Parathyroid hormone (PTH) decreases sodium-phosphate cotransporter type IIa (NpT2a) mRNA stability

American Journal of Physiology - Renal Physiology

Volumn 304, Issue 8, 2013, Pages 1076-1085

  Murray, Rebecca D ^b   Holthouser, Kristine ^b   Clark, Barbara J ^c   Salyer, Sarah A ^b   Barati, Michelle T ^b   Khundmiri, Syed J ^a,b   Lederer, Eleanor D ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b University of Louisville School of Medicine   (United States)

^c UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

mRNA half life; NHERF; Phosphate transport; Proximal renal tubule; PTH

Indexed keywords

CYCLIN D1; GAMMA GLUTAMYLTRANSFERASE; MESSENGER RNA; PARATHYROID HORMONE; PARATHYROID HORMONE RECEPTOR; SODIUM PHOSPHATE COTRANSPORTER 2A;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASOLATERAL MEMBRANE; BRUSH BORDER; CONTROLLED STUDY; DESENSITIZATION; GENE EXPRESSION; HORMONE ACTION; KIDNEY PROXIMAL TUBULE; LONG TERM EXPOSURE; MOUSE; NONHUMAN; PHOSPHATE TRANSPORT; PHOSPHATURIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RNA STABILITY; RNA TRANSCRIPTION; TRANSGENIC MOUSE;

EID: 84878642066     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00632.2012     Document Type: Article

References (62)

