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Volumn 5, Issue 2, 2013, Pages 591-616

Current therapeutic strategies and novel approaches in osteosarcoma

Author keywords

Chemotherapy; Emerging drugs; Multidisciplinary treatment; Osteosarcoma; Radiotherapy; Surgery

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; CISPLATIN; CIXUTUMUMAB; DASATINIB; DENOSUMAB; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FOLINIC ACID; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IFOSFAMIDE; IMATINIB; INTERFERON; LEXIDRONAM SAMARIUM SM 153; MAMMALIAN TARGET OF RAPAMYCIN; METHOTREXATE; MIFAMURTIDE; PEMETREXED; PROTEIN INHIBITOR; PROTEIN TYROSINE KINASE; RAPAMYCIN; RIDAFOROLIMUS; ROBATUMUMAB; SARACATINIB; SOMATOMEDIN; SONIC HEDGEHOG PROTEIN; SORAFENIB; TEPROTUMUMAB; TRASTUZUMAB; UNINDEXED DRUG; ZOLEDRONIC ACID;

EID: 84878876242     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers5020591     Document Type: Review
Times cited : (201)

References (180)
  • 3
    • 35649014764 scopus 로고    scopus 로고
    • International patterns of cancer incidence in adolescents
    • Stiller, C.A. International patterns of cancer incidence in adolescents. Cancer Treat. Rev. 2007, 33, 631-645.
    • (2007) Cancer Treat. Rev , vol.33 , pp. 631-645
    • Stiller, C.A.1
  • 4
    • 0000705010 scopus 로고
    • Osteogenic sarcoma-A critical analysis of 430 cases
    • Coventry, M.B.; Dahlin, D.C. Osteogenic sarcoma-A critical analysis of 430 cases. J. Bone Joint Surg. Am. 1957, 39, 741-757.
    • (1957) J. Bone Joint Surg. Am , vol.39 , pp. 741-757
    • Coventry, M.B.1    Dahlin, D.C.2
  • 5
    • 0014770729 scopus 로고
    • Osteogenic sarcoma under the age of twenty-one-A review of one hundred and forty-five operative cases
    • Marcove, R.C.; Mike, V.; Hajek, J.V.; Levin, A.G.; Hutter, R.V. Osteogenic sarcoma under the age of twenty-one-A review of one hundred and forty-five operative cases. J. Bone Joint Surg. Am. 1970, 52, 411-423.
    • (1970) J. Bone Joint Surg. Am. , vol.52 , pp. 411-423
    • Marcove, R.C.1    Mike, V.2    Hajek, J.V.3    Levin, A.G.4    Hutter, R.V.5
  • 6
    • 0034671416 scopus 로고    scopus 로고
    • Long-term outcome for patients with nonmetastatic osteosarcoma of the extremity treated at the istituto ortopedico rizzoli according to the istituto ortopedico rizzoli/osteosarcoma-2 protocol: An updated report
    • Bacci, G.; Ferrari, S.; Bertoni, F.; Ruggieri, P.; Picci, P.; Longhi, A.; Casadei, R.; Fabbri, N.; Forni, C.; Versari, M.; et al. Long-term outcome for patients with nonmetastatic osteosarcoma of the extremity treated at the istituto ortopedico rizzoli according to the istituto ortopedico rizzoli/osteosarcoma-2 protocol: An updated report. J. Clin. Oncol. 2000, 18, 4016-4027.
    • (2000) J. Clin. Oncol , vol.18 , pp. 4016-4027
    • Bacci, G.1    Ferrari, S.2    Bertoni, F.3    Ruggieri, P.4    Picci, P.5    Longhi, A.6    Casadei, R.7    Fabbri, N.8    Forni, C.9    Versari, M.10
  • 10
    • 84878748628 scopus 로고    scopus 로고
    • Bone sarcomas: Pathogenesis and new therapeutic approaches
    • Heymann, D.; Rédini, F. Bone sarcomas: Pathogenesis and new therapeutic approaches. IBMS BoneKEy 2011, 8, 402-414.
    • (2011) IBMS BoneKEy , vol.8 , pp. 402-414
    • Heymann, D.1    Rédini, F.2
  • 11
    • 0037110691 scopus 로고    scopus 로고
    • Can cure in patients with osteosarcoma be achieved exclusively with chemotherapy and abrogation of surgery?
    • Jaffe, N.; Carrasco, H.; Raymond, K.; Ayala, A.; Eftekhari, F. Can cure in patients with osteosarcoma be achieved exclusively with chemotherapy and abrogation of surgery? Cancer 2002, 95, 2202-2210.
    • (2002) Cancer , vol.95 , pp. 2202-2210
    • Jaffe, N.1    Carrasco, H.2    Raymond, K.3    Ayala, A.4    Eftekhari, F.5
  • 12
    • 3543035771 scopus 로고    scopus 로고
    • Biology and therapeutic advances for pediatric osteosarcoma
    • Marina, N.; Gebhardt, M.; Teot, L.; Gorlick, R. Biology and therapeutic advances for pediatric osteosarcoma. Oncologist 2004, 9, 422-441.
    • (2004) Oncologist , vol.9 , pp. 422-441
    • Marina, N.1    Gebhardt, M.2    Teot, L.3    Gorlick, R.4
  • 13
    • 34347392648 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy for osteosarcoma of the extremities in patients aged 41-60 years: Outcome in 34 cases treated with adriamycin, cisplatinum and ifosfamide between 1984 and 1999
    • Bacci, G.; Ferrari, S.; Mercuri, M.; Longhi, A.; Fabbri, N.; Galletti, S.; Forni, C.; Balladelli, A.; Serra, M.; Picci, P. Neoadjuvant chemotherapy for osteosarcoma of the extremities in patients aged 41-60 years: Outcome in 34 cases treated with adriamycin, cisplatinum and ifosfamide between 1984 and 1999. Acta Orthop. 2007, 78, 377-384.
    • (2007) Acta Orthop. , vol.78 , pp. 377-384
    • Bacci, G.1    Ferrari, S.2    Mercuri, M.3    Longhi, A.4    Fabbri, N.5    Galletti, S.6    Forni, C.7    Balladelli, A.8    Serra, M.9    Picci, P.10
  • 14
    • 0020059356 scopus 로고
    • Preoperative chemotherapy for osteogenic sarcoma: Selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy
    • Rosen, G.; Caparros, B.; Huvos, A.G.; Kosloff, C.; Nirenberg, A.; Cacavio, A.; Marcove, R.C.; Lane, J.M.; Mehta, B.; Urban, C. Preoperative chemotherapy for osteogenic sarcoma: Selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy. Cancer 1982, 49, 1221-1230.
    • (1982) Cancer , vol.49 , pp. 1221-1230
    • Rosen, G.1    Caparros, B.2    Huvos, A.G.3    Kosloff, C.4    Nirenberg, A.5    Cacavio, A.6    Marcove, R.C.7    Lane, J.M.8    Mehta, B.9    Urban, C.10
  • 17
  • 19
    • 0015460906 scopus 로고
    • The therapy of osteogenic sarcoma: Current status and thoughts for the future
    • Friedman, M.A.; Carter, S.K. The therapy of osteogenic sarcoma: Current status and thoughts for the future. J. Surg. Oncol. 1972, 4, 482-510.
    • (1972) J. Surg. Oncol. , vol.4 , pp. 482-510
    • Friedman, M.A.1    Carter, S.K.2
  • 20
    • 13344284023 scopus 로고    scopus 로고
    • Surgical options for children with osteosarcoma
    • Grimer, R.J. Surgical options for children with osteosarcoma. Lancet Oncol. 2005, 6, 85-92.
    • (2005) Lancet Oncol , vol.6 , pp. 85-92
    • Grimer, R.J.1
  • 21
    • 0022838393 scopus 로고
    • Limb-salvage treatment versus amputation for osteosarcoma of the distal end of the femur
    • Simon, M.A.; Aschliman, M.A.; Thomas, N.; Mankin, H.J. Limb-salvage treatment versus amputation for osteosarcoma of the distal end of the femur. J. Bone Joint Surg. Am. 1986, 68, 1331-1337.
    • (1986) J. Bone Joint Surg. Am. , vol.68 , pp. 1331-1337
    • Simon, M.A.1    Aschliman, M.A.2    Thomas, N.3    Mankin, H.J.4
  • 22
    • 0028227184 scopus 로고
    • Limb salvage compared with amputation for osteosarcoma of the distal end of the femur. A long-term oncological, functional, and quality-of-life study
    • Rougraff, B.T.; Simon, M.A.; Kneisl, J.S.; Greenberg, D.B.; Mankin, H.J. Limb salvage compared with amputation for osteosarcoma of the distal end of the femur. A long-term oncological, functional, and quality-of-life study. J. Bone Joint Surg. Am. 1994, 76, 649-656.
