Mapping helper T-cell epitopes on platelet membrane glycoprotein IIIa in chronic autoimmune thrombocytopenic purpura

Blood

Volumn 109, Issue 10, 2007, Pages 4528-4538

  Sukati, Hosea ^a,b   Watson, Henry G ^c   Urbaniak, Stanislaw J ^a,b   Barker, Robert N ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b Department of Medicine   (United Kingdom)

^c ABERDEEN ROYAL INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CD3 ANTIGEN; CORTICOSTEROID DERIVATIVE; DAPSONE; GLYCOPROTEIN IIIA; HLA ANTIGEN CLASS 2; IMMUNOGLOBULIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE;

ADULT; AGED; ARTICLE; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CHRONIC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; EPITOPE MAPPING; FEMALE; HELPER CELL; HUMAN; MALE; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; THROMBOCYTE MEMBRANE; THROMBOCYTOPENIC PURPURA;

EID: 34248336272     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2006-09-044388     Document Type: Article

References (52)

1. Semple JW. Immune pathophysiology of autoimmune thrombocytopenic purpura. Blood Rev. 2002;16:9-12.
2. Cines DB, Blanchette VS. Medical progress: immune thrombocytopenic purpura. N Engl J Med. 2002;346:995-1008.
3. Lechner K. Management of adult immune thrombocytopenia. Rev Clin Exp Hematol. 2001;5:222-235.
4. British Committee for Standards in Haematology Taskforce. Guidance on the investigation and management of idiopathic thrombocytopenic purpura in adults, children and pregnancy. Br J Haematol. 2003;120:574-596.
5. Lazarus AH, Freedman J, Semple JW. Intravenous immunoglobulin and anti-D in idiopathic thrombocytopenic purpura (ITP): mechanisms of action. Transfus Sci. 1998;19:289-294.
6. Fabris F, Tassan T, Ramon R. Age as the major predictive factor of long term response to splenectomy in immune thrombocytopenic purpura. Br J Haematol. 2001;112:637-640.
7. He R, Reid DM, Jones CE. Spectrum of Ig classes, specificities, and titers of serum antiglycoproteins in chronic idiopathic thrombocytopenic purpura. Blood. 1994;83:1024-1032.
8. McMillan R. Autoantibodies and autoantigens in chronic immune thrombocytopenic purpura. Semin Hematol. 2000;37:239-248.
9. Hurlimann-Forster M, Steiner B, von Felten A. Quantitation of platelet-specific autoantibodies in platelet eluates of ITP patients measured by a novel ELISA using the purified glycoprotein complexes GPIIb/IIIa and GPIb/IX as antigens. Br J Haematol. 1997;98:328-335.
10. Kuwana M, Okazaki Y, Kaburaki J, Ikeda Y. Detection of circulating B cells secreting platelet-specific autoantibody is useful in the diagnosis of autoimmune thrombocytopenia. Am J Med. 2003;114:322-325.
11. Elson CJ, Barker RN. Helper T cells in antibody-mediated, organ-specific autoimmunity. Curr Opin Immunol. 2000;12:664-669.
12. Shen C-R, Youssef A-R, Devine A, et al. Peptides containing a dominant T-cell epitope from red cell Band 3 have in vivo immunomodulatory properties in NZB mice with autoimmune hemolytic anemia. Blood. 2003;102:3800-3806.
13. Semple JW, Freedman J. Increased antiplatelet T-helper lymphocyte reactivity in patients with autoimmune thrombocytopenia. Blood. 1991;78:2619-2625.
14. Ware RE, Howard TA. Phenotypic and clonal analysis of T lymphocytes in childhood immune thrombocytopenic purpura. Blood. 1993;82:2137-2142.
15. Shimomura T, Fujimura K, Takafuta T. Oligoclonal accumulation of T cells in peripheral blood from patients with idiopathic thrombocytpenic purpura. Br J Haematol. 1996; 95:732-737.
16. Filion MC, Bradley AJ, Devine DV. Autoreactive T-cells in healthy individuals show tolerance in vitro with characteristics similar to but distinct from clonal anergy. Eur J Immunol. 1995;25:3123-3127.
17. Kuwana M, Kaburaki J, Ikeda Y. Autoreactive T cells to platelet GPIIb-IIIa in thrombocytopenic purpura. J Clin Invest. 1998;102:1393-1402.
18. Kuwana M, Kaburaki J, Kitasato H, Miyako K. Immuodominant epitopes on glycoprotein IIb-IIIa recognized by autoreactive T cells in patients with immune thrombocytopenic purpura. Blood. 2001;98:130-139.
19. Kuwana M, Okazaki Y, Kaburaki J. Spleen is a primary site for activation of platelet-reactive T and B cells in patients with immune thrombocytopenic purpura. J Immunol. 2002;168:3675-3682.
20. Olsson B, Andersson PO, Jernas M, et al. T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Nat Med. 2003;9:1123-1124.
21. Kuwana M, Nomura S, Fujimura K, et al. Effect of a single injection of humanized anti-CD154 monoclonal antibody on the platelet-specific autoimmune response in patients with immune thrombocytopenic purpura. Blood. 2004;103:1229-1236.
22. Watts C. Capture and processing of exogenous antigens for presentation on MHC molecules. Annu Rev Immunol. 1997;15:821-850.
23. Larche M, Wraith DC. Peptide-based therapeutic vaccines for allergic and autoimmune diseases. Nat Med. 2005;11:S69-76.
