Application of near-infrared (NIR) spectroscopy for screening of raw materials used in the cell culture medium for the production of a recombinant therapeutic protein

Biotechnology Progress

Volumn 26, Issue 2, 2010, Pages 527-531

  Kirdar, Alime Ozlem ^a   Chen, Guoxiang ^a   Weidner, James ^b   Rathore, Anurag S ^c  

^a AMGEN INC   (United States)

^b Amgen Inc   (United States)

^c INDIAN INSTITUTE OF TECHNOLOGY DELHI   (India)

Author keywords

Cell culture media; MVDA; NIR; Raw material screening

Indexed keywords

BASAL MEDIUM; BLENDING PROCESS; CELL CULTURE MEDIA; CELL CULTURE MEDIUMS; CHEMICAL COMPATIBILITY; CONTROL STRATEGIES; DIFFERENT SCALE; FINGER PRINT; HEAT SENSITIVITY; IDENTICAL PROCESS; IMPURITY LEVEL; MEDIA TYPES; MEDIUM COMPONENTS; MILLING PROCESS; MULTIVARIATE DATA ANALYSIS; MVDA; NIR SPECTRUM; PROCESS PERFORMANCE; PRODUCT ATTRIBUTES; QUALITY BY DESIGNS; SCALE OF PRODUCTION; THERAPEUTIC PROTEIN;

BLENDING; IMPURITIES; INFRARED DEVICES; INFRARED SPECTROSCOPY; MILLING (MACHINING); MULTIVARIANT ANALYSIS; QUALITY CONTROL; SENSITIVITY ANALYSIS;

CELL CULTURE;

RECOMBINANT PROTEIN;

ARTICLE; BIOSYNTHESIS; CHEMISTRY; COMPUTER PROGRAM; CULTURE MEDIUM; CULTURE TECHNIQUE; METABOLISM; METHODOLOGY; MULTIVARIATE ANALYSIS; NEAR INFRARED SPECTROSCOPY;

CELL CULTURE TECHNIQUES; CULTURE MEDIA; MULTIVARIATE ANALYSIS; RECOMBINANT PROTEINS; SOFTWARE; SPECTROSCOPY, NEAR-INFRARED;

EID: 77950877204     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.329     Document Type: Article

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