    • (1994) J. Bone Joint Surg. Am , vol.76 , pp. 649-656
    • Rougraff, B.T.1    Simon, M.A.2    Kneisl, J.S.3    Greenberg, D.B.4    Mankin, H.J.5
  • 24
    • 0037112186 scopus 로고    scopus 로고
    • Limb salvage and amputation in survivors of pediatric lower-extremity bone tumors: What are the long-term implications?
    • Nagarajan, R.; Neglia, J.P.; Clohisy, D.R.; Robison, L.L. Limb salvage and amputation in survivors of pediatric lower-extremity bone tumors: What are the long-term implications? J. Clin. Oncol. 2002, 20, 4493-4501.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 4493-4501
    • Nagarajan, R.1    Neglia, J.P.2    Clohisy, D.R.3    Robison, L.L.4
  • 25
    • 0028935594 scopus 로고
    • Phantom limb pain and chemotherapy in pediatric amputees
    • Smith, J.; Thompson, J.M. Phantom limb pain and chemotherapy in pediatric amputees. Mayo Clin. Proc. 1995, 70, 357-364.
    • (1995) Mayo Clin. Proc. , vol.70 , pp. 357-364
    • Smith, J.1    Thompson, J.M.2
  • 26
    • 0028937833 scopus 로고
    • The prevalence of phantom sensation and pain in pediatric amputees
    • Krane, E.J.; Heller, L.B. The prevalence of phantom sensation and pain in pediatric amputees. J. Pain Symptom Manage. 1995, 10, 21-29.
    • (1995) J. Pain Symptom Manage. , vol.10 , pp. 21-29
    • Krane, E.J.1    Heller, L.B.2
  • 27
    • 0036467661 scopus 로고    scopus 로고
    • Prognostic factors in high-grade osteosarcoma of the extremities or trunk: An analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols
    • Bielack, S.S.; Kempf-Bielack, B.; Delling, G.; Exner, G.U.; Flege, S.; Helmke, K.; Kotz, R.; Salzer-Kuntschik, M.; Werner, M.; Winkelmann, W.; et al. Prognostic factors in high-grade osteosarcoma of the extremities or trunk: An analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols. J. Clin. Oncol. 2002, 20, 776-790.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 776-790
    • Bielack, S.S.1    Kempf-Bielack, B.2    Delling, G.3    Exner, G.U.4    Flege, S.5    Helmke, K.6    Kotz, R.7    Salzer-Kuntschik, M.8    Werner, M.9    Winkelmann, W.10
  • 28
    • 84860669845 scopus 로고    scopus 로고
    • Common musculoskeletal tumors of childhood and adolescence
    • Arndt, C.A.; Rose, P.S.; Folpe, A.L.; Laack, N.N. Common musculoskeletal tumors of childhood and adolescence. Mayo Clin. Proc. 2012, 87, 475-487.
    • (2012) Mayo Clin. Proc , vol.87 , pp. 475-487
    • Arndt, C.A.1    Rose, P.S.2    Folpe, A.L.3    Laack, N.N.4
  • 32
    • 33644837672 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy with high-dose ifosfamide, high-dose methotrexate, cisplatin, and doxorubicin for patients with localized osteosarcoma of the extremity: A joint study by the italian and scandinavian sarcoma groups
    • Ferrari, S.; Smeland, S.; Mercuri, M.; Bertoni, F.; Longhi, A.; Ruggieri, P.; Alvegard, T.A.; Picci, P.; Capanna, R.; Bernini, G.; et al. Neoadjuvant chemotherapy with high-dose ifosfamide, high-dose methotrexate, cisplatin, and doxorubicin for patients with localized osteosarcoma of the extremity: A joint study by the italian and scandinavian sarcoma groups. J. Clin. Oncol. 2005, 23, 8845-8852.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 8845-8852
    • Ferrari, S.1    Smeland, S.2    Mercuri, M.3    Bertoni, F.4    Longhi, A.5    Ruggieri, P.6    Alvegard, T.A.7    Picci, P.8    Capanna, R.9    Bernini, G.10
  • 33
    • 0026603285 scopus 로고
    • Limb sparing versus amputation in osteosarcoma. Correlation between local control, surgical margins and tumor necrosis: Istituto rizzoli experience
    • Gherlinzoni, F.; Picci, P.; Bacci, G.; Campanacci, D. Limb sparing versus amputation in osteosarcoma. Correlation between local control, surgical margins and tumor necrosis: Istituto rizzoli experience. Ann. Oncol. 1992, 3, S23-S27.
    • (1992) Ann. Oncol , vol.3
    • Gherlinzoni, F.1    Picci, P.2    Bacci, G.3    Campanacci, D.4
  • 34
    • 34548383124 scopus 로고    scopus 로고
    • Surgical trauma, minimal residual disease and locoregional cancer recurrence
    • Ceelen, W.P.; Morris, S.; Paraskeva, P.; Pattyn, P. Surgical trauma, minimal residual disease and locoregional cancer recurrence. Cancer Treat. Res. 2007, 134, 51-69.
    • (2007) Cancer Treat. Res. , vol.134 , pp. 51-69
    • Ceelen, W.P.1    Morris, S.2    Paraskeva, P.3    Pattyn, P.4
  • 36
    • 0027652246 scopus 로고
    • The blauth total knee endoprosthesis. Eighteen years' experience in practice
    • Maronna, U. The blauth total knee endoprosthesis. Eighteen years' experience in practice. Int. Orthop. 1993, 17, 17-19.
    • (1993) Int. Orthop. , vol.17 , pp. 17-19
    • Maronna, U.1
  • 37
    • 0035013102 scopus 로고    scopus 로고
    • Comparison of two methods of reconstruction for primary malignant tumors at the knee: A sequential cohort study
    • Wunder, J.S.; Leitch, K.; Griffin, A.M.; Davis, A.M.; Bell, R.S. Comparison of two methods of reconstruction for primary malignant tumors at the knee: A sequential cohort study. J. Surg. Oncol. 2001, 77, 89-99.
    • (2001) J. Surg. Oncol. , vol.77 , pp. 89-99
    • Wunder, J.S.1    Leitch, K.2    Griffin, A.M.3    Davis, A.M.4    Bell, R.S.5
  • 38
    • 16844381385 scopus 로고    scopus 로고
    • Periprosthetic infection in patients treated for an orthopaedic oncological condition
    • Jeys, L.M.; Grimer, R.J.; Carter, S.R.; Tillman, R.M. Periprosthetic infection in patients treated for an orthopaedic oncological condition. J. Bone Joint Surg. Am. 2005, 87, 842-849.
    • (2005) J. Bone Joint Surg. Am , vol.87 , pp. 842-849
    • Jeys, L.M.1    Grimer, R.J.2    Carter, S.R.3    Tillman, R.M.4
  • 41
    • 0034879425 scopus 로고    scopus 로고
    • Skeletal reconstruction with a free vascularized fibula graft associated to bone allograft after resection of malignant bone tumor of limbs
    • Ceruso, M.; Falcone, C.; Innocenti, M.; Delcroix, L.; Capanna, R.; Manfrini, M. Skeletal reconstruction with a free vascularized fibula graft associated to bone allograft after resection of malignant bone tumor of limbs. Handchir. Mikrochir. Plast. Chir. 2001, 33, 277-282.
    • (2001) Handchir. Mikrochir. Plast. Chir. , vol.33 , pp. 277-282
    • Ceruso, M.1    Falcone, C.2    Innocenti, M.3    Delcroix, L.4    Capanna, R.5    Manfrini, M.6
  • 42
    • 1442359281 scopus 로고    scopus 로고
    • The role of vascularized fibula in skeletal reconstruction
    • Manfrini, M. The role of vascularized fibula in skeletal reconstruction. Chir. Organi Mov. 2003, 88, 137-142.
    • (2003) Chir. Organi Mov. , vol.88 , pp. 137-142
    • Manfrini, M.1
  • 44
    • 1542498999 scopus 로고    scopus 로고
    • Pasteurized tumoral autograft and adjuvant chemotherapy for the treatment of canine distal radial osteosarcoma: 13 cases
    • Morello, E.; Vasconi, E.; Martano, M.; Peirone, B.; Buracco, P. Pasteurized tumoral autograft and adjuvant chemotherapy for the treatment of canine distal radial osteosarcoma: 13 cases. Vet. Surg. 2003, 32, 539-544.
    • (2003) Vet. Surg , vol.32 , pp. 539-544
    • Morello, E.1    Vasconi, E.2    Martano, M.3    Peirone, B.4    Buracco, P.5
  • 46
    • 0031026810 scopus 로고    scopus 로고
    • The results of transplantation of intercalary allografts after resection of tumors. A long-term follow-up study
    • Ortiz-Cruz, E.; Gebhardt, M.C.; Jennings, L.C.; Springfield, D.S.; Mankin, H.J. The results of transplantation of intercalary allografts after resection of tumors. A long-term follow-up study. J. Bone Joint Surg. Am. 1997, 79, 97-106.
