메뉴 건너뛰기




Volumn 173, Issue 1, 2013, Pages 38-46

Predominance of activated, clonally expanded T helper type 17 cells within the CD4+ T cell population in psoriatic lesions

Author keywords

Clonal expansion; IL 10; Psoriasis; Regulatory T cell subsets; T helper type 17 cell

Indexed keywords

CD4 ANTIGEN; CD45RO ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 17; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR BETA CHAIN; TRANSCRIPTION FACTOR FOXP3;

EID: 84878795813     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/cei.12086     Document Type: Article
Times cited : (22)

References (43)
  • 1
    • 42149161160 scopus 로고    scopus 로고
    • T-helper 17 cells in psoriatic plaques and additional genetic links between IL-23 and psoriasis
    • Blauvelt A. T-helper 17 cells in psoriatic plaques and additional genetic links between IL-23 and psoriasis. J Invest Dermatol 2008; 128:1064-1067.
    • (2008) J Invest Dermatol , vol.128 , pp. 1064-1067
    • Blauvelt, A.1
  • 2
    • 33846889522 scopus 로고    scopus 로고
    • A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis
    • Krueger GG, Langley RG, Leonardi C etal. A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis. N Engl J Med 2007; 356:580-592.
    • (2007) N Engl J Med , vol.356 , pp. 580-592
    • Krueger, G.G.1    Langley, R.G.2    Leonardi, C.3
  • 3
    • 13244283212 scopus 로고    scopus 로고
    • IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
    • Langrish CL, Chen Y, Blumenschein WM etal. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 2005; 201:233-240.
    • (2005) J Exp Med , vol.201 , pp. 233-240
    • Langrish, C.L.1    Chen, Y.2    Blumenschein, W.M.3
  • 4
    • 34249079176 scopus 로고    scopus 로고
    • Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells
    • Acosta-Rodriguez EV, Rivino L, Geginat J etal. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat Immunol 2007; 8:639-646.
    • (2007) Nat Immunol , vol.8 , pp. 639-646
    • Acosta-Rodriguez, E.V.1    Rivino, L.2    Geginat, J.3
  • 5
    • 39449110445 scopus 로고    scopus 로고
    • The link between IL-23 and Th17 cell-mediated immune pathologies
    • McGeachy MJ, Cua DJ. The link between IL-23 and Th17 cell-mediated immune pathologies. Semin Immunol 2007; 19:372-376.
    • (2007) Semin Immunol , vol.19 , pp. 372-376
    • McGeachy, M.J.1    Cua, D.J.2
  • 6
    • 67349230808 scopus 로고    scopus 로고
    • The IL-23/Th17 axis in the immunopathogenesis of psoriasis
    • Di Cesare A, Di Meglio P, Nestle FO. The IL-23/Th17 axis in the immunopathogenesis of psoriasis. J Invest Dermatol 2009; 129:1339-1350.
    • (2009) J Invest Dermatol , vol.129 , pp. 1339-1350
    • Di Cesare, A.1    Di Meglio, P.2    Nestle, F.O.3
  • 7
    • 39649108216 scopus 로고    scopus 로고
    • Safety and efficacy of ABT-874, a fully human interleukin 12/23 monoclonal antibody, in the treatment of moderate to severe chronic plaque psoriasis: results of a randomized, placebo-controlled, phase 2 trial
    • Kimball AB, Gordon KB, Langley RG, Menter A, Chartash EK, Valdes J. Safety and efficacy of ABT-874, a fully human interleukin 12/23 monoclonal antibody, in the treatment of moderate to severe chronic plaque psoriasis: results of a randomized, placebo-controlled, phase 2 trial. Arch Dermatol 2008; 144:200-207.
    • (2008) Arch Dermatol , vol.144 , pp. 200-207
    • Kimball, A.B.1    Gordon, K.B.2    Langley, R.G.3    Menter, A.4    Chartash, E.K.5    Valdes, J.6
  • 8
    • 43449111187 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)
    • Leonardi CL, Kimball AB, Papp KA etal. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1). Lancet 2008; 371:1665-1674.
    • (2008) Lancet , vol.371 , pp. 1665-1674
    • Leonardi, C.L.1    Kimball, A.B.2    Papp, K.A.3
  • 9
    • 43449139402 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)
    • Papp KA, Langley RG, Lebwohl M etal. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2). Lancet 2008; 371:1675-1684.
