메뉴 건너뛰기




Volumn 217, Issue 3, 2013, Pages

Testosterone: A metabolic hormone in health and disease

Author keywords

Metabolic syndrome; Metabolism; Testosterone; Type 2 diabetes

Indexed keywords

CHOLESTEROL; GLYCOGEN; LIPID; PLACEBO; TESTOSTERONE; TESTOSTERONE ESTER; TRIACYLGLYCEROL;

EID: 84878801588     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-12-0455     Document Type: Review
Times cited : (384)

References (199)
  • 2
    • 55249111590 scopus 로고    scopus 로고
    • Impact of testosterone treatment on postprandial triglyceride metabolism in elderly men with subnormal testosterone levels
    • doi:10.1080/00365510801999068
    • Agledahl I,Hansen JB&Svartberg J 2008 Impact of testosterone treatment on postprandial triglyceride metabolism in elderly men with subnormal testosterone levels. Scandinavian Journal of Clinical and Laboratory Investigation 68 641-648. (doi:10.1080/00365510801999068)
    • (2008) Scandinavian Journal of Clinical and Laboratory Investigation , vol.68 , pp. 641-648
    • Agledahl, I.1    Hansen, J.B.2    Svartberg, J.3
  • 3
    • 0037059330 scopus 로고    scopus 로고
    • Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action
    • doi:10.1074/jbc.M101521200
    • Aguirre V, Werner ED, Giraud J, Lee YH, Shoelson SE & White MF 2002 Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. Journal of Biological Chemistry 277 1531-1537. (doi:10.1074/ jbc.M101521200)
    • (2002) Journal of Biological Chemistry , vol.277 , pp. 1531-1537
    • Aguirre, V.1    Werner, E.D.2    Giraud, J.3    Lee, Y.H.4    Shoelson, S.E.5    White, M.F.6
  • 4
    • 38149032364 scopus 로고    scopus 로고
    • Testosterone therapy prevents gain in visceral adipose tissue and loss of skeletal muscle in nonobese aging men
    • doi:10.1210/jc.2007-1291
    • Allan CA, Strauss BJ, Burger HG, Forbes EA & McLachlan RI 2008 Testosterone therapy prevents gain in visceral adipose tissue and loss of skeletal muscle in nonobese aging men. Journal of Clinical Endocrinology and Metabolism 93 139-146. (doi:10.1210/jc.2007-1291)
    • (2008) Journal of Clinical Endocrinology and Metabolism , vol.93 , pp. 139-146
    • Allan, C.A.1    Strauss, B.J.2    Burger, H.G.3    Forbes, E.A.4    McLachlan, R.I.5
  • 5
    • 78651154753 scopus 로고
    • The effect of testosterone propionate on glycolytic and transamination enzyme activities in the liver, biceps muscle and levator ani muscle in rats
    • Apostolakis M, Matzelt D & Voigt KD 1963 The effect of testosterone propionate on glycolytic and transamination enzyme activities in the liver, biceps muscle and levator ani muscle in rats. Biochemische Zeitschrift 337 414-424.
    • (1963) Biochemische Zeitschrift , vol.337 , pp. 414-424
    • Apostolakis, M.1    Matzelt, D.2    Voigt, K.D.3
  • 7
    • 29244465509 scopus 로고    scopus 로고
    • Human fat cell lipolysis: biochemistry, regulation and clinical role. Best Practice & Research. Clinical Endocrinology & Metabolism
    • doi:10.1016/j.beem.2005.07.004
    • Arner P 2005 Human fat cell lipolysis: biochemistry, regulation and clinical role. Best Practice & Research. Clinical Endocrinology & Metabolism 19 471-482. (doi:10.1016/j.beem.2005.07.004)
    • (2005) , vol.19 , pp. 471-482
    • Arner, P.1
  • 8
    • 77957561521 scopus 로고    scopus 로고
    • Efficacy and safety of two different testosterone undecanoate formulations in hypogonadal men with metabolic syndrome
    • Aversa A, Bruzziches R, Francomano D, Spera G & Lenzi A 2010b Efficacy and safety of two different testosterone undecanoate formulations in hypogonadal men with metabolic syndrome. Journal of Endocrinological Investigation 33 776-783.
    • (2010) Journal of Endocrinological Investigation , vol.33 , pp. 776-783
    • Aversa, A.1    Bruzziches, R.2    Francomano, D.3    Spera, G.4    Lenzi, A.5
  • 10
    • 0026458356 scopus 로고
    • Lower endogenous androgen levels and dyslipidemia in men with non-insulin-dependent diabetes mellitus
    • Barrett-Connor E 1992 Lower endogenous androgen levels and dyslipidemia in men with non-insulin-dependent diabetes mellitus. Annals of Internal Medicine 117 807-811.
    • (1992) Annals of Internal Medicine , vol.117 , pp. 807-811
    • Barrett-Connor, E.1
  • 11
    • 0023695139 scopus 로고
    • Endogenous sex hormones and cardiovascular disease in men. A prospective population-based study
    • doi:10.1161/01.CIR.78.3.539
    • Barrett-Connor E & Khaw KT 1988 Endogenous sex hormones and cardiovascular disease in men. A prospective population-based study. Circulation 78 539-545. (doi:10.1161/01.CIR.78.3.539)
    • (1988) Circulation , vol.78 , pp. 539-545
    • Barrett-Connor, E.1    Khaw, K.T.2
  • 12
    • 0036802944 scopus 로고    scopus 로고
    • Inverse relationship between total testosterone and anti-oxidized low density lipoprotein antibody levels in ageing males
    • doi:10.1016/S0021-9150(02)00069-2
    • Barud W, Palusiński R, Beltowski J & Wójcicka G 2002 Inverse relationship between total testosterone and anti-oxidized low density lipoprotein antibody levels in ageing males. Atherosclerosis 164 283-288. (doi:10.1016/S0021-9150(02)00069-2)
    • (2002) Atherosclerosis , vol.164 , pp. 283-288
    • Barud, W.1    Palusiński, R.2    Beltowski, J.3    Wójcicka, G.4
  • 13
    • 34547660521 scopus 로고    scopus 로고
    • Effect of 2 years of testosterone replacement on insulin secretion, insulin action, glucose effectiveness, hepatic insulin clearance, and postprandial glucose turnover in elderly men
    • doi:10.2337/dc07-0359
    • Basu R, Dalla Man C, Campioni M, Basu A, Nair KS, Jensen MD, Khosla S, Klee G, Toffolo G, Cobelli C et al. 2007 Effect of 2 years of testosterone replacement on insulin secretion, insulin action, glucose effectiveness, hepatic insulin clearance, and postprandial glucose turnover in elderly men. Diabetes Care 30 1972-9078. (doi:10.2337/dc07-0359)
    • (2007) Diabetes Care , vol.30 , pp. 1972-9078
    • Basu, R.1    Dalla Man, C.2    Campioni, M.3    Basu, A.4    Nair, K.S.5    Jensen, M.D.6    Khosla, S.7    Klee, G.8    Toffolo, G.9    Cobelli, C.10
  • 14
    • 0016426830 scopus 로고
    • Different mechanisms in testosterone action on glycogen metabolism in rat perineal and skeletal muscles
    • doi:10.1210/endo-96-1-77
    • Bergamini E 1975 Different mechanisms in testosterone action on glycogen metabolism in rat perineal and skeletal muscles. Endocrinology 96 77-84. (doi:10.1210/endo-96-1-77)
    • (1975) Endocrinology , vol.96 , pp. 77-84
    • Bergamini, E.1
  • 15
    • 0014495290 scopus 로고
    • The effect of testosterone on glycogen metabolism in rat levator ani muscle
    • doi:10.1016/0304-4165(69)90131-7
    • Bergamini E, Bombara G & Pellegrino C 1968 The effect of testosterone on glycogen metabolism in rat levator ani muscle. Biochimica et Biophysica Acta 177 220-234. (doi:10.1016/0304-4165(69)90131-7)
    • (1968) Biochimica et Biophysica Acta , vol.177 , pp. 220-234
    • Bergamini, E.1    Bombara, G.2    Pellegrino, C.3
  • 16
    • 70349665186 scopus 로고    scopus 로고
    • Testosterone stimulates extra-hepatic but not hepatic fat oxidation (Fox): comparison of oral and transdermal testosterone administration in hypopituitary men
    • doi:10.1111/j.1365-2265. 2009.03524.x
    • Birzniece V, Meinhardt UJ, Handelsman DJ & Ho KK 2009 Testosterone stimulates extra-hepatic but not hepatic fat oxidation (Fox): comparison of oral and transdermal testosterone administration in hypopituitary men. Clinical Endocrinology 71 715-721. (doi:10.1111/j.1365-2265. 2009.03524.x)
    • (2009) Clinical Endocrinology , vol.71 , pp. 715-721
    • Birzniece, V.1    Meinhardt, U.J.2    Handelsman, D.J.3    Ho, K.K.4
  • 17
    • 0038823605 scopus 로고    scopus 로고
    • Testosterone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency
    • Boyanov M, Boneva Z & Christov V 2003 Testosterone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency. Aging Male 6 1-7.
    • (2003) Aging Male , vol.6 , pp. 1-7
    • Boyanov, M.1    Boneva, Z.2    Christov, V.3
  • 19
    • 79952048597 scopus 로고    scopus 로고
    • Testosterone, sex hormone-binding globulin and the metabolic syndrome: a systematic review and meta-analysis of observational studies
    • doi:10.1093/ije/dyq158
    • Brand JS, van der Tweel I, Grobbee DE, Emmelot-Vonk MH & van der Schouw YT 2010 Testosterone, sex hormone-binding globulin and the metabolic syndrome: a systematic review and meta-analysis of observational studies. International Journal of Epidemiology 40 189-207. (doi:10.1093/ije/dyq158)
    • (2010) International Journal of Epidemiology , vol.40 , pp. 189-207
    • Brand, J.S.1    van der Tweel, I.2    Grobbee, D.E.3    Emmelot-Vonk, M.H.4    van der Schouw, Y.T.5
  • 20
    • 0033613147 scopus 로고    scopus 로고
    • A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
    • doi:10.1073/pnas.96.20.11041
    • Brown MS & Goldstein JL 1999 A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. PNAS 96 11041-11048. (doi:10.1073/pnas.96.20.11041)
    • (1999) PNAS , vol.96 , pp. 11041-11048
    • Brown, M.S.1    Goldstein, J.L.2
  • 22
    • 68949172537 scopus 로고    scopus 로고
    • Effect of long-acting testosterone treatment on functional exercise capacity, skeletal muscle performance, insulin resistance, and baroreflex sensitivity in elderly patients with chronic heart failure a double-blind, placebo-controlled, randomized study
    • doi:10.1016/j.jacc.2009.04.078
    • Caminiti G, Volterrani M, Iellamo F, Marazzi G, Massaro R, Miceli M, Mammi C, Piepoli M, Fini M & Rosano GM 2009 Effect of long-acting testosterone treatment on functional exercise capacity, skeletal muscle performance, insulin resistance, and baroreflex sensitivity in elderly patients with chronic heart failure a double-blind, placebo-controlled, randomized study. Journal of the American College of Cardiology 54 990-927. (doi:10.1016/j.jacc.2009.04.078)
    • (2009) Journal of the American College of Cardiology , vol.54 , pp. 990-927
    • Caminiti, G.1    Volterrani, M.2    Iellamo, F.3    Marazzi, G.4    Massaro, R.5    Miceli, M.6    Mammi, C.7    Piepoli, M.8    Fini, M.9    Rosano, G.M.10
  • 23
    • 33746949893 scopus 로고    scopus 로고
    • Effects of testosterone on insulin receptor substrate-1 and glucose transporter 4 expression in cells sensitive to insulin
    • Chen X, Li X, Huang HY, Li X & Lin JF 2006 Effects of testosterone on insulin receptor substrate-1 and glucose transporter 4 expression in cells sensitive to insulin. Zhonghua Yi Xue Za Zhi 86 1474-1477.