    • (1997) J. Bone Joint Surg. Am. , vol.79 , pp. 97-106
    • Ortiz-Cruz, E.1    Gebhardt, M.C.2    Jennings, L.C.3    Springfield, D.S.4    Mankin, H.J.5
  • 50
    • 0019978378 scopus 로고
    • Rotation-plasty for childhood osteosarcoma of the distal part of the femur
    • Kotz, R.; Salzer, M. Rotation-plasty for childhood osteosarcoma of the distal part of the femur. J. Bone Joint Surg. Am. 1982, 64, 959-969.
    • (1982) J. Bone Joint Surg. Am. , vol.64 , pp. 959-969
    • Kotz, R.1    Salzer, M.2
  • 51
    • 0018972612 scopus 로고
    • Psychologic effects of illness in adolescence. II. Impact of illness in adolescents-Crucial issues and coping styles
    • Zeltzer, L.; Kellerman, J.; Ellenberg, L.; Dash, J.; Rigler, D. Psychologic effects of illness in adolescence. II. Impact of illness in adolescents-Crucial issues and coping styles. J. Pediatr. 1980, 97, 132-138.
    • (1980) J. Pediatr. , vol.97 , pp. 132-138
    • Zeltzer, L.1    Kellerman, J.2    Ellenberg, L.3    Dash, J.4    Rigler, D.5
  • 53
    • 28244477646 scopus 로고    scopus 로고
    • Adjuvant and neoadjuvant chemotherapy for osteosarcoma of the extremities: 27 year experience at rizzoli institute, Italy
    • Bacci, G.; Longhi, A.; Fagioli, F.; Briccoli, A.; Versari, M.; Picci, P. Adjuvant and neoadjuvant chemotherapy for osteosarcoma of the extremities: 27 year experience at rizzoli institute, Italy. Eur. J. Cancer 2005, 41, 2836-2845.
    • (2005) Eur. J. Cancer , vol.41 , pp. 2836-2845
    • Bacci, G.1    Longhi, A.2    Fagioli, F.3    Briccoli, A.4    Versari, M.5    Picci, P.6
  • 57
    • 0034841885 scopus 로고    scopus 로고
    • Presurgical window of carboplatin and surgery and multidrug chemotherapy for the treatment of newly diagnosed metastatic or unresectable osteosarcoma: Pediatric oncology group trial
    • Ferguson, W.S.; Harris, M.B.; Goorin, A.M.; Gebhardt, M.C.; Link, M.P.; Shochat, S.J.; Siegal, G.P.; Devidas, M.; Grier, H.E. Presurgical window of carboplatin and surgery and multidrug chemotherapy for the treatment of newly diagnosed metastatic or unresectable osteosarcoma: Pediatric oncology group trial. J. Pediatr. Hematol. Oncol. 2001, 23, 340-348.
    • (2001) J. Pediatr. Hematol. Oncol. , vol.23 , pp. 340-348
    • Ferguson, W.S.1    Harris, M.B.2    Goorin, A.M.3    Gebhardt, M.C.4    Link, M.P.5    Shochat, S.J.6    Siegal, G.P.7    Devidas, M.8    Grier, H.E.9
  • 58
    • 0031015035 scopus 로고    scopus 로고
    • Osteogenic sarcoma of the extremity with detectable lung metastases at presentation. Results of treatment of 23 patients with chemotherapy followed by simultaneous resection of primary and metastatic lesions
    • Bacci, G.; Mercuri, M.; Briccoli, A.; Ferrari, S.; Bertoni, F.; Donati, D.; Monti, C.; Zanoni, A.; Forni, C.; Manfrini, M. Osteogenic sarcoma of the extremity with detectable lung metastases at presentation. Results of treatment of 23 patients with chemotherapy followed by simultaneous resection of primary and metastatic lesions. Cancer 1997, 79, 245-254.
    • (1997) Cancer , vol.79 , pp. 245-254
    • Bacci, G.1    Mercuri, M.2    Briccoli, A.3    Ferrari, S.4    Bertoni, F.5    Donati, D.6    Monti, C.7    Zanoni, A.8    Forni, C.9    Manfrini, M.10
  • 60
    • 0015814720 scopus 로고
    • Prolonged survival in osteogenic sarcoma with multiple pulmonary metastases. A case report and review of the literature
    • Marcove, R.C.; Lewis, M.M. Prolonged survival in osteogenic sarcoma with multiple pulmonary metastases. A case report and review of the literature. J. Bone Joint Surg. Am. 1973, 55, 1516-1520.
    • (1973) J. Bone Joint Surg. Am. , vol.55 , pp. 1516-1520
    • Marcove, R.C.1    Lewis, M.M.2
  • 61
    • 31744450019 scopus 로고    scopus 로고
    • Management of osteosarcoma pulmonary metastases
    • Harting, M.T.; Blakely, M.L. Management of osteosarcoma pulmonary metastases. Semin. Pediatr. Surg. 2006, 15, 25-29.
    • (2006) Semin. Pediatr. Surg. , vol.15 , pp. 25-29
    • Harting, M.T.1    Blakely, M.L.2
  • 63
    • 0026502220 scopus 로고
    • Survival, prognosis, and therapeutic response in osteogenic sarcoma. The memorial hospital experience
    • Glasser, D.B.; Lane, J.M.; Huvos, A.G.; Marcove, R.C.; Rosen, G. Survival, prognosis, and therapeutic response in osteogenic sarcoma. The memorial hospital experience. Cancer 1992, 69, 698-708.
    • (1992) Cancer , vol.69 , pp. 698-708
    • Glasser, D.B.1    Lane, J.M.2    Huvos, A.G.3    Marcove, R.C.4    Rosen, G.5
  • 65
    • 66549093802 scopus 로고    scopus 로고
    • Osteosarcoma: Esmo clinical recommendations for diagnosis, treatment and follow-up
    • Bielack, S.; Carrle, D.; Casali, P. Osteosarcoma: Esmo clinical recommendations for diagnosis, treatment and follow-up. Ann. Oncol. 2009, 20, iv137-iv139.
    • (2009) Ann. Oncol , vol.20 , pp. 4137-4139
    • Bielack, S.1    Carrle, D.2    Casali, P.3
  • 66
    • 33746450466 scopus 로고    scopus 로고
    • Chemotherapy resistance in osteosarcoma: Current challenges and future directions
    • Chou, A.J.; Gorlick, R. Chemotherapy resistance in osteosarcoma: Current challenges and future directions. Expert Rev. Anticancer Ther. 2006, 6, 1075-1085.
    • (2006) Expert Rev. Anticancer Ther. , vol.6 , pp. 1075-1085
    • Chou, A.J.1    Gorlick, R.2
  • 67
    • 0019835631 scopus 로고
    • The treatment of osteosarcoma of the extremities: Twenty year's experience at the istituto ortopedico rizzoli
    • Campanacci, M.; Bacci, G.; Bertoni, F.; Picci, P.; Minutillo, A.; Franceschi, C. The treatment of osteosarcoma of the extremities: Twenty year's experience at the istituto ortopedico rizzoli. Cancer 1981, 48, 1569-1581.
    • (1981) Cancer , vol.48 , pp. 1569-1581
    • Campanacci, M.1    Bacci, G.2    Bertoni, F.3    Picci, P.4    Minutillo, A.5    Franceschi, C.6
  • 68
    • 0018297022 scopus 로고
    • Advances and treatment of primary bone tumors
    • Enneking, W.F. Advances and treatment of primary bone tumors. J. Fla. Med. Assoc. 1979, 66, 28-30.
    • (1979) J. Fla. Med. Assoc , vol.66 , pp. 28-30
    • Enneking, W.F.1
  • 70
    • 0017265496 scopus 로고
    • Chemotherapy, en bloc resection, and prosthetic bone replacement in the treatment of osteogenic sarcoma
    • Rosen, G.; Murphy, M.L.; Huvos, A.G.; Gutierrez, M.; Marcove, R.C. Chemotherapy, en bloc resection, and prosthetic bone replacement in the treatment of osteogenic sarcoma. Cancer 1976, 37, 1-11.
    • (1976) Cancer , vol.37 , pp. 1-11
    • Rosen, G.1    Murphy, M.L.2    Huvos, A.G.3    Gutierrez, M.4    Marcove, R.C.5
  • 72
    • 0036233586 scopus 로고    scopus 로고
    • High dose ifosfamide in combination with high dose methotrexate, adriamycin and cisplatin in the neoadjuvant treatment of extremity osteosarcoma: Preliminary results of an italian sarcoma group/scandinavian sarcoma group pilot study
    • Bacci, G.; Ferrari, S.; Longhi, A.; Picci, P.; Mercuri, M.; Alvegard, T.A.; Saeter, G.; Donati, D.; Manfrini, M.; Lari, S.; et al. High dose ifosfamide in combination with high dose methotrexate, adriamycin and cisplatin in the neoadjuvant treatment of extremity osteosarcoma: Preliminary results of an italian sarcoma group/scandinavian sarcoma group pilot study. J. Chemother. 2002, 14, 198-206.
