Primary hyperparathyroidism caused by parathyroid-targeted overexpression of cyclin d1 in transgenic mice

Journal of Clinical Investigation

Volumn 107, Issue 9, 2001, Pages 1093-1102

  Imanishi, Yasuo ^a,e   Hosokawa, Yoshitaka ^b,f   Yoshimoto, Katsuhiko ^a,g   Schipani, Ernestina ^b   Mallya, Sanjay ^a   Papanikolaou, Alexandros ^a   Kifor, Olga ^c   Tokura, Takehiko ^a   Sablosky, Marilyn ^a   Ledgard, Felicia ^a   Gronowicz, Gloria ^a   Wang, Timothy C ^b,h   Schmidt, Emmett V ^b   Hall, Charles ^a   Brown, Edward M ^c   Bronson, Roderick ^d   Arnold, Andrew ^a  

^a UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d TUFTS UNIVERSITY   (United States)

^e OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^f AICHI CANCER CENTER HOSPITAL   (Japan)

^g UNIVERSITY OF TOKUSHIMA   (Japan)

^h UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CYCLIN D1; PARATHYROID HORMONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM BLOOD LEVEL; CARCINOGENESIS; CELL CYCLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; ENDOCRINE TUMOR; GENE CONTROL; GENE OVEREXPRESSION; GENE REARRANGEMENT; HORMONE RELEASE; HUMAN; MOUSE; NONHUMAN; ONCOGENE; PARATHYROID HORMONE RELEASE; PRIMARY HYPERPARATHYROIDISM; PRIORITY JOURNAL; TRANSGENIC MOUSE;

EID: 0035014450     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI10523     Document Type: Article

References (40)

1. Abnormal calcium-regulated PTH release in normal parathyroid tissue from patients with adenoma
2. Calcium infusion suggests a "set-point" abnormality of parathyroid gland function in familial benign hypercalcemia and more complex disturbances in primary hyperparathyroidism
3. Parathyroid growth: Normal and abnormal
4. A novel cyclin encoded by a bcl1-linked candidate oncogene
5. Somatic mutation of the MEN1 gene in parathyroid tumours
6. Cancer cell cycles
7. The cyclin D1/PRAD1 oncogene in human neoplasia
8. Cyclin D1/PRAD1 expression in parathyroid adenomas: An immunohistochemical study
9. Expression of cyclin D1 in parathyroid carcinomas, adenomas, and hyperplasias: A paraffin immunohistochemical study
10. Expression of PRAD1/cyclin D1, retinoblastoma gene products, and Ki67 in parathyroid hyperplasia caused by chronic renal failure versus primary adenoma
11. Heritable formation of pancreatic beta-cell rumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes
12. Immortalization of neuroendocrine cells by targeted oncogenesis
13. SV40 T antigen transforms calcitonin cells of the thyroid but not CGRP-containing neurons in transgenic mice
14. Nucleotide sequence of the human parathyroid hormone gene
15. PRAD1/cyclin D1 proto-oncogene: Genomic organization, 5′ DNA sequence, and sequence of a tumor-specific rearrangement breakpoint
16. Absence of cyclin D1/PRAD1 point mutations in human breast cancers and parathyroid adenomas and identification of a new cyclin D1 gene polymorphism
17. Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development
18. Monoclonal antibody against PRAD1/cyclin D1 stains nuclei of tumor cells with translocation or amplification at BCL-1 locus
19. Immunohistochemical analysis of cyclin D1 protein in hematopoietic neoplasms with special reference to mantle cell lymphoma
20. Enzyme histochemistry
21. Bone histomorphometry: Standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee
22. A new method for determining micro quantities of calcium in biological materials
23. Four-parameter model of the sigmoidal relationship between parathyroid hormone release and extracellular calcium concentration in normal and abnormal parathyroid tissue
24. Reduced immunostaining for the extracellular Ca2+-sensing receptor in primary and uremic secondary hyperparathyroidism
25. The calcium-sensing receptor is localized in caveolin-rich plasma membrane domains of bovine parathyroid cells
26. Sequence analysis of hypothalamic parathyroid hormone messenger ribonucleic acid
27. Genetic ablation of parathyroid glands reveals another source of parathyroid hormone
28. Novel chromosomal abnormalities identified by comparative genomic hybridization in parathyroid adenomas
29. The histomorphometry of bone in primary hyperparathyroidism: Preservation of cancellous bone structure
30. Nonlinear mixed effects models for repeated measures data
31. Gompertzian growth curves in parathyroid tumours: Further evidence for the set-point hypothesis
32. Rates of cell proliferation in adenomatous, suppressed, and normal parathyroid tissue: Implications for pathogenesis
33. Secretion of parathyroid hormone by abnormal human parathyroid glands in vitro
34. Direct comparison in vivo and in vitro of suppressibility of parathyroid function by calcium in primary hyperparathyroidism
35. Depressed expression of calcium receptor in parathyroid gland tissue of patients with hyperparathyroidism
36. Decreased expression of calcium-sensing receptor messenger ribonucleic acids in parathyroid adenomas
37. A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism
38. Mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism
39. Familial hypercalcemia and hypercalciuria caused by a novel mutation in the cytoplasmic tail of the calcium receptor
40. Mutational analysis of the extracellular Ca(2+)-sensing receptor gene in human parathyroid tumors