    • (2006) Zhonghua Yi Xue Za Zhi , vol.86 , pp. 1474-1477
    • Chen, X.1    Li, X.2    Huang, H.Y.3    Li, X.4    Lin, J.F.5
  • 24
    • 80052762932 scopus 로고    scopus 로고
    • A selective estrogen receptor a agonist ameliorates hepatic steatosis in the male aromatase knockout mouse
    • doi:10.1530/JOE-10-0462
    • Chow JD, Jones ME, Prelle K, Simpson ER & Boon WC 2011 A selective estrogen receptor a agonist ameliorates hepatic steatosis in the male aromatase knockout mouse. Journal of Endocrinology 210 323-334. (doi:10.1530/JOE-10-0462)
    • (2011) Journal of Endocrinology , vol.210 , pp. 323-334
    • Chow, J.D.1    Jones, M.E.2    Prelle, K.3    Simpson, E.R.4    Boon, W.C.5
  • 25
    • 85030355530 scopus 로고    scopus 로고
    • The hypogonadal-obesity cycle
    • doi:10.1054/mehy.9097.0624
    • Cohen P 1999 The hypogonadal-obesity cycle. Medical Hypotheses 52 49-51. (doi:10.1054/mehy.9097.0624)
    • (1999) Medical Hypotheses , vol.52 , pp. 49-51
    • Cohen, P.1
  • 27
    • 70049083600 scopus 로고    scopus 로고
    • Hypogonadism, ED, metabolic syndrome and obesity: a pathological link supporting cardiovascular diseases
    • doi:10.1111/j.1365-2605.2008.00951.x
    • Corona G, Mannucci E, Forti G & Maggi M 2009 Hypogonadism, ED, metabolic syndrome and obesity: a pathological link supporting cardiovascular diseases. International Journal of Andrology 32 587-598. (doi:10.1111/j.1365-2605.2008.00951.x)
    • (2009) International Journal of Andrology , vol.32 , pp. 587-598
    • Corona, G.1    Mannucci, E.2    Forti, G.3    Maggi, M.4
  • 32
    • 35148842094 scopus 로고    scopus 로고
    • Risk of new-onset diabetes mellitus and worsening glycaemic variables for established diabetes in men undergoing androgen-deprivation therapy for prostate cancer
    • Derweesh IH, Diblasio CJ, Kincade MC, Malcolm JB, Lamar KD, Patterson AL, Kitabchi AE & Wake RW 2007 Risk of new-onset diabetes mellitus and worsening glycaemic variables for established diabetes in men undergoing androgen-deprivation therapy for prostate cancer. BJU International 100 1060-1065.
    • (2007) BJU International , vol.100 , pp. 1060-1065
    • Derweesh, I.H.1    Diblasio, C.J.2    Kincade, M.C.3    Malcolm, J.B.4    Lamar, K.D.5    Patterson, A.L.6    Kitabchi, A.E.7    Wake, R.W.8
  • 34
    • 34447119419 scopus 로고    scopus 로고
    • The effects of hypogonadism on body composition and bone mineral density in type 2 diabetic patients
    • doi:10.2337/dc07-0337
    • Dhindsa S, Bhatia V, Dhindsa G, Chaudhuri A, Gollapudi GM & Dandona P 2007 The effects of hypogonadism on body composition and bone mineral density in type 2 diabetic patients. Diabetes Care 30 1860-1861. (doi:10.2337/dc07-0337)
    • (2007) Diabetes Care , vol.30 , pp. 1860-1861
    • Dhindsa, S.1    Bhatia, V.2    Dhindsa, G.3    Chaudhuri, A.4    Gollapudi, G.M.5    Dandona, P.6
  • 36
    • 1842833569 scopus 로고    scopus 로고
    • Effect of testosterone on lipolysis in human preadipocytes from different fat depots
    • doi:10.1007/s00125-003-1324-0
    • Dicker A, Rydén M, Näslund E, Muehlen IE, Wirén M, Lafontan M & Arner P 2004 Effect of testosterone on lipolysis in human preadipocytes from different fat depots. Diabetologia 47 420-428. (doi:10.1007/s00125-003-1324-0)
    • (2004) Diabetologia , vol.47 , pp. 420-428
    • Dicker, A.1    Rydén, M.2    Näslund, E.3    Muehlen, I.E.4    Wirén, M.5    Lafontan, M.6    Arner, P.7
  • 37
    • 33644981693 scopus 로고    scopus 로고
    • Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and metaanalysis
    • doi:10.1001/jama.295.11.1288
    • Ding EL, Song Y, Malik VS & Liu S 2006 Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and metaanalysis. Journal of the American Medical Association 295 1288-1299. (doi:10.1001/jama.295.11.1288)
    • (2006) Journal of the American Medical Association , vol.295 , pp. 1288-1299
    • Ding, E.L.1    Song, Y.2    Malik, V.S.3    Liu, S.4
  • 38
    • 77953807871 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase and insulin signaling - what is the molecular switch?
    • doi:10.1016/j.bbabio.2010.02.007
    • Dobrzyn P, Jazurek M & Dobrzyn A 2010 Stearoyl-CoA desaturase and insulin signaling - what is the molecular switch?. Biochimica et Biophysica Acta 1797 1189-1904. (doi:10.1016/j.bbabio.2010.02.007)
    • (2010) Biochimica et Biophysica Acta , vol.1797 , pp. 1189-1904
    • Dobrzyn, P.1    Jazurek, M.2    Dobrzyn, A.3
  • 39
    • 0037326906 scopus 로고    scopus 로고
    • Testosterone suppression in men with prostate cancer leads to an increase in arterial stiffness and hyperinsulinaemia
    • doi:10.1042/CS20020209
    • Dockery F, Bulpitt CJ, Agarwal S, Donaldson M & Rajkumar C 2003 Testosterone suppression in men with prostate cancer leads to an increase in arterial stiffness and hyperinsulinaemia. Clinical Science 104 195-201. (doi:10.1042/CS20020209)
    • (2003) Clinical Science , vol.104 , pp. 195-201
    • Dockery, F.1    Bulpitt, C.J.2    Agarwal, S.3    Donaldson, M.4    Rajkumar, C.5
  • 40
    • 74949085842 scopus 로고    scopus 로고
    • Testosterone inhibits the activity of peroxisome proliferator-activated receptor g in a transcriptional transaction assay
    • Du J, Zhang L & Wang Z 2009 Testosterone inhibits the activity of peroxisome proliferator-activated receptor g in a transcriptional transaction assay. Die Pharmazie 64 692-693.
    • (2009) Die Pharmazie , vol.64 , pp. 692-693
    • Du, J.1    Zhang, L.2    Wang, Z.3
  • 41
    • 0024500560 scopus 로고
    • Lipoprotein lipase. A multifunctional enzyme relevant to common metabolic diseases
    • doi:10.1056/NEJM908904203201607
    • Eckel RH 1989 Lipoprotein lipase. A multifunctional enzyme relevant to common metabolic diseases. New England Journal of Medicine 320 1060-1068. (doi:10.1056/NEJM908904203201607)
    • (1989) New England Journal of Medicine , vol.320 , pp. 1060-1068
    • Eckel, R.H.1
  • 42
    • 77951787502 scopus 로고    scopus 로고
    • Metabolic sequelae associated with androgen deprivation therapy for prostate cancer
    • doi:10.1097/MED. 0b013e3283391fd1
    • Faris JE & Smith MR 2010 Metabolic sequelae associated with androgen deprivation therapy for prostate cancer. Current Opinion in Endocrinology, Diabetes, and Obesity 17 240-246. (doi:10.1097/MED. 0b013e3283391fd1)
    • (2010) Current Opinion in Endocrinology, Diabetes, and Obesity , vol.17 , pp. 240-246
    • Faris, J.E.1    Smith, M.R.2
  • 43
    • 0031768209 scopus 로고    scopus 로고
    • The stimulatory effect of leptin on the neuroendocrine reproductive axis of the monkey
    • doi:10.1210/ en.139.11.4652
    • Finn PD, Cunningham MJ, Pau KY, Spies HG, Clifton DK & Steiner RA 1998 The stimulatory effect of leptin on the neuroendocrine reproductive axis of the monkey. Endocrinology 139 4652-4662. (doi:10.1210/ en.139.11.4652)
    • (1998) Endocrinology , vol.139 , pp. 4652-4662
    • Finn, P.D.1    Cunningham, M.J.2    Pau, K.Y.3    Spies, H.G.4    Clifton, D.K.5    Steiner, R.A.6
  • 44
    • 84862326636 scopus 로고    scopus 로고
    • Testosterone therapy increased muscle mass and lipid oxidation in aging men
    • doi:10.1007/s11357-011-9213-9
    • Frederiksen L, Højlund K, Hougaard DM, Brixen K & Andersen M 2012a Testosterone therapy increased muscle mass and lipid oxidation in aging men. Age 34 145-156. (doi:10.1007/s11357-011-9213-9)
    • (2012) Age , vol.34 , pp. 145-156
    • Frederiksen, L.1    Højlund, K.2    Hougaard, D.M.3    Brixen, K.4    Andersen, M.5
  • 46
    • 0033674551 scopus 로고    scopus 로고
    • Anthropometric, computed tomography and fat cell data in an obese population: relationship with insulin, leptin, tumor necrosis factor-a, sex hormone-binding globulin and sex hormones
    • doi:10.1530/eje.0.1430657
    • Garaulet M, Pérex-Llamas F, Fuente T, Zamora S & Tebar FJ 2000 Anthropometric, computed tomography and fat cell data in an obese population: relationship with insulin, leptin, tumor necrosis factor-a, sex hormone-binding globulin and sex hormones. European Journal of Endocrinology 143 657-666. (doi:10.1530/eje.0.1430657)
    • (2000) European Journal of Endocrinology , vol.143 , pp. 657-666
    • Garaulet, M.1    Pérex-Llamas, F.2    Fuente, T.3    Zamora, S.4    Tebar, F.J.5
  • 47
    • 18144375206 scopus 로고    scopus 로고
    • Identification of two functional estrogen response elements complexed with AP-1-like sites in the human insulin receptor gene promoter
    • doi:10.1016/j.jsbmb.2004.12.020
    • García-Arencibia M, Dávila N, Campión J, Carmen Carranza M & Calle C 2005 Identification of two functional estrogen response elements complexed with AP-1-like sites in the human insulin receptor gene promoter. Journal of Steroid Biochemistry and Molecular Biology 94 1-14. (doi:10.1016/j.jsbmb.2004.12.020)
    • (2005) Journal of Steroid Biochemistry and Molecular Biology , vol.94 , pp. 1-14
    • García-Arencibia, M.1    Dávila, N.2    Campión, J.3    Carmen Carranza, M.4    Calle, C.5
  • 48
    • 77954647851 scopus 로고    scopus 로고
    • Hypothesis: kisspeptin mediates male hypogonadism in obesity and type 2 diabetes
    • doi:10.1159/000299767
    • George JT, Millar RP & Anderson RA 2010 Hypothesis: kisspeptin mediates male hypogonadism in obesity and type 2 diabetes. Neuroendocrinology 91 302-307. (doi:10.1159/000299767)
    • (2010) Neuroendocrinology , vol.91 , pp. 302-307
    • George, J.T.1    Millar, R.P.2    Anderson, R.A.3
  • 49
    • 23044485112 scopus 로고    scopus 로고
