The hydrolase DDAH2 enhances pancreatic insulin secretion by transcriptional regulation of secretagogin through a Sirt1-dependent mechanism in mice

FASEB Journal

Volumn 27, Issue 6, 2013, Pages 2301-2315

  Hasegawa, Kazuhiro ^a   Wakino, Shu ^a   Kimoto, Masumi ^b   Minakuchi, Hitoshi ^a   Fujimura, Keiko ^a   Hosoya, Koji ^a   Komatsu, Motoaki ^a   Kaneko, Yuka ^a   Kanda, Takeshi ^a   Tokuyama, Hirobumi ^a   Hayashi, Koichi ^a   Itoh, Hiroshi ^a  

^a KEIO UNIVERSITY   (Japan)

^b OKAYAMA PREFECTURAL UNIVERSITY   (Japan)

Author keywords

cells; Glucose tolerance; Glucose stimulated insulin secretion; Knockout; Overexpression

Indexed keywords

DIMETHYLARGININASE; DIMETHYLARGININE DIMETHYLAMINOHYDROLASE 2; DOCKING PROTEIN; GLUCOSE; INSULIN; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE; SECRETAGOGIN; SIRTUIN 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; INSULIN RELEASE; LIPID DIET; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UPREGULATION;

Β CELLS; GLUCOSE TOLERANCE; GLUCOSE-STIMULATED INSULIN SECRETION; KNOCKOUT; OVEREXPRESSION;

AMIDOHYDROLASES; ANIMALS; BLOOD GLUCOSE; CALCIUM-BINDING PROTEINS; CELL LINE; FEMALE; INSULIN; INSULIN RESISTANCE; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; PANCREAS; SIGNAL TRANSDUCTION; SIRTUIN 1; UP-REGULATION;

MUS; MUS MUSCULUS;

EID: 84878765036     PISSN: None     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.12-226092     Document Type: Article

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