toxic plasticizers
    • Loff S, Kabs F, Witt K, et al. Polyvinylchloride infusion lines expose infants to large amounts of toxic plasticizers. J Pediatr Surg. 2000;35(12):1775-1781
    • (2000) J Pediatr Surg , vol.35 , Issue.12 , pp. 1775-1781
    • Loff, S.1    Kabs, F.2    Witt, K.3
  • 26
    • 33745659073 scopus 로고    scopus 로고
    • Extraction of Di-ethylhexyl-phthalate from perfusion lines of various material, length and brand by lipid emulsions
    • Loff S, Subotic U, Reinicke F, Wischmann H, Brade J. Extraction of Di-ethylhexyl-phthalate from perfusion lines of various material, length and brand by lipid emulsions. J Pediatr Gastroenterol Nutr. 2004;39(4):341-345
    • (2004) J Pediatr Gastroenterol Nutr , vol.39 , Issue.4 , pp. 341-345
    • Loff, S.1    Subotic, U.2    Reinicke, F.3    Wischmann, H.4    Brade, J.5
  • 27
    • 0023922356 scopus 로고
    • Effects of chronic phthalate exposure on the kidney
    • Crocker JF, Safe SH, Acott P. Effects of chronic phthalate exposure on the kidney. J Toxicol Environ Health. 1988;23(4):433-444
    • (1988) J Toxicol Environ Health , vol.23 , Issue.4 , pp. 433-444
    • Crocker, J.F.1    Safe, S.H.2    Acott, P.3
  • 28
    • 0022375644 scopus 로고
    • Effects of repeated intravenous infusions of the plasticizer di-(2-ethylhexyl) phthalate in young male rats
    • Sjöberg P, Lindquist NG, Montin G, Ploen L. Effects of repeated intravenous infusions of the plasticizer di-(2-ethylhexyl) phthalate in young male rats. Arch Toxicol. 1985;58(2):78-83
    • (1985) Arch Toxicol , vol.58 , Issue.2 , pp. 78-83
    • Sjöberg, P.1    Lindquist, N.G.2    Montin, G.3    Ploen, L.4
  • 29
    • 0024094548 scopus 로고
    • Cardiotoxic effects of the plasticizer metabolite, mono (2-ethylhexyl)phthalate (MEHP), on human myocardium
    • Barry YA, Labow RS, Rock G, Keon WJ. Cardiotoxic effects of the plasticizer metabolite, mono (2-ethylhexyl)phthalate (MEHP), on human myocardium. Blood. 1988;72(4):1438-1439
    • (1988) Blood , vol.72 , Issue.4 , pp. 1438-1439
    • Barry, Y.A.1    Labow, R.S.2    Rock, G.3    Keon, W.J.4
  • 30
    • 0017687270 scopus 로고
    • Effects of a plasticizer leached from polyvinyl chloride on the subhuman primate: A consequence of chronic transfusion therapy
    • Jacobson MS, Kevy SV, Grand RJ. Effects of a plasticizer leached from polyvinyl chloride on the subhuman primate: a consequence of chronic transfusion therapy. J Lab Clin Med. 1977;89(5): 1066-1079
    • (1977) J Lab Clin Med , vol.89 , Issue.5 , pp. 1066-1079
    • Jacobson, M.S.1    Kevy, S.V.2    Grand, R.J.3
  • 31
    • 0021804301 scopus 로고
    • Hereditary chronic conjugated hyperbilirubinemia in mutant rats caused by defective hepatic anion transport
    • Jansen PL, Peters WH, Lamers WH. Hereditary chronic conjugated hyperbilirubinemia in mutant rats caused by defective hepatic anion transport. Hepatology. 1985;5(4):573-579
    • (1985) Hepatology , vol.5 , Issue.4 , pp. 573-579
    • Jansen, P.L.1    Peters, W.H.2    Lamers, W.H.3
  • 32
    • 33745204653 scopus 로고    scopus 로고
    • Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver
    • Rusyn I, Peters JM, Cunningham ML. Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver. Crit Rev Toxicol. 2006;36(5):459-479
    • (2006) Crit Rev Toxicol , vol.36 , Issue.5 , pp. 459-479
    • Rusyn, I.1    Peters, J.M.2    Cunningham, M.L.3
  • 33
    • 0026989133 scopus 로고
    • Induction of peroxisomal enzyme activities by di-(2-ethylhexyl) phthalate in thyroidectomized rats with parathyroid replants
    • Badr MZ. Induction of peroxisomal enzyme activities by di-(2-ethylhexyl) phthalate in thyroidectomized rats with parathyroid replants. J Pharmacol Exp Ther. 1992;263(3):1105-1110
    • (1992) J Pharmacol Exp Ther , vol.263 , Issue.3 , pp. 1105-1110
    • Badr, M.Z.1
  • 34
    • 0017714154 scopus 로고
    • Three hypolipidemic drugs increase hepatic palmitoyl-coenzyme A oxidation in the rat
    • Lazarow PB. Three hypolipidemic drugs increase hepatic palmitoyl-coenzyme A oxidation in the rat. Science. 1977;197(4303):580-581
    • (1977) Science , vol.197 , Issue.4303 , pp. 580-581
    • Lazarow, P.B.1
  • 35
    • 0022402091 scopus 로고
    • Effects of the hepatocarcinogen nafenopin, a peroxisome proliferator, on the activities of rat liver glutathione-requiring enzymes and catalase in comparison to the action of phenobarbital
    • Furukawa K, Numoto S, Furuya K, Furukawa NT, Williams GM. Effects of the hepatocarcinogen nafenopin, a peroxisome proliferator, on the activities of rat liver glutathione-requiring enzymes and catalase in comparison to the action of phenobarbital. Cancer Res. 1985;45(10):5011-5019
    • (1985) Cancer Res , vol.45 , Issue.10 , pp. 5011-5019
    • Furukawa, K.1    Numoto, S.2    Furuya, K.3    Furukawa, N.T.4    Williams, G.M.5
  • 36
    • 0025017388 scopus 로고
    • Carcinogenicity of peroxisome proliferators: Evaluation and mechanisms
    • Reddy JK. Carcinogenicity of peroxisome proliferators: evaluation and mechanisms. Biochem Soc Trans. 1990;18(1):92-94
    • (1990) Biochem Soc Trans , vol.18 , Issue.1 , pp. 92-94
    • Reddy, J.K.1
  • 37
    • 0018888058 scopus 로고
    • Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens
    • Reddy JK, Azarnoff DL, Hignite CE. Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens. Nature. 1980;283(5745):397-398
    • (1980) Nature , vol.283 , Issue.5745 , pp. 397-398
    • Reddy, J.K.1    Azarnoff, D.L.2    Hignite, C.E.3
  • 38
    • 0029609755 scopus 로고
    • PPAR: A mediator of peroxisome proliferator action
    • Green S. PPAR: a mediator of peroxisome proliferator action. Mutat Res. 1995;333(1-2):101-109
    • (1995) Mutat Res , vol.333 , Issue.1-2 , pp. 101-109
    • Green, S.1
  • 39
    • 0030047184 scopus 로고    scopus 로고
    • Identification of a peroxisome proliferator-responsive element upstream of the human peroxisomal fatty acyl coenzyme A oxidase gene
    • Varanasi U, Chu R, Huang Q, Castellon R, Yeldandi AV, Reddy JK. Identification of a peroxisome proliferator-responsive element upstream of the human peroxisomal fatty acyl coenzyme A oxidase gene. J Biol Chem. 1996;271(4):2147-2155
    • (1996) J Biol Chem , vol.271 , Issue.4 , pp. 2147-2155
    • Varanasi, U.1    Chu, R.2    Huang, Q.3    Castellon, R.4    Yeldandi, A.V.5    Reddy, J.K.6
  • 40
