The acute effects of mono(2-ethylhexyl)phthalate (MEHP) on testes of prepubertal Wistar rats

Toxicology Letters

Volumn 122, Issue 1, 2001, Pages 69-79

  Dalgaard, Majken ^a   Nellemann, Christine ^a   Lam, Henrik Rye ^a   Sørensen, Ilona Kryspin ^a   Ladefoged, Ole ^a  

^a DANISH VETERINARY AND FOOD ADMINISTRATION   (Denmark)

Author keywords

Caspase 3; DEHP metabolism; DNA laddering; TRPM 2 gene expression; TUNEL staining; Vimentin

Indexed keywords

ANDROGEN RECEPTOR; CASPASE 3; DNA FRAGMENT; PHTHALIC ACID 2 ETHYLHEXYL MONOESTER; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; TOXIN; VIMENTIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; EXPOSURE; GENE EXPRESSION; GERM CELL; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PREPUBERTY; PRIORITY JOURNAL; RAT; SERTOLI CELL; TESTIS; TOXICITY;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CLUSTERIN; DIETHYLHEXYL PHTHALATE; DNA; GENE EXPRESSION REGULATION; GLYCOPROTEINS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MOLECULAR CHAPERONES; RATS; RATS, WISTAR; TESTIS; TIME FACTORS; VIMENTIN;

RATTUS NORVEGICUS;

EID: 0035978461     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(01)00348-4     Document Type: Article

References (36)

1. Effects of di(2-ethylhexyl) phthalate on the gonadal pathophysiology, sperm morphology, and reproductive performance of male rats
2. Absorption, metabolism, and excretion of di(2-ethylhexyl) phthalate by rats and mice
3. Oral toxicity of bis(2-ethylhexyl) phthalate during pregnancy and suckling in the Long-Evans rat
4. Regional and cellular distribution within the rat prostate of two mRNA species undergoing opposite regulation by androgens
5. Apoptosis in testis germ cells: Developmental changes in gonadotropin dependence and localization to selective tubule stages
6. Apoptosis pattern elicited by several apoptogenic agents on the seminiferous epithelium of the adult rat testis
7. Identification of male germ cells undergoing apoptosis in adult rats
8. In situ detection of apoptosis in young rat testis: An evaluation of the TUNEL method
9. Toxicity study of di(2-ethylhexyl)phthalate (DEHP) in combination with acetone in rats
10. Deltamethrin-induced testicular apoptosis in rats: The protective effect of nitric oxide synthase inhibitor
11. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis
12. Differential gene regulation during programmed death (apoptosis) versus proliferation of prostatic glandular cells induced by androgen manipulation
13. Isolation and characterization of all-trans-retinoic acid-responsive genes in the rat testis
14. Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p′-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat
15. Inhibition of FSH-stimulated cAMP accumulation by mono(2-ethylhexyl) phthalate in primary rat Sertoli cell cultures
16. Involvement of apoptosis in the induction of germ cell degeneration in adult rats after gonadotropin-releasing hormone antagonist treatment
17. The apoptosis cascade - Morphological and immunohistochemical methods for its visualization
18. Caspase-3 activation is required for Leydig cell apoptosis induced by ethane dimethanesulfonate
19. The Fas system is a key regulator of germ cell apoptosis in the testis
20. In situ end-labeling of human testicular tissue demonstrates increased apoptosis in conditions of abnormal spermatogenesis
21. Disruption of androgen-regulated male reproductive development by di(n-butyl) phthalate during late gestation in rats is different from flutamide
22. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
23. The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat
24. Subchronic oral toxicity of di-n-octyl phthalate and di(2-ethylhexyl)phthalate in the rat
25. Mono-(2-ethylhexyl)phthalate rapidly alters both Sertoli cell vimentin filaments and germ cell apoptosis in young rat testes
26. Participation of the Fas-signaling system in the initiation of germ cell apoptosis in young rat testes after exposure to mono-(2-ethylhexyl)phthalate
27. Regulators for the rat clusterin gene: DNA methylation and cis-acting regulatory elements
28. Involvement of germ cell apoptosis in the induction of testicular toxicity following hydroxyurea treatment
29. Involvement of apoptosis in the rat germ cell degeneration induced by nitrobenzene
30. Apoptotic DNA fragmentation is detected by a semiquantitative ligation-mediated PCR of blunt DNA ends
31. Interleukin-1 beta converting enzyme
32. Genomic organization and expression of the rat TRPM-2 (clusterin) gene, a gene implicated in apoptosis
33. Changes in the distribution of intermediate filaments in rat Sertoli cells during the seminiferous epithelium cycle and postnatal development