Transition between Acute and Chronic Hepatotoxicity in Mice Is Associated with Impaired Energy Metabolism and Induction of Mitochondrial Heme Oxygenase-1

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Nikam, Aniket ^a   Patankar, Jay V ^a   Lackner, Carolin ^a   Schöck, Elisabeth ^a   Kratky, Dagmar ^a   Zatloukal, Kurt ^a   Abuja, Peter M ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDRO 2,4,6 TRIMETHYL 3,5 PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER; 8 HYDROXYDEOXYGUANOSINE; ADENOSINE TRIPHOSPHATE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; HEME OXYGENASE 1; LACTATE DEHYDROGENASE; MALONALDEHYDE; MITOCHONDRIAL DNA; SUCCINATE DEHYDROGENASE (UBIQUINONE); TRANSCRIPTION FACTOR NRF2; 3,5-DIETHOXYCARBONYL-1,4-DIHYDROCOLLIDINE; HEAT SHOCK PROTEIN; KERATIN; PYRIDINE DERIVATIVE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SQSTM1 PROTEIN, MOUSE;

ACUTE TOXICITY; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELLULAR DISTRIBUTION; CHRONIC TOXICITY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENERGY METABOLISM; ENZYME ACTIVITY; LACTATE DEHYDROGENASE BLOOD LEVEL; LIPID PEROXIDATION; LIVER MITOCHONDRION; LIVER TOXICITY; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; WEIGHT REDUCTION; ACUTE DISEASE; ANIMAL; BODY WEIGHT; DRUG EFFECTS; ENZYME INDUCTION; GENE EXPRESSION; GENETICS; LIVER; LIVER CELL; MALLORY BODY; METABOLISM; MITOCHONDRION; PATHOLOGY; PROTEIN FOLDING; TIME; TOXIC HEPATITIS; TOXICITY;

MUS;

ACUTE DISEASE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOSINE TRIPHOSPHATE; ANIMALS; BODY WEIGHT; DRUG-INDUCED LIVER INJURY; DRUG-INDUCED LIVER INJURY, CHRONIC; ENERGY METABOLISM; ENZYME INDUCTION; GENE EXPRESSION; HEAT-SHOCK PROTEINS; HEME OXYGENASE-1; HEPATOCYTES; KERATINS; LIVER; MALE; MALLORY BODIES; MICE; MITOCHONDRIA; OXIDATIVE STRESS; PROTEIN FOLDING; PYRIDINES; TIME FACTORS;

EID: 84878780962     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066094     Document Type: Article

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