    • Growth hormone and testosterone interact positively to enhance protein and energy metabolism in hypopituitary men
    • Endocrinology and Metabolism,(doi:10.1152/ ajpendo.00483.2004)
    • Gibney J, Wolthers T, Johannsson G, Umpleby AM & Ho KK 2005 Growth hormone and testosterone interact positively to enhance protein and energy metabolism in hypopituitary men. American Journal of Physiology. Endocrinology and Metabolism 289 E266-E271. (doi:10.1152/ ajpendo.00483.2004)
    • (2005) American Journal of Physiology , vol.289
    • Gibney, J.1    Wolthers, T.2    Johannsson, G.3    Umpleby, A.M.4    Ho, K.K.5
  • 52
    • 0018234212 scopus 로고
    • Increased adipose tissue lipoprotein lipase activity during the development of the genetically obese rat (fa/fa)
    • doi:10.1016/ S0026-0495(78)80012-2
    • Gruen R, Hietanen E & Greenwood MR 1978 Increased adipose tissue lipoprotein lipase activity during the development of the genetically obese rat (fa/fa). Metabolism 12(Suppl 2) 1955-9066. (doi:10.1016/ S0026-0495(78)80012-2)
    • (1978) Metabolism 12(Suppl , vol.2 , pp. 1955-9066
    • Gruen, R.1    Hietanen, E.2    Greenwood, M.R.3
  • 54
    • 0027131198 scopus 로고
    • Relationship of sex hormones to lipids and lipoproteins in non-diabetic men
    • doi:10.1210/ jc.77.6.1610
    • Haffner S, Mykkanen L, Valdez R & Katz M 1993 Relationship of sex hormones to lipids and lipoproteins in non-diabetic men. Journal of Clinical Endocrinology and Metabolism 77 1610-1615. (doi:10.1210/ jc.77.6.1610)
    • (1993) Journal of Clinical Endocrinology and Metabolism , vol.77 , pp. 1610-1615
    • Haffner, S.1    Mykkanen, L.2    Valdez, R.3    Katz, M.4
  • 55
    • 0029874336 scopus 로고    scopus 로고
    • Low levels of sex hormone binding globulin and testosterone predict the development of non insulin dependent diabetes mellitus in men
    • doi:10.1093/oxfordjournals.aje.a008832
    • Haffner SM, Shaten J, Stern MP, Smith GD & Kuller L 1996 Low levels of sex hormone binding globulin and testosterone predict the development of non insulin dependent diabetes mellitus in men. American Journal of Epidemiology 143 889-897. (doi:10.1093/oxfordjournals.aje.a008832)
    • (1996) American Journal of Epidemiology , vol.143 , pp. 889-897
    • Haffner, S.M.1    Shaten, J.2    Stern, M.P.3    Smith, G.D.4    Kuller, L.5
  • 56
    • 36348951600 scopus 로고    scopus 로고
    • Effect of androgen deprivation on glycaemic control and on cardiovascular risk factors in men with advanced prostate cancer with diabetes
    • doi:10.1080/13685530701653538
    • Haider A, Yassin A, Saad F & Shabsigh R 2007 Effect of androgen deprivation on glycaemic control and on cardiovascular risk factors in men with advanced prostate cancer with diabetes. Aging Male 10 189-906. (doi:10.1080/13685530701653538)
    • (2007) Aging Male , vol.10 , pp. 189-906
    • Haider, A.1    Yassin, A.2    Saad, F.3    Shabsigh, R.4
  • 58
    • 79851506306 scopus 로고    scopus 로고
    • Increase in visceral and subcutaneous abdominal fat in men with prostate cancer treated with androgen deprivation therapy
    • doi:10.1111/ j.1365-2265.2010.03942.x
    • Hamilton EJ, Gianatti E, Strauss BJ, Wentworth J, Lim-Joon D, Bolton D, Zajac JD & Grossmann M 2011 Increase in visceral and subcutaneous abdominal fat in men with prostate cancer treated with androgen deprivation therapy. Clinical Endocrinology 74 377-383. (doi:10.1111/ j.1365-2265.2010.03942.x)
    • (2011) Clinical Endocrinology , vol.74 , pp. 377-383
    • Hamilton, E.J.1    Gianatti, E.2    Strauss, B.J.3    Wentworth, J.4    Lim-Joon, D.5    Bolton, D.6    Zajac, J.D.7    Grossmann, M.8
  • 59
    • 0019276024 scopus 로고
    • The influence of sexual hormones on lipogenesis and lipolysis in rat fat cells
    • Hansen FM, Fahmy N & Nielsen JH 1980 The influence of sexual hormones on lipogenesis and lipolysis in rat fat cells. Acta Endocrinologica 95 566-570.
    • (1980) Acta Endocrinologica , vol.95 , pp. 566-570
    • Hansen, F.M.1    Fahmy, N.2    Nielsen, J.H.3
  • 62
    • 0035143822 scopus 로고    scopus 로고
    • Differential regulation of gonadotropin secretion by testosterone in the human male: absence of a negative feedback effect of testosterone on follicle-stimulating hormone secretion
    • doi:10.1210/jc.86.1.53
    • Hayes FJ, DeCruz S, Seminara SB, Boepple PA & Crowley WF Jr 2001 Differential regulation of gonadotropin secretion by testosterone in the human male: absence of a negative feedback effect of testosterone on follicle-stimulating hormone secretion. Journal of Clinical Endocrinology and Metabolism 86 53-58. (doi:10.1210/jc.86.1.53)
    • (2001) Journal of Clinical Endocrinology and Metabolism , vol.86 , pp. 53-58
    • Hayes, F.J.1    DeCruz, S.2    Seminara, S.B.3    Boepple, P.A.4    Crowley, W.F.Jr.5
  • 63
    • 0034791515 scopus 로고    scopus 로고
    • Androgens stimulate lipogenic gene expression in prostate cancer cells by activation of the sterol regulatory element-binding protein cleavage activating protein/sterol regulatory element-binding protein pathway
    • doi:10.1210/me.15.10.1817
    • Heemers H, Maes B, Foufelle F, Heyns W, Verhoeven G & Swinnen JV 2001 Androgens stimulate lipogenic gene expression in prostate cancer cells by activation of the sterol regulatory element-binding protein cleavage activating protein/sterol regulatory element-binding protein pathway. Molecular Endocrinology 15 1817-1828. (doi:10.1210/me.15.10.1817)
    • (2001) Molecular Endocrinology , vol.15 , pp. 1817-1828
    • Heemers, H.1    Maes, B.2    Foufelle, F.3    Heyns, W.4    Verhoeven, G.5    Swinnen, J.V.6
  • 64
    • 3142739478 scopus 로고    scopus 로고
    • Identification of an androgen response element in intron 8 of the sterol regulatory element-binding protein cleavageactivating protein gene allowing direct regulation by the androgen receptor
    • doi:10.1074/jbc.M401615200
    • Heemers H, Verrijdt G, Organe S, Claessens F, Heyns W, Verhoeven G & Swinnen JV 2004 Identification of an androgen response element in intron 8 of the sterol regulatory element-binding protein cleavageactivating protein gene allowing direct regulation by the androgen receptor. Journal of Biological Chemistry 279 30880-30887. (doi:10.1074/jbc.M401615200)
    • (2004) Journal of Biological Chemistry , vol.279 , pp. 30880-30887
    • Heemers, H.1    Verrijdt, G.2    Organe, S.3    Claessens, F.4    Heyns, W.5    Verhoeven, G.6    Swinnen, J.V.7
  • 65
    • 69949178483 scopus 로고    scopus 로고
    • Fifty-two-week treatment with diet and exercise plus transdermal testosterone reverses the metabolic syndrome and improves glycemic control in men with newly diagnosed type 2 diabetes and subnormal plasma testosterone
    • doi:10.2164/jandrol.108.007005
    • Heufelder AE, Saad F, Bunck MC & Gooren L 2009 Fifty-two-week treatment with diet and exercise plus transdermal testosterone reverses the metabolic syndrome and improves glycemic control in men with newly diagnosed type 2 diabetes and subnormal plasma testosterone. Journal of Andrology 30 726-733. (doi:10.2164/jandrol.108.007005)
    • (2009) Journal of Andrology , vol.30 , pp. 726-733
    • Heufelder, A.E.1    Saad, F.2    Bunck, M.C.3    Gooren, L.4
  • 66
    • 84862908756 scopus 로고    scopus 로고
    • Activation of androgen receptor, lipogenesis, and oxidative stress converged by SREBP-1 is responsible for regulating growth and progression of prostate cancer cells
    • doi:10.1158/1541-7786. MCR-11-0206
    • Huang WC, Li X, Liu J, Lin J & Chung LW 2012 Activation of androgen receptor, lipogenesis, and oxidative stress converged by SREBP-1 is responsible for regulating growth and progression of prostate cancer cells. Molecular Cancer Research 10 133-142. (doi:10.1158/1541-7786. MCR-11-0206)
    • (2012) Molecular Cancer Research , vol.10 , pp. 133-142
    • Huang, W.C.1    Li, X.2    Liu, J.3    Lin, J.4    Chung, L.W.5
  • 68
    • 24144489427 scopus 로고    scopus 로고
    • Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a metaanalysis
    • doi:10.1111/j.1365-2265. 2005.02339.x
    • Isidori AM, Giannetta E, Greco EA, Gianfrilli D, Bonifacio V, Isidori A, Lenzi A & Fabbri A 2005 Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a metaanalysis. Clinical Endocrinology 63 280-293. (doi:10.1111/j.1365-2265. 2005.02339.x)
    • (2005) Clinical Endocrinology , vol.63 , pp. 280-293
    • Isidori, A.M.1    Giannetta, E.2    Greco, E.A.3    Gianfrilli, D.4    Bonifacio, V.5    Isidori, A.6    Lenzi, A.7    Fabbri, A.8
  • 69
    • 0036300538 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkB-a
    • doi:10.2337/diabetes.51.7.2005
    • Itani SI, Ruderman NB, Schmieder F & Boden G 2002 Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkB-a. Diabetes 51 2005-2011. (doi:10.2337/diabetes.51.7.2005)
    • (2002) Diabetes , vol.51 , pp. 2005-2011
    • Itani, S.I.1    Ruderman, N.B.2    Schmieder, F.3    Boden, G.4
  • 71
    • 34548028223 scopus 로고    scopus 로고
    • Testosterone associations with erectile dysfunction, diabetes and the metabolic syndrome
    • doi:10.1016/j.eursup.2007.07.002
    • Jones TH 2007 Testosterone associations with erectile dysfunction, diabetes and the metabolic syndrome. European Urology Supplements 6 847-857. (doi:10.1016/j.eursup.2007.07.002)
    • (2007) European Urology Supplements , vol.6 , pp. 847-857
    • Jones, T.H.1
  • 72
    • 77955272470 scopus 로고    scopus 로고
    • Testosterone deficiency: a risk factor for cardiovascular disease?