    • 0034809137 scopus 로고    scopus 로고
    • Bisphenol-A, an environmental estrogen, activates the human orphan nuclear receptor, steroid and xenobiotic receptormediated transcription
    • Takeshita A, Koibuchi N, Oka J, Taguchi M, Shishiba Y, Ozawa Y. Bisphenol-A, an environmental estrogen, activates the human orphan nuclear receptor, steroid and xenobiotic receptormediated transcription. Eur J Endocrinol. 2001;145(4):513-517
    • (2001) Eur J Endocrinol , vol.145 , Issue.4 , pp. 513-517
    • Takeshita, A.1    Koibuchi, N.2    Oka, J.3    Taguchi, M.4    Shishiba, Y.5    Ozawa, Y.6
  • 41
    • 0030273048 scopus 로고    scopus 로고
    • Differential effect of peroxisome proliferators on rat glutathione S-transferase isoenzymes
    • Voskoboinik I, Drew R, Ahokas JT. Differential effect of peroxisome proliferators on rat glutathione S-transferase isoenzymes. Toxicol Lett. 1996;87(2-3):147-155
    • (1996) Toxicol Lett , vol.87 , Issue.2-3 , pp. 147-155
    • Voskoboinik, I.1    Drew, R.2    Ahokas, J.T.3
  • 43
    • 25844472682 scopus 로고    scopus 로고
    • Use of di(2-ethylhexyl) phthalate-containing medical products and urinary levels of mono(2-ethylhexyl) phthalate in neonatal intensive care unit infants
    • Green R, Hauser R, Calafat AM, et al. Use of di(2-ethylhexyl) phthalate-containing medical products and urinary levels of mono(2-ethylhexyl) phthalate in neonatal intensive care unit infants. Environ Health Perspect. 2005;113(9):1222-1225
    • (2005) Environ Health Perspect , vol.113 , Issue.9 , pp. 1222-1225
    • Green, R.1    Hauser, R.2    Calafat, A.M.3
  • 44
    • 33645231471 scopus 로고    scopus 로고
    • Di(2-ethylhexyl)phthalate (DEHP): Human metabolism and internal exposure: an update and latest results
    • discussion 181-185
    • Koch HM, Preuss R, Angerer J. Di(2-ethylhexyl)phthalate (DEHP): human metabolism and internal exposure: an update and latest results. Int J Androl. 2006;29(1):155-165; discussion 181-185
    • (2006) Int J Androl , vol.29 , Issue.1 , pp. 155-165
    • Koch, H.M.1    Preuss, R.2    Angerer, J.3
  • 45
    • 0021752532 scopus 로고
    • Incorporation of plasticizer into red cells during storage
    • Rock G, Tocchi M, Ganz PR, Tackaberry ES. Incorporation of plasticizer into red cells during storage. Transfusion. 1984;24(6):493-498
    • (1984) Transfusion , vol.24 , Issue.6 , pp. 493-498
    • Rock, G.1    Tocchi, M.2    Ganz, P.R.3    Tackaberry, E.S.4
  • 46
    • 34247575132 scopus 로고    scopus 로고
    • Diethylhexylphthalate extracted by typical newborn lipid emulsions from polyvinylchloride infusion systems causes significant changes in histology of rabbit liver
    • Loff PD, Subotic U, Oulmi-Kagermann J, Kranzlin B, Reinecke MF, Staude C. Diethylhexylphthalate extracted by typical newborn lipid emulsions from polyvinylchloride infusion systems causes significant changes in histology of rabbit liver. JPEN J Parenter Enteral Nutr. 2007;31(3):188-193
    • (2007) JPEN J Parenter Enteral Nutr , vol.31 , Issue.3 , pp. 188-193
    • Loff, P.D.1    Subotic, U.2    Oulmi-Kagermann, J.3    Kranzlin, B.4    Reinecke, M.F.5    Staude, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.