N-Propynyl analogs of β-phenylethylidenehydrazines: Synthesis and evaluation of effects on glycine, GABA, and monoamine oxidase

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 17, 2008, Pages 8254-8263

  MacKenzie, Erin M ^a   Fassihi, Afshin ^b   Davood, Asghar ^b   Chen, Qiao Hong ^b   Rauw, Gillian ^a   Rauw, Gail ^a   Knaus, Edward E ^b   Baker, Glen B ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Aminobutyric acid (GABA); Glycine; Monoamine oxidase (MAO); N Propynyl analogs of phenylethylidenehydrazine (PEH)

Indexed keywords

4 AMINOBUTYRATE AMINOTRANSFERASE; 4 AMINOBUTYRIC ACID; ALANINE; AMINE OXIDASE (FLAVIN CONTAINING); BETA PHENYLETHYLIDENEHYDRAZINE DERIVATIVE; GLUTAMIC ACID; GLYCINE; HYDRAZINE DERIVATIVE; PROPANE; PROPYNYL DERIVATIVE; UNCLASSIFIED DRUG;

4 AMINOBUTYRIC ACID BRAIN LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; NEUROPROTECTION; NONHUMAN; PROTEIN BLOOD LEVEL; RAT; SUBSTITUTION REACTION;

4-AMINOBUTYRATE TRANSAMINASE; ALKYNES; ANIMALS; BRAIN; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; ENZYME INHIBITORS; GLYCINE; HYDRAZINES; MALE; MOLECULAR STRUCTURE; MONOAMINE OXIDASE; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 50349086297     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.07.027     Document Type: Article

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