    • doi:10.1016/j.tem.2010.03.002
    • Jones TH 2010a Testosterone deficiency: a risk factor for cardiovascular disease?. Trends in Endocrinology and Metabolism 21 496-503. (doi:10.1016/j.tem.2010.03.002)
    • (2010) Trends in Endocrinology and Metabolism , vol.21 , pp. 496-503
    • Jones, T.H.1
  • 73
    • 77955822370 scopus 로고    scopus 로고
    • Effects of testosterone on type 2 diabetes and components of the metabolic syndrome
    • doi:10.1111/ j.1753-0407.2010.00085.x
    • Jones TH 2010b Effects of testosterone on type 2 diabetes and components of the metabolic syndrome. Journal of Diabetes 2 146-156. (doi:10.1111/ j.1753-0407.2010.00085.x)
    • (2010) Journal of Diabetes , vol.2 , pp. 146-156
    • Jones, T.H.1
  • 74
    • 84859004310 scopus 로고    scopus 로고
    • Cardiovascular risk during androgen deprivation therapy for prostate cancer
    • doi:10.1136/bmj.d3105)
    • Jones TH 2011 Cardiovascular risk during androgen deprivation therapy for prostate cancer. BMJ 342 d3105. (doi:10.1136/bmj.d3105)
    • (2011) BMJ , vol.342
    • Jones, T.H.1
  • 75
    • 70549086629 scopus 로고    scopus 로고
    • The effects of testosterone on risk factors for, and the mediators of, the atherosclerotic process
    • doi:10.1016/j.atherosclerosis.2009.04.016
    • Jones TH & Saad F 2009 The effects of testosterone on risk factors for, and the mediators of, the atherosclerotic process. Atherosclerosis 207 318-327. (doi:10.1016/j.atherosclerosis.2009.04.016)
    • (2009) Atherosclerosis , vol.207 , pp. 318-327
    • Jones, T.H.1    Saad, F.2
  • 77
    • 78449294931 scopus 로고    scopus 로고
    • Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: the double-blinded placebo-controlled Moscow study
    • doi:10.1111/j.1365-2265. 2010.03845.x
    • Kalinchenko SY, Tishova YA, Mskhalaya GJ, Gooren LJ, Giltay EJ & Saad F 2010 Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: the double-blinded placebo-controlled Moscow study. Clinical Endocrinology 73 602-612. (doi:10.1111/j.1365-2265. 2010.03845.x)
    • (2010) Clinical Endocrinology , vol.73 , pp. 602-612
    • Kalinchenko, S.Y.1    Tishova, Y.A.2    Mskhalaya, G.J.3    Gooren, L.J.4    Giltay, E.J.5    Saad, F.6
  • 78
    • 24144493455 scopus 로고    scopus 로고
    • Androgens, insulin resistance and vascular disease in men
    • doi:10.1111/j.1365-2265.2005.02299.x
    • Kapoor D, Malkin CJ, Channer KS & Jones TH 2005 Androgens, insulin resistance and vascular disease in men. Clinical Endocrinology 63 239-250. (doi:10.1111/j.1365-2265.2005.02299.x)
    • (2005) Clinical Endocrinology , vol.63 , pp. 239-250
    • Kapoor, D.1    Malkin, C.J.2    Channer, K.S.3    Jones, T.H.4
  • 79
    • 33745684473 scopus 로고    scopus 로고
    • Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes
    • doi:10.1530/eje.1.02166
    • Kapoor D, Goodwin E, Channer KS & Jones TH 2006 Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes. European Journal of Endocrinology 154 899-906. (doi:10.1530/eje.1.02166)
    • (2006) European Journal of Endocrinology , vol.154 , pp. 899-906
    • Kapoor, D.1    Goodwin, E.2    Channer, K.S.3    Jones, T.H.4
  • 80
    • 34147104552 scopus 로고    scopus 로고
    • Clinical and biochemical assessment of hypogonadism in men with type 2 diabetes: correlations with bioavailable testosterone and visceral adiposity
    • doi:10.2337/dc06-1426
    • Kapoor D, Aldred H, Clark S, Channer KS & Jones TH 2007a Clinical and biochemical assessment of hypogonadism in men with type 2 diabetes: correlations with bioavailable testosterone and visceral adiposity. Diabetes Care 30 911-917. (doi:10.2337/dc06-1426)
    • (2007) Diabetes Care , vol.30 , pp. 911-917
    • Kapoor, D.1    Aldred, H.2    Clark, S.3    Channer, K.S.4    Jones, T.H.5
  • 81
    • 34249103249 scopus 로고    scopus 로고
    • The effects of testosterone replacement therapy on adipocytokines and C-reactive protein in hypogonadal men with type 2 diabetes
    • doi:10.1530/EJE-06-0737
    • Kapoor D, Clark S, Stanworth R, Channer KS & Jones TH 2007b The effects of testosterone replacement therapy on adipocytokines and C-reactive protein in hypogonadal men with type 2 diabetes. European Journal of Endocrinology 156 595-602. (doi:10.1530/EJE-06-0737)
    • (2007) European Journal of Endocrinology , vol.156 , pp. 595-602
    • Kapoor, D.1    Clark, S.2    Stanworth, R.3    Channer, K.S.4    Jones, T.H.5
  • 82
    • 33749058933 scopus 로고    scopus 로고
    • Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancer
    • doi:10.1200/JCO.2006. 06.2497
    • Keating NL, O'Malley AJ & Smith MR 2006 Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancer. Journal of Clinical Oncology 24 4448-4456. (doi:10.1200/JCO.2006. 06.2497)
    • (2006) Journal of Clinical Oncology , vol.24 , pp. 4448-4456
    • Keating, N.L.1    O'Malley, A.J.2    Smith, M.R.3
  • 83
    • 0034076660 scopus 로고    scopus 로고
    • Fuel selection in human skeletal muscle in insulin resistance: a reexamination
    • doi:10.2337/ diabetes.49.5.677
    • Kelley DE & Mandarino LJ 2000 Fuel selection in human skeletal muscle in insulin resistance: a reexamination. Diabetes 49 677-683. (doi:10.2337/ diabetes.49.5.677)
    • (2000) Diabetes , vol.49 , pp. 677-683
    • Kelley, D.E.1    Mandarino, L.J.2
  • 84
    • 84878776339 scopus 로고    scopus 로고
    • Testosterone increases hepatic liver X receptor and ApoE expression and improves lipid metabolism in the testicular feminized mouse: a potential protective mechanism against atherosclerosis and fatty liver disease
    • Kelly DM, Akhtar S, Brooke JC, Muraleedharan V, Channer KS & Jones TH 2012 Testosterone increases hepatic liver X receptor and ApoE expression and improves lipid metabolism in the testicular feminized mouse: a potential protective mechanism against atherosclerosis and fatty liver disease. Endocrine Reviews 33 OR22-OR25.
    • (2012) Endocrine Reviews , vol.33
    • Kelly, D.M.1    Akhtar, S.2    Brooke, J.C.3    Muraleedharan, V.4    Channer, K.S.5    Jones, T.H.6
  • 85
    • 33845881411 scopus 로고    scopus 로고
    • Mechanisms linking obesity to insulin resistance and type 2 diabetes
    • doi:10.1038/nature05482
    • Kahn SE, Hull RL & Utzschneider KM 2006 Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444 840-846. (doi:10.1038/nature05482)
    • (2006) Nature , vol.444 , pp. 840-846
    • Kahn, S.E.1    Hull, R.L.2    Utzschneider, K.M.3
  • 86
    • 37349118353 scopus 로고    scopus 로고
    • Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men: European prospective investigation into cancer in Norfolk (EPIC-Norfolk) Prospective Population Study
    • doi:10.1161/CIRCULATIONAHA. 107.790005
    • Khaw KT, DowsettM, Folkerd E, Bingham S, Wareham N, Luben R,Welch A & Day N 2007 Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men: European prospective investigation into cancer in Norfolk (EPIC-Norfolk) Prospective Population Study. Circulation 116 2694-2701. (doi:10.1161/CIRCULATIONAHA. 107.790005)
    • (2007) Circulation , vol.116 , pp. 2694-2701
    • Khaw, K.T.1    Dowsett, M.2    Folkerd, E.3    Bingham, S.4    Wareham, N.5    Luben, R.6    Welch, A.7    Day, N.8
  • 88
    • 0016784308 scopus 로고
    • Steroid hormones and their binding in plasma of male patients with fatty liver, chronic hepatitis and liver cirrhosis
    • Kley HK, Nieschlag E,WiegelmannW, Solbach HG & Krüskemper HL 1975 Steroid hormones and their binding in plasma of male patients with fatty liver, chronic hepatitis and liver cirrhosis. Acta Endocrinologica 79 275-285.