    • (2008) Lancet , vol.371 , pp. 1675-1684
    • Papp, K.A.1    Langley, R.G.2    Lebwohl, M.3
  • 10
    • 70349753261 scopus 로고    scopus 로고
    • Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis
    • Harper EG, Guo C, Rizzo H etal. Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis. J Invest Dermatol 2009; 129:2175-2183.
    • (2009) J Invest Dermatol , vol.129 , pp. 2175-2183
    • Harper, E.G.1    Guo, C.2    Rizzo, H.3
  • 11
    • 65449142556 scopus 로고    scopus 로고
    • Prolactin enhances basal and IL-17-induced CCL20 production by human keratinocytes
    • Kanda N, Shibata S, Tada Y, Nashiro K, Tamaki K, Watanabe S. Prolactin enhances basal and IL-17-induced CCL20 production by human keratinocytes. Eur J Immunol 2009; 39:996-1006.
    • (2009) Eur J Immunol , vol.39 , pp. 996-1006
    • Kanda, N.1    Shibata, S.2    Tada, Y.3    Nashiro, K.4    Tamaki, K.5    Watanabe, S.6
  • 12
    • 42149087160 scopus 로고    scopus 로고
    • Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells
    • Lowes MA, Kikuchi T, Fuentes-Duculan J etal. Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells. J Invest Dermatol 2008; 128:1207-1211.
    • (2008) J Invest Dermatol , vol.128 , pp. 1207-1211
    • Lowes, M.A.1    Kikuchi, T.2    Fuentes-Duculan, J.3
  • 13
    • 47249125726 scopus 로고    scopus 로고
    • Chronically inflamed human tissues are infiltrated by highly differentiated th17 lymphocytes
    • Pene J, Chevalier S, Preisser L etal. Chronically inflamed human tissues are infiltrated by highly differentiated th17 lymphocytes. J Immunol 2008; 180:7423-7430.
    • (2008) J Immunol , vol.180 , pp. 7423-7430
    • Pene, J.1    Chevalier, S.2    Preisser, L.3
  • 14
    • 34347237623 scopus 로고    scopus 로고
    • Flow cytometry-based methods for studying signaling in human CD4+CD25+FOXP3+ T regulatory cells
    • Crellin NK, Garcia RV, Levings MK. Flow cytometry-based methods for studying signaling in human CD4+CD25+FOXP3+ T regulatory cells. J Immunol Methods 2007; 324:92-104.
    • (2007) J Immunol Methods , vol.324 , pp. 92-104
    • Crellin, N.K.1    Garcia, R.V.2    Levings, M.K.3
  • 16
    • 0033738329 scopus 로고    scopus 로고
    • The role of different subsets of T regulatory cells in controlling autoimmunity
    • Roncarolo MG, Levings MK. The role of different subsets of T regulatory cells in controlling autoimmunity. Curr Opin Immunol 2000; 12:676-683.
    • (2000) Curr Opin Immunol , vol.12 , pp. 676-683
    • Roncarolo, M.G.1    Levings, M.K.2
  • 17
    • 2442484053 scopus 로고    scopus 로고
    • Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses
    • Sakaguchi S. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 2004; 22:531-562.
    • (2004) Annu Rev Immunol , vol.22 , pp. 531-562
    • Sakaguchi, S.1
  • 18
    • 0347361653 scopus 로고    scopus 로고
    • The role of the combination of IL-2 and TGF-beta or IL-10 in the generation and function of CD4+CD25+ and CD8+ regulatory T cell subsets
    • Horwitz DA, Zheng SG, Gray JD. The role of the combination of IL-2 and TGF-beta or IL-10 in the generation and function of CD4+CD25+ and CD8+ regulatory T cell subsets. J Leukoc Biol 2003; 74:471-478.
    • (2003) J Leukoc Biol , vol.74 , pp. 471-478
    • Horwitz, D.A.1    Zheng, S.G.2    Gray, J.D.3
  • 19
    • 10844222790 scopus 로고    scopus 로고
    • Dysfunctional blood and target tissue CD4+CD25high regulatory T cells in psoriasis: mechanism underlying unrestrained pathogenic effector T cell proliferation
    • Sugiyama H, Gyulai R, Toichi E etal. Dysfunctional blood and target tissue CD4+CD25high regulatory T cells in psoriasis: mechanism underlying unrestrained pathogenic effector T cell proliferation. J Immunol 2005; 174:164-173.