24. Hall AM, Cairns LS, Altmann DM, Barker RN, Urbaniak SJ. Immune responses and tolerance to the RhD blood group protein in HLA-transgenic mice. Blood. 2005;105:2175-2179.
25. + interferon-γ T helper type 1 cells to sites of allergen-induced late-phase skin reactions in cat-allergic subjects. Clin Exp Allergy. 2005;35:52-58.
26. Prakken BJ, Samodal R, Le TD, et al. Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2004;101:4228-4233.
27. Raz I, Elias D, Avron A, Tamir M, Metzger M, Cohen IR. Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial. Lancet. 2001;358:1749-1753.
28. Barker RN, Hall AM, Standen GR, Jones J, Elson CJ. Identification of T-cell epitopes on the rhesus polypeptides in autoimmune haemolytic anemia. Blood. 1997;90:2701-2715.
29. Stott L, Barker RN, Urbaniak SJ. Identification of alloreactive T-cell epitopes on the rhesus D protein. Blood. 2000;96:4011-4019.
30. Cairns LS, Phelps RG, Bowie L, et al. The fine specificity and cytokine profile of T-helper cells responsive to the α3 chain of type IV collagen in Goodpasture's disease. J Am Soc Nephrol. 2003;14:2801-2812.
31. Kekomaki R, Dawson B, McFarland J. Localization of human platelet autoantigens to the cysteine-rich region of glycoprotein IIIa. J Clin Invest. 1991;88: 847-854.
32. Young NS, Calado RT, Scheinberg P. Current concepts in the pathophysiology and treatment of aplastic anemia. Blood. 2006;108:2509-2519.
33. Bessos H, Hofner M, Salamat A. An international trial demonstrates suitability of a newly developed whole-blood ELISA kit for multicentre platelet HPA-1 phenotyping. Vox Sang. 1999;77:103-106.
34. Sukati H, Bessos H, Barker RN, Urbaniak SJ. Characterization of the alloreactive helper T-cell response to the platelet membrane glycoprotein IIIa (integrin-β3) in human platelet antigen-1a alloimmunized human platelet antigen-1b1b women. Transfusion. 2005;45:1165-1177.
35. Frachet P, Uzan G, Thevenon D. GPIIb and GPIIIa amino acid sequences deduced from human megakaryocyte cDNAs. Mol Biol Rep. 1990;14:27-33.
36. Barker RN, Elson CJ. Multiple self epitopes on the Rhesus polypeptides stimulate immunologically ignorant human T cells in vitro. Eur J Immunol. 1994;24:1578-1582.
37. Devereux G, Hall AM, Barker RN. Measurement of T-helper cytokines secreted by cord blood mononuclear cells in response to allergens. J Immunol Methods. 2000;234:13-22.
38. Singh H, Raghava GPS. ProPred: prediction of HLA-DR binding sites. Bioinformatics. 2001;17:1236-1237.
39. Stumiolo T, Bono E, Ding J, et al. Generation of tissue-specific and promiscuous HLA ligand database using DNA microarrays and virtual HLA class II matrices. Nat Biotechnol. 1999;17:555-561.
40. Tuohy VK, Yu M, Weinstock-Guttman B, Kinkel RP. Diversity and plasticity of self-recognition during development of multiple sclerosis. J Clin Invest. 1997;99:1682-1690.
41. Mazza G, Ponsford M, Lowrey P, Campbell MJ, Zajicek J, Wraith DC. Diversity and dynamics of the T-cell response to MBP in DR2+ve individuals. Clin Exp Immunol. 2002;128:538-547.
42. Takashiba S, Ohyama H, Oyaizu K, Kogoe-Kato N, Murayama Y. HLA genetics for diagnosis of susceptibility to early-onset periodontitis. J Periodontal Res. 1999;34:374-378.
43. 3. J Clin Invest. 2005;115:3363-3369.
44. Elson CJ, Barker RN, Thompson SJ, Williams NA. Immunologically ignorant autoreactive T cells, epitope spreading and repertoire limitation. Immunol Today. 1995;16:71-76.
45. Manoury B, Mazzeo D, Fugger L, et al. Destructive processing by asparagine endopeptidase limits presentation of a dominant T cell epitope in MBP. Nat Immunol. 2002;3:169-174.
46. Liu GY, Fairchild PJ, Smith RM, Prowle JR, Kioussis D, Wraith DC. Low avidity recognition of self-antigen by T cells permits escape from central tolerance. Immunity. 1995;3:407-415.
47. Fairchild PJ, Wraith DC. Lowering the tone: mechanisms of immunodominance among epitopes with low affinity for MHC. Immunol Today. 1996;17:80-85.
48. + T cell clones - implications for molecular mimicry and T cell survival. Int Immunol. 1999;12:375-383.
49. Arif S, Tree TI, Astill TP, et al. Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health. J Clin Invest. 2004;113:451-463.
50. Ohnishi Y, Tsutsumi A, Sakamaki T, Sumida T. T cell epitopes of type II collagen in HLA-DRB1*0101 or DRB1*0405-positive Japanese patients with rheumatoid arthritis. Int J Mol Med. 2003;11:331-335.
51. Shen CR, Wraith DC, Elson CJ. Splenic but not thymic autoreactive T cells from New Zealand Black mice respond to a dominant erythrocyte Band 3 peptide. Immunology. 1999;96:595-599.
52. Kuwana M, Kaburaki J, Pandey JP, et al. HLA class II alleles in Japanese patients with immune thrombocytopenic purpura. Associations with anti-platelet glycoprotein autoantibodies and responses to splenectomy. Tissue Antigens. 2000;56:337-343.