    • (1975) Acta Endocrinologica , vol.79 , pp. 275-285
    • Kley, H.K.1    Nieschlag, E.2    Wiegelmann, W.3    Solbach, H.G.4    Krüskemper, H.L.5
  • 91
    • 33644828241 scopus 로고    scopus 로고
    • Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in non-obese men
    • doi:10.1210/jc.2005-1326
    • Kupelian V, Page ST, Araujo AB, Travison TG, Bremner WJ & McKinlay JB 2006 Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in non-obese men. Journal of Clinical Endocrinology and Metabolism 91 843-850. (doi:10.1210/jc.2005-1326)
    • (2006) Journal of Clinical Endocrinology and Metabolism , vol.91 , pp. 843-850
    • Kupelian, V.1    Page, S.T.2    Araujo, A.B.3    Travison, T.G.4    Bremner, W.J.5    McKinlay, J.B.6
  • 94
    • 1842684155 scopus 로고    scopus 로고
    • Serum adiponectin levels in hypogonadal males: influence of testosterone replacement therapy
    • doi:10.1111/ j.1365-2265.2004.02007.x
    • Lanfranco F, Zitzmann M, Simoni M & Nieschlag E 2004 Serum adiponectin levels in hypogonadal males: influence of testosterone replacement therapy. Clinical Endocrinology 60 500-507. (doi:10.1111/ j.1365-2265.2004.02007.x)
    • (2004) Clinical Endocrinology , vol.60 , pp. 500-507
    • Lanfranco, F.1    Zitzmann, M.2    Simoni, M.3    Nieschlag, E.4
  • 95
    • 84873791571 scopus 로고
    • The effect of castration and testosterone propionate injection on glycogen storage in skeletal muscle
    • doi:10.1210/endo-51-4-293
    • Leonard SL 1952 The effect of castration and testosterone propionate injection on glycogen storage in skeletal muscle. Endocrinology 51 293-297. (doi:10.1210/endo-51-4-293)
    • (1952) Endocrinology , vol.51 , pp. 293-297
    • Leonard, S.L.1
  • 96
    • 77149172555 scopus 로고    scopus 로고
    • Androgen deprivation therapy in prostate cancer and cardiovascular risk: a science advisory from the American Heart Association, American Cancer Society and American Urological Association: endorsed by the American Society for Radiation Oncology
    • doi:10.1161/CIRCULATIONAHA.109.902695
    • Levine GN, D'Amico AV, Berger P, Clark PE, Eckel RH, Keating NL, Milani RV, Sagalowsky AI, Smith MR & Zakai N 2010 Androgen deprivation therapy in prostate cancer and cardiovascular risk: a science advisory from the American Heart Association, American Cancer Society and American Urological Association: endorsed by the American Society for Radiation Oncology. Circulation 121 833-840. (doi:10.1161/CIRCULATIONAHA.109.902695)
    • (2010) Circulation , vol.121 , pp. 833-840
    • Levine, G.N.1    D'Amico, A.V.2    Berger, P.3    Clark, P.E.4    Eckel, R.H.5    Keating, N.L.6    Milani, R.V.7    Sagalowsky, A.I.8    Smith, M.R.9    Zakai, N.10
  • 97
    • 57949086076 scopus 로고    scopus 로고
    • Fat in liver/muscle correlates more strongly with insulin sensitivity in rats than abdominal fat
    • doi:10.1038/oby.2008.486
    • Lim S, Son KR, Song IC, Park HS, Jin CJ, Jang HC, Park KS, Kim YB & Lee HK 2008 Fat in liver/muscle correlates more strongly with insulin sensitivity in rats than abdominal fat. Obesity 17 188-905. (doi:10.1038/oby.2008.486)
    • (2008) Obesity , vol.17 , pp. 188-905
    • Lim, S.1    Son, K.R.2    Song, I.C.3    Park, H.S.4    Jin, C.J.5    Jang, H.C.6    Park, K.S.7    Kim, Y.B.8    Lee, H.K.9
  • 99
    • 64649104155 scopus 로고    scopus 로고
    • Sex and depot differences in adipocyte insulin sensitivity and glucose metabolism
    • doi:10.2337/db08-1054
    • Macotela Y, Boucher J, Tran TT & Kahn CR 2009 Sex and depot differences in adipocyte insulin sensitivity and glucose metabolism. Diabetes 58 803-812. (doi:10.2337/db08-1054)
    • (2009) Diabetes , vol.58 , pp. 803-812
    • Macotela, Y.1    Boucher, J.2    Tran, T.T.3    Kahn, C.R.4
  • 101
    • 23744443912 scopus 로고    scopus 로고
    • Hypogonadism and metabolic syndrome: implications for testosterone therapy
    • doi:10.1097/01.ju.0000169490.78443.59
    • Makhsida N, Shah J, Yan G, Fisch H & Shabsigh R 2005 Hypogonadism and metabolic syndrome: implications for testosterone therapy. Journal of Urology 174 827-834. (doi:10.1097/01.ju.0000169490.78443.59)
    • (2005) Journal of Urology , vol.174 , pp. 827-834
    • Makhsida, N.1    Shah, J.2    Yan, G.3    Fisch, H.4    Shabsigh, R.5
  • 102
    • 3242717140 scopus 로고    scopus 로고
    • Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life
    • doi:10.1136/hrt.2003.021121
    • Malkin CJ, Pugh PJ, Morris PD, Kerry KE, Jones RD, Jones TH & Channer KS 2004a Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life. Heart 19 871-876. (doi:10.1136/hrt.2003.021121)
    • (2004) Heart , vol.19 , pp. 871-876
    • Malkin, C.J.1    Pugh, P.J.2    Morris, P.D.3    Kerry, K.E.4    Jones, R.D.5    Jones, T.H.6    Channer, K.S.7
  • 103
    • 3242667701 scopus 로고    scopus 로고
    • The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men
    • doi:10.1210/jc.2003- 031069
    • Malkin CJ, Pugh PJ, Jones RD, Kapoor D, Channer KS & Jones TH 2004b The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men. Journal of Clinical Endocrinology and Metabolism 89 3313-3318. (doi:10.1210/jc.2003- 031069)
    • (2004) Journal of Clinical Endocrinology and Metabolism , vol.89 , pp. 3313-3318
    • Malkin, C.J.1    Pugh, P.J.2    Jones, R.D.3    Kapoor, D.4    Channer, K.S.5    Jones, T.H.6
  • 104
    • 33846045511 scopus 로고    scopus 로고
    • The effect of testosterone on insulin sensitivity in men with heart failure
    • doi:10.1016/j.ejheart.2006.04.006
    • Malkin CJ, Jones TH & Channer KS 2007 The effect of testosterone on insulin sensitivity in men with heart failure. European Journal of Heart Failure 9 44-50. (doi:10.1016/j.ejheart.2006.04.006)
    • (2007) European Journal of Heart Failure , vol.9 , pp. 44-50
    • Malkin, C.J.1    Jones, T.H.2    Channer, K.S.3
  • 105
    • 0033586747 scopus 로고    scopus 로고
    • The role of leptin in human obesity and disease: a review of current evidence
    • Mårin P & Arver S 1998 Androgens and abdominal obesity. Baillière's Clinical Endocrinology and Metabolism 12 441-451. (doi:10.1016/S0950- 351X(98)80901-2
    • Mantzoros CS 1999 The role of leptin in human obesity and disease: a review of current evidence. Annals of Internal Medicine 130 671-680. Mårin P & Arver S 1998 Androgens and abdominal obesity. Baillière's Clinical Endocrinology and Metabolism 12 441-451. (doi:10.1016/S0950- 351X(98)80901-2)
    • (1999) Annals of Internal Medicine , vol.130 , pp. 671-680
    • Mantzoros, C.S.1
  • 106
    • 0026929033 scopus 로고
    • Androgen treatment of middle-aged, obese men: effects on metabolism, muscle and adipose tissues
    • Mårin P, Krotkiewski M & Bjorntorp P 1992a Androgen treatment of middle-aged, obese men: effects on metabolism, muscle and adipose tissues. European Journal of Medicine 1 329-336.
    • (1992) European Journal of Medicine , vol.1 , pp. 329-336
    • Mårin, P.1    Krotkiewski, M.2    Bjorntorp, P.3
  • 108
    • 0028797188 scopus 로고
    • Assimilation and mobilization of triglycerides in subcutaneous abdominal and femoral adipose tissue in vivo in men: effects of androgens
    • doi:10.1210/jc.80.1.239
    • Mårin P, Odén B & Björntorp P 1995 Assimilation and mobilization of triglycerides in subcutaneous abdominal and femoral adipose tissue in vivo in men: effects of androgens. Journal of Clinical Endocrinology and Metabolism 80 239-243. (doi:10.1210/jc.80.1.239)
    • (1995) Journal of Clinical Endocrinology and Metabolism , vol.80 , pp. 239-243
    • Mårin, P.1    Odén, B.2    Björntorp, P.3
  • 111
    • 0021749029 scopus 로고
    • Androgen-estrogen synergy in rat levator ani muscle: glucose- 6-phosphate dehydrogenase
    • doi:10.1016/0303-7207(84)90108-4
    • Max SR 1984 Androgen-estrogen synergy in rat levator ani muscle: glucose- 6-phosphate dehydrogenase. Molecular and Cellular Endocrinology 38 103-107. (doi:10.1016/0303-7207(84)90108-4)
    • (1984) Molecular and Cellular Endocrinology , vol.38 , pp. 103-107
    • Max, S.R.1
  • 112
    • 0018837232 scopus 로고
    • Effect of sex hormones on glucose-6-phosphate dehydrogenase in rat levator ani muscle
    • doi:10.1016/0303-7207(80)90123-9
    • Max SR & Knudsen JF 1980 Effect of sex hormones on glucose-6-phosphate dehydrogenase in rat levator ani muscle. Molecular and Cellular Endocrinology 17 111-118. (doi:10.1016/0303-7207(80)90123-9)
    • (1980) Molecular and Cellular Endocrinology , vol.17 , pp. 111-118
    • Max, S.R.1    Knudsen, J.F.2
  • 113
    • 84860548566 scopus 로고    scopus 로고
    • Deletion of the androgen receptor in adipose tissue in male mice elevates retinol binding protein 4 and reveals independent effects on visceral fat mass and on glucose homeostasis
    • doi:10.2337/db11-1136
    • McInnes KJ, Smith LB, Hunger NI, Saunders PT, Andrew R & Walker BR 2012 Deletion of the androgen receptor in adipose tissue in male mice elevates retinol binding protein 4 and reveals independent effects on visceral fat mass and on glucose homeostasis. Diabetes 61 1072-1081. (doi:10.2337/db11-1136)
    • (2012) Diabetes , vol.61 , pp. 1072-1081
    • McInnes, K.J.1    Smith, L.B.2    Hunger, N.I.3    Saunders, P.T.4    Andrew, R.5    Walker, B.R.6
  • 114
    • 84878773997 scopus 로고    scopus 로고
    • Low testosterone is associated with decreased expression of glut-4 and hexokinase 2 in muscle of the testicular feminised mouse
    • McLaren D, Kelly D, Akhtar S, Channer K & Jones T 2012 Low testosterone is associated with decreased expression of glut-4 and hexokinase 2 in muscle of the testicular feminised mouse. Endocrine Abstracts 29 P559.
    • (2012) Endocrine Abstracts , vol.29 , pp. 559
    • McLaren, D.1    Kelly, D.2    Akhtar, S.3    Channer, K.4    Jones, T.5
  • 115
    • 84860877671 scopus 로고    scopus 로고
    • Testosterone and cardiovascular disease in men
    • doi:10.1038/aja.2012.21
    • Morris PD & Channer KS 2012 Testosterone and cardiovascular disease in men. Asian Journal of Andrology 14 428-435. (doi:10.1038/aja.2012.21)
    • (2012) Asian Journal of Andrology , vol.14 , pp. 428-435
    • Morris, P.D.1    Channer, K.S.2
  • 116
    • 79955962031 scopus 로고    scopus 로고
    • Metabolic syndrome, androgens, and hypertension
    • doi:10.1007/s19006-011-0184-0
    • Moulana M, Lima R & Reckelhoff JF 2011 Metabolic syndrome, androgens, and hypertension. Current Hypertension Reports 13 158-162. (doi:10.1007/s19006-011-0184-0)
    • (2011) Current Hypertension Reports , vol.13 , pp. 158-162
    • Moulana, M.1    Lima, R.2    Reckelhoff, J.F.3
  • 119
    • 84878778681 scopus 로고    scopus 로고
    • Long-term testosterone replacement improves survival in men with type 2 diabetes and hypogonadism
    • 03_Meeting Abstracts)
    • Muraleedharan V, Marsh H, Channer KS & Jones TH 2011 Long-term testosterone replacement improves survival in men with type 2 diabetes and hypogonadism. Endocrine Reviews 32 (03_Meeting Abstracts) OR35-2.