    • (2005) J Immunol , vol.174 , pp. 164-173
    • Sugiyama, H.1    Gyulai, R.2    Toichi, E.3
  • 20
    • 80051801522 scopus 로고    scopus 로고
    • Foxp3+ regulatory T cells of psoriasis patients easily differentiate into IL-17A-producing cells and are found in lesional skin
    • Bovenschen HJ, van de Kerkhof PC, van Erp PE, Woestenenk R, Joosten I, Koenen HJ. Foxp3+ regulatory T cells of psoriasis patients easily differentiate into IL-17A-producing cells and are found in lesional skin. J Invest Dermatol 2011; 131:1853-1860.
    • (2011) J Invest Dermatol , vol.131 , pp. 1853-1860
    • Bovenschen, H.J.1    van de Kerkhof, P.C.2    van Erp, P.E.3    Woestenenk, R.4    Joosten, I.5    Koenen, H.J.6
  • 21
    • 77649235565 scopus 로고    scopus 로고
    • Increased Th17 cells are accompanied by FoxP3(+) Treg cell accumulation and correlated with psoriasis disease severity
    • Zhang L, Yang XQ, Cheng J, Hui RS, Gao TW. Increased Th17 cells are accompanied by FoxP3(+) Treg cell accumulation and correlated with psoriasis disease severity. Clin Immunol 2010; 135:108-117.
    • (2010) Clin Immunol , vol.135 , pp. 108-117
    • Zhang, L.1    Yang, X.Q.2    Cheng, J.3    Hui, R.S.4    Gao, T.W.5
  • 22
    • 58149331211 scopus 로고    scopus 로고
    • Psoriasis is characterized by accumulation of immunostimulatory and Th1/Th17 cell-polarizing myeloid dendritic cells
    • Zaba LC, Fuentes-Duculan J, Eungdamrong NJ etal. Psoriasis is characterized by accumulation of immunostimulatory and Th1/Th17 cell-polarizing myeloid dendritic cells. J Invest Dermatol 2009; 129:79-88.
    • (2009) J Invest Dermatol , vol.129 , pp. 79-88
    • Zaba, L.C.1    Fuentes-Duculan, J.2    Eungdamrong, N.J.3
  • 23
    • 77954143695 scopus 로고    scopus 로고
    • Innate IL-17-producing cells: the sentinels of the immune system
    • Cua DJ, Tato CM. Innate IL-17-producing cells: the sentinels of the immune system. Nat Rev Immunol 2010; 10:479-489.
    • (2010) Nat Rev Immunol , vol.10 , pp. 479-489
    • Cua, D.J.1    Tato, C.M.2
  • 24
    • 79959584686 scopus 로고    scopus 로고
    • Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis
    • Lin AM, Rubin CJ, Khandpur R etal. Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis. J Immunol 2011; 187:490-500.
    • (2011) J Immunol , vol.187 , pp. 490-500
    • Lin, A.M.1    Rubin, C.J.2    Khandpur, R.3
  • 25
    • 0032787816 scopus 로고    scopus 로고
    • Use of a mechanical dissociation device to improve standardization of flow cytometric cytokeratin DNA measurements of colon carcinomas
    • Brockhoff G, Fleischmann S, Meier A, Wachs FP, Hofstaedter F, Knuechel R. Use of a mechanical dissociation device to improve standardization of flow cytometric cytokeratin DNA measurements of colon carcinomas. Cytometry 1999; 38:184-191.
    • (1999) Cytometry , vol.38 , pp. 184-191
    • Brockhoff, G.1    Fleischmann, S.2    Meier, A.3    Wachs, F.P.4    Hofstaedter, F.5    Knuechel, R.6
  • 26
    • 0034502715 scopus 로고    scopus 로고
    • Flow cytometric characterization of lesional T cells in psoriasis: intracellular cytokine and surface antigen expression indicates an activated, memory/effector type 1 immunophenotype
    • Friedrich M, Krammig S, Henze M, Docke WD, Sterry W, Asadullah K. Flow cytometric characterization of lesional T cells in psoriasis: intracellular cytokine and surface antigen expression indicates an activated, memory/effector type 1 immunophenotype. Arch Dermatol Res 2000; 292:519-521.