    • (2002) J. Chemother. , vol.14 , pp. 198-206
    • Bacci, G.1    Ferrari, S.2    Longhi, A.3    Picci, P.4    Mercuri, M.5    Alvegard, T.A.6    Saeter, G.7    Donati, D.8    Manfrini, M.9    Lari, S.10
  • 75
    • 0023946575 scopus 로고
    • Adjuvant chemotherapy with six drugs (adriamycin, methotrexate, cisplatinum, bleomycin, cyclophosphamide and dactinomycin) for non-metastatic high grade osteosarcoma of the extremities. Results of 32 patients and comparison to 127 patients concomitantly treated with the same drugs in a neoadjuvant form
    • Avella, M.; Bacci, G.; McDonald, D.J.; di Scioscio, M.; Picci, P.; Campanacci, M. Adjuvant chemotherapy with six drugs (adriamycin, methotrexate, cisplatinum, bleomycin, cyclophosphamide and dactinomycin) for non-metastatic high grade osteosarcoma of the extremities. Results of 32 patients and comparison to 127 patients concomitantly treated with the same drugs in a neoadjuvant form. Chemioterapia 1988, 7, 133-137.
    • (1988) Chemioterapia , vol.7 , pp. 133-137
    • Avella, M.1    Bacci, G.2    McDonald, D.J.3    di Scioscio, M.4    Picci, P.5    Campanacci, M.6
  • 76
    • 27744438167 scopus 로고    scopus 로고
    • Pemetrexed: A multitargeted antifolate
    • Rollins, K.D.; Lindley, C. Pemetrexed: A multitargeted antifolate. Clin. Ther. 2005, 27, 1343-1382.
    • (2005) Clin. Ther , vol.27 , pp. 1343-1382
    • Rollins, K.D.1    Lindley, C.2
  • 79
    • 70350225538 scopus 로고    scopus 로고
    • Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: A randomised, double-blind, phase 3 study
    • Ciuleanu, T.; Brodowicz, T.; Zielinski, C.; Kim, J.H.; Krzakowski, M.; Laack, E.; Wu, Y.-L.; Bover, I.; Begbie, S.; Tzekova, V. Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: A randomised, double-blind, phase 3 study. Lancet 2009, 374, 1432-1440.
    • (2009) Lancet , vol.374 , pp. 1432-1440
    • Ciuleanu, T.1    Brodowicz, T.2    Zielinski, C.3    Kim, J.H.4    Krzakowski, M.5    Laack, E.6    Wu, Y.-L.7    Bover, I.8    Begbie, S.9    Tzekova, V.10
  • 80
    • 40449108220 scopus 로고    scopus 로고
    • Pemetrexed, a multitargeted antifolate drug, demonstrates lower efficacy in comparison to methotrexate against osteosarcoma cell lines
    • Bodmer, N.; Walters, D.; Fuchs, B. Pemetrexed, a multitargeted antifolate drug, demonstrates lower efficacy in comparison to methotrexate against osteosarcoma cell lines. Pediatr. Blood Cancer 2008, 50, 905-908.
    • (2008) Pediatr. Blood Cancer , vol.50 , pp. 905-908
    • Bodmer, N.1    Walters, D.2    Fuchs, B.3
  • 81
    • 84857062135 scopus 로고    scopus 로고
    • A phase II trial of second-line pemetrexed in adults with advanced/metastatic osteosarcoma
    • Duffaud, F.; Egerer, G.; Ferrari, S.; Rassam, H.; Boecker, U.; Bui-Nguyen, B. A phase II trial of second-line pemetrexed in adults with advanced/metastatic osteosarcoma. Eur. J. Cancer 2012, 48, 564-570.
    • (2012) Eur. J. Cancer , vol.48 , pp. 564-570
    • Duffaud, F.1    Egerer, G.2    Ferrari, S.3    Rassam, H.4    Boecker, U.5    Bui-Nguyen, B.6
  • 87
    • 40749143460 scopus 로고    scopus 로고
    • Liposomal muramyl tripeptide phosphatidyl ethanolamine: A safe and effective agent against osteosarcoma pulmonary metastases
    • Mori, K.; Ando, K.; Heymann, D. Liposomal muramyl tripeptide phosphatidyl ethanolamine: A safe and effective agent against osteosarcoma pulmonary metastases. Expert Rev. Anticancer Ther. 2008, 8, 151-159.
    • (2008) Expert Rev. Anticancer Ther. , vol.8 , pp. 151-159
    • Mori, K.1    Ando, K.2    Heymann, D.3
  • 89
    • 24644441655 scopus 로고    scopus 로고
    • The role of radiotherapy in cancer treatment: Estimating optimal utilization from a review of evidence-based clinical guidelines
    • Delaney, G.; Jacob, S.; Featherstone, C.; Barton, M. The role of radiotherapy in cancer treatment: Estimating optimal utilization from a review of evidence-based clinical guidelines. Cancer 2005, 104, 1129-1137.
    • (2005) Cancer , vol.104 , pp. 1129-1137
    • Delaney, G.1    Jacob, S.2    Featherstone, C.3    Barton, M.4
  • 94
    • 0015164185 scopus 로고
    • Treatment of bone sarcoma
    • Lee, E.S. Treatment of bone sarcoma. Proc. R. Soc. Med. 1971, 64, 1179-1180.
    • (1971) Proc. R. Soc. Med. , vol.64 , pp. 1179-1180
    • Lee, E.S.1
  • 95
    • 0014528899 scopus 로고
    • Radiatio herapy of malignant bone tumors
    • Phillips, T.L.; Sheline, G.E. Radiatio herapy of malignant bone tumors. Radiology 1969, 92, 1537-1545.
    • (1969) Radiology , vol.92 , pp. 1537-1545
    • Phillips, T.L.1    Sheline, G.E.2
  • 98
    • 0031797976 scopus 로고    scopus 로고
    • Heavy-ion radiobiology: New approaches to delineate mechanisms underlying enhanced biological effectiveness
    • Blakely, E.A.; Kronenberg, A. Heavy-ion radiobiology: New approaches to delineate mechanisms underlying enhanced biological effectiveness. Radiat. Res. 1998, 150, 126-145.
    • (1998) Radiat. Res. , vol.150 , pp. 126-145
    • Blakely, E.A.1    Kronenberg, A.2
  • 100
    • 0014326860 scopus 로고
    • Extracorporeal irradiation of bone tumors. A preliminary report
    • Spira, E.; Lubin, E. Extracorporeal irradiation of bone tumors. A preliminary report. Isr. J. Med. Sci. 1968, 4, 1015-1019.
    • (1968) Isr. J. Med. Sci. , vol.4 , pp. 1015-1019
    • Spira, E.1    Lubin, E.2
  • 103
    • 0036144850 scopus 로고    scopus 로고
    • Osteosarcoma of the distal radius treated by intraoperative extracorporeal irradiation
    • Yamamoto, T.; Akisue, T.; Marui, T.; Nagira, K.; Kurosaka, M. Osteosarcoma of the distal radius treated by intraoperative extracorporeal irradiation. J. Hand Surg. Am. 2002, 27, 160-164.
    • (2002) J. Hand Surg. Am. , vol.27 , pp. 160-164
    • Yamamoto, T.1    Akisue, T.2    Marui, T.3    Nagira, K.4    Kurosaka, M.5
  • 104
    • 0017723926 scopus 로고
    • Preliminary results of aggressive multimodality therapy for metastatic osteosarcoma
    • Weichselbaum, R.R.; Cassady, J.R.; Jaffe, N.; Filler, R.M. Preliminary results of aggressive multimodality therapy for metastatic osteosarcoma. Cancer 1977, 40, 78-83.
    • (1977) Cancer , vol.40 , pp. 78-83
    • Weichselbaum, R.R.1    Cassady, J.R.2    Jaffe, N.3    Filler, R.M.4
  • 105
    • 0017855529 scopus 로고
    • Pulmonary resection in children with metastatic osteogenic sarcoma: Improved survival with surgery, chemotherapy, and irradiation
    • Giritsky, A.S.; Etcubanas, E.; Mark, J.B. Pulmonary resection in children with metastatic osteogenic sarcoma: Improved survival with surgery, chemotherapy, and irradiation. J. Thorac. Cardiovasc. Surg. 1978, 75, 354-362.
    • (1978) J. Thorac. Cardiovasc. Surg. , vol.75 , pp. 354-362
    • Giritsky, A.S.1    Etcubanas, E.2    Mark, J.B.3
  • 106
    • 0017075080 scopus 로고
    • Elective whole lung irradiation in the treatment of osteogenic sarcoma
    • Rab, G.T.; Ivins, J.C.; Childs, D.S., Jr.; Cupps, R.E.; Pritchard, D.J. Elective whole lung irradiation in the treatment of osteogenic sarcoma. Cancer 1976, 38, 939-942.