1. Armbrecht JH, Hodam TL, Boltz MA. Hormonal regulation of 25-hydroxyvitamin D3-1a-hydroxylase and 24-hydroxylase gene transcription in opossum kidney cells. Arch Biochem Biophysics 402: 298-304, 2003.
2. + exchanger NHE-3 isoform in renal cells (OK) via a dual signaling cascade involving protein kinase A and C. J Biol Chem 270: 20004-20010, 1995.
3. Ba J, Brown D, Friedman PA. Calcium-sensing receptor regulation of PTH-inhibitable proximal tubule phosphate transport. Am J Physiol Renal Physiol 285: F1233-F1243, 2003.
4. +/phosphate cotransporter NaPi-IIa is internalized via the receptor-mediated endocytic route in response to parathyroid hormone. Kidney Int 69: 495-503, 2006.
5. Bank N, Aynediian HS. A micropuncture study of the effect of parathyroid hormone on renal bicarbonate reabsorption. J Clin Invest 58: 336-344, 1976.
6. Beck L, Karaplis AC, Amizuka N, Hewson AS, Ozawa H, Tenenhouse HS. Targeted inactivation of Npt2 in mice leads to severe phosphate wasting, hypercalciuria and skeletal abnormalities. Proc Natl Acad Sci USA 95: 5372-5377, 1998.
7. Bezerra CN, Girardi AC, Carraro-Lacroix LR, Rebouças NA. Mechanisms underlying the long-term regulation of NHE3 by parathyroid hormone. Am J Physiol Renal Physiol 294: F1232-F1237, 2008.
8. Bisello A, Chorev M, Rosenblatt M, Monticelli L, Mierke DF, Ferrari SL. Selective ligand-induced stabilization of active and desensitized parathyroid hormone type 1 receptor conformations. J Biol Chem 277: 38524-38530, 2002.
9. Blaine J, Weinman EJ, Cunningham R. The regulation of renal phosphate transport. Adv Chronic Kidney Dis 18: 77-84, 2011.
10. +-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice. Am J Physiol Cell Physiol 292: C927-C934, 2007.
11. Carpenter TO, McPhee MD, Bort R, Mitnick MA, Carnes DL. Dissociation of phosphaturia and 25(OH)D-1a-hydroxylase trophism using a novel analogue of parathyroid hormone. Am J Physiol Endocrinol Metab 262: E483-E487, 1992.
12. Chao WI, Forte LR. Rat kidney cells in primary culture: hormone-mediated desensitization of the adenosine 3',5'-monophosphate response to parathyroid hormone and calcitonin. Endocrinology 111: 252-259, 1982.
13. Chauvin S, Bencsik M, Bambino T, Nissenson. Parathyroid hormone receptor recycling: role of receptor dephosphorylation and fj-arrestin. Mol Endocrinol 16: 2720-2732, 2002.
14. Chen YC, Meier RK, Zheng S, Khundmiri SJ, Tseng MT, Lederer ED, Epstein PN, Clark BJ. Steroidogenic acute regulatory-related lipid transfer domain protein 5 localization, and regulation in renal tubules. Am J Physiol Renal Physiol 297: F380-F388, 2009.
15. Chobanian MC, Hammerman MR. Parathyroid hormone stimulates ammoniagenesis in canine renal proximal tubular segments. Am J Physiol Renal Fluid Electrolyte Physiol 255: F847-F852, 1988.
16. Cunningham R, Steplock D, Wang F, Huang H, EX, Shenolikar S, Weinman EJ. Defective parathyroid hormone regulation of NHE3 activity and phosphate adaptation in cultured NHERF-1- /- renal proximal tubule cells. J Biol Chem 279: 37815-37821, 2004.
17. +-ATPase through Gq/G11 and the calcium-independent phospholipase A2. Am J Physiol Renal Physiol 272: F781-F788, 1997.
18. Dicker F, Quitterer U, Winstel R, Honold K, Lohse MJ. Phosphory-lation-independent inhibition of parathyroid hormone receptor signaling by G protein-coupled receptor kinases. Proc Natl Acad Sci USA 96: 5476-5481, 1999.
19. Ferrari SL, Behar V, Chorev M, Rosenblatt M, Bisello A. Endocytosis of ligand-human parathyroid hormone receptor 1 complexes is protein kinase c-dependent and involves fj-arrestin2. J Biol Chem 272: 29968-29975, 1999.
20. Flannery PJ, Spurney RF. Domains of the parathyroid hormone (PTH) receptor required for regulation by G protein-coupled receptor kinases (GRKs). Biochem Pharm 62: 1047-1058, 2001.
21. Forster I, Hernando N, Sorribas V, Werner A. Phosphate transporters in renal, gastrointestinal, and other tissues. Adv Chronic Kidney Dis 18: 63-76, 2011.
