Oestrogen improves glucose metabolism and insulin signal transduction in HepG2 cells

Clinical and Experimental Pharmacology and Physiology

Volumn 30, Issue 9, 2003, Pages 643-648

  Xie, Ping ^a   Liu, Mei Lian ^a   Gu, Ya Peng ^a   Lu, Jin ^a   Xu, Xia ^a   Zeng, Wei Min ^a   Song, Hui Ping ^a  

^a Central South University   (China)

Author keywords

Gene expression; Glucose; Insulin; Metabolism; Oestradiol

Indexed keywords

6 PHOSPHOFRUCTOKINASE; ESTRADIOL; GLYCOGEN SYNTHASE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; PYRUVATE DEHYDROGENASE;

ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ESTROGEN ACTIVITY; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; INSULIN RESISTANCE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

CELL LINE, TUMOR; ESTRADIOL; GLUCOSE; HUMANS; INSULIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PHOSPHOPROTEINS; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

EID: 0141707753     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1681.2003.03899.x     Document Type: Article

References (40)

1. Yip J, Facchini FS, Reaven GM. Resistance to insulin-mediated glucose disposal as a predicator of cardiovascular disease. J. Clin. Endocrinol. Metab. 1998; 83: 2773-6.
2. Laasko M. Hyperglycaemia and cardiovascular disease in type 2 diabetes. Diabetes 1999; 48: 937-42.
3. Lindheim SR, Buchanan TA, Duffy DM, Vijod MA, Kojima T, Stanezyk FZ. Comparison of estimates of insulin sensitivity in pre- and postmenopausal women using the insulin tolerance test and the frequently sampled intravenous glucose tolerance test. J. Soc. Gynecol. Invest. 1994; 1: 150-4.
4. Spencer CP, Godsland IF, Cooper AJ, Ross D, Whitehead MI, Stevenson JC. Effects of oral and transdermal 17beta-estradiol with cyclical oral norethindrone acetate on insulin sensitivity, secretion, and elimination in postmenopausal women. Metabolism 2000; 49: 742-7.
5. Cefalu WT. The use of hormone replacement therapy in postmenopausal women with type 2 diabetes. J. Womens Health Gend. Based Med. 2001; 10: 241-55.
6. Enserink M. Epidemiology. Despite safety concerns, UK Hormone study to proceed. Science 2002; 297: 492.
7. Lindheim SR, Presser SC, Ditkoff EC, Vijod BS, Stancayk FZ, Lobo RA. A possible bimodal effect of estrogen on insulin sensitivity in postmenopausal women and the attenuating effect of added progestin. Fertil. Steril. 1993; 60: 664-7.
8. Larsson-Cohn U, Wallentin L. Metabolic and hormonal effects of postmenopausal oestrogen replacement treatment. Acta Endocrinol. 1997; 86: 583-96.
9. Palin SL, Kumar S, Sturdee DW, Barnett AH. HRT in women with diabetes: Review of the effects on glucose and lipid metabolism. Diabetes Res. Clin. Pract. 2001; 54: 67-77.
10. Jimenez de Asua L, Rozengurt E. Multiple control mechanisms underlie initiation of growth in animal cells. Nature 1974; 251: 624-6.
11. Falkner B, Sherif K, Sumner A, Kushner H. Hyperinsulinism and sex hormone in young adult african Americans. Metabolism 1999; 48: 107-12.
12. Saltiel AR, Kahn CR. Insulin signaling and the regulation of glucose and lipid metabolism. Nature 2001; 414: 799-806.
13. Astiazaran AM, Chico Y, Ruiz MB, Alonso MT, Ochoa B, Lacort M. Metabolic changes due to the in vitro addition of estradiol in rat hepatocytes. Rev. Esp. Fisiol. 1989; 45 (Suppl.): 19-24.
14. Hunter SJ, Garrey WT. Insulin action and insulin resistance: Diseases involving defects in insulin receptors, signal transduction, and the glucose transport effector system. Am. J. Med. 1998; 105: 331-45.
15. Sesti G, Federici M, Hribal ML, Lauro D, Sbraccia P, Lauro R. Defects of the insulin receptor substrate (IRS) system in human metabolic disorders. FASEB J. 2001; 15: 2099-111.
16. Mayor P, Maianu L, Garvey WT. Glucose and insulin chronically regulate insulin action via different mechanisms in BC3H1 myocytes. Effects on glucose transporter gene expression. Diabetes 1992; 41: 274-85.
