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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 13, 2013, Pages 3947-3953

Discovery of novel HCV inhibitors: Synthesis and biological activity of 6-(indol-2-yl)pyridine-3-sulfonamides targeting hepatitis C virus NS4B

(25) Zhang, Xiaoyan a Zhang, Nanjing a Chen, Guangming a Turpoff, Anthony a Ren, Hongyu a Takasugi, James a Morrill, Christie a Zhu, Jin a Li, Chunshi a Lennox, William a Paget, Steven a Liu, Yalei a Almstead, Neil a George Njoroge, F b Gu, Zhengxian a Komatsu, Takashi a Clausen, Valerie a Espiritu, Christine a Graci, Jason a Colacino, Joseph a more..

a PTC THERAPEUTICS (United States)

b MERCK RESEARCH LABORATORIES (United States)

Author keywords

6 (Indol 2 yl)pyridine 3 sulfonamides; HCV inhibitors; NS4B; Replicon

Indexed keywords

1,3 DIFLUOROISOPROPYL SULFONAMIDE; 6 (INDOL 2 YL)PYRIDINE 3 SULFONAMIDE; ANTIVIRUS AGENT; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HEPATITIS C VIRUS INHIBITOR; SULFONAMIDE; UNCLASSIFIED DRUG; VIRUS RNA;

AMINO ACID SUBSTITUTION; ARTICLE; BIOLOGICAL ACTIVITY; CELL CULTURE; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG SYNTHESIS; GENOTYPE; HEPATITIS C VIRUS; NONHUMAN; RAT; REPLICON; RNA REPLICATION; VIRUS INHIBITION;

ANIMALS; ANTIVIRAL AGENTS; BIOLOGICAL AVAILABILITY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HEPACIVIRUS; HUMANS; INDOLES; MICROBIAL SENSITIVITY TESTS; MICROSOMES, LIVER; MOLECULAR STRUCTURE; PYRIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

HEPATITIS C VIRUS; RATTUS;

EID: 84878839250 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.04.049 Document Type: Article

Times cited : (35)

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