N-acetylcysteine enhances cystic fibrosis sputum penetration and airway gene transfer by highly compacted DNA nanoparticles

Molecular Therapy

Volumn 19, Issue 11, 2011, Pages 1981-1989

  Suk, Jung Soo ^a   Boylan, Nicholas J ^b   Trehan, Kanika ^c   Tang, Benjamin C ^b,e   Schneider, Craig S ^b   Lin, Jung Ming G ^b   Boyle, Michael P ^a   Zeitlin, Pamela L ^a   Lai, Samuel K ^a,f   Cooper, Mark J ^a,b   Hanes, Justin ^d  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Johns Hopkins University   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d Massachusetts Institute of Technology ^*  (United States)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^f University of North Carolina   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; BACTERIUM LIPOPOLYSACCHARIDE; DNA; DORNASE ALFA; MACROGOL; NANOPARTICLE; POLYLYSINE; SODIUM CHLORIDE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; CYSTIC FIBROSIS; DIFFUSION; DRUG EFFECT; DRUG EFFICACY; EX VIVO STUDY; FEMALE; GENE EXPRESSION; HUMAN; MALE; MONOTHERAPY; MOUSE; MUCOLYSIS; MUCUS SECRETION; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PSEUDOMONAS AERUGINOSA; SPUTUM;

MUS; PSEUDOMONAS AERUGINOSA;

EID: 80455155066     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2011.160     Document Type: Article

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