Beta-aescin: A potent natural inhibitor of proliferation and inducer of apoptosis in human chronic myeloid leukemia K562 cells in vitro

Leukemia and Lymphoma

Volumn 49, Issue 7, 2008, Pages 1384-1391

  Niu, Yang Ping ^a,b   Li, Lian Da ^a   Wu, Li Mao ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Beta aescin; Cell apoptosis; Cell proliferation; Chinese horse chestnut (Aesculus chinensis); Human chronic myeloid leukemia K562 cells

Indexed keywords

BETA ESCIN; DNA; LIPOCORTIN 5; PHOSPHATIDYLINOSITOL;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CELL STRAIN K 562; CELL STRUCTURE; CELL VIABILITY; CHRONIC MYELOID LEUKEMIA; COLONY FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG POTENCY; DRUG STRUCTURE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCIN; G1 PHASE; HUMANS; K562 CELLS; KINETICS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE;

EID: 47649095710     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.1080/10428190802090151     Document Type: Article

References (30)

1. Diehm, G., Trampisch, H. J., Lange, S. and Schmidt, C. (1996) Comparison of leg compression stocking and oral horse-chestnut seed extract therapy in patients with chronic venous insufficiency. Lancet, 347, pp. 92-94.
2. Pittler, M. H. and Ernst, E. (1998) Horse-chestnut seed extract for chronic venous insufficiency. Arch Dermatol, 134, pp. 1356-1360.
3. Suter, A., Bommer, S. and Rechner, J. (2006) Treatment of patients with venous insufficiency with fresh plant horse chestnut seed extract: A review of 5 clinical studies. Adv Ther, 23, pp. 179-190.
4. Sirtori, C. R. (2001) Aescin: Pharmacology, pharmacokinetics and therapeutic profile. Pharmacol Res, 44, pp. 183-193.
5. Muraki, K., Imaizumi, Y. and Watanabe, M. (1992) Ca-dependent K channels in smooth muscle cells permeabilized by Beta-escin recorded using the cell-attached patch-clamp technique. Pflugers Arch, 420, pp. 461-469.
6. Pearson, P. J. and Vanhoutte, P. M. (1993) Vasodilator and vasoconstrictor substance produced by the endothelium. Rev Physiol Biochem Pharmacol, 122, pp. 1-67.
7. Berti, F., Omini, C. and Longiave, D. (1977) The mode of action of aescin and the release of prostaglandins. Prostaglandins, 14, pp. 241-249.
8. Matsuda, H., Li, Y. and Yoshikawa, M. (2000) Possible involvement of 5-HT and 5-HT2 receptors in acceleration of gastrointestinal transit by escin Ib in mice. Life Sci, 66, pp. 2233-2238.
9. Facino, R. M., Carini, M., Stefani, R., Aldini, G. and Saibene, L. (1995) Anti-elastase and anti-hyaluronidase activities of saponins and sapogenins from Hedera helix, Aesculus hippocastanum, and Ruscus aculeatus: Factors contributing to their efficacy in the treatment of venous insufficiency. Arch Pharm (Weinheim), 328, pp. 720-724.
10. Tutton, P. J. and Barkla, D. H. (1980) Influence of prostaglandin analogues on epithelial cell proliferation and xenograft growth. Br J Cancer, 41, pp. 47-51.
11. Reddy, L., Odhav, B. and Bhoola, K. D. (2003) Natural products for cancer prevention: A global perspective. Pharmacol Ther, 99, pp. 1-13.
12. Mann, J. (2002) Natural products in cancer chemotherapy: Past, present and future. Nature Rev/Cancer, 2, pp. 143-148.
13. Yang, X. W., Zhao, J., Cui, J. R. and Guo, W. (2004) Studied on the biotransformation of escin Ia by human intestinal bacteria and the anti-tumor activities of desacylescin I. Beijing Da Xue Xue Bao, 36, pp. 31-35.