    • (2000) Arch Dermatol Res , vol.292 , pp. 519-521
    • Friedrich, M.1    Krammig, S.2    Henze, M.3    Docke, W.D.4    Sterry, W.5    Asadullah, K.6
  • 27
    • 0028332735 scopus 로고
    • Multiple self epitopes on the Rhesus polypeptides stimulate immunologically ignorant human T cells in vitro
    • Barker RN, Elson CJ. Multiple self epitopes on the Rhesus polypeptides stimulate immunologically ignorant human T cells in vitro. Eur J Immunol 1994; 24:1578-1582.
    • (1994) Eur J Immunol , vol.24 , pp. 1578-1582
    • Barker, R.N.1    Elson, C.J.2
  • 28
    • 85027957926 scopus 로고    scopus 로고
    • Interleukin-23 as a potential therapeutic target for rheumatoid arthritis
    • Rong C, Hu W, Wu FR, Cao XJ, Chen FH. Interleukin-23 as a potential therapeutic target for rheumatoid arthritis. Mol Cell Biochem 2012; 361:243-248.
    • (2012) Mol Cell Biochem , vol.361 , pp. 243-248
    • Rong, C.1    Hu, W.2    Wu, F.R.3    Cao, X.J.4    Chen, F.H.5
  • 30
    • 34547734621 scopus 로고    scopus 로고
    • Phenotypic and functional features of human Th17 cells
    • Annunziato F, Cosmi L, Santarlasci V etal. Phenotypic and functional features of human Th17 cells. J Exp Med 2007; 204:1849-1861.
    • (2007) J Exp Med , vol.204 , pp. 1849-1861
    • Annunziato, F.1    Cosmi, L.2    Santarlasci, V.3
  • 31
    • 34547214205 scopus 로고    scopus 로고
    • Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans
    • Roncarolo MG, Battaglia M. Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans. Nat Rev Immunol 2007; 7:585-598.
    • (2007) Nat Rev Immunol , vol.7 , pp. 585-598
    • Roncarolo, M.G.1    Battaglia, M.2
  • 32
    • 0025733855 scopus 로고
    • The role of IL-10 in crossregulation of TH1 and TH2 responses
    • Mosmann TR, Moore KW. The role of IL-10 in crossregulation of TH1 and TH2 responses. Immunol Today 1991; 12:A49-53.
    • (1991) Immunol Today , vol.12
    • Mosmann, T.R.1    Moore, K.W.2
  • 33
    • 72849131815 scopus 로고    scopus 로고
    • Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling
    • Eyerich S, Eyerich K, Pennino D etal. Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. J Clin Invest 2009; 119:3573-3585.
    • (2009) J Clin Invest , vol.119 , pp. 3573-3585
    • Eyerich, S.1    Eyerich, K.2    Pennino, D.3
  • 34
    • 79956077563 scopus 로고    scopus 로고
    • T cell exhaustion
    • Wherry EJ. T cell exhaustion. Nat Immunol 2011; 12:492-499.
    • (2011) Nat Immunol , vol.12 , pp. 492-499
    • Wherry, E.J.1
  • 35
    • 65449141433 scopus 로고    scopus 로고
    • Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation
    • Hoffmann P, Boeld TJ, Eder R etal. Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation. Eur J Immunol 2009; 39:1088-1097.
    • (2009) Eur J Immunol , vol.39 , pp. 1088-1097
    • Hoffmann, P.1    Boeld, T.J.2    Eder, R.3
  • 36
    • 72949104568 scopus 로고    scopus 로고
    • Translational mini-review series on Th17 cells: CD4 T helper cells: functional plasticity and differential sensitivity to regulatory T cell-mediated regulation
    • O'Connor RA, Taams LS, Anderton SM. Translational mini-review series on Th17 cells: CD4 T helper cells: functional plasticity and differential sensitivity to regulatory T cell-mediated regulation. Clin Exp Immunol 2010; 159:137-147.
