TAT-BH4 counteracts Aβ toxicity on capillary endothelium

FEBS Letters

Volumn 581, Issue 4, 2007, Pages 702-706

  Cantara, S ^a   Thorpe, P E ^b   Ziche, M ^a   Donnini, S ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Beta amyloid; Cerebral amyloid angiopathy; Endothelium; TAT BH4

Indexed keywords

AMYLOID BETA PROTEIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; PROTEIN BCL XL; TRANSACTIVATOR PROTEIN;

ALZHEIMER DISEASE; ARTICLE; BRAIN HEMORRHAGE; CAPILLARY ENDOTHELIUM; CELL DEATH; ENDOTHELIUM CELL; ENZYME ACTIVATION; MITOCHONDRION; NERVE CELL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DOMAIN; SURVIVAL; VASCULAR AMYLOIDOSIS;

AMYLOID BETA-PROTEIN; ANIMALS; APOPTOSIS; CASPASE 3; CATTLE; CELL SURVIVAL; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; GENE PRODUCTS, TAT; NITRIC OXIDE SYNTHASE TYPE III; OXIDATION-REDUCTION; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES;

EID: 33846781454     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2007.01.037     Document Type: Article

References (17)

1. Haass C., and Selkoe D.J. A technical KO of amyloid beta peptide. Nature 391 (1998) 339-340
2. Yan S.D., Fu J., Soto C., Zhu H., Al-Mohanna F., Collison K., Zhu A., Stern E., Saido T., Tohyama M., Ogawa S., Roher A., and Stern D. An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease. Nature 389 (1997) 689-695
3. del Zoppo G., and Takuma M. Cerebral microvessel responses to cerebral ischemia. Int. Soc. Cereb. Blood Flow Met. 23 (2003) 879-894
4. Xu J., Chen S., Ku G., Ahmed HS., Xu J., Chen H., and Hsu C. Amyloid beta peptide-induced cerebral endothelial cell death involves mitochondrial dysfunction and caspase activation. J. Cereb. Blood Flow Met. 21 (2001) 702-710
5. Marsden V.S., O'Connor L., O'Reilly L.A., Silke J., Metcalf D., Ekert P.G., Huang D.C., Cecconi F., Kuida K., Tomaselli K.J., Roy S., Nicholson D.W., Vaux D.L., Bouillet P., Adams J.M., and Strasser A. Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome. Nature 419 (2002) 634-637
6. Shimizu S., Konishi A., Kodama T., and Tsujimoto Y. BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death. PNAS 97 (2000) 3100-3105
7. Sugioka R., Shimizu S., Funatsu T., Tamagawa H., Sawa Y., Kawakami T., and Tsujimoto Y. BH4-domain peptide from Bcl-xL exerts anti-apoptotic activity in vivo. Oncogene 22 (2003) 8432-8440
8. Cantara S., Donnini S., Giachetti A., Thorpe P.E., and Ziche M. Exogenous BH4/Bcl-2 peptide reverts coronary endothelial cell apoptosis induced by oxidative stress. J. Vasc. Res. 41 (2004) 202-207
9. Ziche M., Parenti A., Ledda F., Dell'Era P., Granger H.J., Maggi C.A., and Presta M. Nitric oxide promotes proliferation and plasminogen activator production by coronary venular endothelium through endogenous bFGF. Circ. Res. 80 (1997) 845-852
10. Parenti A., Morbidelli L., Cui X.L., Douglas J.G., Hood J.D., Granger H.J., Ledda F., and Ziche M. Nitric oxide is an upstream signal of vascular endothelial growth factor-induced extracellular signal-regulated kinase 1/2 activation in postcapillary endothelium. J. Biol. Chem. 273 (1998) 4220-4226
11. Dhitavat S., Ortiz D., Rogers E., Rivera E., and Shea T.B. Folate, vitamin E, and acetyl-l-carnitine provide synergistic protection against oxidative stress resulting from exposure of human neuroblastoma cells to amyloid-beta. Brain Res. 1061 (2005) 114-117
12. Kadowaki H., Nishitoh H., Urano F., Sadamitsu C., Matsuzawa A., Takeda K., Masutani H., Yodoi J., Urano Y., Nagano T., and Ichijo H. Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation. Cell Death Diff. 12 (2005) 19-24
13. Le Bras M., Clement M.V., Pervaiz S., and Brenner C. Reactive oxygen species and the mitochondrial signaling pathway of cell death. Histol. Histopathol. 20 (2005) 205-219
14. Venturini G., Colasanti M., Persichini T., Fioravanti E., Ascenzi P., Palomba L., Cantoni O., and Musci G. Beta-amyloid inhibits NOS activity by subtracting NADPH availability. FASEB J. 16 14 (2002) 1970-1972
15. Gentile M.T., Vecchione C., Maffei A., Aretini A., Marino G., Poulet R., Capobianco L., Selvetella G., and Lembo G. Mechanisms of soluble beta-amyloid impairment of endothelial function. J. Biol. Chem. 279 46 (2004) 48135-48142
16. Kim D., and Chung J. Akt: versatile mediator of cell survival and beyond. J. Biochem. Mol. Biol. 35 (2002) 106-115
17. Lai C.H., Kuo K.H., and Leo J.M. Critical role of actin in modulating BBB permeability. Brain Res. Brain Res. Rev. 50 1 (2005) 7-13