14. Patlolla, J. M., Raju, J., Swamy, M. V. and Rao, C. V. (2006) Beta-Escin inhibits colonic aberrant crypt foci formationin rats and regulates the cell cycle growth by inducing p21waf1/cip1 in colon cancer cells. Mol Cancer Ther, 5, pp. 1459-1466.
15. Niu, Y. P., Gao, R. and Helen, T. (2002) Study on induction of ginsenosides on HL-60 cell apoptosis. Zhongguo Zhong Xi Yi Jie He Za Zhi, 22, pp. 450-452.
16. Niu, Y. P., Jin, J. M., Gao, R. L., Xie, G. L. and Chen, X. H. (2001) Effects of Ginsenosides Rg1 and Rb1 on Proliferation of human marrow granulocyte-macrophage progenitor cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 9, pp. 178-180.
17. Niu, Y. P., Qian, X. D. and Wang, W. X. (2004) Effect of panaxadiol saponin and panaxtrol saponin on proliferation of human bone marrow hemopoietic progenitor cells. Zhongguo Zhong Xi Yi Jie He Za Zhi, 24, pp. 127-129.
18. Vermes, I., Haanen, C., Steffens-Nakken, H. and Reutelingsperger, C. (1995) A novel assay for apoptosis. Flow cytometic detection of phosphatidylserine expression on early apoptosis cells using fluorescein labeled Annexin V. J Immunol Method, 184, pp. 39-51.
19. Herrmann, M., Lorenz, H. M., Voll, R., Grunke, M., Woith, W. and Kalden, J. R. (1994) A rapid and simple method for the isolation of apoptotic DNA fragments. Nucleic Acids Res, 22, pp. 5506-5507.
20. Nicoletti, I., Migliorati, G., Pagliacci, M. C., Grignani, F. and Riccardi, C. (1991) A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods, 139, pp. 271-279.
21. Arends, M. J., Morris, R. G. and Wyllie, A. H. (1990) Apoptosis: The role of endonuclease. Am J Pathol, 136, pp. 593-608.
22. Lacaille-Dubois, M. A. and Wagner, H. (2000) Bioactive saponins from plants: An update. Studies in natural products. Chemistry. Vol. 21, pp. 633-687. Amsterdam, Elsevier
23. Kikuchi, Y., Sasa, H., Kita, T., Hirata, J., Tode, T. and Nagata, I. (1991) Inhibition of human ovarian cancer cell proliferation in vitro by ginsenoside Rh2 and adjuvant effects to cisplatin in vivo. Anti-cancer Drugs, 2, pp. 63-67.
24. Tode, T., Kikuchi, Y., Kita, T., Hirata, J., Imaizumi, E. and Nagata, I. (1993) Inhibitory effects by oral administration of ginsenoside Rh2 on the growth of human ovarian cancer cells in nude mice. J Cancer Res Clin Oncol, 120, pp. 24-26.
25. Lee, Y. N., Lee, H. Y., Chung, H. Y., Kim, S. I., Lee, S. K. Park, B. C. et al. (1996) In vitro induction of differentiation by ginsenoides in F9 teratocarcinoma cells. Eur J Cancer, 32, pp. 1420-1428.
26. Park, J. A., Lee, K. Y., Oh, Y. J., Kim, K. W. and Lee, S. K. (1997) Activation of caspase-3 protease via a Bcl-2-insensitive pathway during the process of ginsenoside Rh2-induced apoptosis. Cancer Lett, 12, pp. 73-81.
27. Yui, S., Ubukata, K., Hodono, K., Kitahara, M., Mimaki, Y. Kuroda, M. et al. (2001) Macrophage-oriented cytotoxic activity of novel triterpene saponins extracted from roots of Securidaca inappendiculata. Int Immunopharmacol, 1, pp. 1989-2000.
28. Gaidi, G., Miyamoto, T., Laurens, V. and Lacaille-Dubois, M. A. (2002) New acylated triterpene saponins from Silene fortunei that modulate lymphocyte proliferation. J Nat Prod, 65, pp. 1568-1572.
29. Mujoo, K., Haridas, V., Hoffmann, J. J., Wachter, G. A., Hutter, L. K. Lu, Y. et al. (2001) Triterpenoid saponins from Acacia victoriae (Bentham) decrease tumor cell proliferation and induce apoptosis. Cancer Res, 61, pp. 5486-5490.
30. Haridas, V., Higuchi, M., Jayatilake, G. S., Bailey, D., Mujoo, K. Blake, M. E. et al. (2001) Avicins: Triterpenoid saponins from Acacia victoriae (Bentham) induce apoptosis by mitochondrial perturbation. Proc Natl Acad Sci USA, 98, pp. 5821-5826.