Synthesis, molecular modeling, and in vitro screening of monoamine oxidase inhibitory activities of some novel hydrazone derivatives

Journal of Neural Transmission

Volumn 120, Issue 6, 2013, Pages 883-891

  Salgin Gökşen, Umut ^a,b   Gökhan Kelekçi, Nesrin ^a   Yabanoglu Çiftci, Samiye ^a   Yelekçi, Kemal ^c   Uçar, Gülberk ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

^b Turkish Medicines and Medical Devices Agency Analyses and Control Laboratories   (Turkey)

^c KADIR HAS UNIVERSITY   (Turkey)

Author keywords

5 methyl 2 benzoxazolinone; Human monoamine oxidase B inhibitors; Hydrazone; Molecular docking

Indexed keywords

2 [2 (5 METHYL 2 BENZOXAZOLINONE 3 YL)ACETYL] 3/4/5 SUBSTITUTED BENZYLIDENEHYDRAZINE DERIVATIVE; AMINE OXIDASE (FLAVIN CONTAINING); AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; BENZALDEHYDE DERIVATIVE; HYDRAZONE DERIVATIVE; MONOAMINE OXIDASE B INHIBITOR; SELEGILINE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CRYSTAL STRUCTURE; DRUG BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; IN VITRO STUDY; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION TIME;

DRUG EVALUATION, PRECLINICAL; HUMANS; HYDRAZONES; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PROTEIN BINDING; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84878699680     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-013-0968-2     Document Type: Article

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