    • (2011) Endocrine Reviews , vol.32 , pp. 35-42
    • Muraleedharan, V.1    Marsh, H.2    Channer, K.S.3    Jones, T.H.4
  • 120
    • 70449728067 scopus 로고    scopus 로고
    • Sex steroids deficiency impairs glucose transporter 4 expression and its translocation through defective Akt phosphorylation in target tissues of adult male rat
    • doi:10.1016/j.metabol.2009.05.010
    • Muthusamy T, Murugesan P & Balasubramanian K 2009 Sex steroids deficiency impairs glucose transporter 4 expression and its translocation through defective Akt phosphorylation in target tissues of adult male rat. Metabolism 58 1581-1592. (doi:10.1016/j.metabol.2009.05.010)
    • (2009) Metabolism , vol.58 , pp. 1581-1592
    • Muthusamy, T.1    Murugesan, P.2    Balasubramanian, K.3
  • 121
    • 79959224996 scopus 로고    scopus 로고
    • Sex steroids influence glucose oxidation through modulation of insulin receptor expression and IRS-1 serine phosphorylation in target tissues of adult male rat
    • doi:10.1007/s11010-011-0737-1
    • Muthusamy T, Murugesan P, Srinivasan C & Balasubramanian K 2011 Sex steroids influence glucose oxidation through modulation of insulin receptor expression and IRS-1 serine phosphorylation in target tissues of adult male rat. Molecular and Cellular Biochemistry 352 35-45. (doi:10.1007/s11010-011-0737-1)
    • (2011) Molecular and Cellular Biochemistry , vol.352 , pp. 35-45
    • Muthusamy, T.1    Murugesan, P.2    Srinivasan, C.3    Balasubramanian, K.4
  • 122
    • 0023191764 scopus 로고
    • Androgen-oestrogen imbalance in men with chronic alcoholism and fatty liver
    • Myking O, Aakvaag A & Digranes O 1987 Androgen-oestrogen imbalance in men with chronic alcoholism and fatty liver. Alcohol and Alcoholism 22 7-15.
    • (1987) Alcohol and Alcoholism , vol.22 , pp. 7-15
    • Myking, O.1    Aakvaag, A.2    Digranes, O.3
  • 123
    • 34249952109 scopus 로고    scopus 로고
    • Inverse relationship between serum levels of interleukin-1b and testosterone in men with stable coronary artery disease
    • doi:10.1055/s-2007-976543
    • Nettleship JE, Pugh PJ, Channer KS, Jones T & Jones RD 2007 Inverse relationship between serum levels of interleukin-1b and testosterone in men with stable coronary artery disease. Hormone and Metabolic Research 39 366-371. (doi:10.1055/s-2007-976543)
    • (2007) Hormone and Metabolic Research , vol.39 , pp. 366-371
    • Nettleship, J.E.1    Pugh, P.J.2    Channer, K.S.3    Jones, T.4    Jones, R.D.5
  • 124
    • 34447131545 scopus 로고    scopus 로고
    • Visceral and subcutaneous adipose tissue assessed by magnetic resonance imaging in relation to circulating androgens, sex hormone-binding globulin, and luteinizing hormone in young men
    • doi:10.1210/jc.2006-1847
    • Nielsen TL, Hagen C, Wraae K, Brixen K, Petersen PH, Haug E, Larsen R & Andersen M 2007 Visceral and subcutaneous adipose tissue assessed by magnetic resonance imaging in relation to circulating androgens, sex hormone-binding globulin, and luteinizing hormone in young men. Journal of Clinical Endocrinology and Metabolism 92 2696-2705. (doi:10.1210/jc.2006-1847)
    • (2007) Journal of Clinical Endocrinology and Metabolism , vol.92 , pp. 2696-2705
    • Nielsen, T.L.1    Hagen, C.2    Wraae, K.3    Brixen, K.4    Petersen, P.H.5    Haug, E.6    Larsen, R.7    Andersen, M.8
  • 126
    • 0036357643 scopus 로고    scopus 로고
    • Endogenous sex hormones and the development of type 2 diabetes in older men and women: the Rancho Bernardo Study
    • doi:10.2337/diacare.25.1.55
    • Oh J, Barrett-Connor E, Wedick N & Wingard D 2002 Endogenous sex hormones and the development of type 2 diabetes in older men and women: the Rancho Bernardo Study. Diabetes Care 25 55-60. (doi:10.2337/diacare.25.1.55)
    • (2002) Diabetes Care , vol.25 , pp. 55-60
    • Oh, J.1    Barrett-Connor, E.2    Wedick, N.3    Wingard, D.4
  • 127
    • 84861440713 scopus 로고    scopus 로고
    • Testosterone and orchidectomy modulates intestinal fluid and glucose transport in Albino Wistar rat
    • Olorunshola KV, Aliyu OF & Achie LN 2012 Testosterone and orchidectomy modulates intestinal fluid and glucose transport in Albino Wistar rat. European Journal of Scientific Research 76 281-287.
    • (2012) European Journal of Scientific Research , vol.76 , pp. 281-287
    • Olorunshola, K.V.1    Aliyu, O.F.2    Achie, L.N.3
  • 128
    • 35948990044 scopus 로고    scopus 로고
    • Retinol-binding protein-4 attenuates insulin-induced phosphorylation of IRS1 and ERK1/2 in primary human adipocytes
    • doi:10.1096/fj.07-8173com
    • Ost A, Danielsson A, Lidén M, Eriksson U, Nystrom FH & Strålfors P 2007 Retinol-binding protein-4 attenuates insulin-induced phosphorylation of IRS1 and ERK1/2 in primary human adipocytes. FASEB Journal 21 3696-3704. (doi:10.1096/fj.07-8173com)
    • (2007) FASEB Journal , vol.21 , pp. 3696-3704
    • Ost, A.1    Danielsson, A.2    Lidén, M.3    Eriksson, U.4    Nystrom, F.H.5    Strålfors, P.6
  • 130
    • 57049111488 scopus 로고    scopus 로고
    • Sex steroids enhance insulin receptors and glucose oxidation in Chang liver cells
    • doi:10.1016/j.cca.2008.09.011
    • Parthasarathy C, Renuka VN & Balasubramanian K 2009 Sex steroids enhance insulin receptors and glucose oxidation in Chang liver cells. Clinica Chimica Acta 399 49-53. (doi:10.1016/j.cca.2008.09.011)
    • (2009) Clinica Chimica Acta , vol.399 , pp. 49-53
    • Parthasarathy, C.1    Renuka, V.N.2    Balasubramanian, K.3
  • 131
    • 0023937649 scopus 로고
    • Influence of androgenic status on the a2/b-adrenergic control of lipolysis in white fat cells: predominant a2-antilipolytic response in testosterone-treatedcastrated hamsters
    • doi:10.1210/ endo-122-6-2590
    • Pecquery R, Leneveu MC & Giudicelli Y 1988 Influence of androgenic status on the a2/b-adrenergic control of lipolysis in white fat cells: predominant a2-antilipolytic response in testosterone-treatedcastrated hamsters. Endocrinology 122 2590-2596. (doi:10.1210/ endo-122-6-2590)
    • (1988) Endocrinology , vol.122 , pp. 2590-2596
    • Pecquery, R.1    Leneveu, M.C.2    Giudicelli, Y.3
  • 132
    • 0033913213 scopus 로고    scopus 로고
    • Signaling pathways in insulin action: molecular targets of insulin resistance
    • doi:10.1172/JCI10582
    • Pessin JE & Saltiel AR 2000 Signaling pathways in insulin action: molecular targets of insulin resistance. Journal of Clinical Investigation 106 165-169. (doi:10.1172/JCI10582)
    • (2000) Journal of Clinical Investigation , vol.106 , pp. 165-169
    • Pessin, J.E.1    Saltiel, A.R.2
  • 133
    • 0027459061 scopus 로고
    • Relationship between serum sex hormones and the glucose-insulin-lipid defect in men with obesity
    • doi:10.1016/0026-0495(93)90181-M
    • Phillips G 1993 Relationship between serum sex hormones and the glucose-insulin-lipid defect in men with obesity. Metabolism 42 116-120. (doi:10.1016/0026-0495(93)90181-M)
    • (1993) Metabolism , vol.42 , pp. 116-120
    • Phillips, G.1
  • 136
    • 0032851030 scopus 로고    scopus 로고
    • Differential response of rat skeletal muscle glycogen metabolism to testosterone and estradiol
    • doi:10.1139/y99-016
    • Ramamani A, Aruldhas MM & Govindarajulu P 1999 Differential response of rat skeletal muscle glycogen metabolism to testosterone and estradiol. Canadian Journal of Physiology and Pharmacology 77 300-304. (doi:10.1139/y99-016)
    • (1999) Canadian Journal of Physiology and Pharmacology , vol.77 , pp. 300-304
    • Ramamani, A.1    Aruldhas, M.M.2    Govindarajulu, P.3
  • 137
    • 0031048003 scopus 로고    scopus 로고
    • Evidence for sex steroid inhibition of lipoprotein lipase in men: comparison of abdominal and femoral adipose tissue
    • doi:10.1016/S0026-0495(97)90299-7
    • Ramirez ME, McMurry MP, Wiebke GA, Felten KJ, Ren K, Meikle AW & Iverius PH 1997 Evidence for sex steroid inhibition of lipoprotein lipase in men: comparison of abdominal and femoral adipose tissue. Metabolism 46 179-185. (doi:10.1016/S0026-0495(97)90299-7)
    • (1997) Metabolism , vol.46 , pp. 179-185
    • Ramirez, M.E.1    McMurry, M.P.2    Wiebke, G.A.3    Felten, K.J.4    Ren, K.5    Meikle, A.W.6    Iverius, P.H.7
  • 139
    • 70349628426 scopus 로고    scopus 로고
    • Body composition alterations, energy expenditure and fat oxidation in elderly males suffering from prostate cancer, pre and post orchiectomy
    • doi:10.1590/S1807-59322009000800012
    • Reis C, Liberman S, Pompeo AC, Srougi M, Halpern A & Jacob FilhoW2009 Body composition alterations, energy expenditure and fat oxidation in elderly males suffering from prostate cancer, pre and post orchiectomy. Clinics 64 781-784. (doi:10.1590/S1807-59322009000800012)
    • (2009) Clinics , vol.64 , pp. 781-784
    • Reis, C.1    Liberman, S.2    Pompeo, A.C.3    Srougi, M.4    Halpern, A.5    Jacob Filho, W.6
  • 141
    • 60149110147 scopus 로고    scopus 로고
    • The role of kisspeptin in the control of gonadotrophin secretion
    • doi:10.1093/humupd/dmn058
    • Roseweir AK & Millar RP 2009 The role of kisspeptin in the control of gonadotrophin secretion. Human Reproduction Update 15 203-212. (doi:10.1093/humupd/dmn058)
    • (2009) Human Reproduction Update , vol.15 , pp. 203-212
    • Roseweir, A.K.1    Millar, R.P.2
  • 142
    • 0041562541 scopus 로고    scopus 로고
    • Involvement of the SREBP pathway in the mode of action of androgens in sebaceous glands in vivo
    • doi:10.1034/j.1600- 0625.2003.00014.x
    • Rosignoli C, Nicolas JC, Jomard A & Michel S 2003 Involvement of the SREBP pathway in the mode of action of androgens in sebaceous glands in vivo. Experimental Dermatology 12 480-489. (doi:10.1034/j.1600- 0625.2003.00014.x)
    • (2003) Experimental Dermatology , vol.12 , pp. 480-489