    • (1976) Cancer , vol.38 , pp. 939-942
    • Rab, G.T.1    Ivins, J.C.2    Childs Jr., D.S.3    Cupps, R.E.4    Pritchard, D.J.5
  • 107
    • 0017881308 scopus 로고
    • Irradiation of the lungs as an adjuvant therapy in the treatment of osteosarcoma of the limbs. An EORTC randomized study
    • Breur, K.; Cohen, P.; Schweisguth, O.; Hart, A.M. Irradiation of the lungs as an adjuvant therapy in the treatment of osteosarcoma of the limbs. An EORTC randomized study. Eur. J. Cancer 1978, 14, 461-471.
    • (1978) Eur. J. Cancer , vol.14 , pp. 461-471
    • Breur, K.1    Cohen, P.2    Schweisguth, O.3    Hart, A.M.4
  • 109
    • 0036230776 scopus 로고    scopus 로고
    • A systematic review of the role of pulmonary irradiation in the management of primary bone tumours
    • Whelan, J.S.; Burcombe, R.J.; Janinis, J.; Baldelli, A.M.; Cassoni, A.M. A systematic review of the role of pulmonary irradiation in the management of primary bone tumours. Ann. Oncol. 2002, 13, 23-30.
    • (2002) Ann. Oncol. , vol.13 , pp. 23-30
    • Whelan, J.S.1    Burcombe, R.J.2    Janinis, J.3    Baldelli, A.M.4    Cassoni, A.M.5
  • 110
    • 0023855174 scopus 로고
    • Age and dose of chemotherapy as major prognostic factors in a trial of adjuvant therapy of osteosarcoma combining two alternating drug combinations and early prophylactic lung irradiation
    • French Bone Tumor Study Group
    • French Bone Tumor Study Group. Age and dose of chemotherapy as major prognostic factors in a trial of adjuvant therapy of osteosarcoma combining two alternating drug combinations and early prophylactic lung irradiation. Cancer 1988, 61, 1304-1311.
    • (1988) Cancer , vol.61 , pp. 1304-1311
  • 111
    • 0036137678 scopus 로고    scopus 로고
    • High-dose samarium-153 ethylene diamine tetramethylene phosphonate: Low toxicity of skeletal irradiation in patients with osteosarcoma and bone metastases. J
    • Anderson, P.M.; Wiseman, G.A.; Dispenzieri, A.; Arndt, C.A.; Hartmann, L.C.; Smithson, W.A.; Mullan, B.P.; Bruland, O.S. High-dose samarium-153 ethylene diamine tetramethylene phosphonate: Low toxicity of skeletal irradiation in patients with osteosarcoma and bone metastases. J. Clin. Oncol. 2002, 20, 189-196.
    • (2002) Clin. Oncol. , vol.20 , pp. 189-196
    • Anderson, P.M.1    Wiseman, G.A.2    Dispenzieri, A.3    Arndt, C.A.4    Hartmann, L.C.5    Smithson, W.A.6    Mullan, B.P.7    Bruland, O.S.8
  • 112
    • 0029905309 scopus 로고    scopus 로고
    • Targeted radiotherapy of osteosarcoma using 153 sm-edtmp. A new promising approach
    • Bruland, O.S.; Skretting, A.; Solheim, O.P.; Aas, M. Targeted radiotherapy of osteosarcoma using 153 sm-edtmp. A new promising approach. Acta Oncol. 1996, 35, 381-384.
    • (1996) Acta Oncol , vol.35 , pp. 381-384
    • Bruland, O.S.1    Skretting, A.2    Solheim, O.P.3    Aas, M.4
  • 113
    • 37349120734 scopus 로고    scopus 로고
    • Samarium lexidronam (153sm-edtmp): Skeletal radiation for osteoblastic bone metastases and osteosarcoma
    • Anderson, P.; Nunez, R. Samarium lexidronam (153sm-edtmp): Skeletal radiation for osteoblastic bone metastases and osteosarcoma. Expert Rev. Anticancer Ther. 2007, 7, 1517-1527.
    • (2007) Expert Rev. Anticancer Ther. , vol.7 , pp. 1517-1527
    • Anderson, P.1    Nunez, R.2
  • 114
    • 0035668596 scopus 로고    scopus 로고
    • High.-activity samarium-153-edtmp therapy followed by autologous peripheral blood stem cell support in unresectable osteosarcoma
    • Franzius, C.; Bielack, S.; Flege, S.; Eckardt, J.; Sciuk, J.; Jurgens, H.; Schober, O. High.-activity samarium-153-edtmp therapy followed by autologous peripheral blood stem cell support in unresectable osteosarcoma. Nuklearmedizin 2001, 40, 215-220.
    • (2001) Nuklearmedizin , vol.40 , pp. 215-220
    • Franzius, C.1    Bielack, S.2    Flege, S.3    Eckardt, J.4    Sciuk, J.5    Jurgens, H.6    Schober, O.7
  • 116
    • 0017756462 scopus 로고
    • Is interferon tissue specific?-Effect of human leukocyte and fibroblast interferons on the growth of lymphoblastoid and osteosarcoma cell lines
    • Einhorn, S.; Strander, H. Is interferon tissue specific?-Effect of human leukocyte and fibroblast interferons on the growth of lymphoblastoid and osteosarcoma cell lines. J. Gen. Virol. 1977, 35, 573-577.
    • (1977) J. Gen. Virol. , vol.35 , pp. 573-577
    • Einhorn, S.1    Strander, H.2
  • 117
    • 0017617563 scopus 로고
    • Effect of human leukocyte interferon on the growth of human osteosarcoma cells in tissue culture
    • Strander, H.; Einhorn, S. Effect of human leukocyte interferon on the growth of human osteosarcoma cells in tissue culture. Int. J. Cancer 1977, 19, 468-473.
    • (1977) Int. J. Cancer , vol.19 , pp. 468-473
    • Strander, H.1    Einhorn, S.2
  • 118
    • 0023130623 scopus 로고
    • Growth inhibition of human osteosarcomas in nude mice by human interferon-alpha: Significance of dose and tumor differentiation
    • Brosjo, O.; Bauer, H.C.; Brostrom, L.A.; Nilsson, O.S.; Reinholt, F.P.; Tribukait, B. Growth inhibition of human osteosarcomas in nude mice by human interferon-alpha: Significance of dose and tumor differentiation. Cancer Res. 1987, 47, 258-262.
    • (1987) Cancer Res , vol.47 , pp. 258-262
    • Brosjo, O.1    Bauer, H.C.2    Brostrom, L.A.3    Nilsson, O.S.4    Reinholt, F.P.5    Tribukait, B.6
  • 119
    • 33645736049 scopus 로고    scopus 로고
    • Osteosarcoma: Current status of immunotherapy and future trends (review)
    • Mori, K.; Rédini, F.; Gouin, F.; Cherrier, B.; Heymann, D. Osteosarcoma: Current status of immunotherapy and future trends (review). Oncol. Rep. 2006, 15, 693-700.
    • (2006) Oncol. Rep , vol.15 , pp. 693-700
    • Mori, K.1    Rédini, F.2    Gouin, F.3    Cherrier, B.4    Heymann, D.5
  • 120
    • 23944474283 scopus 로고    scopus 로고
    • Interferon-alpha as the only adjuvant treatment in high-grade osteosarcoma: Long term results of the karolinska hospital series
    • Muller, C.R.; Smeland, S.; Bauer, H.C.; Saeter, G.; Strander, H. Interferon-alpha as the only adjuvant treatment in high-grade osteosarcoma: Long term results of the karolinska hospital series. Acta Oncol. 2005, 44, 475-480.
    • (2005) Acta Oncol , vol.44 , pp. 475-480
    • Muller, C.R.1    Smeland, S.2    Bauer, H.C.3    Saeter, G.4    Strander, H.5
  • 124
    • 77955122716 scopus 로고    scopus 로고
    • Inhaled granulocyte-macrophage colony stimulating factor for first pulmonary recurrence of osteosarcoma: Effects on disease-free survival and immunomodulation. A report from the children's oncology group
    • Arndt, C.A.; Koshkina, N.V.; Inwards, C.Y.; Hawkins, D.S.; Krailo, M.D.; Villaluna, D.; Anderson, P.M.; Goorin, A.M.; Blakely, M.L.; Bernstein, M.; et al. Inhaled granulocyte-macrophage colony stimulating factor for first pulmonary recurrence of osteosarcoma: Effects on disease-free survival and immunomodulation. A report from the children's oncology group. Clin. Cancer Res. 2010, 16, 4024-4030.
    • (2010) Clin. Cancer Res , vol.16 , pp. 4024-4030
    • Arndt, C.A.1    Koshkina, N.V.2    Inwards, C.Y.3    Hawkins, D.S.4    Krailo, M.D.5    Villaluna, D.6    Anderson, P.M.7    Goorin, A.M.8    Blakely, M.L.9    Bernstein, M.10
  • 125
    • 2942618768 scopus 로고    scopus 로고
    • A renaissance for src
    • Yeatman, T.J. A renaissance for src. Nat. Rev. Cancer 2004, 4, 470-480.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 470-480
    • Yeatman, T.J.1
  • 126
    • 34047265691 scopus 로고    scopus 로고
    • Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on src kinase for survival
    • Shor, A.C.; Keschman, E.A.; Lee, F.Y.; Muro-Cacho, C.; Letson, G.D.; Trent, J.C.; Pledger, W.J.; Jove, R. Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on src kinase for survival. Cancer Res. 2007, 67, 2800-2808.
