New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells

Journal of Medicinal Chemistry

Volumn 49, Issue 14, 2006, Pages 4127-4139

  Nielsen, Flemming E ^a   Ebdrup, Soøren ^a   Jensen, Anette Frost ^a   Ynddal, Lars ^a   Bodvarsdottir, Thora B ^a   Stidsen, Carsten ^a   Worsaae, Anne ^a   Boonen, Harrie C M ^a   Arkhammar, Per O G ^a   Fremming, Tinna ^a   Wahl, Philip ^a   Kornø, Hanne T ^a   Hansen, J Bondo ^a  

^a NOVO NORDISK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

6 CHLORO 3 (1 METHYL 1 PHENYLETHYL)AMINO 4H THIENO[3,2 E] 1,2,4 THIADIAZINE 1,1 DIOXIDE; 6 CHLORO 3 (1 METHYLCYCLOPROPYL)AMINO 4H THIENO[3,2 E] 1,2,4 THIADIAZINE 1,1 DIOXIDE; 6 CHLORO 3 (1 METHYLCYCLOPROPYL)AMINO 4H THIENO[3,2 E] 1,2,4 THIADIAZINE 1,1 DIOXIDE DERIVATIVE; ADENOSINE TRIPHOSPHATE; AMINO 4H THIENO 1,2,4 THIADIAZINE 1,1 DIOXIDE DERIVATIVE; ANTIDIABETIC AGENT; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; NN 414; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BLOOD LEVEL; DRUG SYNTHESIS; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; RAT; RAT STRAIN;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BIOLOGICAL AVAILABILITY; CELL LINE; CRYSTALLOGRAPHY, X-RAY; CYCLIC S-OXIDES; FEMALE; HUMANS; INSULIN; ION CHANNEL GATING; ISLETS OF LANGERHANS; MALE; MEMBRANE POTENTIALS; MOLECULAR STRUCTURE; MUSCLE RELAXATION; MUSCLE, SMOOTH; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RATS, ZUCKER; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZINES;

EID: 33745854821     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060042j     Document Type: Article

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