A new therapeutic approach in Alzheimer disease: Some novel pyrazole derivatives as dual MAO-B inhibitors and antiinflammatory analgesics

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 17, 2007, Pages 5775-5786

  Gökhan Kelekçi, Nesrin ^a   Yabanoǧlu, Samiye ^a   Küpeli, Esra ^b   Salgin, Umut ^a   Özgen, Özen ^a   Uçar, Gülberk ^a   Yeşilada, Erdem ^c   Kendi, Engin ^a   Yeşilada, Akgül ^a   Bilgin, A Altan ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

^b GAZI UNIVERSITY   (Turkey)

^c YEDITEPE UNIVERSITY   (Turkey)

Author keywords

Alzheimer; Analgesic antiinflammatory activity; Monoamine oxidase A B inhibition; Pyrazole derivatives

Indexed keywords

1 N ALLYLTHIOCARBAMOYL 3 (4 METHOXYPHENYL) 5 (2 PYRROLYL) 4,5 DIHYDRO (1H) PYRAZOLE; 1,4 BENZOQUINONE; ACETIC ACID; ACETYLSALICYLIC ACID; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; CARRAGEENAN; CLORGYLINE; INDOMETACIN; MONOAMINE OXIDASE B INHIBITOR; PARGYLINE; PYRAZOLE DERIVATIVE; THIOCARBAMIC ACID DERIVATIVE; THIOCARBAMOYL 3 PHENYL 5 (PYRROL 2 YL) 4,5 DIHYDRO (1H) PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CAPILLARY PERMEABILITY; CONTROLLED STUDY; DRUG MECHANISM; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; MALE; MOUSE; NONHUMAN; PAW EDEMA; RAT; ULCEROGENESIS;

ALZHEIMER DISEASE; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; EDEMA; HINDLIMB; HYDROGEN BONDING; ISOENZYMES; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; MUS;

EID: 34447280369     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.06.004     Document Type: Article

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