    • (2007) Cancer Res. , vol.67 , pp. 2800-2808
    • Shor, A.C.1    Keschman, E.A.2    Lee, F.Y.3    Muro-Cacho, C.4    Letson, G.D.5    Trent, J.C.6    Pledger, W.J.7    Jove, R.8
  • 127
    • 36148945220 scopus 로고    scopus 로고
    • Identification of a novel pyrazolo [3,4-d] pyrimidine able to inhibit cell proliferation of a human osteogenic sarcoma in vitro and in a xenograft model in mice
    • Manetti, F.; Santucci, A.; Locatelli, G.A.; Maga, G.; Spreafico, A.; Serchi, T.; Orlandini, M.; Bernardini, G.; Caradonna, N.P.; Spallarossa, A.; et al. Identification of a novel pyrazolo [3,4-d] pyrimidine able to inhibit cell proliferation of a human osteogenic sarcoma in vitro and in a xenograft model in mice. J. Med. Chem. 2007, 50, 5579-5588.
    • (2007) J. Med. Chem. , vol.50 , pp. 5579-5588
    • Manetti, F.1    Santucci, A.2    Locatelli, G.A.3    Maga, G.4    Spreafico, A.5    Serchi, T.6    Orlandini, M.7    Bernardini, G.8    Caradonna, N.P.9    Spallarossa, A.10
  • 128
    • 66149192409 scopus 로고    scopus 로고
    • Inhibition of src phosphorylation alters metastatic potential of osteosarcoma in vitro but not in vivo
    • Hingorani, P.; Zhang, W.; Gorlick, R.; Kolb, E.A. Inhibition of src phosphorylation alters metastatic potential of osteosarcoma in vitro but not in vivo. Clin. Cancer Res. 2009, 15, 3416-3422.
    • (2009) Clin. Cancer Res , vol.15 , pp. 3416-3422
    • Hingorani, P.1    Zhang, W.2    Gorlick, R.3    Kolb, E.A.4
  • 129
    • 0033548071 scopus 로고    scopus 로고
    • The fkbp12-rapamycin-binding domain is required for fkbp12-rapamycin-associated protein kinase activity and g1 progression
    • Vilella-Bach, M.; Nuzzi, P.; Fang, Y.; Chen, J. The fkbp12-rapamycin-binding domain is required for fkbp12-rapamycin-associated protein kinase activity and g1 progression. J. Biol. Chem. 1999, 274, 4266-4272.
    • (1999) J. Biol. Chem. , vol.274 , pp. 4266-4272
    • Vilella-Bach, M.1    Nuzzi, P.2    Fang, Y.3    Chen, J.4
  • 130
    • 34250197914 scopus 로고    scopus 로고
    • Mtor inhibitors (rapamycin and its derivatives) and nitrogen containing bisphosphonates: Bi-functional compounds for the treatment of bone tumours
    • Ory, B.; Moriceau, G.; Redini, F.; Heymann, D. Mtor inhibitors (rapamycin and its derivatives) and nitrogen containing bisphosphonates: Bi-functional compounds for the treatment of bone tumours. Curr. Med. Chem. 2007, 14, 1381-1387.
    • (2007) Curr. Med. Chem. , vol.14 , pp. 1381-1387
    • Ory, B.1    Moriceau, G.2    Redini, F.3    Heymann, D.4
  • 131
    • 16844366544 scopus 로고    scopus 로고
    • Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma
    • Wan, X.; Mendoza, A.; Khanna, C.; Helman, L.J. Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma. Cancer Res. 2005, 65, 2406-2411.
    • (2005) Cancer Res. , vol.65 , pp. 2406-2411
    • Wan, X.1    Mendoza, A.2    Khanna, C.3    Helman, L.J.4
  • 134
    • 0002452569 scopus 로고    scopus 로고
    • 1 Developmental roles and clinical significance of hedgehog signaling
    • McMahon, A.P.; Ingham, P.W.; Tabin, C.J. 1 Developmental roles and clinical significance of hedgehog signaling. Curr. Top. Dev. Biol. 2003, 53, 1-114.
    • (2003) Curr. Top. Dev. Biol , vol.53 , pp. 1-114
    • McMahon, A.P.1    Ingham, P.W.2    Tabin, C.J.3
  • 135
    • 2942738996 scopus 로고    scopus 로고
    • The hedgehog response network: Sensors, switches, and routers
    • Lum, L.; Beachy, P.A. The hedgehog response network: Sensors, switches, and routers. Science 2004, 304, 1755-1759.
    • (2004) Science , vol.304 , pp. 1755-1759
    • Lum, L.1    Beachy, P.A.2
  • 136
    • 33751549095 scopus 로고    scopus 로고
    • Targeting the hedgehog pathway in cancer
    • Rubin, L.L.; de Sauvage, F.J. Targeting the hedgehog pathway in cancer. Nat. Rev. Drug Discov. 2006, 5, 1026-1033.
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 1026-1033
    • Rubin, L.L.1    de Sauvage, F.J.2
  • 137
    • 84861352086 scopus 로고    scopus 로고
    • Hedgehog pathway as a drug target: Smoothened inhibitors in development
    • Lin, T.L.; Matsui, W. Hedgehog pathway as a drug target: Smoothened inhibitors in development. Oncotargets Ther. 2012, 5, 47.
    • (2012) Oncotargets Ther. , vol.5 , pp. 47
    • Lin, T.L.1    Matsui, W.2
  • 138
    • 68149124175 scopus 로고    scopus 로고
    • Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancer
    • Xu, F.-G.; Ma, Q.-Y.; Wang, Z. Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancer. Cancer Lett. 2009, 283, 119-124.
    • (2009) Cancer Lett. , vol.283 , pp. 119-124
    • Xu, F.-G.1    Ma, Q.-Y.2    Wang, Z.3
  • 142
    • 84878884888 scopus 로고    scopus 로고
    • Studying the role of the immune system on the antitumor activity of a hedgehog inhibitor against murine osteosarcoma
    • Paget, C.; Duret, H.; Ngiow, S.F.; Kansara, M.; Thomas, D.M.; Smyth, M.J. Studying the role of the immune system on the antitumor activity of a hedgehog inhibitor against murine osteosarcoma. Oncoimmunology 2012, 1, 1313-1322.
    • (2012) Oncoimmunology , vol.1 , pp. 1313-1322
    • Paget, C.1    Duret, H.2    Ngiow, S.F.3    Kansara, M.4    Thomas, D.M.5    Smyth, M.J.6
  • 145
    • 84860389568 scopus 로고    scopus 로고
    • Increased expression of insulin-like growth factor-1 receptor is correlated with tumor metastasis and prognosis in patients with osteosarcoma
    • Wang, Y.H.; Han, X.D.; Qiu, Y.; Xiong, J.; Yu, Y.; Wang, B.; Zhu, Z.Z.; Qian, B.P.; Chen, Y.X.; Wang, S.F.; et al. Increased expression of insulin-like growth factor-1 receptor is correlated with tumor metastasis and prognosis in patients with osteosarcoma. J. Surg. Oncol. 2012, 105, 235-243.
    • (2012) J. Surg. Oncol. , vol.105 , pp. 235-243
    • Wang, Y.H.1    Han, X.D.2    Qiu, Y.3    Xiong, J.4    Yu, Y.5    Wang, B.6    Zhu, Z.Z.7    Qian, B.P.8    Chen, Y.X.9    Wang, S.F.10
  • 147
    • 77953256426 scopus 로고    scopus 로고
    • R1507, a fully human monoclonal antibody targeting igf-1r, is effective alone and in combination with rapamycin in inhibiting growth of osteosarcoma xenografts
    • Kolb, E.A.; Kamara, D.; Zhang, W.; Lin, J.; Hingorani, P.; Baker, L.; Houghton, P.; Gorlick, R. R1507, a fully human monoclonal antibody targeting igf-1r, is effective alone and in combination with rapamycin in inhibiting growth of osteosarcoma xenografts. Pediatr. Blood Cancer 2010, 55, 67-75.
    • (2010) Pediatr. Blood Cancer , vol.55 , pp. 67-75
    • Kolb, E.A.1    Kamara, D.2    Zhang, W.3    Lin, J.4    Hingorani, P.5    Baker, L.6    Houghton, P.7    Gorlick, R.8
  • 150
    • 0035216142 scopus 로고    scopus 로고
    • Clinicopathologic analysis of her-2/neu immunoexpression among various histologic subtypes and grades of osteosarcoma
    • Kilpatrick, S.E.; Geisinger, K.R.; King, T.S.; Sciarrotta, J.; Ward, W.G.; Gold, S.H.; Bos, G.D. Clinicopathologic analysis of her-2/neu immunoexpression among various histologic subtypes and grades of osteosarcoma. Mod. Pathol. 2001, 14, 1277-1283.