17. Grau M, Tebar F, Ramirez I, Soley M. Epidermal growth factor administration decreases liver glycogen and causes mild hyperglycaemia in mice. Biochem. J. 1996; 315: 289-93.
18. Blum A, Cannon 3rd RO. Effects of oestrogens and selective oestrogen receptor modulators on serum lipoproteins and vascular function. Curr. Opin. Lipidol. 1998; 9: 575-86.
19. Chambon P, Dierich A, Gaub MP et al. Promoter elements of genes coding for proteins and modulation of transcription by estrogens and progesterone. Recent Prog. Horm. Res. 1984; 40: 1-42.
20. Zhu YS, Yen P, Chin WW, Pfaff DW. Estrogen and thyroid hormone interaction on regulation of gene expression. Proc. Natl Acad. Sci. USA 1996; 93: 12 587-92.
21. Jackson S, Bagstaff SM, Lynn S, Yeaman SJ, Turnbull DM, Walker M. Decreased insulin responsiveness of glucose uptake in cultured human skeletal muscle cells from insulin-resistant nondiabetic relatives of type 2 diabetic families. Diabetes 2000; 49: 1169-77.
22. Liu YQ, Tornheim K, Jack L. Fatty acid-induced cell hypersensitivity to glucose increased phosphofructokinase activity and lowered glucose-6-phosphate content. J. Clin. Invest. 1998; 101: 1870-5.
23. Liu YQ, Tornheim K, Leahy JL. Glucose-fatty acid cycle to inhibit glucose utilization and oxidation is not operative in fatty acid-cultured islets. Diabetes 1999; 48: 1747-53.
24. Kankel KF, Reinauer H. Activity of pyruvate dehydrogenase complex in the mammary gland of normal and diabetic rats. Diabetologia 1976; 12: 149-54.
25. Liu J, Brautigan DL. Insulin-stimulated phosphorylation of the protein phosphatase-1 striated muscle glycogen-targeting subunit and activation of glycogen synthase. J. Biol. Chem. 2000; 275: 15 940-7.
26. Sambrook J, Fristch EF, Maniatis T. Molecular Cloning: A Laboratory Manual, 2nd edn. Cold Spring Harbor Laboratory Press, New York. 1989.
27. Wang XH, Li YM, Zhao YQ. Practical Protocols in Molecular Biology. Science Press, Beijing. 1995.
28. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976; 72: 248-54.
29. Henry RR, Ciaraldi TP, Mudaliar S, Abram L, Nikoulina SE. Acquired defects of glycogen synthase activity in cultured human skeletal muscle cells: Influence of high glucose and insulin levels. Diabetes 1996; 45: 400-7.
30. Tamemoto H, Kadowaki T, Toke K et al. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature 1994; 372: 182-6.
31. Withers DJ, Gutierrez JS, Towery H et al. Disruption of IRS-2 causes type 2 diabetes in mice. Nature 1998; 391: 900-4.
32. Michael MD, Kulkarni RN, Postic C et al. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol. Cell. 2000; 6: 87-97.
33. Mueckler M. Facilitative glucose transporters. Eur. J. Biochem. 1994; 219: 713-25.
34. Hah J, Jo I, Chakrabarti R, Jung CY. Demonstration of an insulin-insensitive storage pool of glucose transporters in rat hepatocytes and HepG2 cells. J. Cell Physiol. 1992; 152: 56-63.
35. Rebrin K, Steil GM, Getty L, Bergman RN. Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin. Diabetes 1995; 44: 1038-45.
36. Studer RK. Sexual dimorphism in adrenergic regulation of hepatic glycogenolysis. Am. J. Physiol. 1987; 252: E467-76.
37. Petersen IM, Sand O, Korsgaard B. A time course study of the effect of repetitive doses of estradiol-17 beta on serum glucose and lipids, liver glycogen and some carbohydrate metabolizing enzymes in liver of male flounder (Platichtys flesus L.). Comp. Biochem. Physiol. B 1983; 74: 459-66.
38. Welch RD, Gorski J. Regulation of glucose transporters by estradiol in the immature rat uterus. Endocrinology 1999; 140: 3602-8.
39. Lee AV, Jackson JG, Gooch JL et al. Ehancement of insulin-like growth factor signaling in human breast cancer: Estrogen regulation of insulin receptor substrate-1 expression in vitro and in vivo. Mol. Endocrinol. 1999; 13: 787-96.
40. Collison M, Campbell IW, Salt IP et al. Sex hormones induce insulin resistance in 3T3-L1 adipocytes by reducing cellular content of IRS proteins. Diabetologia 2000; 43: 1374-80.