    • Rosignoli, C.1    Nicolas, J.C.2    Jomard, A.3    Michel, S.4
  • 143
    • 43749115158 scopus 로고    scopus 로고
    • An exploratory study of the effects of 12 month administration of the novel long-acting testosterone undecanoate on measures of sexual function and the metabolic syndrome
    • doi:10.1080/ 01485010701730880
    • Saad F, Gooren L, Haider A & Yassin A 2007 An exploratory study of the effects of 12 month administration of the novel long-acting testosterone undecanoate on measures of sexual function and the metabolic syndrome. Archives of Andrology 53 353-357. (doi:10.1080/ 01485010701730880)
    • (2007) Archives of Andrology , vol.53 , pp. 353-357
    • Saad, F.1    Gooren, L.2    Haider, A.3    Yassin, A.4
  • 144
    • 38049169172 scopus 로고    scopus 로고
    • A dose-response study of testosterone on sexual dysfunction and features of the metabolic syndrome using testosterone gel and parenteral testosterone undecanoate
    • doi:10.2164/jandrol.107. 002774
    • Saad F, Gooren LJ, Haider A & Yassin A 2008 A dose-response study of testosterone on sexual dysfunction and features of the metabolic syndrome using testosterone gel and parenteral testosterone undecanoate. Journal of Andrology 29 102-105. (doi:10.2164/jandrol.107. 002774)
    • (2008) Journal of Andrology , vol.29 , pp. 102-105
    • Saad, F.1    Gooren, L.J.2    Haider, A.3    Yassin, A.4
  • 145
    • 84857778085 scopus 로고    scopus 로고
    • Testosterone as potential effective therapy in treatment of obesity in men with testosterone deficiency: a review
    • doi:10.2174/ 157339912799424573
    • Saad F, Aversa A, Isidori AM & Gooren LJ 2012 Testosterone as potential effective therapy in treatment of obesity in men with testosterone deficiency: a review. Current Diabetes Reports 8 131-143. (doi:10.2174/ 157339912799424573)
    • (2012) Current Diabetes Reports , vol.8 , pp. 131-143
    • Saad, F.1    Aversa, A.2    Isidori, A.M.3    Gooren, L.J.4
  • 147
    • 80052564156 scopus 로고    scopus 로고
    • Testosterone or 17b-estradiol exposure reveals sex-specific effects on glucose and lipid metabolism in human myotubes
    • doi:10.1530/JOE-10-0497
    • Salehzadeh F, Rune A, Osler M & Al-Khalili L 2011 Testosterone or 17b-estradiol exposure reveals sex-specific effects on glucose and lipid metabolism in human myotubes. Journal of Endocrinology 210 290-229. (doi:10.1530/JOE-10-0497)
    • (2011) Journal of Endocrinology , vol.210 , pp. 290-229
    • Salehzadeh, F.1    Rune, A.2    Osler, M.3    Al-Khalili, L.4
  • 148
    • 0015128633 scopus 로고
    • Sebaceous gland lipogenesis induced by testosterone: early metabolic events
    • doi:10.1111/1523-1747. ep12261491
    • Sansone G, DavidsonW, Cummings B & Reisner RM 1971 Sebaceous gland lipogenesis induced by testosterone: early metabolic events. Journal of Investigative Dermatology 57 144-148. (doi:10.1111/1523-1747. ep12261491)
    • (1971) Journal of Investigative Dermatology , vol.57 , pp. 144-148
    • Sansone, G.1    Davidson, W.2    Cummings, B.3    Reisner, R.M.4
  • 149
    • 84857426282 scopus 로고    scopus 로고
    • Effects of male hypogonadism on regional adipose tissue fatty acid storage and lipogenic proteins
    • doi:10.1371/journal.pone.0031473
    • Santosa S & Jensen MD 2012 Effects of male hypogonadism on regional adipose tissue fatty acid storage and lipogenic proteins. PLoS ONE 7 e31473. (doi:10.1371/journal.pone.0031473)
    • (2012) PLoS ONE , vol.7
    • Santosa, S.1    Jensen, M.D.2
  • 150
    • 45549109873 scopus 로고    scopus 로고
    • Testosterone and DHEA activate the glucose metabolism-related signaling pathway in skeletal muscle
    • doi:10.1152/ajpendo.00678.2007
    • Sato K, Iemitsu M, Aizawa K & Ajisaka R 2008 Testosterone and DHEA activate the glucose metabolism-related signaling pathway in skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism 294 E961-E968. (doi:10.1152/ajpendo.00678.2007)
    • (2008) American Journal of Physiology. Endocrinology and Metabolism , vol.294
    • Sato, K.1    Iemitsu, M.2    Aizawa, K.3    Ajisaka, R.4
  • 151
    • 79960489624 scopus 로고    scopus 로고
    • Obesity and the development of type 2 diabetes: the effects of fatty tissue inflammation
    • doi:10.2147/DMSOTT.S7354
    • Schuster DP 2010 Obesity and the development of type 2 diabetes: the effects of fatty tissue inflammation. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 3 253-262. (doi:10.2147/DMSOTT.S7354)
    • (2010) Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy , vol.3 , pp. 253-262
    • Schuster, D.P.1
  • 152
    • 0025083282 scopus 로고
    • Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels
    • doi:10.1016/0026-0495(90)90297-P
    • Seidell JC, Bjorntorp P, Sjostrom L, Kvist H & Sannerstedt R 1990 Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels. Metabolism 39 897-901. (doi:10.1016/0026-0495(90)90297-P)
    • (1990) Metabolism , vol.39 , pp. 897-901
    • Seidell, J.C.1    Bjorntorp, P.2    Sjostrom, L.3    Kvist, H.4    Sannerstedt, R.5
  • 156
    • 45149116659 scopus 로고    scopus 로고
    • Androgen deprivation therapy in prostate cancer and metabolic risk for atherosclerosis
    • doi:10.1210/ jc.2007-2595
    • Shahani S, Braga-BasariaM& Basaria S 2008 Androgen deprivation therapy in prostate cancer and metabolic risk for atherosclerosis. Journal of Clinical Endocrinology and Metabolism 93 2042-2049. (doi:10.1210/ jc.2007-2595)
    • (2008) Journal of Clinical Endocrinology and Metabolism , vol.93 , pp. 2042-2049
    • Shahani, S.1    Braga-Basaria, M.2    Basaria, S.3
  • 163
    • 33646029746 scopus 로고    scopus 로고
    • Insulin sensitivity during combined androgen blockade for prostate cancer
    • doi:10.1210/jc.2005-2507
    • Smith MR, Lee H & Nathan DM 2006 Insulin sensitivity during combined androgen blockade for prostate cancer. Journal of Clinical Endocrinology and Metabolism 91 1305-1308. (doi:10.1210/jc.2005-2507)
    • (2006) Journal of Clinical Endocrinology and Metabolism , vol.91 , pp. 1305-1308
    • Smith, M.R.1    Lee, H.2    Nathan, D.M.3
  • 165
    • 80052520508 scopus 로고    scopus 로고
    • Relative muscle mass is inversely associated with insulin resistance and prediabetes. Findings from the Third National Health and Nutrition Examination Survey
    • doi:10.1210/ jc.2011-0435
    • Srikanthan P & Karlamangla AS 2011 Relative muscle mass is inversely associated with insulin resistance and prediabetes. Findings from the Third National Health and Nutrition Examination Survey. Journal of Clinical Endocrinology and Metabolism 96 2898-2903. (doi:10.1210/ jc.2011-0435)
    • (2011) Journal of Clinical Endocrinology and Metabolism , vol.96 , pp. 2898-2903
    • Srikanthan, P.1    Karlamangla, A.S.2
  • 166
    • 59849096860 scopus 로고    scopus 로고
    • Testosterone in obesity, metabolic syndrome and type 2 diabetes
    • Stanworth RD & Jones TH 2009 Testosterone in obesity, metabolic syndrome and type 2 diabetes. Frontiers of Hormone Research 37 74-90.
    • (2009) Frontiers of Hormone Research , vol.37 , pp. 74-90
    • Stanworth, R.D.1    Jones, T.H.2
  • 167
    • 58149343861 scopus 로고    scopus 로고
    • Androgen receptor CAG repeat polymorphism is associated with serum testosterone levels, obesity and serum leptin in men with type 2 diabetes
    • doi:10.1530/EJE-08-0266
    • Stanworth RD, Kapoor D, Channer KS & Jones TH 2008 Androgen receptor CAG repeat polymorphism is associated with serum testosterone levels, obesity and serum leptin in men with type 2 diabetes. European Journal of Endocrinology 159 736-746. (doi:10.1530/EJE-08-0266)
    • (2008) European Journal of Endocrinology , vol.159 , pp. 736-746
    • Stanworth, R.D.1    Kapoor, D.2    Channer, K.S.3    Jones, T.H.4
  • 168
    • 79953741235 scopus 로고    scopus 로고
    • Dyslipidaemia is associated with testosterone, oestradiol and androgen receptor CAG repeat polymorphism in men with type 2 diabetes
    • doi:10.1111/j.1365-2265.2011.03969.x
    • Stanworth RD, Kapoor D, Channer KS & Jones TH 2011 Dyslipidaemia is associated with testosterone, oestradiol and androgen receptor CAG repeat polymorphism in men with type 2 diabetes. Clinical Endocrinology 74 624-630. (doi:10.1111/j.1365-2265.2011.03969.x)
    • (2011) Clinical Endocrinology , vol.74 , pp. 624-630
    • Stanworth, R.D.1    Kapoor, D.2    Channer, K.S.3    Jones, T.H.4
  • 169
    • 0034106347 scopus 로고    scopus 로고
    • Testosterone, sex hormone binding globulin and the development of type 2 diabetes in middle aged men
    • doi:10.2337/diacare.23.4.490
    • Stellato RK, Feldman HA, Hamdy O, Horton ES & McKinlay JB 2000 Testosterone, sex hormone binding globulin and the development of type 2 diabetes in middle aged men. Diabetes Care 23 490-494. (doi:10.2337/diacare.23.4.490)
    • (2000) Diabetes Care , vol.23 , pp. 490-494
    • Stellato, R.K.1    Feldman, H.A.2    Hamdy, O.3    Horton, E.S.4    McKinlay, J.B.5
  • 170
    • 4344614649 scopus 로고    scopus 로고
    • Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B
    • doi:10.1074/jbc.M406499200
    • Stratford S, Hoehn KL, Liu F & Summers SA 2004 Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B. Journal of Biological Chemistry 279 36608-36615. (doi:10.1074/jbc.M406499200)
    • (2004) Journal of Biological Chemistry , vol.279 , pp. 36608-36615
    • Stratford, S.1    Hoehn, K.L.2    Liu, F.3    Summers, S.A.4
  • 172
    • 84871261428 scopus 로고    scopus 로고
    • The effects of testosterone on the expression of inflammatory factors in 3T3-L1 adipocytes and its mechanism
    • Su CL, Huang HY, Shen ZQ & Lin JF 2009 The effects of testosterone on the expression of inflammatory factors in 3T3-L1 adipocytes and its mechanism. Zhonghua Yi Xue Za Zhi 89 1493-1497.