    • (2001) Mod. Pathol. , vol.14 , pp. 1277-1283
    • Kilpatrick, S.E.1    Geisinger, K.R.2    King, T.S.3    Sciarrotta, J.4    Ward, W.G.5    Gold, S.H.6    Bos, G.D.7
  • 151
    • 84864044404 scopus 로고    scopus 로고
    • Phase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: A report from the children's oncology group
    • Ebb, D.; Meyers, P.; Grier, H.; Bernstein, M.; Gorlick, R.; Lipshultz, S.E.; Krailo, M.; Devidas, M.; Barkauskas, D.A.; Siegal, G.P.; et al. Phase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: A report from the children's oncology group. J. Clin. Oncol. 2012, 30, 2545-2551.
    • (2012) J. Clin. Oncol. , vol.30 , pp. 2545-2551
    • Ebb, D.1    Meyers, P.2    Grier, H.3    Bernstein, M.4    Gorlick, R.5    Lipshultz, S.E.6    Krailo, M.7    Devidas, M.8    Barkauskas, D.A.9    Siegal, G.P.10
  • 152
    • 84856343533 scopus 로고    scopus 로고
    • A phase ii trial of sorafenib in relapsed and unresectable high-grade osteosarcoma after failure of standard multimodal therapy: An. italian sarcoma group study
    • Grignani, G.; Palmerini, E.; Dileo, P.; Asaftei, S.D.; D'Ambrosio, L.; Pignochino, Y.; Mercuri, M.; Picci, P.; Fagioli, F.; Casali, P.G.; et al. A phase ii trial of sorafenib in relapsed and unresectable high-grade osteosarcoma after failure of standard multimodal therapy: An. italian sarcoma group study. Ann. Oncol. 2012, 23, 508-516.
    • (2012) Ann. Oncol. , vol.23 , pp. 508-516
    • Grignani, G.1    Palmerini, E.2    Dileo, P.3    Asaftei, S.D.4    D'Ambrosio, L.5    Pignochino, Y.6    Mercuri, M.7    Picci, P.8    Fagioli, F.9    Casali, P.G.10
  • 153
    • 0025949878 scopus 로고
    • Human osteoblasts synthesize and respond to platelet-derived growth factor
    • Zhang, L.; Leeman, E.; Carnes, D.C.; Graves, D.T. Human osteoblasts synthesize and respond to platelet-derived growth factor. Am. J. Physiol. 1991, 261, C348-C354.
    • (1991) Am. J. Physiol. , vol.261
    • Zhang, L.1    Leeman, E.2    Carnes, D.C.3    Graves, D.T.4
  • 154
    • 0343628689 scopus 로고    scopus 로고
    • Platelet-derived growth factor-aa and-alpha receptor expression suggests an autocrine and/or paracrine loop in osteosarcoma
    • Sulzbacher, I.; Traxler, M.; Mosberger, I.; Lang, S.; Chott, A. Platelet-derived growth factor-aa and-alpha receptor expression suggests an autocrine and/or paracrine loop in osteosarcoma. Mod. Pathol. 2000, 13, 632-637.
    • (2000) Mod. Pathol. , vol.13 , pp. 632-637
    • Sulzbacher, I.1    Traxler, M.2    Mosberger, I.3    Lang, S.4    Chott, A.5
  • 155
    • 43049095679 scopus 로고    scopus 로고
    • Platelet-derived growth factor receptor as a prognostic marker and a therapeutic target for imatinib mesylate therapy in osteosarcoma
    • Kubo, T.; Piperdi, S.; Rosenblum, J.; Antonescu, C.R.; Chen, W.; Kim, H.S.; Huvos, A.G.; Sowers, R.; Meyers, P.A.; Healey, J.H.; et al. Platelet-derived growth factor receptor as a prognostic marker and a therapeutic target for imatinib mesylate therapy in osteosarcoma. Cancer 2008, 112, 2119-2129.
    • (2008) Cancer , vol.112 , pp. 2119-2129
    • Kubo, T.1    Piperdi, S.2    Rosenblum, J.3    Antonescu, C.R.4    Chen, W.5    Kim, H.S.6    Huvos, A.G.7    Sowers, R.8    Meyers, P.A.9    Healey, J.H.10
  • 156
    • 78649261532 scopus 로고    scopus 로고
    • Expression of platelet-derived growth factor-alpha receptor in human osteosarcoma is not a predictor of outcome
    • Sulzbacher, I.; Birner, P.; Dominkus, M.; Pichlhofer, B.; Mazal, P.R. Expression of platelet-derived growth factor-alpha receptor in human osteosarcoma is not a predictor of outcome. Pathology 2010, 42, 664-668.
    • (2010) Pathology , vol.42 , pp. 664-668
    • Sulzbacher, I.1    Birner, P.2    Dominkus, M.3    Pichlhofer, B.4    Mazal, P.R.5
  • 157
    • 0036847703 scopus 로고    scopus 로고
    • Inhibition of platelet-derived growth factor-mediated proliferation of osteosarcoma cells by the novel tyrosine kinase inhibitor sti571
    • McGary, E.C.; Weber, K.; Mills, L.; Doucet, M.; Lewis, V.; Lev, D.C.; Fidler, I.J.; Bar-Eli, M. Inhibition of platelet-derived growth factor-mediated proliferation of osteosarcoma cells by the novel tyrosine kinase inhibitor sti571. Clin. Cancer Res. 2002, 8, 3584-3591.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 3584-3591
    • McGary, E.C.1    Weber, K.2    Mills, L.3    Doucet, M.4    Lewis, V.5    Lev, D.C.6    Fidler, I.J.7    Bar-Eli, M.8
  • 158
    • 37549041711 scopus 로고    scopus 로고
    • A phase II study of imatinib mesylate in children with refractory or relapsed solid tumors: A children's oncology group study
    • Bond, M.; Bernstein, M.L.; Pappo, A.; Schultz, K.R.; Krailo, M.; Blaney, S.M.; Adamson, P.C. A phase II study of imatinib mesylate in children with refractory or relapsed solid tumors: A children's oncology group study. Pediatr. Blood Cancer 2008, 50, 254-258.
    • (2008) Pediatr. Blood Cancer , vol.50 , pp. 254-258
    • Bond, M.1    Bernstein, M.L.2    Pappo, A.3    Schultz, K.R.4    Krailo, M.5    Blaney, S.M.6    Adamson, P.C.7
  • 159
    • 84861456394 scopus 로고    scopus 로고
    • Methylene diphosphonate-conjugated adriamycin liposomes: Preparation, characteristics, and targeted therapy for osteosarcomas in vitro and in vivo
    • Wu, D.; Wan, M. Methylene diphosphonate-conjugated adriamycin liposomes: Preparation, characteristics, and targeted therapy for osteosarcomas in vitro and in vivo. Biomed. Microdevices 2012, 14, 497-510.
    • (2012) Biomed. Microdevices , vol.14 , pp. 497-510
    • Wu, D.1    Wan, M.2
  • 161
    • 67650305793 scopus 로고    scopus 로고
    • Novel therapeutic agents for osteosarcoma
    • O'Day, K.; Gorlick, R. Novel therapeutic agents for osteosarcoma. Expert Rev. Anticancer Ther. 2009, 9, 511-523.
    • (2009) Expert Rev. Anticancer Ther. , vol.9 , pp. 511-523
    • O'Day, K.1    Gorlick, R.2
  • 162
    • 28044467108 scopus 로고    scopus 로고
    • Zoledronic acid suppresses lung metastases and prolongs overall survival of osteosarcoma-bearing mice
    • Ory, B.; Heymann, M.F.; Kamijo, A.; Gouin, F.; Heymann, D.; Redini, F. Zoledronic acid suppresses lung metastases and prolongs overall survival of osteosarcoma-bearing mice. Cancer 2005, 104, 2522-2529.
    • (2005) Cancer , vol.104 , pp. 2522-2529
    • Ory, B.1    Heymann, M.F.2    Kamijo, A.3    Gouin, F.4    Heymann, D.5    Redini, F.6
  • 164
    • 3042796964 scopus 로고    scopus 로고
    • Bisphosphonates: New therapeutic agents for the treatment of bone tumors
    • Heymann, D.; Ory, B.; Gouin, F.; Green, J.R.; Rédini, F. Bisphosphonates: New therapeutic agents for the treatment of bone tumors. Trends Mol. Med. 2004, 10, 337-343.