    • (2010) Clin Exp Immunol , vol.159 , pp. 137-147
    • O'Connor, R.A.1    Taams, L.S.2    Anderton, S.M.3
  • 37
    • 33646505764 scopus 로고    scopus 로고
    • Altered keratin 17 peptide ligands inhibit in vitro proliferation of keratinocytes and T cells isolated from patients with psoriasis
    • Shen Z, Chen L, Liu YF etal. Altered keratin 17 peptide ligands inhibit in vitro proliferation of keratinocytes and T cells isolated from patients with psoriasis. J Am Acad Dermatol 2006; 54:992-1002.
    • (2006) J Am Acad Dermatol , vol.54 , pp. 992-1002
    • Shen, Z.1    Chen, L.2    Liu, Y.F.3
  • 38
    • 0032825299 scopus 로고    scopus 로고
    • Selection of conserved TCR VDJ rearrangements in chronic psoriatic plaques indicates a common antigen in psoriasis vulgaris
    • Prinz JC, Vollmer S, Boehncke WH, Menssen A, Laisney I, Trommler P. Selection of conserved TCR VDJ rearrangements in chronic psoriatic plaques indicates a common antigen in psoriasis vulgaris. Eur J Immunol 1999; 29:3360-3368.
    • (1999) Eur J Immunol , vol.29 , pp. 3360-3368
    • Prinz, J.C.1    Vollmer, S.2    Boehncke, W.H.3    Menssen, A.4    Laisney, I.5    Trommler, P.6
  • 39
    • 80052143748 scopus 로고    scopus 로고
    • Multiparameter grouping delineates heterogeneous populations of human IL-17 and/or IL-22 T-cell producers that share antigen specificities with other T-cell subsets
    • Larsen M, Arnaud L, Hie M etal. Multiparameter grouping delineates heterogeneous populations of human IL-17 and/or IL-22 T-cell producers that share antigen specificities with other T-cell subsets. Eur J Immunol 2011; 41:2596-2605.
    • (2011) Eur J Immunol , vol.41 , pp. 2596-2605
    • Larsen, M.1    Arnaud, L.2    Hie, M.3
  • 40
    • 0142151733 scopus 로고    scopus 로고
    • The fine specificity and cytokine profile of T-helper cells responsive to the alpha3 chain of type IV collagen in Goodpasture's disease
    • Cairns LS, Phelps RG, Bowie L etal. The fine specificity and cytokine profile of T-helper cells responsive to the alpha3 chain of type IV collagen in Goodpasture's disease. J Am Soc Nephrol 2003; 14:2801-2812.
    • (2003) J Am Soc Nephrol , vol.14 , pp. 2801-2812
    • Cairns, L.S.1    Phelps, R.G.2    Bowie, L.3
  • 41
    • 0037114635 scopus 로고    scopus 로고
    • Interleukin-10-mediated regulatory T-cell responses to epitopes on a human red blood cell autoantigen
    • Hall AM, Ward FJ, Vickers MA, Stott LM, Urbaniak SJ, Barker RN. Interleukin-10-mediated regulatory T-cell responses to epitopes on a human red blood cell autoantigen. Blood 2002; 100:4529-4536.
    • (2002) Blood , vol.100 , pp. 4529-4536
    • Hall, A.M.1    Ward, F.J.2    Vickers, M.A.3    Stott, L.M.4    Urbaniak, S.J.5    Barker, R.N.6
  • 42
    • 34248336272 scopus 로고    scopus 로고
    • Mapping helper T-cell epitopes on platelet membrane glycoprotein IIIa in chronic autoimmune thrombocytopenic purpura
    • Sukati H, Watson HG, Urbaniak SJ, Barker RN. Mapping helper T-cell epitopes on platelet membrane glycoprotein IIIa in chronic autoimmune thrombocytopenic purpura. Blood 2007; 109:4528-4538.
    • (2007) Blood , vol.109 , pp. 4528-4538
    • Sukati, H.1    Watson, H.G.2    Urbaniak, S.J.3    Barker, R.N.4
  • 43
    • 36248965294 scopus 로고    scopus 로고
    • TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
    • McGeachy MJ, Bak-Jensen KS, Chen Y etal. TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat Immunol 2007; 8:1390-1397.
    • (2007) Nat Immunol , vol.8 , pp. 1390-1397
    • McGeachy, M.J.1    Bak-Jensen, K.S.2    Chen, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.