Mitochondrial aldehyde dehydrogenase-2 activation prevents β-amyloid-induced endothelial cell dysfunction and restores angiogenesis

Journal of Cell Science

Volumn 126, Issue 9, 2013, Pages 1952-1961

  Solito, Raffaella ^a   Corti, Federico ^a   Chen, Che Hong ^b   Mochly Rosen, Daria ^b   Giachetti, Antonio ^a   Ziche, Marina ^a   Donnini, Sandra ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aldehyde dehydrogenase 2; Amyloid ; Angiogenesis; Mitochondria

Indexed keywords

4 HYDROXYNONEAL; ALDA 1; ALDEHYDE; ALDEHYDE DEHYDROGENASE ISOENZYME 2; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; BETA CATENIN; CYTOCHROME C; ENZYME INHIBITOR; FIBROBLAST GROWTH FACTOR 2; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANGIOGENESIS; APOPTOSIS; ARTICLE; CELL CULTURE; CELL MIGRATION; CONTROLLED STUDY; DETOXIFICATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENDOTHELIUM; ENDOTHELIUM CELL; ENDOTHELIUM INJURY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; TIGHT JUNCTION;

ALDEHYDE DEHYDROGENASE 2; AMYLOID Β; ANGIOGENESIS; MITOCHONDRIA;

ALDEHYDE DEHYDROGENASE; AMYLOID BETA-PEPTIDES; BENZAMIDES; BENZODIOXOLES; BETA CATENIN; ENZYME ACTIVATION; ENZYME ACTIVATORS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MEMBRANE POTENTIALS; MITOCHONDRIAL PROTEINS; NEOVASCULARIZATION, PHYSIOLOGIC; OXIDATIVE STRESS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES;

EID: 84878646821     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.117184     Document Type: Article

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