22. Friedlaender MM, Wald H, Dranitzki-Elhalel M, Zajicek HK, Levi M, Popovtzer MM. Vitamin D reduces renal NaPi-2 in PTH-infused rats: complexity of vitamin D action on renal Pi handling. Am J Physiol Renal Physiol 281: F428-F433, 2001.
23. Gesty-Palmer D, Chen M, Reiter E, Ahn S, Nelson CD, Want G, Eckhardt AE, Cowan CL, Spurney RF, Luttrell LM, Lefkowitz RJ. Distinct fj-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK 1/2 activation. J Biol Chem 281: 10856-10864, 2006.
24. Henry HL, Cunningham NS, Noland TA Jr. Homologous desensitization of cultured chick kidney cells to parathyroid hormone. Endocrinology 113: 1942-1949, 1983.
25. Hilfiker H, Kvietikova I, Hartmann CM, Stange G, Murer H. Characterization of the human type II Na/Pi-cotransporter promoter. Pflügers Arch 436: 591-598, 1998.
26. 2+, vitamin D, and Pi in acid-base homeostasis. Am J Physiol Renal Fluid Electrolyte Physiol 248: F739-F752, 1985.
27. Hulter HN, Peterson JC. Acid-base homeostasis during chronic PTH excess in humans. Kidney Int 28: 187-192, 1985.
28. Imanishi Y, Hosokawa Y, Yoshimoto K, Schipani E, Mallya S, Papa-nikolaou A, Kifor O, Tokura T, Sablosky M, Ledgard F, Gronowicz G, Wang TC, Schmidt EV, Hall C, Brown EM, Bronson R, Arnold A. Primary hyperparathyroidism caused by parathyroid-targeted overexpres-sion of cyclin D1 in transgenic mice. J Clin Invest 107: 1093-1102, 2001.
29. Jaeger P, Jones W, Kashgarian M, Baron R, Clemens TL, Segre GV, Hayslett JP. Animal model of primary hyperparathyroidism. AmJ Physiol Endocrinol Metab 252: E790-E798, 1987.
30. Jaeger P, Jones W, Kashgarian M, Segre GV, Hayslett JP. Parathyroid hormone directly inhibits tubular reabsorption of bicarbonate in normo-calcaemic rats with chronic hyperparathyroidism. Eur J Clin Invest 17: 415-420, 1987.
31. Janulis M, Tembe V, Favus MJ. Role of protein kinase C in parathyroid hormone stimulation of renal 1,25-dihydroxyvitamin D3 secretion. J Clin Invest 90: 2278-2283, 1992.
32. Kaufmann M, Muff R, Stieger B, Biber J, Murer H, Fischer JA. Apical and basolateral parathyroid hormone receptors in rat renal cortical membranes. Endocrinology 134: 1173-1178, 1994.
33. +-ATPase in response to parathyroid hormone requires ERK-dependent phosphorylation of Ser-11 within the alpha1-subunit. J Biol Chem 279: 17418-17427, 2004.
34. Khundmiri SJ, Lederer E. PTH and dopamine regulate Na-K ATPase through divergent pathways. Am J Physiol Renal Physiol 282: F512-F522, 2002.
35. Khundmiri SJ, Rane MJ, Lederer ED. Parathyroid hormone regulation of type II sodium-phosphate cotransporters is dependent on an A kinase anchoring protein. J Biol Chem 278: 10134-10141, 2003.
36. Kinyamu HK, Gallagher JC, Petranick KM, Ryschon KL. Effect of parathyroid hormone (hPTH(1-34)) infusion on serum 1,25-dihydroxyvitamin D and parathyroid hormone in normal women. J Bone Miner Res 11: 1400-1405, 1996.
37. Lederer E, Miyamoto K. Clinical consequences of mutations in sodium phosphate cotransporters. Clin J Am Soc Nephrol 7: 1179-1187, 2012.
38. Lederer ED, Sohi SS, Mathiesen JM, Klein JB. Regulation of type II sodium-phosphate cotransporters by protein kinases A and C. Am J Physiol Renal Physiol 275: F270-F277, 1998.
39. Mahon MJ. Ezrin promotes functional expression and parathyroid hormone-mediated regulation of the sodium-phosphate cotransporter 2a in LLC-PK1 cells. Am J Physiol Renal Physiol 294: F667-D675, 2008.
40. Mallya SM, Gallagher JJ, Wild YK, Kifor O, Costa-Guda J, Saucier K, Brown EM, Arnold A. Abnormal parathyroid cell proliferation precedes biochemical abnormalities in a mouse model of primary hypertension. Mol Endocrinol 19: 2603-2609, 2005.
41. Martin K, McConkey CL, Jacob AK, Gonzalez EA, Khan M, Baldas-sare JJ. Effect of U-73,122, an inhibitor of phospholipase C, on actions of parathyroid hormone in opossum kidney cells. Am J Physiol Renal Fluid Electrolyte Physiol 266: F254-F258, 1994.
42. Maw-Song W, Kurokawa K. Renal gluconeogenesis: axial and inter-nephron heterogeneity and the effect of parathyroid hormone. Am J Physiol Renal Fluid Electrolyte Physiol 246: F49-F66, 1984.
43. 2+ is related to inhibition of Pi transport in OK cells. Am J Physiol Renal Physiol 259: F485-F493, 1990.