    • (2004) Trends Mol. Med. , vol.10 , pp. 337-343
    • Heymann, D.1    Ory, B.2    Gouin, F.3    Green, J.R.4    Rédini, F.5
  • 165
    • 1942454714 scopus 로고    scopus 로고
    • Alendronate regulates cell invasion and mmp-2 secretion in human osteosarcoma cell lines
    • Cheng, Y.Y.; Huang, L.; Lee, K.M.; Li, K.; Kumta, S.M. Alendronate regulates cell invasion and mmp-2 secretion in human osteosarcoma cell lines. Pediatr. Blood Cancer 2004, 42, 410-415.
    • (2004) Pediatr. Blood Cancer , vol.42 , pp. 410-415
    • Cheng, Y.Y.1    Huang, L.2    Lee, K.M.3    Li, K.4    Kumta, S.M.5
  • 166
    • 37549048038 scopus 로고    scopus 로고
    • Zoledronic acid inhibits osteosarcoma growth in an orthotopic model
    • Dass, C.R.; Choong, P.F. Zoledronic acid inhibits osteosarcoma growth in an orthotopic model. Mol. Cancer Ther. 2007, 6, 3263-3270.
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 3263-3270
    • Dass, C.R.1    Choong, P.F.2
  • 167
    • 78650330534 scopus 로고    scopus 로고
    • Zoledronic acid potentiates mtor inhibition and abolishes the resistance of osteosarcoma cells to rad001 (everolimus): Pivotal role of the prenylation process
    • Moriceau, G.; Ory, B.; Mitrofan, L.; Riganti, C.; Blanchard, F.; Brion, R.; Charrier, C.; Battaglia, S.; Pilet, P.; Denis, M.G. Zoledronic acid potentiates mtor inhibition and abolishes the resistance of osteosarcoma cells to rad001 (everolimus): Pivotal role of the prenylation process. Cancer Res. 2010, 70, 10329-10339.
    • (2010) Cancer Res. , vol.70 , pp. 10329-10339
    • Moriceau, G.1    Ory, B.2    Mitrofan, L.3    Riganti, C.4    Blanchard, F.5    Brion, R.6    Charrier, C.7    Battaglia, S.8    Pilet, P.9    Denis, M.G.10
  • 168
    • 66149165883 scopus 로고    scopus 로고
    • Zoledronic acid inhibits both the osteolytic and osteoblastic components of osteosarcoma lesions in a mouse model
    • Labrinidis, A.; Hay, S.; Liapis, V.; Ponomarev, V.; Findlay, D.M.; Evdokiou, A. Zoledronic acid inhibits both the osteolytic and osteoblastic components of osteosarcoma lesions in a mouse model. Clin. Cancer Res. 2009, 15, 3451-3461.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 3451-3461
    • Labrinidis, A.1    Hay, S.2    Liapis, V.3    Ponomarev, V.4    Findlay, D.M.5    Evdokiou, A.6
  • 169
    • 77953690136 scopus 로고    scopus 로고
    • Zoledronic acid protects against osteosarcoma-induced bone destruction but lacks efficacy against pulmonary metastases in a syngeneic rat model
    • Labrinidis, A.; Hay, S.; Liapis, V.; Findlay, D.M.; Evdokiou, A. Zoledronic acid protects against osteosarcoma-induced bone destruction but lacks efficacy against pulmonary metastases in a syngeneic rat model. Int. J. Cancer 2010, 127, 345-354.
    • (2010) Int. J. Cancer , vol.127 , pp. 345-354
    • Labrinidis, A.1    Hay, S.2    Liapis, V.3    Findlay, D.M.4    Evdokiou, A.5
  • 170
    • 9244252016 scopus 로고    scopus 로고
    • The molecular triad opg/rank/rankl: Involvement in the orchestration of pathophysiological bone remodeling
    • Theoleyre, S.; Wittrant, Y.; Tat, S.K.; Fortun, Y.; Redini, F.; Heymann, D. The molecular triad opg/rank/rankl: Involvement in the orchestration of pathophysiological bone remodeling. Cytokine Growth Factor Rev. 2004, 15, 457-475.
    • (2004) Cytokine Growth Factor Rev. , vol.15 , pp. 457-475
    • Theoleyre, S.1    Wittrant, Y.2    Tat, S.K.3    Fortun, Y.4    Redini, F.5    Heymann, D.6
  • 171
    • 0142182080 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor kappab ligand (rankl)/osteoprotegerin (opg) ratio is increased in severe osteolysis
    • Grimaud, E.; Soubigou, L.; Couillaud, S.; Coipeau, P.; Moreau, A.; Passuti, N.; Gouin, F.; Redini, F.; Heymann, D. Receptor activator of nuclear factor kappab ligand (rankl)/osteoprotegerin (opg) ratio is increased in severe osteolysis. Am. J. Pathol. 2003, 163, 2021-2031.
    • (2003) Am. J. Pathol. , vol.163 , pp. 2021-2031
    • Grimaud, E.1    Soubigou, L.2    Couillaud, S.3    Coipeau, P.4    Moreau, A.5    Passuti, N.6    Gouin, F.7    Redini, F.8    Heymann, D.9
  • 174
    • 34547629223 scopus 로고    scopus 로고
    • Therapeutic relevance of osteoprotegerin gene therapy in osteosarcoma: Blockade of the vicious cycle between tumor cell proliferation and bone resorption
    • Lamoureux, F.; Richard, P.; Wittrant, Y.; Battaglia, S.; Pilet, P.; Trichet, V.; Blanchard, F.; Gouin, F.; Pitard, B.; Heymann, D.; et al. Therapeutic relevance of osteoprotegerin gene therapy in osteosarcoma: Blockade of the vicious cycle between tumor cell proliferation and bone resorption. Cancer Res. 2007, 67, 7308-7318.
    • (2007) Cancer Res , vol.67 , pp. 7308-7318
    • Lamoureux, F.1    Richard, P.2    Wittrant, Y.3    Battaglia, S.4    Pilet, P.5    Trichet, V.6    Blanchard, F.7    Gouin, F.8    Pitard, B.9    Heymann, D.10
  • 175
    • 84861213409 scopus 로고    scopus 로고
    • Homotypic rank signaling differentially regulates proliferation, motility and cell survival in osteosarcoma and mammary epithelial cells
    • Beristain, A.G.; Narala, S.R.; di Grappa, M.A.; Khokha, R. Homotypic rank signaling differentially regulates proliferation, motility and cell survival in osteosarcoma and mammary epithelial cells. J. Cell. Sci. 2012, 125, 943-955.
    • (2012) J. Cell. Sci , vol.125 , pp. 943-955
    • Beristain, A.G.1    Narala, S.R.2    di Grappa, M.A.3    Khokha, R.4
  • 176
    • 54949093656 scopus 로고    scopus 로고
    • Novel bone cancer drugs: Investigational agents and control paradigms for primary bone sarcomas (ewing's sarcoma and osteosarcoma)
    • Anderson, P.; Kopp, L.; Anderson, N.; Cornelius, K.; Herzog, C.; Hughes, D.; Huh, W. Novel bone cancer drugs: Investigational agents and control paradigms for primary bone sarcomas (ewing's sarcoma and osteosarcoma). Expert Opin. Investig. Drugs 2008, 17, 1703-1715.
    • (2008) Expert Opin. Investig. Drugs , vol.17 , pp. 1703-1715
    • Anderson, P.1    Kopp, L.2    Anderson, N.3    Cornelius, K.4    Herzog, C.5    Hughes, D.6    Huh, W.7
  • 177
    • 84988414961 scopus 로고    scopus 로고
    • Monoclonal antibodies targeting rankl in bone metastasis treatment
    • In Uckum, F.M., Ed.; eBook Future Medicine Ltd., Chapter 5
    • Gobin, B.; Baud'huin, M.; Isidor, B.; Heymann, D.; Heymann, M.F. Monoclonal antibodies targeting rankl in bone metastasis treatment. In Monoclonal Antibodies in Oncology; Uckum, F.M., Ed.; eBook Future Medicine Ltd., 2013; Chapter 5, 42-53.
    • (2013) Monoclonal Antibodies in Oncology , pp. 42-53
    • Gobin, B.1    Baud'huin, M.2    Isidor, B.3    Heymann, D.4    Heymann, M.F.5
  • 178
    • 84864276297 scopus 로고    scopus 로고
    • Anti-rankl therapy for bone tumours: Basic, pre-clinical and clinical evidences
    • Heymann, D. Anti-rankl therapy for bone tumours: Basic, pre-clinical and clinical evidences. J. Bone Oncol. 2012, 1, 2-11.
    • (2012) J. Bone Oncol. , vol.1 , pp. 2-11
    • Heymann, D.1
  • 180
    • 84858121164 scopus 로고    scopus 로고
    • Molecular alterations associated with osteosarcoma development
    • Ando, K.; Mori, K.; Verrecchia, F.; Marc, B.; Rédini, F.; Heymann, D. Molecular alterations associated with osteosarcoma development. Sarcoma 2012, 2012, 523432.
    • (2012) Sarcoma , vol.2012 , pp. 523432
    • Ando, K.1    Mori, K.2    Verrecchia, F.3    Marc, B.4    Rédini, F.5    Heymann, D.6


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