    • (2009) Zhonghua Yi Xue Za Zhi , vol.89 , pp. 1493-1497
    • Su, C.L.1    Huang, H.Y.2    Shen, Z.Q.3    Lin, J.F.4
  • 173
    • 48349144149 scopus 로고    scopus 로고
    • Testosterone treatment in elderly men with subnormal testosterone levels improves body composition and BMD in the hip
    • doi:10.1038/ijir.2008.90
    • Svartberg J, Agledahl I, Figenschau Y, Sildnes T,Waterloo K & Jorde R 2008 Testosterone treatment in elderly men with subnormal testosterone levels improves body composition and BMD in the hip. International Journal of Impotence Research 20 378-387. (doi:10.1038/ijir.2008.90)
    • (2008) International Journal of Impotence Research , vol.20 , pp. 378-387
    • Svartberg, J.1    Agledahl, I.2    Figenschau, Y.3    Sildnes, T.4    Waterloo, K.5    Jorde, R.6
  • 174
    • 0032053210 scopus 로고    scopus 로고
    • Androgens and the control of lipid metabolismin human prostate cancer cells
    • doi:10.1016/S0960-0760(97)00187-8
    • Swinnen JV & Verhoeven G 1998 Androgens and the control of lipid metabolismin human prostate cancer cells. Journal of Steroid Biochemistry and Molecular Biology 65 191-908. (doi:10.1016/S0960-0760(97)00187-8)
    • (1998) Journal of Steroid Biochemistry and Molecular Biology , vol.65 , pp. 191-908
    • Swinnen, J.V.1    Verhoeven, G.2
  • 175
    • 0029743674 scopus 로고    scopus 로고
    • Androgens markedly stimulate the accumulation of neutral lipids in the human prostatic adenocarcinoma cell line LNCaP
    • doi:10.1210/en.137.10.4468
    • Swinnen JV, Van Veldhoven PP, Esquenet M, Heyns W & Verhoeven G 1996 Androgens markedly stimulate the accumulation of neutral lipids in the human prostatic adenocarcinoma cell line LNCaP. Endocrinology 137 4468-4474. (doi:10.1210/en.137.10.4468)
    • (1996) Endocrinology , vol.137 , pp. 4468-4474
    • Swinnen, J.V.1    Van Veldhoven, P.P.2    Esquenet, M.3    Heyns, W.4    Verhoeven, G.5
  • 176
    • 0030666828 scopus 로고    scopus 로고
    • Coordinate regulation of lipogenic gene expression by androgens: evidence for a cascade mechanisminvolving sterol regulatory element binding proteins
    • doi:10.1073/pnas.94.24.12975
    • Swinnen JV, Ulrix W, HeynsW& Verhoeven G 1997 Coordinate regulation of lipogenic gene expression by androgens: evidence for a cascade mechanisminvolving sterol regulatory element binding proteins. PNAS 94 12975-12980. (doi:10.1073/pnas.94.24.12975)
    • (1997) PNAS , vol.94 , pp. 12975-12980
    • Swinnen, J.V.1    Ulrix, W.2    Heyns, W.3    Verhoeven, G.4
  • 178
    • 58149299559 scopus 로고    scopus 로고
    • The dark side of testosterone deficiency: I. Metabolic syndrome and erectile dysfunction
    • doi:10.2164/jandrol.108.005215
    • Traish AM, Guay A, Feeley R & Saad F 2009 The dark side of testosterone deficiency: I. Metabolic syndrome and erectile dysfunction. Journal of Andrology 30 10-22. (doi:10.2164/jandrol.108.005215)
    • (2009) Journal of Andrology , vol.30 , pp. 10-22
    • Traish, A.M.1    Guay, A.2    Feeley, R.3    Saad, F.4
  • 180
    • 0030899133 scopus 로고    scopus 로고
    • Beneficial effects of testosterone undecanoate on the lipoprotein profiles in healthy elderly men. A placebo controlled study
    • doi:10.1536/ihj.38.73
    • Uyanik BS, Ari Z, Gümüs B, Yigǐtoǧlu MR & Arslan T 1997 Beneficial effects of testosterone undecanoate on the lipoprotein profiles in healthy elderly men. A placebo controlled study. Japanese Heart Journal 38 73-82. (doi:10.1536/ihj.38.73)
    • (1997) Japanese Heart Journal , vol.38 , pp. 73-82
    • Uyanik, B.S.1    Ari, Z.2    Gümüs, B.3    Yigǐtoǧlu, M.R.4    Arslan, T.5
  • 181
    • 1842834450 scopus 로고    scopus 로고
    • Differential contribution of testosterone and estradiol in the determination of cholesterol and lipoprotein profile in healthymiddle-aged men
    • doi:10.1016/S0021-9150(02)00308-8
    • Van Pottelbergh I, Braeckman L, De Bacquer D, De Backer G & Kaufman JM 2003 Differential contribution of testosterone and estradiol in the determination of cholesterol and lipoprotein profile in healthymiddle-aged men. Atherosclerosis 166 95-102. (doi:10.1016/S0021-9150(02)00308-8)
    • (2003) Atherosclerosis , vol.166 , pp. 95-102
    • Van Pottelbergh, I.1    Braeckman, L.2    De Bacquer, D.3    De Backer, G.4    Kaufman, J.M.5
  • 182
    • 70349254624 scopus 로고    scopus 로고
    • Endogenous sex hormones and the prospective association with cardiovascular disease and mortality in men: the Tromsø Study
    • doi:10.1530/EJE-09-0284
    • Vikan T, Schirmer H, Njølstad I & Svartberg J 2009 Endogenous sex hormones and the prospective association with cardiovascular disease and mortality in men: the Tromsø Study. European Journal of Endocrinology 161 435-442. (doi:10.1530/EJE-09-0284)
    • (2009) European Journal of Endocrinology , vol.161 , pp. 435-442
    • Vikan, T.1    Schirmer, H.2    Njølstad, I.3    Svartberg, J.4
  • 185
    • 80054698216 scopus 로고    scopus 로고
    • Low testosterone associated with obesity and the metabolic syndrome contributes to sexual dysfunction and cardiovascular disease risk inmen with type 2 diabetes
    • doi:10.2337/dc10-2339
    • Wang C, Jackson G, Jones TH, Matsumoto AM, Nehra A, Perelman MA, Swerdloff RS, Traish A, Zitzmann M& Cunningham G 2011 Low testosterone associated with obesity and the metabolic syndrome contributes to sexual dysfunction and cardiovascular disease risk inmen with type 2 diabetes. Diabetes Care 34 1669-1675. (doi:10.2337/dc10-2339)
    • (2011) Diabetes Care , vol.34 , pp. 1669-1675
    • Wang, C.1    Jackson, G.2    Jones, T.H.3    Matsumoto, A.M.4    Nehra, A.5    Perelman, M.A.6    Swerdloff, R.S.7    Traish, A.8    Zitzmann, M.9    Cunningham, G.10
  • 187
    • 0034819462 scopus 로고    scopus 로고
    • Intramuscular testosterone esters and plasma lipids in hypogonadal men: a meta-analysis
    • doi:10.1016/S0002-9343(01)00833-6
    • Whitsel EA, Boyko EJ, Matsumoto AM, Anawalt BD & Siscovick DS 2001 Intramuscular testosterone esters and plasma lipids in hypogonadal men: a meta-analysis. American Journal of Medicine 111 261-269. (doi:10.1016/S0002-9343(01)00833-6)
    • (2001) American Journal of Medicine , vol.111 , pp. 261-269
    • Whitsel, E.A.1    Boyko, E.J.2    Matsumoto, A.M.3    Anawalt, B.D.4    Siscovick, D.S.5
  • 189
    • 0037396460 scopus 로고    scopus 로고
    • Androgens and coronary artery disease
    • doi:10.1210/er.2001-0025)
    • Wu FC & von Eckardstein A 2003 Androgens and coronary artery disease. Endocrine Reviews 24 183-217. (doi:10.1210/er.2001-0025)
    • (2003) Endocrine Reviews , vol.24 , pp. 183-217
    • Wu, F.C.1    von Eckardstein, A.2
  • 192
  • 193
    • 33745240384 scopus 로고    scopus 로고
    • The effect of androgen deprivation therapy on fasting serum lipid and glucose parameters
    • doi:10.1016/j.juro.2006.03.057
    • Yannucci J, Manola J, GarnickMB, Bhat G & Bubley GJ 2006 The effect of androgen deprivation therapy on fasting serum lipid and glucose parameters. Journal of Urology 176 520-525. (doi:10.1016/j.juro.2006.03.057)
    • (2006) Journal of Urology , vol.176 , pp. 520-525
    • Yannucci, J.1    Manola, J.2    Garnick, M.B.3    Bhat, G.4    Bubley, G.J.5
  • 194
    • 47749109127 scopus 로고    scopus 로고
    • Metabolic syndrome, testosterone deficiency and erectile dysfunction never come alone
    • doi:10.1111/j.1439-0272.2008.00851.x
    • Yassin AA, Saad F & Gooren LJ 2008 Metabolic syndrome, testosterone deficiency and erectile dysfunction never come alone. Andrologia 40 259-264. (doi:10.1111/j.1439-0272.2008.00851.x)
    • (2008) Andrologia , vol.40 , pp. 259-264
    • Yassin, A.A.1    Saad, F.2    Gooren, L.J.3
  • 195
    • 20344400660 scopus 로고    scopus 로고
    • Adipocyte signaling and lipid homeostasis: sequelae of insulin-resistant adipose tissue
    • doi:10.1161/01.RES.0000165803.47776.38
    • Yu YH & Ginsberg HN 2005 Adipocyte signaling and lipid homeostasis: sequelae of insulin-resistant adipose tissue. Circulation Research 96 1042-1052. (doi:10.1161/01.RES.0000165803.47776.38)
    • (2005) Circulation Research , vol.96 , pp. 1042-1052
    • Yu, Y.H.1    Ginsberg, H.N.2
  • 197
    • 70849117428 scopus 로고    scopus 로고
    • Testosterone deficiency, insulin resistance and the metabolic syndrome
    • doi:10.1038/nrendo.2009.212
    • Zitzmann M 2009a Testosterone deficiency, insulin resistance and the metabolic syndrome. Nature Reviews. Endocrinology 5 673-681. (doi:10.1038/nrendo.2009.212)
    • (2009) Nature Reviews. Endocrinology , vol.5 , pp. 673-681
    • Zitzmann, M.1
  • 198
    • 59849123606 scopus 로고    scopus 로고
    • The role of the CAG repeat androgen receptor polymorphism in andrology
    • Zitzmann M 2009b The role of the CAG repeat androgen receptor polymorphism in andrology. Frontiers of Hormone Research 37 52-61.
    • (2009) Frontiers of Hormone Research , vol.37 , pp. 52-61
    • Zitzmann, M.1
  • 199
    • 35349019230 scopus 로고    scopus 로고
    • Androgen receptor gene CAG repeat length and body mass index modulate the safety of long-term intramuscular testosterone undecanoate therapy in hypogonadal men
    • doi:10.1210/jc.2007-0620)
    • Zitzmann M & Nieschlag E 2007 Androgen receptor gene CAG repeat length and body mass index modulate the safety of long-term intramuscular testosterone undecanoate therapy in hypogonadal men. Journal of Clinical Endocrinology and Metabolism 92 3844-3853. (doi:10.1210/jc.2007-0620)
    • (2007) Journal of Clinical Endocrinology and Metabolism , vol.92 , pp. 3844-3853
    • Zitzmann, M.1    Nieschlag, E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.