44. Moe SM, Radcliffe JS, White KE, Gattone VH 2nd, Seifert MF, Chen X, Aldridge B, Chen NX. The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response to phosphate binders in rat. J Bone Miner Res 26: 2672-2681, 2011.
45. Moosgaard B, Vestergaard P, Heickendorff L, Mosekilde L. Plasma 1,25-dihydroxyvitamin D levels in primary hyperparathyroidism depend on sex, body mass index, plasma phosphate and renal function. Clin Endocrinol 66: 35-42, 2007.
46. Murayama A, Takeyama K, Kitanaka S, Kodera Y, Kawaguchi Y, Hosoya T, Kato T. Positive and negative regulations of the renal 25-hydroxyvitamin D3 1a-hydroxylase gene by parathyroid hormone, calcitonin, and 1a,25(OH)2D3 in intact animals. Endocrinology 140: 2224-2231, 1999.
47. Nissim I, States B, Nissim I, Lin ZP, Yudkoff M. Hormonal regulation of glutamine metabolism in OK cells. Kidney Int 47: 96-105, 1995.
48. Pfister MF, Forgo J, Ziegler U, Biber J, Murer H. cAMP-dependent and -independent downregulation of type II Na-Pi cotransporters by PTH. Am J Physiol Renal Physiol 276: F720-F725, 1999.
49. Rubin MR, Bilezikian JP, McMahon DJ, Jacobs T, Shane E, Siris E, Udesky J, Silverberg SJ. The natural history of primary hyperparathyroidism with or without parathyroid surgery after 15 years. J Clin Endocrinol Metab 93: 3462-3470, 2008.
50. Sacktor B, Lepor N, Schneider EG. Stimulation of the efflux of L-glu-tamate from renal brush-border membrane vesicles by extravesicular potassium. Biosci Rep 1: 709-713, 1981.
51. Segawa H, Onitsuka A, Furutani Kaneko I J, Aranami F, Matsumoto N, Tomoe Y, Kuwahata M, Ito M, Matsumoto M, Li M, Amizuka N, Miyamoto K. Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development. Am J Physiol Renal Physiol 297: F671-F678, 2009.
52. Segawa H, Yamanaka S, Onitsuka A, Tomoe Y, Kuwahata M, Ito M, Taketani Y, Miyamoto K. Parathyroid hormone-dependent endocytosis of the renal type IIc Na-Pi cotransporter. Am J Physiol Renal Physiol 292: F395-F403, 2007.
53. Seki G, Taniguchi S, Uwatoko S, Suzuki K, Kurokawa K. Effect of parathyroid hormone on acid/base transport in rabbit renal proximal tubule S3 segment. Pflügers Arch 423: 7-13, 1993.
54. Sneddon WB, Friedman PA. fj-Arrestin-dependent parathyroid hormone-stimulated extracellular signal-regulated kinase activation and parathyroid hormone type 1 receptor internalization. Endocrinology 148: 4073-4079, 2007.
55. Syme CA, Friedman PA, Bisello A. Parathyroid hormone receptor trafficking contributes to the activation of extracellular signal-regulated kinases but is not required for regulation of cAMP signaling. J Biol Chem 280: 11281-11288, 2005.
56. +-dependent transport of phosphate across renal brush border membrane. J Biol Chem 261: 6375-6383, 1986.
57. Tenenhouse HS, Martel J, Gauthier C, Segawa H, Miyamoto K. Differential effects of Npt2a gene ablation and X-linked Hyp mutation on renal expression of Npt2c. Am J Physiol Renal Physiol 285: F1271-F1278, 2003.
58. Vilardaga JP, Frank M, Krasel C, Dees C, Nissenson RA, Lohse MJ. Differential conformational requirements for activation of G proteins and the regulatory proteins arrestin and G protein-coupled receptor kinase in the G protein-coupled receptor for parathyroid hormone (PTH)/PTH-related protein. J Biol Chem 276: 33435-33443, 2001.
59. +-Pi cotransporter PiT-2 (SLC20A2) is expressed in the apical membrane of rat renal proximal tubules and regulated by dietary Pi. Am J Physiol Renal Physiol 297: F691-F699, 2009.
60. Wang B, Yang Y, Abou-Samra AB, Friedman PA. NHERF1 regulates parathyroid hormone receptor desensitization: interference with fj-arrestin binding. Mol Pharmacol 75: 1189-1197, 2009.
61. + transporters in rats with PTH-induced hypercalcemia. Am J Physiol Renal Physiol 286: F534-F545, 2004.
62. Weinman EJ, Steplock D, Cha B, Kovbasnjuk O, Frost NA, Cunningham R, Shenolikar S, Blanpied TA, Donowitz M. PTH transiently increases the percent mobile fraction of Npt2a in OK cells as determined by FRAP. Am J Physiol Renal Physiol 297: F1560-F1565, 2009.